公开(公告)号：US11674132B2

公开(公告)日：2023-06-13

申请号：US16997614

申请日：2020-08-19

Applicant: Purigen Biosystems, Inc.

Inventor： Lewis A. Marshall ,  Amy L. Hiddessen ,  Nathan P. Hoverter ,  Klint A. Rose ,  Juan G. Santiago

IPC: G01N27/453 ,  C12N15/10 ,  G01N27/447 ,  B01L3/00 ,  C12Q1/6806 ,  B81B1/00 ,  B81B7/00

CPC classification number: C12N15/101 ,  B01L3/502753 ,  C12N15/10 ,  C12Q1/6806 ,  G01N27/4473 ,  G01N27/44739 ,  G01N27/44791 ,  G01N27/44795 ,  B01L3/502738 ,  B01L2300/0627 ,  B01L2300/0867 ,  B81B1/004 ,  B81B7/0087 ,  B81B2201/0278 ,  B81B2201/05 ,  B81B2203/0338 ,  G01N27/44704 ,  C12N15/101 ,  C12Q2565/125

Abstract: The present disclosure relates to fluidic systems and devices for processing, extracting, or purifying one or more analytes. These systems and devices can be used for processing samples and extracting nucleic acids, for example by isotachophoresis. In particular, the systems and related methods can allow for extraction of nucleic acids, including non-crosslinked nucleic acids, from samples such as tissue or cells. The systems and devices can also be used for multiplex parallel sample processing.

公开(公告)号：US20180038758A1

公开(公告)日：2018-02-08

申请号：US15723752

申请日：2017-10-03

Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

Inventor： Hajime YOSHIDA ,  Kenta ARAI ,  Tokihiko KOBATA

IPC: G01L27/00 ,  G01M3/00 ,  B81B7/00 ,  G01M3/20 ,  G01M3/26

CPC classification number: G01L27/002 ,  B81B7/0009 ,  B81B2201/05 ,  G01M3/007 ,  G01M3/207 ,  G01M3/26

Abstract: A static expansion method is performed by expanding a volume of a testing gas from V0 to V0+V1 between a second chamber of the volume V1 which is connected to an upstream side of a measurement chamber and a first chamber of the volume V0 which is connected to an upstream side of the second chamber, wherein the first camber is in communication with the second chamber via a first valve, wherein the second chamber is in communication with the measurement chamber via each of a second valve and an orifice or porous plug, respectively. When the first valve is opened and the second valve is closed, the testing gas flows from the first chamber via the second chamber into the measurement chamber only through the orifice or porous plug.

公开(公告)号：US20150073061A1

公开(公告)日：2015-03-12

申请号：US14486290

申请日：2014-09-15

Applicant: Cambridge Enterprise Limited

Inventor： Wolfgang Andreas BAUER ,  Wilhelm T.S. HUCK ,  Martin FISCHLECHNER

IPC: B01L3/00 ,  B01F17/00

CPC classification number: B01L3/502707 ,  B01F17/00 ,  B01J2219/00511 ,  B01J2219/0059 ,  B01J2219/00637 ,  B01J2219/00783 ,  B01J2219/00788 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00837 ,  B01J2219/0097 ,  B01L2200/0636 ,  B01L2300/0867 ,  B01L2300/16 ,  B01L2300/161 ,  B05C7/04 ,  B05D7/22 ,  B05D7/222 ,  B81B2201/0214 ,  B81B2201/05 ,  B81B2201/052 ,  B81B2201/058 ,  B81C1/00119 ,  B81C1/00206 ,  Y10T137/8593

Abstract: We describe a method of layer-by-layer deposition of a plurality of layers of material onto the wall or walls of a channel of a microfluidic device, the method comprising: loading a tube with a series of segments of solution, a said segment of solution bearing a material to be deposited; coupling said tube to said microfluidic device; and injecting said segments of solution into said microfluidic device such that said segments of solution pass, in turn, through said channel depositing successive layers of material to perform said layer-by-layer deposition onto said wall or walls of said channel. Embodiments of the methods are particularly useful for automated surface modification of plastic, for example PDMS (Poly(dimethylsiloxane)), microchannels. We also describe methods and apparatus for forming double-emulsions.

Abstract translation: 我们描述了将多层材料层逐层沉积到微流体装置的通道的壁或壁上的方法，该方法包括：将具有一系列溶液段的管装载， 含有待沉积材料的溶液; 将所述管连接到所述微流体装置; 以及将所述溶液段注射到所述微流体装置中，使得所述溶液段又通过所述通道沉积连续的材料层，以在所述通道的所述壁或壁上执行所述逐层沉积。 该方法的实施方案对于塑料的自动表面改性特别有用，例如PDMS（聚（二甲基硅氧烷）），微通道。 我们还描述了形成双重乳液的方法和设备。

公开(公告)号：US08851442B2

公开(公告)日：2014-10-07

申请号：US12017944

申请日：2008-01-22

Applicant: Robert J. Carlson

Inventor： Robert J. Carlson

IPC: B29C33/56 ,  B81C1/00 ,  B81C99/00

CPC classification number: B29C33/3842 ,  B29C41/00 ,  B29C59/14 ,  B29C59/16 ,  B29K2909/00 ,  B29K2995/0037 ,  B81B7/00 ,  B81B2201/05 ,  B81B2201/058 ,  B81B2203/0127 ,  B81C99/009 ,  B81C2201/0132 ,  B81C2201/0143 ,  B81C2201/034 ,  C23F1/02 ,  H01L21/30604 ,  Y10T428/24496

Abstract: The invention is directed to a patterned aerogel-based layer that serves as a mold for at least part of a microelectromechanical feature. The density of an aerogel is less than that of typical materials used in MEMS fabrication, such as poly-silicon, silicon oxide, single-crystal silicon, metals, metal alloys, and the like. Therefore, one may form structural features in an aerogel-based layer at rates significantly higher than the rates at which structural features can be formed in denser materials. The invention further includes a method of patterning an aerogel-based layer to produce such an aerogel-based mold. The invention further includes a method of fabricating a microelectromechanical feature using an aerogel-based mold. This method includes depositing a dense material layer directly onto the outline of at least part of a microelectromechanical feature that has been formed in the aerogel-based layer.

Abstract translation: 本发明涉及用作至少部分微机电特征的模具的图案化气凝胶基层。 气凝胶的密度小于MEMS制造中使用的典型材料的密度，例如多晶硅，氧化硅，单晶硅，金属，金属合金等。 因此，可以以明显高于在较致密的材料中形成结构特征的速率的速率在气凝胶层中形成结构特征。 本发明还包括一种图案化气凝胶层以产生这种基于气凝胶的模具的方法。 本发明还包括使用基于气凝胶的模具制造微机电特征的方法。 该方法包括将致密材料层直接沉积在已经形成在气凝胶层中的微机电特征的至少一部分的轮廓上。

公开(公告)号：US20090184088A1

公开(公告)日：2009-07-23

申请号：US12017944

申请日：2008-01-22

Applicant: Robert J. Carlson

Inventor： Robert J. Carlson

IPC: B29C33/56 ,  B29C41/00

CPC classification number: B29C33/3842 ,  B29C41/00 ,  B29C59/14 ,  B29C59/16 ,  B29K2909/00 ,  B29K2995/0037 ,  B81B7/00 ,  B81B2201/05 ,  B81B2201/058 ,  B81B2203/0127 ,  B81C99/009 ,  B81C2201/0132 ,  B81C2201/0143 ,  B81C2201/034 ,  C23F1/02 ,  H01L21/30604 ,  Y10T428/24496

Abstract: The invention is directed to a patterned aerogel-based layer that serves as a mold for at least part of a microelectromechanical feature. The density of an aerogel is less than that of typical materials used in MEMS fabrication, such as poly-silicon, silicon oxide, single-crystal silicon, metals, metal alloys, and the like. Therefore, one may form structural features in an aerogel-based layer at rates significantly higher than the rates at which structural features can be formed in denser materials. The invention further includes a method of patterning an aerogel-based layer to produce such an aerogel-based mold. The invention further includes a method of fabricating a microelectromechanical feature using an aerogel-based mold. This method includes depositing a dense material layer directly onto the outline of at least part of a microelectromechanical feature that has been formed in the aerogel-based layer.

Abstract translation: 本发明涉及用作至少部分微机电特征的模具的图案化气凝胶基层。 气凝胶的密度小于MEMS制造中使用的典型材料的密度，例如多晶硅，氧化硅，单晶硅，金属，金属合金等。 因此，可以以明显高于在较致密的材料中形成结构特征的速率的速率在气凝胶层中形成结构特征。 本发明还包括一种图案化气凝胶层以产生这种基于气凝胶的模具的方法。 本发明还包括使用基于气凝胶的模具制造微机电特征的方法。 该方法包括将致密材料层直接沉积在已经形成在气凝胶层中的微机电特征的至少一部分的轮廓上。

公开(公告)号：KR101818864B1

公开(公告)日：2018-01-16

申请号：KR1020160129979

申请日：2016-10-07

Applicant: 연세대학교 산학협력단

Inventor： 심우영 ,  김혜온 ,  김태훈 ,  김도헌

IPC: C23C16/44 ,  C23C14/28 ,  H04R7/12

CPC classification number: C23C16/4415 ,  B81B2201/05 ,  C23C14/28 ,  H04R7/12

Abstract: 본발명은음파진동을이용한미세물질어레이및 그제조방법을제공한다. 일실시예에따르면, 음파진동을이용한미세물질어레이는, 기판; 및음파진동에따른 2차원정상파형태의미세패턴구조에따라서상기기판상에형성된미세물질;을포함한다.

Abstract translation: 本发明提供了一种使用声波振动的微材料阵列及其制造方法。 根据一个实施例，使用声波振动的微材料阵列包括：衬底; 并且根据声波振动根据二维驻波型精细图案结构在基板上形成精细材料。

公开(公告)号：KR101305149B1

公开(公告)日：2013-09-12

申请号：KR1020130004361

申请日：2013-01-15

Applicant: 서강대학교산학협력단

Inventor： 신운섭

IPC: B81B7/02 ,  F04B37/02 ,  F04B19/00 ,  B01D61/42

CPC classification number: B81B3/0035 ,  B81B7/02 ,  B81B2201/036 ,  B81B2201/05

Abstract: PURPOSE: An electro-osmosis pump using a reversible electrode reaction and a fluid pumping system using the same are provided to transfer a large amount of fluid for a long time while the size and a configuration of the electro-osmosis pump are intactly maintained. CONSTITUTION: An electro-osmosis pump (10) using a reversible electrode reaction includes a transfer line, a first check valve, a second check valve, a pumping line, and a separator. The transfer line provides a passage for transferring a target fluid (16) from a container to the outside. The first and second check valves are installed to be spaced from the transfer line respectively and prevent the target fluid flowing to a reverse direction of a transferring direction. The pumping line is connected to a part of the transferring line between the first and second check valves. The electro-osmosis pump provides a pumping force to the pumping line. The separator separates the electro-osmosis pump from the target fluid and transmits the pumping force to the target fluid. [Reference numerals] (14) Power providing unit

Abstract translation: 目的：提供使用可逆电极反应的电渗透泵和使用该电渗透泵的流体泵送系统，以在电渗透泵的尺寸和构造完好保持的情况下长时间转移大量流体。 构成：使用可逆电极反应的电渗泵（10）包括传输线，第一止回阀，第二止回阀，泵送管线和分离器。 传送线提供用于将目标流体（16）从容器传送到外部的通道。 第一止回阀和第二止回阀分别安装成与传送管线分开，并防止目标流体沿传送方向反向流动。 泵送线连接到第一和第二止回阀之间的输送管线的一部分。 电渗泵为泵送管线提供泵送力。 分离器将电渗泵与目标流体分离，并将泵送力传递到目标流体。 （附图标记）（14）供电单元

公开(公告)号：KR1020140015211A

公开(公告)日：2014-02-06

申请号：KR1020130089033

申请日：2013-07-26

Applicant: 서울대학교산학협력단

Inventor： 권성훈 ,  이호원 ,  박태준 ,  정유신

IPC: B81C1/00 ,  G01N33/48 ,  G06K7/10

CPC classification number: B81C1/00119 ,  B81B2201/0214 ,  B81B2201/05 ,  B81C1/00349 ,  G01N33/48 ,  G06K7/10

Abstract: Provided is a fabrication method for fine structures with variable micropatterns including: a step of forming a mixture containing photochromic materials and curable materials; a step of providing the mixture for a microfluidic tube; a step of forming variable micropatterns by applying patterned energy to a desired spot of the mixture and hardening the mixture; and a step of forming fine structures by injecting curable materials and applying additional energy to the microfluidic tube. [Reference numerals] (AA) Start; (BB) End; (S1) Forming a mixture containing photochromic materials and curable materials; (S2) Providing the mixture for a microfluidic tube; (S3) Forming variable micropatterns by applying patterned energy to a desired spot of the mixture and hardening the mixture; (S4) Forming fine structures by injecting curable materials and applying additional energy to the microfluidic tube

Abstract translation: 提供了一种具有可变微图案的精细结构的制造方法，包括：形成含有光致变色材料和可固化材料的混合物的步骤; 提供微流体管的混合物的步骤; 通过将图案化的能量施加到混合物的所需点并硬化混合物来形成可变微图案的步骤; 以及通过注射可固化材料并向微流体管施加附加能量来形成精细结构的步骤。 （附图标记）（AA）开始; （BB）结束; （S1）形成含有光致变色材料和可固化材料的混合物; （S2）提供微流体管的混合物; （S3）通过将图案化的能量施加到混合物的所需点并硬化混合物来形成可变微图案; （S4）通过注射可固化材料并向微流体管施加额外的能量来形成精细结构

公开(公告)号：KR1020090080918A

公开(公告)日：2009-07-27

申请号：KR1020090005584

申请日：2009-01-22

Applicant: 허니웰 인터내셔널 인코포레이티드

Inventor： 칼슨로버트제이.

IPC: B81B7/00 ,  B29C33/38

CPC classification number: B29C33/3842 ,  B29C41/00 ,  B29C59/14 ,  B29C59/16 ,  B29K2909/00 ,  B29K2995/0037 ,  B81B7/00 ,  B81B2201/05 ,  B81B2201/058 ,  B81B2203/0127 ,  B81C99/009 ,  B81C2201/0132 ,  B81C2201/0143 ,  B81C2201/034 ,  C23F1/02 ,  H01L21/30604 ,  Y10T428/24496

Abstract: An aerogel-based mold for MEMS fabrication and formation is provided to reduce time to manufacture a micro electric machine characteristic part by reducing time to form a patterned material layer. An aerogel-based mold for MEMS fabrication and formation comprises an aerogel layer(11). The aerogel layer approximately has the thickness of 10 nm ~ 1 mm. The aerogel layer has a structural characteristic part having the same surface contour with a partial surface contour of a micro electric machine characteristic part and is evaporated on a substrate.

Abstract translation: 提供用于MEMS制造和形成的基于气凝胶的模具，以通过减少形成图案化材料层的时间来减少制造微电机特征部件的时间。 用于MEMS制造和形成的基于气凝胶的模具包括气凝胶层（11）。 气凝胶层的厚度约为10nm〜1mm。 气凝胶层具有具有与微电机特征部分的局部表面轮廓相同的表面轮廓并在基底上蒸发的结构特征部分。

公开(公告)号：KR1020030012724A

公开(公告)日：2003-02-12

申请号：KR1020010047135

申请日：2001-08-04

Applicant: 학교법인 포항공과대학교

Inventor： 김동성 ,  권태헌 ,  이승섭 ,  이광철 ,  김성재

IPC: B81B7/00

CPC classification number: B81B7/008 ,  B81B2201/05 ,  B81B2203/0338 ,  B81C1/00015 ,  B81C1/00436

Abstract: PURPOSE: A micro channel generating a helical flow using electroosmosis and a method for manufacturing the same are provided to generate three-dimensional helical flow of an electrolyte. CONSTITUTION: A micro channel(100) having surface potential includes helical surface potential patterns composed of a plurality of first potential patterns(102) arranged on the upper wall surface inside the micro channel at regular gaps; a plurality of second surface potential patterns(104) arranged on the lower wall surface inside the micro channel at regular gaps to be connected to both ends of the first surface potential pattern; and a plurality of third potential patterns(108) arranged on the side wall surface inside the micro channel connecting the first surface potential patterns with the second surface potential patterns.

Abstract translation: 目的：提供使用电渗法产生螺旋流的微通道及其制造方法，以产生电解质的三维螺旋流。 构成：具有表面电位的微通道（100）包括螺旋形表面电位图案，其由以规则间隙布置在微通道内的上壁表面上的多个第一电位图案（102）组成; 多个第二表面电势图案（104），其以规则的间隙布置在所述微通道内的所述下壁表面上，以连接到所述第一表面电位图案的两端; 以及布置在所述微通道内的所述侧壁表面上的多个第三电位图案（108），其将所述第一表面电位图案与所述第二表面电位图案连接。