Abstract:
하기 화학식 1로 표시되는 수용성 포르피린 유도체를 포함하는 광역학치료용 수용성 나노구조체가 제공된다.
상기 식 중, R 1 및 R 2 는 각각 독립적으로 -H 또는 -CH 3 이고, R 3 및 R 4 는 각각 독립적으로 -OH, -OCH 3 , -NH 2 , -NHCH 3 , -NH(CH 3 ) 2 , -NHCOCH 3 , -N(COCH 3 ) 2 , -COR 5 , 또는 -CH 2 COR 5 (여기서, R 5 =-OH, -OCH 3 , -NH 2 , -NHCH 3 , 또는 -NH(CH 3 ) 2 )이고, m 및 n은 각각 독립적으로 21 내지 226의 정수이다.
Abstract:
PURPOSE: A metal hydroxide based flame retardant-silica nanostructure, a manufacturing method thereof, and a flame-resistant insulating material including thereof are provided to improve dispersibility within a polymer resin of the metal hydroxide based flame retardant. CONSTITUTION: A manufacturing method of a metal hydroxide based flame retardant-silica nanostructure comprises next steps: forming an emulsion solution; dispersing the metal hydroxide based flame retardant into basic silicate aqueous solution; and reacting silicate solution with the emulsion solution. The basic silicate includes more than one kind which is selected from lithium silicate, sodium silicate, potassium silicate, magnesium silicate and sodium silicate potassium. The metal hydroxide based flame retardant includes more than one kind which is selected from magnesium hydroxide, calcium hydroxide, and aluminium hydroxide. A content amount of the metal hydroxide based flame retardant is 4-40 parts by weight based on 100.0 parts by weight of the basic silicate solution. The metal hydroxide based flame retardant-mixing silica nanostructure includes 1-60 parts by weight of the metal-hydroxide group flame retardant based on 100.0 parts by weight of silica nanoparticle.
Abstract:
PURPOSE: A hydrogel is provided to give stimulation reaction by including negative polymers and positive ions and to maintain gel persistence. CONSTITUTION: A hydrogel comprises a hydrophilic or amphipathic polymer including two or more of phosphate(PO4 ^2) groups and polyhydric cation corresponding with negative charged phosphate (PO4^2). The polyhydric cation is selected from low molecular weight compound or polycation including more than 2 cations selected from -NH3 and -N2(CH3)3, and positive charged metal ion having more than bivalent, and combinations thereof. The hydrogel additionally includes 0-20 parts by weight of additive selected from NaCl, CaCl2, NaCSN, PEG and a combination thereof based on 100.0 parts by weight of membranous polymers.
Abstract:
PURPOSE: A manufacturing method of cellulose ester is provided to improve substitution efficiency of a substituent, by using ionic liquid/dimethyl sulfoxide co-solvent system, and to effectively controlling reactivity, by stabilizing viscosity of reaction system. CONSTITUTION: A manufacturing method of cellulose ester comprises: a step of preparing a first solution comprising cellulose dissolved into ionic liquid; a step of preparing a second solution comprising a cyclic ester based monomer dissolved into dimethyl sulfoxide; and a step of esterificating the cellulose through ring opening-graft polymerization of reactive solution which is formed by mixing the first solution and the second solution. The volume ratio of the ionic liquid to the dimethyl sulfoxide is 1:0.5 - 1:4.
Abstract:
PURPOSE: A method for manufacturing thermoplastic cellulose polyester is provided to prepare cellulose ester having various thermal characteristics satisfying heat resistance of end-products and environmental-friendliness. CONSTITUTION: A method for manufacturing thermoplastic cellulose polyester comprises the steps of: acetylating at least a part of a hydroxyl group of the cellulose in ionic liquid to form cellulose acetate; and consecutively performing the ring opening graft polymerization of cyclic ester to a residual hydroxyl group of the cellulose acetate without the separation of the cellulose acetate from the ionic liquid. The acetylation is performed so that the cellulose is 1.0 ~ 2.9 per glucose unit.
Abstract:
본 발명은 하기 화학식 1로 표시되는 바이오 물질 감지 활성 표면 용도의 화합물에 관한 것이다: 화학식 1
상기 화학식에서, X는 산소, 황, 포스핀, 셀렌(selenium) 또는 아민 화합물이고, R 1 은 C 1 -C 24 알킬렌기 또는 이며, Q는 산소, 질소 또는 황이고, R 2 는 C 0 -C 12 알칼렌기이며, Z는 카르복실기, 아미노기, 이미드기 또는 에폭시기이고, n은 1-1000의 정수이며, m은 1-100의 정수이다. 또한, 본 발명은 상기 링커가 표면에 코팅된 고체 기질 및 상기 고체 기질을 포함하는 바이오칩을 제공한다. 링커, 고정화, 기질, 바이오칩, 화학센서
Abstract:
PURPOSE: A method for manufacturing a nanostructure for photodynamic therapy is provided to ensure dispersion stability and generation efficiency of singlet oxygen. CONSTITUTION: A nanostructure for photodynamic therapy contains titania(TiO_2) nanoparticles and photosensitizer adsorbed on the surface of titania nanoparticle. A polymer dispersing agent is adsorbed on the surface of titania nanoparticles. The polymer dispersing agent is selected from polymethacrylic acid sodium salt, glycol chitosan, polyvinyl alcohol, polyethyleneimine, and polyethylene glycol. The photosensitizer is a phthalocyanine derivative containing copper phthalocyanine, zinc phthalocyanine, and aluminum phthalocyanine, and a porphyrin derivative containing protoporphyrin IX, aminolevulinic acid, and hematoporphyrin. A method for manufacturing the nanostructure comprises: a step of preparing titania sol; a step of inputting polymer dispersing agent to the titania sol to adsorb on the titania surface; and a step of inputting the photosensitizer to titania sol.
Abstract:
A thiol derivative is provided to obtain an immobilization linker capable of controlling the surface characteristics of a solid substrate and immobilizing biomolecules such as protein and nucleic acid molecules stably to the surface of a substrate. A thiol derivative is represented by the formula of R-(CH2)m-(OCH2CH2)m-OCO-Z-Q. In the formula, R is a thiol group; Z is a C1-C12 alkylene, C1-C6 alkoxy or phenyl group; Q is a carboxyl, nitro, imide, epoxy, aldehyde, hydroxyl, amino or isocyanate group, and when Q is imide or epoxy group, the imide or epoxy group is directly bound to Z or indirectly bound to Z via -OCO- or -OCO-(CH2)n; n is an integer of 10-15; and m is an integer of 0-10.
Abstract:
A highly sensitive field effect transistor type bio sensor is provided to increase driving current and physical contacting area with a bio sensing target material, and enhance electric capacity of the device by structurally modifying the shape of a semiconductor substrate, and improve sensing reproducibility and accuracy of the bio sensor by increasing S/N ratio(signal to noise ratio) of the bio sensor. A highly sensitive field effect transistor type bio sensor comprises: a gate insulating membrane(203) deposited on a semiconductor substrate; a gate electrode(204) formed on the gate insulating membrane; a source region(201) and a drain region(202) formed in both sides of the gate insulating membrane; and a bio sensing membrane formed on the gate electrode, wherein a reference electrode is formed on the gate electrode and the semiconductor substrate has at least one predetermined prominence and depression part. The prominence and depression part is prepared by coating a polymer thin film with resist materials, performing an imprinting process on the resist with a micro stamp, repeating the imprinting process to form the pattern on the total substrate, removing a residual layer from the resist, and forming a predetermined shape on the semiconductor substrate with the resist pattern as a mask.