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公开(公告)号：PT950057E
公开(公告)日：2003-04-30
申请号：PT97952392
申请日：1997-12-10
Applicant: ABBOTT LAB
Inventor： HOLLADAY MARK W , BAI HAO , DART MICHAEL J , LYNCH JOHN K , OR YAT SUN , RYTHER KEITH B , SULLIVAN JAMES P , WASICAK JAMES T , EHRLICH PAUL P , ARNERIC STEPHEN P , LIN NAN-HORNG
IPC: A61P25/04 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/485 , A61P25/28 , A61P29/00 , C07D205/04 , C07D401/12 , C07D401/14 , C07D405/14 , A61K31/44
Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.
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公开(公告)号：HU0001110A2
公开(公告)日：2001-04-28
申请号：HU0001110
申请日：1997-12-10
Applicant: ABBOTT LAB
Inventor： ARNERIC STEPHEN P , BAI HAO , DART MICHAEL J , EHRLICH PAUL P , HOLLADAY MARK W , LIN NAN-HORNG , LYNCH JOHN K , OR YAT SUN , RYTHER KEITH B , SULLIVAN JAMES P , WASICAK JAMES T
IPC: A61P25/04 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/485 , A61P25/28 , A61P29/00 , C07D205/04 , C07D401/12 , C07D401/14 , C07D405/14
Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.
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公开(公告)号：NO992705A
公开(公告)日：1999-08-03
申请号：NO992705
申请日：1999-06-03
Applicant: ABBOTT LAB
Inventor： HOLLADAY MARK W , ARNERIC STEPHEN P , BAI HAO , DART MICHAEL J , LIN NAN-HORNG , LYNCH JOHN K , OR YAT SUN , RYTHER KEITH B , SULLIVAN JAMES P , WASICAK JAMES T , EHRLICH PAUL P
IPC: A61P25/04 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/485 , A61P25/28 , A61P29/00 , C07D205/04 , C07D401/12 , C07D401/14 , C07D405/14 , A61K31/44
CPC classification number: C07D401/12 , A61K31/4427 , A61K31/485 , C07D205/04 , Y02P20/55 , A61K2300/00
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Patent Agency Ranking
公开(公告)号：AU6318898A
公开(公告)日：1998-09-09
申请号：AU6318898
申请日：1998-02-05
Applicant: ABBOTT LAB
Inventor： WASICAK JAMES T , GARVEY DAVID S , HOLLADAY MARK W , LIN NAN-HORNG , RYTHER KEITH B
IPC: A61P25/04 , A61K31/422 , A61K31/4439 , A61K31/4725 , A61P25/00 , A61P43/00 , C07D487/04 , A61K31/44
Abstract: 7a-Substituted hexahydro-1H-pyrrolizine compounds having the formula wherein A is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to selectively control synaptic transmission in mammals.
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公开(公告)号：ZA9711056B
公开(公告)日：1998-06-15
申请号：ZA9711056
申请日：1997-12-09
Applicant: ABBOTT LAB
Inventor： HOLLADAY MARK W , ARNERIC STEPHEN P , BAI HAO , DART MICHAEL J , LIN NAN-HORNG , LYNCH JOHN K , OR YAT SUN , RYTHER KEITH , SULLIVAN JAMES P , WASICAK JAMES T , EHRLICH PAUL P
IPC: A61K20060101 , A61K31/395 , C07D20060101 , C07D403/12 , A61K , C07D
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公开(公告)号：MX9800776A
公开(公告)日：1998-04-30
申请号：MX9800776
申请日：1996-07-25
Applicant: ABBOTT LAB
Inventor： ELLIOTT RICHARD L , RYTHER KEITH B , HOLLADAY MARK W , WASICAK JAMES T , DAANEN JEROME F
IPC: A61K31/00 , A61K31/435 , A61K31/4353 , A61K31/4355 , A61P9/00 , A61P25/00 , A61P25/30 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/044 , C07D491/048 , C07D495/04 , C07D519/00
Abstract: Novedosos compuestos de éteres heterocíclicos que tienen la formula (I) en donde A, m, R, X, Y1, Y2 y Y3 son definidos específicamente, los cuales sonutiles en controlar selectivamente la transmision sináptica química, composiciones farmacéuticas terapéuticamente efectivas de los mismos; y uso de dichas composiciones para controlar selectivamente la transmision sináptica en mamíferos.
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公开(公告)号：AU5355794A
公开(公告)日：1994-05-09
申请号：AU5355794
申请日：1993-10-08
Applicant: ABBOTT LAB
Inventor： ABREO MELWYN A , GUNN DAVID E , LIN NAN-HORNG , ELLIOTT RICHARD L , GARVEY DAVID S , LEBOLD SUZANNE A , WASICAK JAMES T
IPC: A61K31/427 , A61K31/439 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/497 , A61K31/501 , A61P25/00 , A61P25/28 , C07D401/12 , C07D403/12 , C07D411/12 , C07D417/12 , C07D471/08 , C07D487/04 , A61K31/425 , A61K31/445 , A61K31/495 , A61K31/50 , A61K31/505
Abstract: Novel heterocyclic ether compounds of formula (I), wherein A, B and R are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are selective and potent ligands at cholinergic channel receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function.
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公开(公告)号：MX9306274A
公开(公告)日：1994-04-29
申请号：MX9306274
申请日：1993-10-08
Applicant: ABBOTT LAB
Inventor： ELLIOTT RICHARD L , LEBOLD SUZANNE A , WASICAK JAMES T , GARVEY DAVID S , ABREO MELWYN A , GUNN DAVID E , LIN NAN-HORNG
IPC: C07D403/12
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