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公开(公告)号：CH689001A5
公开(公告)日：1998-07-15
申请号：CH233897
申请日：1991-11-19
Applicant: ABBOTT LAB
Inventor： WITTENBERGER STEVEN J , KEMPF DALE J , NORBECK DANIEL W , ZHAO CHEN , SOWIN THOMAS J , PLATTNER JACOB J , LYNN CODACONI M , HING LEUNG SHAM
IPC: A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/435 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K38/00 , A61P31/12 , A61P31/18 , A61P43/00 , C07C53/134 , C07C211/00 , C07C215/18 , C07C215/20 , C07C215/28 , C07C215/30 , C07C215/80 , C07C219/18 , C07C233/40 , C07C237/10 , C07C237/22 , C07C269/04 , C07C271/02 , C07C271/16 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/24 , C07D20060101 , C07D213/00 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/36 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D213/79 , C07D215/20 , C07D233/54 , C07D233/84 , C07D235/14 , C07D235/16 , C07D237/10 , C07D239/26 , C07D241/12 , C07D261/08 , C07D261/12 , C07D263/20 , C07D263/32 , C07D277/20 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/32 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/02 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/34 , C07D307/42 , C07D307/66 , C07D333/16 , C07D333/36 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D521/00 , C07K1/113 , C07K5/06 , C07K5/065 , C07K5/08 , C07K14/81
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Patent Agency Ranking
公开(公告)号：ES2088839T3
公开(公告)日：1997-02-01
申请号：ES94905429
申请日：1993-12-16
Applicant: ABBOTT LAB
Inventor： KEMPF DALE J , NORBECK DANIEL W , SHAM HING LEUNG , ZHAO CHEN , SOWIN THOMAS J , RENO DANIEL S
IPC: C07D275/02 , A61K31/395 , A61K31/415 , A61K31/4164 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K38/00 , A61K45/06 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/04 , A61P43/00 , C07C33/46 , C07C43/164 , C07C43/174 , C07C43/205 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/56 , C07C45/62 , C07C45/67 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D20060101 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D233/54 , C07D233/84 , C07D235/10 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D261/06 , C07D261/08 , C07D263/24 , C07D263/30 , C07D263/32 , C07D263/48 , C07D265/30 , C07D277/22 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/32 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D521/00 , C07F5/02 , C07F5/04 , C07K5/06 , C07K5/065
Abstract: A retroviral protease inhibiting compound of formula (A) is disclosed for use in combination with other active pharmaceutical agents for treating a human infected by HIV. Intermediates and processes useful in the manufacture of compounds of formula (A) are also disclosed.
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公开(公告)号：GR950300059T1
公开(公告)日：1995-11-30
申请号：GR950300059
申请日：1995-11-30
Applicant: ABBOTT LAB
Inventor： KEMPF DALE J , NORBECK DANIEL W , SHAM HING LEUNG , ZHAO CHEN , SOWIN THOMAS J , RENO DANIEL S , HAIGHT ANTHONY R , COOPER ARTHUR J
IPC: C07D275/02 , A61K31/395 , A61K31/415 , A61K31/4164 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K38/00 , A61K45/06 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/04 , A61P43/00 , C07C33/46 , C07C43/164 , C07C43/174 , C07C43/205 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/56 , C07C45/62 , C07C45/67 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D20060101 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D233/54 , C07D233/84 , C07D235/10 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D261/06 , C07D261/08 , C07D263/24 , C07D263/30 , C07D263/32 , C07D263/48 , C07D265/30 , C07D277/22 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/32 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D521/00 , C07F5/02 , C07F5/04 , C07K5/06 , C07K5/065
Abstract: A retroviral protease inhibiting compound of formula (A) is disclosed for use in combination with other active pharmaceutical agents for treating a human infected by HIV. Intermediates and processes useful in the manufacture of compounds of formula (A) are also disclosed.
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公开(公告)号：CA2605872A1
公开(公告)日：1994-06-30
申请号：CA2605872
申请日：1993-12-16
Applicant: ABBOTT LAB
Inventor： RENO DANIEL S , SHAM HING LEUNG , NORBECK DANIEL W , ZHAO CHEN , SOWIN THOMAS J , KEMPF DALE J , COOPER ARTHUR J , HAIGHT ANTHONY R
IPC: C07D275/02 , C07D277/28 , A61K31/395 , A61K31/415 , A61K31/4164 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K38/00 , A61K45/06 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/04 , A61P43/00 , C07C33/46 , C07C43/164 , C07C43/174 , C07C43/205 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/56 , C07C45/62 , C07C45/67 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D20060101 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D233/54 , C07D233/84 , C07D235/10 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D261/06 , C07D261/08 , C07D263/24 , C07D263/30 , C07D263/32 , C07D263/48 , C07D265/30 , C07D277/22 , C07D277/24 , C07D277/30 , C07D277/32 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D521/00 , C07F5/02 , C07F5/04 , C07K5/06 , C07K5/065
Abstract: A retroviral protease inhibiting compound of formula (A) is disclosed for use in combination with other active pharmaceutical agents for treating a human infected by HIV. Intermediates and processes useful in the manufacture of compounds of formula (A) are also disclosed.
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公开(公告)号：CA2001318A1
公开(公告)日：1990-04-25
申请号：CA2001318
申请日：1989-10-24
Applicant: ABBOTT LAB
Inventor： NORBECK DANIEL W , ROSEN TERRY J , PARIZA RICHARD J , SOWIN THOMAS J , PLATTNER JACOB J , GARMAISE DAVID L , HANNICK STEVEN M
IPC: C07D251/18 , A61K31/435 , A61K31/44 , A61K31/4418 , A61K31/4425 , A61K31/505 , A61K31/52 , A61K31/522 , A61P31/12 , C07C61/04 , C07C67/347 , C07C69/635 , C07C215/42 , C07C271/18 , C07C271/20 , C07C271/24 , C07C275/50 , C07C321/24 , C07D213/69 , C07D239/10 , C07D239/46 , C07D239/47 , C07D239/54 , C07D251/16 , C07D253/06 , C07D253/065 , C07D403/04 , C07D471/04 , C07D473/00 , C07D473/02 , C07D473/18 , C07D473/26 , C07D473/34 , C07D473/40 , C07D487/04 , C07F7/18 , C07F9/38 , C07F9/6561
Abstract: CARBOCYCLIC NUCLEOSIDE ANALOGS A compound of the formula: wherein A is a purin-9-yl group, a heterocyclic isostere of a purin-9-yl group, a pyrimidin-1-yl group or a heterocyclic isostere of a pyrimidin-1-yl group; E is hydrogen, -CH2OH or -OH; and G and D are independently selected from hydrogen, C1 to C10 alkyl, OH, -CH2OH, -CH2OR20 wherein R20 i8 C1 to C6 alkyl, -CH20C(O)R21 wherein R21 is C1 to C10 alkyl, -CH20C(O)CH(R22)(NHR23) wherein R22 is tha side chain of any of the naturally occuring amino acids and R23 is hydrogen or -C(O)CH(R24)(NH2) wherein R24 is the side chain of any of the naturally occuring amino acids, -CH2SH, -CH2C1, -CH2F, -CH2Br, -CH2I, -C(O)H, -CH2CN, -CH2N3, -CH2NR1R2, -CO)2R1, -CH2OH2OH, -CH2CH2OR20 R20 is as defined above, -CH2CH20C(O)R21 wherein R21 is as defined above, -CH2CH20C(O)CH(R22)(NHR23) wherein R22 and R23 are as defined above, -CH2CH2PO3H2, -CH2OPO3H2, -OCH2PO3H2 and -CH2CO2R3 wherein R1 and R2 are independently selected from hydrogen and C1 to 10 alkyl and R3 is hydrogen, C1 to C10 alkyl, carboxyalkyl or aminoalkyl; or a pharmaceutically acceptable salt thereof. (11-1088P)
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公开(公告)号：DK529289D0
公开(公告)日：1989-10-24
申请号：DK529289
申请日：1989-10-24
Applicant: ABBOTT LAB
Inventor： NORBECK DANIEL W , ROSEN TERRY J , PARIZA RICHARD J , SOWIN THOMAS J , PLATTNER JACOB J , GARMAISE DAVID L , HANNICK STEVEN M
IPC: C07D251/18 , A61K31/435 , A61K31/44 , A61K31/4418 , A61K31/4425 , A61K31/505 , A61K31/52 , A61K31/522 , A61P31/12 , C07C61/04 , C07C67/347 , C07C69/635 , C07C215/42 , C07C271/18 , C07C271/20 , C07C271/24 , C07C275/50 , C07C321/24 , C07D213/69 , C07D239/10 , C07D239/46 , C07D239/47 , C07D239/54 , C07D251/16 , C07D253/06 , C07D253/065 , C07D403/04 , C07D471/04 , C07D473/00 , C07D473/02 , C07D473/18 , C07D473/26 , C07D473/34 , C07D473/40 , C07D487/04 , C07F7/18 , C07F9/38 , C07F9/6561 , C07C87/34 , C07C91/14 , C07C125/063 , C07C147/06 , C07C149/40 , C07F9/65
Abstract: A compound of the formula: wherein A is a purin-9-yl group, a heterocyclic isostere of a purin-9-yl group, a pyrimidin-1-yl group or a heterocyclic isostere of a pyrimidin-1-yl group; E is hydrogen, -CH2OH or -OH; and G and D are independently selected from hydrogen, C1 to C10 alkyl, -OH, -CH2OH, -CH2OR20 wherein R20 is C1 to C6 alkyl, -CH2OC(O)R21 wherein R21 is C1 to C10 alkyl, -CH2OC(O)CH(R22)(NHR23) wherein R22 is the side chain of any of the naturally occuring amino acids and R23 is hydrogen or -C(O)CH(R24)(NH2) wherein R24 is the side chain of any of the naturally occuring amino acids, -CH2SH, -CH2Cl, -CH2F, -CH2Br, -CH2I, -C(O)H, -CH2CN, -CH2N3, -CH2NR1R2, -CO2R1, -CH2CH2OH, -CH2CH2OR20 wherein R20 is as defined above, -CH2CH2OC(O)R21 wherein R21 is as defined above -CH2CH2OC(O)CH(R22)(NHR23) wherein R22 and R23 are as defined above -CH2CH2PO3H2, -CH2OPO3H2, -OCH2PO3H2 and -CH2CO2R3 wherein R1 and R2 are independently selected from hydrogen and C1 to C10 alkyl and R3 is hydrogen, C1 to C10 alkyl carboxyalkyl or aminoalkyl; or a pharmaceutically acceptable salt thereof.
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