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公开(公告)号：HUE052759T2
公开(公告)日：2021-05-28
申请号：HUE14172991
申请日：2011-03-25
Applicant: VERTEX PHARMA
Inventor： KESHAVARZ-SHOKRI ALI , ZHANG BEILI , ALCACIO TIM EDWARD , LEE ELAINE CHUNGMIN , ZHANG YUEGANG , KRAWIEC MARIUSZ
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公开(公告)号：RS61314B1
公开(公告)日：2021-02-26
申请号：RSP20210007
申请日：2011-03-25
Applicant: VERTEX PHARMA
Inventor： KESHAVARZ-SHOKRI ALI , ZHANG BEILI , ALCACIO TIM EDWARD , LEE ELAINE CHUNGMIN , ZHANG YUEGANG , KRAWIEC MARIUSZ
IPC: A61K9/10 , A61K31/404 , A61P11/00 , C07D405/12
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公开(公告)号：AU2019271928A1
公开(公告)日：2019-12-19
申请号：AU2019271928
申请日：2019-11-26
Applicant: VERTEX PHARMA
Inventor： ANDERSON COREY , HADIDA-RUAH SARA SABINA , GOLEC JULIAN MARIAN CHARLES , ZHANG BEILI , LITTLER BENJAMIN JOSEPH , KESHAVARZ-SHOKRI ALI , ALCACIO TIM EDWARD , BELMONT DANIEL T
IPC: C07F9/576 , A61K31/675 , A61P19/02
Abstract: The invention relates to prodrug compounds of formula I: O -NO-X Ry wherein R2 , R 3, R, R7 and X are as defined herein. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain. The compounds of formula I possess advantageous solubility and physicochemical properties.
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公开(公告)号：CY1121030T1
公开(公告)日：2019-12-11
申请号：CY181101096
申请日：2018-10-24
Applicant: VERTEX PHARMA
Inventor： ANDERSON COREY , HADIDA-RUAH SARA SABINA , GOLEC JULIAN MARIAN CHARLES , ZHANG BEILI , LITTLER BENJAMIN JOSEPH , KESHAVARZ-SHOKRI ALI , ALCACIO TIM EDWARD , BELMONT DANIEL T
IPC: C07F9/576 , A61K31/675 , A61P19/02
Abstract: Ηεφεύρεσησχετίζεταιμεενώσεις-προφάρμακατουτύπου I: όπουοι R2, R3, R5, R7 καιΧ είναιόπωςορίζονταιστοπαρόν. Ηεφεύρεσηεπίσηςπαρέχειαποδεκτέςαπόφαρμακευτικήάποψησυνθέσειςπουπεριλαμβάνουντιςενώσειςτηςεφεύρεσηςκαιμεθόδουςχρήσηςτωνσυνθέσεωνστηναγωγήδιαφόρωνδιαταραχών, συμπεριλαμβανομένουτουπόνου. Οιενώσειςτουτύπου I χαρακτηρίζονταιαπόεπωφελείςιδιότητεςδιαλυτότηταςκαιφυσικοχημικέςιδιότητες.
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公开(公告)号：AU2014362255B2
公开(公告)日：2019-08-29
申请号：AU2014362255
申请日：2014-12-12
Applicant: VERTEX PHARMA
Inventor： ANDERSON COREY , HADIDA-RUAH SARA SABINA , GOLEC JULIAN MARIAN CHARLES , ZHANG BEILI , LITTLER BENJAMIN JOSEPH , KESHAVARZ-SHOKRI ALI , ALCACIO TIM EDWARD , BELMONT DANIEL T
IPC: C07F9/576 , A61K31/675 , A61P19/02
Abstract: The invention relates to prodrug compounds of formula I: wherein R
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Patent Agency Ranking
公开(公告)号：LT3080134T
公开(公告)日：2018-11-12
申请号：LT14824658
申请日：2014-12-12
Applicant: VERTEX PHARMA
Inventor： ANDERSON COREY , HADIDA-RUAH SARA SABINA , GOLEC JULIAN MARIAN CHARLES , ZHANG BEILI , LITTLER BENJAMIN JOSEPH , KESHAVARZ-SHOKRI ALI , ALCACIO TIM EDWARD , BELMONT DANIEL T
IPC: C07F9/576 , A61K31/675 , A61P19/02
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公开(公告)号：PE11312016A1
公开(公告)日：2016-10-29
申请号：PE0007452016
申请日：2014-12-12
Applicant: VERTEX PHARMA
Inventor： ALCACIO TIM EDWARD , ANDERSON COREY , BELMONT DANIEL T , ZHANG BEILI , HADIDA-RUAH SARA SABINA , KESHAVARZ-SHOKRI ALI , LITTLER BENJAMIN JOSEPH , GOLEC JULIAN MARIAN CHARLES
IPC: A61K31/675 , A61P19/02 , C07F9/576
Abstract: Se refiere a compuestos de formula I, en donde R2 y R3 son independientemente H, halogeno, o alquilo C1–C6 opcionalmente sustituido con hasta 6 halogenos; R5 es H, halogeno, OH, alquilo C1–C6, entre otros; R7 es H, halogeno, OH, alquilo C1–C6, entre otros; y X es –PO(OH)2, –PO(OH)O–M+, –PO(O–)2•2M+ o –PO(O–)2•D2+; donde M+ es un cation monovalente, y D2+ es un cation divalente. Tambien se refiere a composiciones farmaceuticas que comprenden dichos compuestos de formula I. Dichos compuestos son inhibidores de canales de sodio dependientes de voltaje, particularmente Nav1.8, por lo cual son utiles en el tratamiento del dolor cronico, dolor intestinal, dolor neuropatico, dolor inflamatorio, dolor por cancer, dolor idiopatico, entre otros
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公开(公告)号：SG11201604477SA
公开(公告)日：2016-07-28
申请号：SG11201604477S
申请日：2014-12-12
Applicant: VERTEX PHARMA
Inventor： ANDERSON COREY , HADIDA-RUAH SARA SABINA , GOLEC JULIAN MARIAN CHARLES , ZHANG BEILI , LITTLER BENJAMIN JOSEPH , KESHAVARZ-SHOKRI ALI , ALCACIO TIM EDWARD , BELMONT DANIEL T
IPC: C07F9/576 , A61K31/675 , A61P19/02
Abstract: The invention relates to a process and intermediates for preparing prodrug compounds of formula I: wherein R2, R3, R5, R7 and X are as defined herein.
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公开(公告)号：AP2016009287A0
公开(公告)日：2016-06-30
申请号：AP2016009287
申请日：2014-12-12
Applicant: VERTEX PHARMA
Inventor： ANDERSON COREY , HADIDA-RUAH SARA SABINA , GOLEC JULIAN MARIAN CHARLES , ZHANG BEILI , LITTLER BENJAMIN JOSEPH , KESHAVARZ-SHOKRI ALI , ALCACIO TIM EDWARD , BELMONT DANIEL T
IPC: A61K31/675 , A61P19/02 , C07F9/576
Abstract: The invention relates to a process and intermediates for preparing prodrug compounds of formula I: wherein R2, R3, R5, R7 and X are as defined herein.
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公开(公告)号：AU2011242457A1
公开(公告)日：2012-11-08
申请号：AU2011242457
申请日：2011-04-22
Applicant: VERTEX PHARMA
Inventor： VAN GOOR FREDRICK F , ALARGOVA ROSSITZA GUEORGUIEVA , ALCACIO TIM EDWARD , BINCH HAYLEY MARIE , BOTFIELD MARTYN CURTIS , FANNING LEV TYLER DEWEY , GROOTENHUIS PETER DIEDERIK JAN , HURLEY DENNIS JAMES , KADIYALA IRINA NIKOLAEVNA , KAUSHIK RITU ROHIT , KESHAVARZ-SHOKRI ALI , KRAWIEC MARIUSZ , LEE ELAINE CHUNGMIN , LUISI BRIAN , MEDEK ALES , NUMA MEHDI , SHETH URVI JAGDISHBHAI , SILINA ALINA , VERWIJS MARINUS JACOBUS , YANG XIAOQING , YOUNG CHRISTOPHER RYAN , ZAMAN NOREEN TASNEEM , ZHANG BEILI , ZHANG YUEGANG , ZLOKARNIK GREGOR
IPC: A61K31/4704 , A61K31/404 , A61K31/443
Abstract: The present invention relates to pharmaceutical compositions comprising a compound of Formula I in combination with one or both of a Compound of Formula II and/or a Compound of Formula III. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.(Formula I), (Formula II), (Formula III).
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