公开(公告)号：HU192363B

公开(公告)日：1987-05-28

申请号：HU354785

申请日：1985-09-20

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER ,  NUERRENBACH AXEL ,  THYES MARCO

IPC: A61K31/41 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  C07D20060101 ,  C07D257/04

公开(公告)号：ZA8508770B

公开(公告)日：1986-08-27

申请号：ZA8508770

申请日：1985-11-15

Applicant: BASF AG

Inventor： HIMMELE WALTER ,  WIERSDORFF WALTER-WIELANT ,  THYES MARCO

IPC: C07D211/12 ,  C07D211/14 ,  C07D211/16 ,  C07D295/023 ,  C07D

CPC classification number: C07D295/023 ,  C07D211/12 ,  C07D211/14

公开(公告)号：DK148940C

公开(公告)日：1986-05-05

申请号：DK257381

申请日：1981-06-12

Applicant: BASF AG

Inventor： THYES MARCO ,  KOENIG HORST ,  LENKE DIETER ,  LEHMANN HANS DIETER ,  GRIES JOSEF

IPC: A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04

Abstract: Novel 6-(p-acylaminophenyl)-4,5-dihydro-3(2H)-pyridazinones, whose acyl radical is derived from a cycloalkylcarboxylic acid, processes for their preparation, pharmaceutical formulations containing these compounds, and their use as drugs in thrombo-embolic disorders and as anti-hypertensives.

公开(公告)号：HU188179B

公开(公告)日：1986-03-28

申请号：HU203482

申请日：1982-06-23

Applicant: BASF AG

Inventor： ROSSY PHIILIP A ,  THYES MARCO ,  FRANKE ALBRECHT ,  KOENIG HORST ,  GRIES JOSEF ,  LEHMANN HANS D ,  LENKE DIETER

IPC: A61K31/50 ,  A61K31/55 ,  A61P7/02 ,  A61P9/12 ,  C07D209/34 ,  C07D215/22 ,  C07D215/227 ,  C07D223/16 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10 ,  C07D401/10

Abstract: 2-Aryl-3,4-diazabicyclo[4.n.O]alk-2-en-5-ones of the formula I I where m and n are identical or different and each is 1, 2 or 3, and R, R1 and R2 are identical or different and each is hydrogen or alkyl of 1 to 6 C atoms, said compounds are useful for treating high blood pressure and thrombo-embolic disorders.

公开(公告)号：AU548396B2

公开(公告)日：1985-12-12

申请号：AU8515382

申请日：1982-06-23

Applicant: BASF AG

Inventor： ROSSY PHILLIP A ,  THYES MARCO ,  FRANKE ALBRECHT ,  KOENIG HORST ,  GRIES JOSEF ,  LEHMANN HANS DIETER ,  LENKE DIETER

IPC: A61K31/50 ,  A61K31/55 ,  A61P7/02 ,  A61P9/12 ,  C07D209/34 ,  C07D215/22 ,  C07D215/227 ,  C07D223/16 ,  C07D401/04 ,  C07D403/04 ,  C07D401/10 ,  C07D403/10

Abstract: 2-Aryl-3,4-diazabicyclo[4.n.O]alk-2-en-5-ones of the formula I I where m and n are identical or different and each is 1, 2 or 3, and R, R1 and R2 are identical or different and each is hydrogen or alkyl of 1 to 6 C atoms, said compounds are useful for treating high blood pressure and thrombo-embolic disorders.

公开(公告)号：ZA8400438B

公开(公告)日：1984-09-26

申请号：ZA8400438

申请日：1984-01-20

Applicant: BASF AG

Inventor： ROSSY PHILIP A ,  THYES MARCO ,  FRANKE ALBRECHT ,  KOENIG HORST ,  LEHMANN HANS DIETER ,  GRIES JOSEF ,  LUDWIG FRIEDRICH ,  LENKE D

IPC: A61K31/50 ,  A61K31/502 ,  A61K31/535 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D237/14 ,  C07D237/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/14 ,  C07D521/00 ,  A61K ,  C07D

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D237/04 ,  C07D237/14 ,  C07D237/26 ,  C07D249/08 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12

公开(公告)号：HU184460B

公开(公告)日：1984-08-28

申请号：HU175781

申请日：1981-06-12

Applicant: BASF AG

Inventor： THYES MARCO ,  KOENIG HORST ,  LENKE DIETER ,  FRANKE ALBRECHT ,  GRIES JOSEF

IPC: A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04

Abstract: Novel 6-(p-acylaminophenyl)-4,5-dihydro-3(2H)-pyridazinones, whose acyl radical is derived from a cycloalkylcarboxylic acid, processes for their preparation, pharmaceutical formulations containing these compounds, and their use as drugs in thrombo-embolic disorders and as anti-hypertensives.

公开(公告)号：AU2366084A

公开(公告)日：1984-07-26

申请号：AU2366084

申请日：1984-01-20

Applicant: BASF AG

Inventor： ROSSY PHILLIP A ,  THYES MARCO ,  FRANKE ALBRECHT ,  KOENIG HORST ,  LEHMANN HANS DIETER ,  GRIES JOSEF ,  FRIEDRICH LUDWIG ,  LENKE DIETER

IPC: A61K31/50 ,  A61K31/502 ,  A61K31/535 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D237/14 ,  C07D237/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/14 ,  C07D521/00 ,  A61K31/495

Abstract: Novel 6-(acylaminaryl)-3(2H)-pyridazinones of the formula (I) where R1, R2, R3, R4, A and B have the meanings given in the description, and their preparation are described. The compounds have thrombocyte aggregation-inhibiting activity.

公开(公告)号：ES2217795T3

公开(公告)日：2004-11-01

申请号：ES99940069

申请日：1999-07-28

Applicant: BASF AG

Inventor： FALKENBERG WOLFGANG ,  THYES MARCO ,  WENZ CONNY ,  SCHNEIDER ULRICH

IPC: C07B61/00 ,  C07C67/343 ,  C07C69/618

Abstract: A process for preparing ethyl atropate by reacting ethyl phenylacetate with paraformaldehyde in the presence of a base is described and entails employing as ethyl phenylacetate a product which contains not more than 0.03% of the corresponding methyl phenylacetate, and carrying out the reaction in N-methyl-pyrrolidone or N,N-dimethylformamide.

公开(公告)号：NZ502675A

公开(公告)日：2001-06-29

申请号：NZ50267598

申请日：1998-08-14

Applicant: BASF AG

Inventor： HOGER THOMAS ,  BLANK STEFAN ,  STARCK DOROTHEA ,  TREIBER HANS-JORG ,  KOSER STEFAN ,  SCHAFER BERND ,  THYES MARCO

IPC: A61K20060101 ,  A61K31/395 ,  C07D239/56 ,  A61K31/497 ,  A61K31/505 ,  A61K31/506 ,  A61P1/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P43/00 ,  C07D20060101 ,  C07D239/42 ,  C07D239/46 ,  C07D295/125 ,  C07D403/00 ,  C07D403/12 ,  C07D403/14

Abstract: The specification describes the fumaric acid salt (A) of 2-(3-(4-(2-tert.butyl-6-trifluoromethyl- pyrimidin-4-yl)piperazin-1yl)propylmercapto)pyrimidin-4-ol (I). The fumaric salt of this known compound (WO96/02519) is reported to have very good affinity and high selectivity for the D3 receptor and is therefore useful for treating disorders which respond to dopamine D3 ligands such as schizophrenia, depressions, neuroses and psychoses.