公开(公告)号：EP1518557A4

公开(公告)日：2008-12-03

申请号：EP03738567

申请日：2003-06-30

Applicant: FUSO PHARMACEUTICAL IND

Inventor： WAKAMIYA NOBUTAKA ,  OHTANI KATSUKI ,  SAKAMOTO TAKASHI ,  KESHI HIROYUKI ,  KISHI YUICHIRO

IPC: A61K38/17 ,  A61P31/18 ,  A61P37/04 ,  A61P43/00 ,  A61K38/16

CPC classification number: A61K38/1709

Abstract: It is intended to disclose an anti-HIV agent which contains as the active ingredient a mannose-binding protein (MBP) and efficaciously contributes to the treatment of patients infected with human immunodeficiency virus (HIV) and inhibits the progress of the disease. It is also intended to disclose a method of evaluating an anti-HIV activity exerted by the MBP which involves the step of culturing HIV-infected cells in the presence of the MBP.

公开(公告)号：EP1533381A4

公开(公告)日：2005-11-16

申请号：EP03730847

申请日：2003-06-05

Applicant: FUSO PHARMACEUTICAL IND ,  MIZUGUCHI HIROYUKI ,  HAYAKAWA TAKAO ,  SAKURAI FUMINORI

Inventor： MIZUGUCHI HIROYUKI ,  HAYAKAWA TAKAO ,  SAKURAI FUMINORI

IPC: C12N15/09 ,  C12N5/10 ,  C12N7/01 ,  C12N15/861

CPC classification number: C12N15/86 ,  C12N2510/00 ,  C12N2710/10343

Abstract: An adenovirus vector which at least contains a partly or fully E1-lacking type 35 adenovirus genome and shows an excellent gene transfer activity on specific cell lines, in particular hematopoietic cells. This adenovirus vector shows an excellent gene transfer activity on specific cell lines, in particular, hematopoietic cells, ES cells, pluripotent stem cells, blood stem cells and tissue stem cells.

公开(公告)号：EP1108786A4

公开(公告)日：2003-08-06

申请号：EP99938607

申请日：1999-08-24

Applicant: FUSO PHARMACEUTICAL IND

Inventor： WAKAMIYA NOBUTAKA

IPC: A61K38/00 ,  C07K14/47 ,  C07K14/78 ,  C12N15/12 ,  C12P21/08 ,  A01K67/027 ,  C07K14/785 ,  C07K16/18 ,  C12Q1/68 ,  G01N33/50

CPC classification number: C07K14/4726 ,  A61K38/00 ,  C07K14/47 ,  C07K14/78 ,  C12Q1/6876

Abstract: Novel collectin-related molecules expected as exerting antibacterial and antiviral activities, etc. particularly in the human body, namely, a novel collectin gene containing the base sequence represented by SEQ ID NO:1 and a novel collectin containing the amino acid sequence represented by SEQ ID NO:2; and a method with the use of the same.

公开(公告)号：EP1132473A4

公开(公告)日：2002-06-12

申请号：EP99972681

申请日：1999-11-19

Applicant: FUSO PHARMACEUTICAL IND

Inventor： UEMURA HIDETOSHI ,  OKUI AKIRA ,  KOMINAMI KATSUYA ,  YAMAGUCHI NOZOMI ,  MITSUI SHINICHI

IPC: C12N1/21 ,  C12N9/64 ,  C12N15/12 ,  C12P21/08 ,  A01K67/027 ,  C07K16/40 ,  C12N5/06 ,  G01N33/543

CPC classification number: C12N9/6424

Abstract: Proteins having the amino acid sequences represented by SEQ ID NOS: 2, 4 and 6 and proteins derived from these proteins by deletion, substitution or addition of one or several amino acids in these amino acid sequences; base sequences encoding these proteins; a transgenic non-human animal having an altered BSSP6 expression level; an antibody against BSSP6; and a method for detecting BSSP6 in a specimen by using this antibody.

公开(公告)号：EP1092767A4

公开(公告)日：2001-10-24

申请号：EP99926899

申请日：1999-07-02

Applicant: FUSO PHARMACEUTICAL IND

Inventor： KOMINAMI KATSUYA ,  OKUI AKIRA ,  MITSUI SHINICHI ,  YAMAGUCHI NOZOMI

IPC: C07K16/40 ,  C12N5/20 ,  C12P21/08 ,  G01N33/573 ,  G01N33/68 ,  C12N15/02 ,  A61K39/395 ,  C12N5/12 ,  G01N33/577

CPC classification number: C07K16/40 ,  G01N33/573 ,  G01N33/6896 ,  Y10S435/96 ,  Y10S436/811

Abstract: A monoclonal antibody binding selectively to neurosin obtained from hybridomas, in particular, strain 2B2-6 and strain S2E5 showing stable proliferation ability. These hybridomas are obtained by fusing mouse spleen cells having a high antibody titer against neurosin with mouse-derived myeloma cells, screening fused cells being highly reactive with neurosin, and thus producing an antibody binding specifically to neurosin. By using this antibody, various diseases in which neurosin participates can be diagnosed.

公开(公告)号：EP0872180A4

公开(公告)日：2001-08-01

申请号：EP96929521

申请日：1996-09-04

Applicant: FUSO PHARMACEUTICAL IND

Inventor： NAKAZAWA TERUKI ,  ARAKI HIROMASA ,  KISHI YUICHIRO ,  SHINODA SANJI ,  YAMADA MORIYUKI ,  OHASHI KAZUTOMO

IPC: A01K67/02 ,  A01K67/027 ,  C12N5/02 ,  C12N5/073 ,  C12N5/00

CPC classification number: A01K67/027 ,  C12N5/0604 ,  C12N2500/32

Abstract: Object: to provide a medium composition for external fertilization, in particular, one to be used in the incubation of an ovum or an early embryo, i.e., a fertilized ovum or in the pretreatment of an ovum or sperms. Means for solution: a medium composition for external fertilization which comprises as the essential components L-phenylalanine, L-tryptophan, L-lysine, L-threonine, L-valine, L-methionine, L-isoleucine, L-leucine, L-proline, glycine, L-alanine, L-tyrosine, L-histidine, L-arginine, L-taurine, L-aspartic acid, L-serine, L-asparagine, L-glutamic acid, L-glutamine and L-cystine.

公开(公告)号：BR112019002848A2

公开(公告)日：2019-06-25

申请号：BR112019002848

申请日：2017-08-10

Applicant: FUSO PHARMACEUTICAL IND ,  UNIV HOKKAIDO NAT UNIV CORP

Inventor： ASAMI NISHIMORI ,  CHIE NAKAJIMA ,  KAZUHIKO OHASHI ,  NAOYA MAEKAWA ,  SATORU KONNAI ,  SHIRO MURATA ,  TOMOHIRO OKAGAWA ,  YASUHIKO SUZUKI

IPC: A61K39/395 ,  A61P15/14 ,  A61P31/00 ,  A61P31/04 ,  A61P31/06 ,  A61P31/10 ,  A61P33/02 ,  A61P35/00 ,  A61P35/02 ,  C07K16/28 ,  C07K16/46 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/08

Abstract: a presente invenção refere-se a um anticorpo anti-lag-3 que pode ser frequentemente administrado a um animal que não seja rato. o anticorpo anti-lag-3 compreende (a) uma cadeia l compreendendo uma região variável de cadeia l que inclui cdr1 tendo uma sequência de aminoácido de qslldsdgnty (seq id no: 16), cdr2 tendo uma sequência de aminoácido de svs e cdr3 tendo uma sequência de aminoácido de mqathvpft (seq id no: 17), e uma região constante de cadeia l de um anticorpo mamífero que não seja rato; e (b) uma cadeia h compreendendo uma região variável de cadeia h que inclui cdr1 tendo uma sequência de aminoácido de gfdfdtyp (seq id no: 18), cdr2 tendo uma sequência de aminoácido de itikthnyat (seq id no: 19) e cdr3 tendo uma sequência aminoá-cido de nredfdy (seq id no: 20), e uma região constante de cadeia h de um anticorpo mamífero que não seja rato. da mesma forma é fornecido uma composição farmacêutica contendo o anticorpo anti-lag-3 como um ingrediente ativo. da mesma forma fornecido é um método de produzir o anticorpo anti-lag-3.

公开(公告)号：CA3033900A1

公开(公告)日：2018-02-22

申请号：CA3033900

申请日：2017-08-10

Applicant: UNIV HOKKAIDO NAT UNIV CORP ,  FUSO PHARMACEUTICAL IND

Inventor： KONNAI SATORU ,  OHASHI KAZUHIKO ,  MURATA SHIRO ,  OKAGAWA TOMOHIRO ,  NISHIMORI ASAMI ,  MAEKAWA NAOYA ,  SUZUKI YASUHIKO ,  NAKAJIMA CHIE

IPC: C12N15/09 ,  A61K39/395 ,  A61P31/00 ,  A61P35/00 ,  C07K16/18 ,  C07K16/28 ,  C07K16/46 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/08

Abstract: Provided is an anti-PD-1 antibody that can be administered frequently even to animals other than rats. An anti-PD-1 antibody including: (a) an L chain that has an L chain variable region including CDR1 having the amino acid sequence of QSLEYSDGYTY (SEQ ID NO: 16), CDR2 having the amino acid sequence of GVS, and CDR3 having the amino acid sequence of FQATHDPDT (SEQ ID NO: 17), and also has an L chain constant region of an animal antibody other than rat; and (b) an H chain that has an H chain variable region including CDR1 having the amino acid sequence of GFSLTSYY (SEQ ID NO: 18), CDR2 having the amino acid sequence of IRSGGST (SEQ ID NO: 19), and CDR3 having the amino acid sequence of ARTSSGYEGGFDY (SEQ ID NO: 20), and also has an H chain constant region of an animal antibody other than rat. A pharmaceutical composition containing the anti-PD-1 antibody as an active ingredient. Also provided is a method for producing the anti-PD-1 antibody.

公开(公告)号：HK1224233A1

公开(公告)日：2017-08-18

申请号：HK16112367

申请日：2016-10-27

Applicant: TAISEI KAKO CO ,  FUSO PHARMACEUTICAL IND ,  3-D MATRIX LTD

IPC: A61M20060101

公开(公告)号：DK2617737T3

公开(公告)日：2017-04-03

申请号：DK11825154

申请日：2011-09-13

Applicant: UNIV MIYAZAKI ,  FUSO PHARMACEUTICAL IND

Inventor： MUGURUMA MICHIO ,  MURATA HIROSHI

IPC: C08B37/10 ,  A61K31/727 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P21/00 ,  A61P29/00 ,  A61P35/04 ,  A61P37/06 ,  A61P37/08