公开(公告)号：CA2223911C

公开(公告)日：2009-03-24

申请号：CA2223911

申请日：1996-07-12

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  JANSSEN BERND ,  KARL ULRICH ,  KLING ANDREAS ,  ZIERKE THOMAS ,  MULLER STEFAN ,  RITTER KURT ,  BUSCHMANN ERNST ,  AMBERG WILHELM ,  BERNARD HARALD

IPC: C07K1/02 ,  C07K11/00 ,  C07K1/12 ,  C07K5/06 ,  C07K5/078 ,  C07K5/08 ,  C07K5/083 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06 ,  C12P21/02

Abstract: The description relates to a process for producing pentapeptides of the formula (I) in which A and R1-R3 have the meanings given, in which the pentapeptide is constructed in steps from a prolinamide of the formula (II) in which R1 and R2 have the meanings given above, and the group -NR1R2 may be hydrolytically separated from the peptide thus obtained.

公开(公告)号：MA29607B1

公开(公告)日：2008-07-01

申请号：MA30534

申请日：2008-01-02

Applicant: BASF AG

Inventor： KORADIN CHRISTOPHER ,  VON DEYN WOLFGANG ,  RACK MICHAEL ,  ZIERKE THOMAS ,  KUHN DAVID G ,  CULBERTSON DEBORAH L ,  ANSPAUGH DOUGLAS D ,  OLOUMI-SADEGHI HASSAN

IPC: A01N43/653 ,  C07D249/10

Abstract: Dérivés d'un 1-Phényltriazole Résumé Composés de formule (I) dans laquelle X est chloro ou bromo; Y est chloro ou trifluorométhyle; et A et B sont hydrogène ou méthyle à condition que l'un parmi A ou B soit méthyle; ou les énantiomères ou les sels de ceux-ci, Utilisation de composés de formule I pour lutter contre des insectes ou des acariens et pour traiter, contrôler, prévenir ou protéger des animaux contre une infestation ou une infection par des parasites, et compositions comprenant des composés de formule I.

公开(公告)号：PE20070799A1

公开(公告)日：2007-09-28

申请号：PE2006001344

申请日：2006-11-02

Applicant: BASF AG

Inventor： ZIERKE THOMAS

IPC: A01N37/52 ,  C07C257/22

Abstract: SE REFIERE A UNA MODIFICACION CRISTALINA I DE N-ETIL-2,2-DICLORO-1-METILCICLOPROPANO-CARBOX-AMIDA-2-(2,6-DICLORO-a,a,a-TRIFLUORO-p-TOLIL)HIDRAZONA (COMPUESTO I) QUE ESTA PRESENTE EN UN SISTEMA TRICLINICO Y TIENE EL GRUPO ESPACIAL P-1, EL CUAL EN UN DIAFRACTOGRAMA DE RAYOS X EN POLVO A 25ºC, EXHIBE LAS REFLEXIONES SIGUIENTES: d = 17,1 ± 0.5Å; 11,5± 0.2Å; 9,9 ± 0.2Å; 8,9 ± 0.2Å; 7,35 ± 0.05Å, ENTRE OTROS, Y TIENE UN PUNTO DE FUSION EN EL INTERVALO 76,0 A 80,5ºC. UN PROCESO DE PREPARACION QUE COMPRENDE EN i)PREPARAR UNA SOLUCION DEL COMPUESTO I AMORFO EN UN DISOLVENTE ORGANICO TAL COMO METANOL O ISOPROPANOL O UNA MEZCLA DE ESTOS, Y OPCIONALMENTE DISOLVENTES ADICIONALES; ii) EFECTUAR LA CRISTALIZACION Y iii) AISLAR EL PRECIPITADO. TAMBIEN SE REFIERE A UNA COMPOSICION UTIL PARA COMBATIR PLAGAS Y PARASITOS

公开(公告)号：PE07992007A1

公开(公告)日：2007-09-28

申请号：PE0013442006

申请日：2006-11-02

Applicant: BASF AG

Inventor： ZIERKE THOMAS

IPC: A01N37/52 ,  C07C257/22

CPC classification number: A01N53/00 ,  C07C257/22 ,  C07C2601/02

Abstract: SE REFIERE A UNA MODIFICACION CRISTALINA I DE N-ETIL-2,2-DICLORO-1-METILCICLOPROPANO-CARBOX-AMIDA-2-(2,6-DICLORO-a,a,a-TRIFLUORO-p-TOLIL)HIDRAZONA (COMPUESTO I) QUE ESTA PRESENTE EN UN SISTEMA TRICLINICO Y TIENE EL GRUPO ESPACIAL P-1, EL CUAL EN UN DIAFRACTOGRAMA DE RAYOS X EN POLVO A 25ºC, EXHIBE LAS REFLEXIONES SIGUIENTES: d = 17,1 ± 0.5Å; 11,5± 0.2Å; 9,9 ± 0.2Å; 8,9 ± 0.2Å; 7,35 ± 0.05Å, ENTRE OTROS, Y TIENE UN PUNTO DE FUSION EN EL INTERVALO 76,0 A 80,5ºC. UN PROCESO DE PREPARACION QUE COMPRENDE EN i)PREPARAR UNA SOLUCION DEL COMPUESTO I AMORFO EN UN DISOLVENTE ORGANICO TAL COMO METANOL O ISOPROPANOL O UNA MEZCLA DE ESTOS, Y OPCIONALMENTE DISOLVENTES ADICIONALES; ii) EFECTUAR LA CRISTALIZACION Y iii) AISLAR EL PRECIPITADO. TAMBIEN SE REFIERE A UNA COMPOSICION UTIL PARA COMBATIR PLAGAS Y PARASITOS

公开(公告)号：BRPI0508602A

公开(公告)日：2007-07-31

申请号：BRPI0508602

申请日：2005-03-16

Applicant: BASF AG

Inventor： ZIERKE THOMAS ,  ENGEL STEFAN ,  OTTO PETER

IPC: C07C281/04 ,  C07C281/14

Abstract: The invention relates to a process for preparing semicarbazone compounds of the formula I, where R1 and R2 are each independently hydrogen, halogen, CN, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-haloalkyl or C1-C4-haloalkoxy, and R3 is C1-C4-alkoxy, C1-C4-haloalkyl or C1-C4-haloalkoxy, by reacting a hydrazone compound of the general formula II, where R is C1-C4-alkoxy, amino, C1-C4-alkylamino or di(C1-C4-alkyl)amino, and R1, R2 are each as defined above, with an aniline compound of the general formula III where R3 is as defined above.

公开(公告)号：BG65212B1

公开(公告)日：2007-07-31

申请号：BG10408900

申请日：2000-01-17

Applicant: BASF AG

Inventor： JANSSEN BERND ,  BARLOZZARI TERESA ,  HAUPT ANDREAS ,  ZIERKE THOMAS ,  KLING ANDREAS

IPC: A61K38/00 ,  C07K7/06 ,  A61K38/08 ,  A61P35/00 ,  C12P19/34

Abstract: The invention relates to inhibitors of the cellular growth and to their adjunctive to acid salts which are peptides with the formula A - B - D - E - F - (G)r - (K)s - L (I) where A, B, D, E, F, G. and K are -aminoacid residues and s and r are, individually, 0 or 1. L is univalent radical, such as aminogroup, N-substituted aminogroup, beta-hydroxyaminogroup, beta-hydroxyaminogroup, hydrasidogroup, alkoxygroup, thioalkoxygroup, aminooxygroup or oximatogroup. The invention also relates to a method for the treatment of cancer in mammals, including humans which includes the administration of an effective quantity of the above compound in a pharmaceutically acceptable composition.

公开(公告)号：PL186721B1

公开(公告)日：2004-02-27

申请号：PL32717596

申请日：1996-12-11

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BARLOZZARI TERESA ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  HEGE HANS-GUENTHER ,  JANSSEN BERND ,  KLING ANDREAS ,  LIETZ HELMUT ,  RITTER KURT ,  ULLRICH MARTINA ,  WEYMANN JUERGEN ,  ZIERKE THOMAS

IPC: A61K31/00 ,  A61K38/08 ,  A61P35/00 ,  A61K38/00 ,  A61P35/02 ,  C07K1/00 ,  C07K7/06

Abstract: Novel peptides of the formula R R N-CHX-CO-A-B-D-E-(G)s-K in which R , R , A, B, D, E, G, K, X, and s have the meanings stated in the description, and the preparation thereof are described. The novel peptides have an antineoplastic effect.

公开(公告)号：AU2003240656A1

公开(公告)日：2003-12-02

申请号：AU2003240656

申请日：2003-05-15

Applicant: BASF AG

Inventor： REINHARD ROBERT ,  SAGASSER INGO ,  SCHMIDT THOMAS ,  GOTZ NORBERT ,  ZIERKE THOMAS ,  HAMPRECHT GERHARD ,  PUHL MICHAEL

IPC: C07D239/54 ,  C07C303/34 ,  C07C303/38 ,  C07C303/40 ,  C07C307/00 ,  C07C307/06 ,  C07C307/08 ,  C07C307/10 ,  C07D207/48 ,  C07D211/96 ,  C07D239/46 ,  C07D295/26 ,  C07C307/02

Abstract: The present invention relates to a process for preparing sulfamoyl halides of primary or secondary amines, comprising the following steps: i) reacting a primary or secondary amine A1 with at least equimolar amounts of SO 3 or an SO 3 source in the presence of at least equimolar amounts of a tertiary amine A2, based in each case on the amine A1, and ii) reacting the reaction mixture obtained in step i) with at least the amount of a phosphorus halide required by the stoichiometry; The invention further relates to a process for preparing sulfonic diamides, comprising the preparation of sulfamoyl halides by means of carrying out steps i) and ii) and subsequently reacting the sulfamoyl halide obtained with ammonia. The invention further relates to the use of this process for preparing active herbicidal ingredients having a sulfuric diamide structure. The invention further relates to novel sulfamoyl chlorides.

公开(公告)号：BG63697B1

公开(公告)日：2002-09-30

申请号：BG10183597

申请日：1997-08-15

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  HOEFFKEN HANS W ,  HORNBERGER WILFRIED ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS

IPC: A61K31/00 ,  A61K38/55 ,  A61P7/02 ,  C07D205/04 ,  C07D207/16 ,  C07D213/53 ,  C07D213/63 ,  C07D213/72 ,  C07D213/78 ,  C07D213/79 ,  C07D239/28 ,  C07D241/14 ,  C07D241/24 ,  C07D401/12 ,  C07K5/06 ,  C07K5/062 ,  C07K5/078 ,  A61K31/40 ,  A61K31/445 ,  A61K31/495

Abstract: The description relates to compounds of formula in which A, B, D, R' and R have the meanings given in the specification. the compounds am suitable for the treatment of diseases The novel compounds are produced via compounds of the formula H2N-CH2.G-M in which G and M have the meanings given in the specification. 3 claims

公开(公告)号：AU750120B2

公开(公告)日：2002-07-11

申请号：AU8475898

申请日：1998-07-07

Applicant: BASF AG ,  BASF BIORES CORP

Inventor： JANSSEN BERND ,  BARLOZZARI TERESA ,  HAUPT ANDREAS ,  ZIERKE THOMAS ,  KLING ANDREAS

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K7/06 ,  C12P19/34

Abstract: Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L  (I), and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a &bgr;-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.