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公开(公告)号：JP2011088918A
公开(公告)日：2011-05-06
申请号：JP2010282815
申请日：2010-12-20
Applicant: Abbott Lab , アボット・ラボラトリーズAbbott Laboratories
Inventor： DAI YUJIA , DAVIDSEN STEVEN K , ERICSSON ANNA M , HARTANDI KRESNA , JI ZHIQIN , MICHAELIDES MICHAEL R
IPC: C07D231/56 , A61K31/416 , A61K31/4178 , A61K31/42 , A61K31/423 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61P9/10 , A61P17/06 , A61P19/02 , A61P27/02 , A61P35/00 , A61P37/06 , A61P43/00 , C07D261/20 , C07D275/04 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/02 , C07D413/12
CPC classification number: C07D231/56 , C07D261/20 , C07D275/04 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/04 , Y02P20/582
Abstract: PROBLEM TO BE SOLVED: To provide a compound useful for inhibiting a protein tyrosine kinase, a method for producing the compound, a composition containing the compound and a therapeutic method using the compound. SOLUTION: The compound is expressed by formula (I), wherein A is selected from the group consisting of indolye, phenyl, pyrazinyl, pyridazinyl, pyridinyl, pyrimidinyl and thienyl; X is selected from the group consisting of O, S, N and the like; and R 1 , R 2 , R 3 , R 4 and R 5 are each selected from hydrogen, alkoxy, alkoxyalkoxy, haloalkyl, heterocyclyl, heterocyclylalkenyl and the like. COPYRIGHT: (C)2011,JPO&INPIT
Abstract translation: 待解决的问题：提供一种可用于抑制蛋白质酪氨酸激酶的化合物，该化合物的制备方法，含该化合物的组合物和使用该化合物的治疗方法。 解决方案：化合物由式（I）表示，其中A选自取代基，苯基，吡嗪基，哒嗪基，吡啶基，嘧啶基和噻吩基; X选自O，S，N等; 和R
1 ，R 2 ，R 3 ，R 4 和R 5 各自选自氢，烷氧基，烷氧基烷氧基，卤代烷基，杂环基，杂环基烯基等。 版权所有（C）2011，JPO＆INPIT -
2.发明申请
公开(公告)号：WO2007067781A3
公开(公告)日：2007-07-26
申请号：PCT/US2006047078
申请日：2006-12-08
Applicant: ABBOTT LAB , MICHAELIDES MICHAEL R , MCCLELLAN WILLIAM J , FREY ROBIN R , CURTIN MICHAEL L , STEINMAN DOUGLAS H , DAI YUJIA , HOLMS JAMES H
Inventor： MICHAELIDES MICHAEL R , MCCLELLAN WILLIAM J , FREY ROBIN R , CURTIN MICHAEL L , STEINMAN DOUGLAS H , DAI YUJIA , HOLMS JAMES H
IPC: C07D487/04 , A61K31/519 , A61P35/00 , C07D495/04
CPC classification number: C07F9/6561 , C07D487/04 , C07D495/04
Abstract: Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating cancer using the compounds are disclosed.
Abstract translation: 公开了抑制蛋白激酶的化合物，含有化合物的组合物和使用该化合物治疗癌症的方法。
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3.发明申请SUBSTITUTED 7, 8-DIHYDRO-1H-PYRIMIDO[4,5-B] [1,4] DIAZEPIN-4-AMINES ARE NOVEL KINASE INHIBITORS 审中-公开取代的7,8-二氢-1H-吡咯并[4,5-B] [1,4]二氮杂-4-胺是新型激酶抑制剂
公开(公告)号：WO2006124813A2
公开(公告)日：2006-11-23
申请号：PCT/US2006018796
申请日：2006-05-16
Applicant: ABBOTT LAB , GRACIAS VIJAYA J , ABAD-ZAPATERO CELERINO , DJURIC STEVAN W , JI ZHIQIN , MICHAELIDES MICHAEL R , STEWART KENT D , ZANZE IRINI
Inventor： GRACIAS VIJAYA J , ABAD-ZAPATERO CELERINO , DJURIC STEVAN W , JI ZHIQIN , MICHAELIDES MICHAEL R , STEWART KENT D , ZANZE IRINI
CPC classification number: C07D487/04
Abstract: Compounds having the Formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
Abstract translation: 具有式（I）的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。
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4.发明申请N-HYDROXYFORMAMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES 审中-公开作为基质金属蛋白酶抑制剂的N-羟基甲酰胺衍生物
公开(公告)号：WO9906361A3
公开(公告)日：1999-04-22
申请号：PCT/US9815486
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F JR , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , A61K31/16 , A61K31/415
CPC classification number: C07D207/404 , C07C311/05 , C07C311/18 , C07C317/28 , C07C323/47 , C07C323/62 , C07D207/408 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
Abstract translation: 具有式（I）的化合物是基质金属蛋白酶抑制剂。 还公开了抑制哺乳动物基质金属蛋白酶的基质金属蛋白酶抑制组合物和抑制基质金属蛋白酶的方法。
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公开(公告)号：EP1496910A4
公开(公告)日：2006-03-29
申请号：EP03718039
申请日：2003-03-21
Applicant: ABBOTT LAB
Inventor： HIRST GAVIN C , ARNOLD LEE D , BURCHAT ANDREW , WISHART NEIL , CALDERWOOD DAVID , WADA CAROL K , MICHAELIDES MICHAEL R , JI ZHIQIN , MUCKEY MELANIE
IPC: A61K31/519 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P7/06 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/08 , A61P17/02 , A61P17/06 , A61P19/02 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P31/22 , A61P33/02 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , A61P43/00 , C07D413/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D498/04
CPC classification number: C07D487/04 , C07D491/04
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Patent Agency Ranking
公开(公告)号：EP0690863A4
公开(公告)日：1995-11-07
申请号：EP94912799
申请日：1994-03-18
Applicant: ABBOTT LAB
Inventor： MICHAELIDES MICHAEL R , HONG YUFENG
IPC: A61K31/435 , A61P1/08 , A61P9/00 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/26 , A61P25/28 , A61P39/02 , C07D491/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , A61K31/47
CPC classification number: C07D491/04 , C07D495/04 , C07D513/04
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7.发明申请THIENO [3, 2-C] PYRIDINE DERIVATIVES AS KINASE INHIBITORS FOR USE IN THE TREATMENT OF CANCER 审中-公开THIENO [3，2-C]吡啶衍生物作为激素治疗癌症用的激酶抑制剂
公开(公告)号：WO2010065825A3
公开(公告)日：2010-08-26
申请号：PCT/US2009066725
申请日：2009-12-04
Applicant: ABBOTT LAB , MICHAELIDES MICHAEL R
Inventor： MICHAELIDES MICHAEL R
IPC: C07D495/04 , A61K31/4365 , A61P35/00
CPC classification number: C07D495/04
Abstract: Compounds that inhibit protein kinases such as Aurora-kinases and the VEGFR and PDGFR families of kinases, with an improved safety profile due to low CYP3A4 inhibition, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
Abstract translation: 公开了抑制蛋白激酶例如Aurora激酶和激素的VEGFR和PDGFR家族的化合物，由于低CYP3A4抑制而具有改善的安全性，包含该化合物的组合物和使用该化合物治疗疾病的方法。
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公开(公告)号：WO2005074603A2
公开(公告)日：2005-08-18
申请号：PCT/US2005003196
申请日：2005-02-03
Applicant: ABBOTT LAB , WISHART NEIL , FRIEDMAN MICHAEL , ARNOLD LEE D , YANG BRYANT , FIX-STENZEL SHANNON R , ERICSSON ANNA , MICHAELIDES MICHAEL R , QIAN XIAO-DONG , HOLMES JAMES H , STEINMAN DOUGLAS H , TIAN ZHENGPING , WITTENBERGER STEVEN J
Inventor： WISHART NEIL , FRIEDMAN MICHAEL , ARNOLD LEE D , YANG BRYANT , FIX-STENZEL SHANNON R , ERICSSON ANNA , MICHAELIDES MICHAEL R , QIAN XIAO-DONG , HOLMES JAMES H , STEINMAN DOUGLAS H , TIAN ZHENGPING , WITTENBERGER STEVEN J
IPC: C07D487/04
CPC classification number: C07D487/04
Abstract: A compound of Formula (I), wherein the substituents are as defined herein, which are useful as kinase inhibitors.
Abstract translation: 式（I）的化合物，其中取代基如本文所定义，其可用作激酶抑制剂。
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公开(公告)号：WO0246129A3
公开(公告)日：2003-01-16
申请号：PCT/US0150931
申请日：2001-10-26
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAI YUJIA , DAVIDSEN STEVEN K , FREY ROBIN R , GUO YAN , HEYMAN HOWARD R , HOLMS JAMES H , JI ZHIQIN , MICHAELIDES MICHAEL R , VASUDEVAN ANIL , WADA CAROL K
IPC: C07C45/29 , C07C45/30 , C07C45/45 , C07C45/51 , C07C45/67 , C07C47/277 , C07C49/255 , C07C59/90 , C07C69/716 , C07C235/14 , C07C235/16 , C07C235/20 , C07C235/74 , C07C235/80 , C07C243/38 , C07C255/54 , C07C255/60 , C07C311/19 , C07C317/32 , C07C317/44 , C07C323/41 , C07C323/60 , C07D209/08 , C07D209/42 , C07D213/30 , C07D213/40 , C07D213/75 , C07D215/38 , C07D231/40 , C07D235/06 , C07D257/04 , C07D263/14 , C07D263/32 , C07D263/58 , C07D271/10 , C07D277/46 , C07D277/56 , C07D277/74 , C07D277/82 , C07D285/08 , C07D295/112 , C07D307/68 , C07D307/85 , C07D317/58 , C07D317/66 , C07D317/68 , C07D413/04 , C07D413/12 , C07D417/04 , C07D491/10 , C07D295/10
CPC classification number: C07D213/30 , C07C45/29 , C07C45/30 , C07C45/45 , C07C45/515 , C07C45/673 , C07C47/277 , C07C49/255 , C07C59/90 , C07C69/716 , C07C235/14 , C07C235/16 , C07C235/20 , C07C235/74 , C07C235/80 , C07C243/38 , C07C255/54 , C07C255/60 , C07C311/19 , C07C317/32 , C07C317/44 , C07C323/41 , C07C323/60 , C07C2601/14 , C07C2603/18 , C07C2603/74 , C07D209/08 , C07D209/42 , C07D213/40 , C07D213/75 , C07D215/38 , C07D231/40 , C07D235/06 , C07D257/04 , C07D263/14 , C07D263/32 , C07D263/58 , C07D271/10 , C07D277/46 , C07D277/56 , C07D277/74 , C07D277/82 , C07D285/08 , C07D295/112 , C07D307/68 , C07D307/85 , C07D317/58 , C07D317/66 , C07D317/68 , C07D413/04 , C07D413/12 , C07D417/04 , C07D491/10
Abstract: Compounds having the formula or therapeutically acceptable salts thereof, are histone deacetylase (HDAC) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.
Abstract translation: 具有式或其治疗上可接受的盐的化合物是组蛋白脱乙酰酶（HDAC）抑制剂。 公开了化合物的制备，含有该化合物的组合物以及使用该化合物治疗疾病。
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公开(公告)号：EP1730148A4
公开(公告)日：2009-08-19
申请号：EP05722668
申请日：2005-02-03
Applicant: ABBOTT LAB
Inventor： WISHART NEIL , FRIEDMAN MICHAEL , ARNOLD LEE D , YANG BRYANT , FIX-STENZEL SHANNON R , ERICSSON ANNA , MICHAELIDES MICHAEL R , QIAN XIAO-DONG , HOLMES JAMES H , STEINMAN DOUGLAS H , TIAN ZHENGPING , WITTENBERGER STEVEN J
IPC: C07D487/04 , A61K31/381 , A61K31/519 , A61K31/5377 , C07D239/70 , C07D263/54 , C07D295/03 , C07D513/06
CPC classification number: C07D487/04
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