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公开(公告)号：WO2009129387A2
公开(公告)日：2009-10-22
申请号：PCT/US2009040803
申请日：2009-04-16
Applicant: ABBOTT LAB , DANDE PRASAD A , HANSEN TODD M , HUBBARD ROBERT D , WADA CAROL K , TIAN LU , ZHAO XIAOBIN
Inventor： DANDE PRASAD A , HANSEN TODD M , HUBBARD ROBERT D , WADA CAROL K , TIAN LU , ZHAO XIAOBIN
IPC: C07C217/28 , C07C219/06 , C07C219/08 , C07C235/08 , C07C237/08 , C07C271/16
CPC classification number: A61K9/0019 , A61K9/1272 , A61K9/1277 , A61K47/543 , A61K47/6911 , C07C235/08 , C07C271/16 , C07D203/10 , C07D207/06 , C07D207/14 , C07D211/44 , C07D211/58 , C07D233/61 , C07D295/088 , C07D317/28 , C12N15/88
Abstract: Cationic lipids, cationic lipid based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.
Abstract translation: 公开了阳离子脂质，基于阳离子脂质的药物递送系统，其制备方法和使用它们治疗疾病的方法。
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2.发明申请N-HYDROXYFORMAMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES 审中-公开作为基质金属蛋白酶抑制剂的N-羟基甲酰胺衍生物
公开(公告)号：WO9906361A3
公开(公告)日：1999-04-22
申请号：PCT/US9815486
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F JR , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , A61K31/16 , A61K31/415
CPC classification number: C07D207/404 , C07C311/05 , C07C311/18 , C07C317/28 , C07C323/47 , C07C323/62 , C07D207/408 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
Abstract translation: 具有式（I）的化合物是基质金属蛋白酶抑制剂。 还公开了抑制哺乳动物基质金属蛋白酶的基质金属蛋白酶抑制组合物和抑制基质金属蛋白酶的方法。
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公开(公告)号：WO0246129A3
公开(公告)日：2003-01-16
申请号：PCT/US0150931
申请日：2001-10-26
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAI YUJIA , DAVIDSEN STEVEN K , FREY ROBIN R , GUO YAN , HEYMAN HOWARD R , HOLMS JAMES H , JI ZHIQIN , MICHAELIDES MICHAEL R , VASUDEVAN ANIL , WADA CAROL K
IPC: C07C45/29 , C07C45/30 , C07C45/45 , C07C45/51 , C07C45/67 , C07C47/277 , C07C49/255 , C07C59/90 , C07C69/716 , C07C235/14 , C07C235/16 , C07C235/20 , C07C235/74 , C07C235/80 , C07C243/38 , C07C255/54 , C07C255/60 , C07C311/19 , C07C317/32 , C07C317/44 , C07C323/41 , C07C323/60 , C07D209/08 , C07D209/42 , C07D213/30 , C07D213/40 , C07D213/75 , C07D215/38 , C07D231/40 , C07D235/06 , C07D257/04 , C07D263/14 , C07D263/32 , C07D263/58 , C07D271/10 , C07D277/46 , C07D277/56 , C07D277/74 , C07D277/82 , C07D285/08 , C07D295/112 , C07D307/68 , C07D307/85 , C07D317/58 , C07D317/66 , C07D317/68 , C07D413/04 , C07D413/12 , C07D417/04 , C07D491/10 , C07D295/10
CPC classification number: C07D213/30 , C07C45/29 , C07C45/30 , C07C45/45 , C07C45/515 , C07C45/673 , C07C47/277 , C07C49/255 , C07C59/90 , C07C69/716 , C07C235/14 , C07C235/16 , C07C235/20 , C07C235/74 , C07C235/80 , C07C243/38 , C07C255/54 , C07C255/60 , C07C311/19 , C07C317/32 , C07C317/44 , C07C323/41 , C07C323/60 , C07C2601/14 , C07C2603/18 , C07C2603/74 , C07D209/08 , C07D209/42 , C07D213/40 , C07D213/75 , C07D215/38 , C07D231/40 , C07D235/06 , C07D257/04 , C07D263/14 , C07D263/32 , C07D263/58 , C07D271/10 , C07D277/46 , C07D277/56 , C07D277/74 , C07D277/82 , C07D285/08 , C07D295/112 , C07D307/68 , C07D307/85 , C07D317/58 , C07D317/66 , C07D317/68 , C07D413/04 , C07D413/12 , C07D417/04 , C07D491/10
Abstract: Compounds having the formula or therapeutically acceptable salts thereof, are histone deacetylase (HDAC) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.
Abstract translation: 具有式或其治疗上可接受的盐的化合物是组蛋白脱乙酰酶（HDAC）抑制剂。 公开了化合物的制备，含有该化合物的组合物以及使用该化合物治疗疾病。
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公开(公告)号：EP1496910A4
公开(公告)日：2006-03-29
申请号：EP03718039
申请日：2003-03-21
Applicant: ABBOTT LAB
Inventor： HIRST GAVIN C , ARNOLD LEE D , BURCHAT ANDREW , WISHART NEIL , CALDERWOOD DAVID , WADA CAROL K , MICHAELIDES MICHAEL R , JI ZHIQIN , MUCKEY MELANIE
IPC: A61K31/519 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P7/06 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/08 , A61P17/02 , A61P17/06 , A61P19/02 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P31/22 , A61P33/02 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , A61P43/00 , C07D413/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D498/04
CPC classification number: C07D487/04 , C07D491/04
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公开(公告)号：AU2009251083A1
公开(公告)日：2010-01-21
申请号：AU2009251083
申请日：2009-12-22
Applicant: ABBOTT LAB
Inventor： CALDERWOOD DAVID J , MUCKEY MELANIE A , FREY ROBIN R , CURTIN MICHAEL L , BETSCHMANN PATRICK , HEYMAN HOWARD R , MICHAELIDES MICHAEL R , WADA CAROL K , RAFFETY PAUL , HIRST GAVIN C , DAVIDSEN STEVEN K , HRNCIAR PETER , BURCHAT ANDREW F , DAVIS HEATHER M
IPC: A61P35/00 , C07D491/04 , C07D495/04 , C07D498/04
Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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Patent Agency Ranking
公开(公告)号：DE602004018780D1
公开(公告)日：2009-02-12
申请号：DE602004018780
申请日：2004-07-26
Applicant: ABBOTT LAB
Inventor： BETSCHMANN PATRICK , BURCHAT ANDREW F , CALDERWOOD DAVID J , CURTIN MICHAEL L , DAVIDSEN STEVEN K , DAVIS HEATHER M , FREY ROBIN R , HEYMAN HOWARD R , HIRST GAVIN C , HRNCIAR PETER , MICHAELIDES MICHAEL R , MUCKEY MELANIE A , RAFFERTY PAUL , WADA CAROL K
IPC: C07D495/04 , A61K31/4355 , A61K31/4365 , A61P35/00 , C07D491/04 , C07D498/04
Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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公开(公告)号：MXPA06010904A
公开(公告)日：2007-06-11
申请号：MXPA06010904
申请日：2005-03-24
Applicant: ABBOTT LAB
Inventor： MICHAELIDES MICHAEL R , HOLMS JAMES H , STEINMAN DOUGLAS H , MUCKEY MELANIE A , WADA CAROL K , ARNOLD LEE D , DINGES JURGEN , DIXON RICHARD W , DJURIC STEVAN W , ERICSSON ANNA M , FISCHER KIMBA , GASIECKI ALAN F , GRACIAS VIJAYA J , RAFFERTY PAUL , XIA ZHIREN , AKRITOPOULOU-ZANZE IRINI , ZHANG HENRY Q , TAKESHITA MAKOTO
IPC: C07D409/04 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61P35/00 , A61P37/00 , C07D231/54 , C07D409/14 , C07D413/14 , C07D491/04 , C07D495/04
Abstract: Se utilizan los compuestos de la presente invencion para inhibir proteinas de tirosin-cinasas. Tambien se describen los metodos para hacer los compuestos, composiciones que los contienen y metodos de tratamiento utilizando los compuestos.
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公开(公告)号：ZA200600658B
公开(公告)日：2007-04-25
申请号：ZA200600658
申请日：2006-01-23
Applicant: ABBOTT LAB
Inventor： PATRICK BETSCHMANN , CALDERWOOD DAVID J , DAVIDSEN STEVEN K , FREY ROBIN R , HIRST GAVIN C , MICHAELIDES MICHAEL R , PAUL RAFFERTY , BURCHAT ANDREW F , CURTIN MICHAEL L , DAVIS HEATHER M , HEYMAN HOWARD R , PETER HRNCIAR , MUCKEY MELANIE A , WADA CAROL K
IPC: A61K20090101 , A61P20090101 , C07D20090101 , C07D491/04 , C07D495/04
Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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公开(公告)号：AU758870B2
公开(公告)日：2003-04-03
申请号：AU8513998
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07C259/00
Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：CA2294171A1
公开(公告)日：1999-02-11
申请号：CA2294171
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： FLORJANCIC ALAN S , MICHAELIDES MICHAEL R , GIESLER JAMIE , GONG JIANCHUN , DAVIDSEN STEVEN K , STEINMAN DOUGLAS , HEYMAN H ROBIN , DELLARIA JOSEPH F JR , CURTIN MICHAEL L , WADA CAROL K , HOLMS JAMES H , XU LIANHONG , GUO YAN
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07C259/00 , C07D249/12 , A61K31/16 , A61K31/35 , A61K31/357 , C07D209/40 , A61K31/40 , A61K31/4164 , A61K31/42 , A61K31/44 , A61K31/445
Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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