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公开(公告)号：HK1028023A1
公开(公告)日：2001-02-02
申请号：HK00107516
申请日：2000-11-23
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F JR , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07C
Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：TR9903287T2
公开(公告)日：2000-09-21
申请号：TR9903287
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F JR , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , A61K31/16 , A61K31/415
CPC classification number: C07D207/404 , C07C311/05 , C07C311/18 , C07C317/28 , C07C323/47 , C07C323/62 , C07D207/408 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12
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Patent Agency Ranking
公开(公告)号：PL337854A1
公开(公告)日：2000-09-11
申请号：PL33785498
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F JR , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , A61K31/16
Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：CZ9904730A3
公开(公告)日：2000-06-14
申请号：CZ473099
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F JR , FLORJANIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN ROBIN H , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: A61K31/16 , A61P19/02 , A61P35/00 , C07C259/00 , C07C259/04
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55.发明专利
公开(公告)号：CO4920222A1
公开(公告)日：2000-05-29
申请号：CO98000266
申请日：1998-01-06
Applicant: ABBOTT LAB
Inventor： DAVIDSEN STEVEN K , GIASLER JAMIE R , CURTIN MICHAEL L , HOLMS JAMES H , FLORJANCIC ALAN SCOTT , LIANHONG XU , SHEPPARD GEORGE S , MICHAELIDES MICHAEL R , YAN GUO , WADA CAROL K
IPC: A61K31/12 , A61K31/16 , A61K31/165 , A61K31/197 , A61K31/381 , A61K31/404 , A61K31/4184 , A61K31/421 , A61K31/426 , A61K31/4406 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C233/32 , C07C259/06 , C07D207/32 , C07D207/323 , C07D207/335 , C07D209/14 , C07D213/50 , C07D235/14 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D333/22
Abstract: Un compuesto de fórmulao una sal, precursor de droga o éster farmacéuticamente aceptable de éste, en donde W es NHOH ú OH; R1 y R4 se seleccionan independientemente en cada ocurrencia del grupo conformado por hidrógeno o un alquil de uno a cuatro átomos de carbono; V es O ó NOR1 , R1 se selecciona del grupo conformado por (a) hidrógeno, (b) hidroxi, (c) alcoxi de uno a seis átomos de carbono, (d) alquil de uno a seis átomos de carbono, (e) alquil de uno a seis átomos de carbono, sustituido con (1) halógeno, (2) hidroxi, (3) alcoxi de uno a seis átomos de carbono, (4) cicloalquil de tres a ocho átomos de carbono, (5) alcanoiloxi en donde la porción alquil es de uno a cuatro átomos de carbono,(6) piridil (7) piridil sustituido con alquil de uno a cuatro átomos de carbono, (8) fenoxi en donde el anillo fenil va no sustituido o sustituido con 1, 2 ó 3 sustituyentes independientemente seleccionados entre alquil de uno a cuatro átomos de carbono, hidroxi, alcoxi de uno a cuatro átomos de carbono, halógeno, haloalquil de uno a cuatro átomos de carbono, ciano, cianoalquil, -CO2 R7 , en donde R7 es hidrógeno y alquil de uno a cuatro átomos de carbono, -CONR7 R8 , en donde R7 corresponde a lo previamente definido y R8 se selecciona entre hidrógeno, alcanoil de uno a cuatro átomos de carbono, alquil de uno a cuatro átomos de carbono, fenil, y fenil sustituido con 1, 2 ó 3 sustituyentes independientemente seleccionados entre alquil de uno a cuatro átomos de carbono, hidroxi, alcoxi de uno a cuatro átomos de carbono, halógeno, haloalquil de 1 - 4 átomos de carbono, ciano, cianoalquil,...
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56.发明专利
公开(公告)号：AU5958298A
公开(公告)日：1998-08-03
申请号：AU5958298
申请日：1998-01-07
Applicant: ABBOTT LAB
Inventor： DAVIDSEN STEVEN K , FLORJANCIC ALAN SCOTT , SHEPPARD GEORGE S , GIESLER JAMIE R , XU LIANHONG , GUO YAN , CURTIN MICHAEL L , MICHAELIDES MICHAEL R , WADA CAROL K , HOLMS JAMES H
IPC: A61K31/165 , A61K31/197 , A61K31/381 , A61K31/404 , A61K31/4184 , A61K31/421 , A61K31/426 , A61K31/4406 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C233/32 , C07C259/06 , C07D207/32 , C07D207/323 , C07D207/335 , C07D209/14 , C07D213/50 , C07D235/14 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D333/22 , C07D209/18 , A61K31/38 , A61K31/40 , A61K31/42 , A61K31/44 , C07D207/337 , C07D213/56 , C07D235/16 , C07D333/24
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57.发明专利
公开(公告)号：CA2277105A1
公开(公告)日：1998-07-16
申请号：CA2277105
申请日：1998-01-07
Applicant: ABBOTT LAB
Inventor： GIESLER JAMIE R , SHEPPARD GEORGE S , XU LIANHONG , FLORJANCIC ALAN SCOTT , HOLMS JAMES H , WADA CAROL K , GUO YAN , DAVIDSEN STEVEN K , CURTIN MICHAEL L , MICHAELIDES MICHAEL R
IPC: A61K31/165 , A61K31/197 , A61K31/381 , A61K31/404 , A61K31/4184 , A61K31/421 , A61K31/426 , A61K31/4406 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C233/32 , C07C259/06 , C07D207/32 , C07D207/323 , C07D207/335 , C07D209/14 , C07D213/50 , C07D235/14 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D333/22 , C07D209/18 , A61K31/38 , A61K31/40 , A61K31/42 , A61K31/44 , C07D207/337 , C07D213/56 , C07D235/16 , C07D333/24
Abstract: C-terminal compounds of formula (I) are potent inhibitors of matrix metalloproteinase and are useful in the treatment of diseases in which matrix metalloproteinase play a role. Also disclosed are matrix metalloproteinase inhibiting compositions and a method of inhibiting matrix metalloproteinase in a mammal.
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