公开(公告)号：DE3260540D1

公开(公告)日：1984-09-13

申请号：DE3260540

申请日：1982-06-16

Applicant: BASF AG

Inventor： ROSSY PHILLIP A DR ,  THYES MARCO DR ,  FRANKE ALBRECHT DR ,  GRIES JOSEF DR ,  LEHMANN HANS DIETER DR ,  LENKE DIETER DR ,  KOENIG HORST DR

IPC: A61K31/50 ,  A61K31/55 ,  A61P7/02 ,  A61P9/12 ,  C07D209/34 ,  C07D215/22 ,  C07D215/227 ,  C07D223/16 ,  C07D401/04 ,  C07D403/04

Abstract: 2-Aryl-3,4-diazabicyclo[4.n.O]alk-2-en-5-ones of the formula I I where m and n are identical or different and each is 1, 2 or 3, and R, R1 and R2 are identical or different and each is hydrogen or alkyl of 1 to 6 C atoms, said compounds are useful for treating high blood pressure and thrombo-embolic disorders.

公开(公告)号：CS227692B2

公开(公告)日：1984-05-14

申请号：CS471082

申请日：1982-06-24

Applicant: BASF AG

Inventor： ROSSY PHILIP A DR ,  THYES MARCO DR ,  FRANKE ALBRECHT DR ,  KOENIG HORST DR ,  GRIES JOSEF DR ,  LEHMANN HANS D DR

IPC: A61K31/50 ,  A61K31/55 ,  A61P7/02 ,  A61P9/12 ,  C07D209/34 ,  C07D215/22 ,  C07D215/227 ,  C07D223/16 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10

Abstract: 2-Aryl-3,4-diazabicyclo[4.n.O]alk-2-en-5-ones of the formula I I where m and n are identical or different and each is 1, 2 or 3, and R, R1 and R2 are identical or different and each is hydrogen or alkyl of 1 to 6 C atoms, said compounds are useful for treating high blood pressure and thrombo-embolic disorders.

公开(公告)号：GR73857B

公开(公告)日：1984-05-08

申请号：GR810164200

申请日：1981-02-20

Applicant: BASF AG

Inventor： MAY HANS-JOACHIM DR ,  LENKE DIETER PROF DR ,  GRIES JOSEF DR ,  TESCHENDORF HANS-JUERGEN DR ,  WORSTMANN WOLFGANG DR

IPC: C07D409/06 ,  A61K31/33 ,  A61K31/415 ,  A61K31/465 ,  A61K31/47 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P43/00 ,  C07D233/54 ,  C07D233/64 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D413/06 ,  C07D417/06

Abstract: 1-Aroyl-2-phenylamino-2-imidazolines of the general formula where R1 and R2 are identical or different and each is chlorine, bromine, fluorine, methyl, ethyl, methoxy, trifluoromethyl or cyano, R3 has the meanings given for R1 and R2 or is hydrogen and Ar is an unsubstituted or substituted monocyclic or bicyclic heteroaromatic radical containing 1, 2 or 3 nitrogen and/or oxygen and/or sulfur atoms, their salts with physiologically tolerated acids, their preparation, and drugs containing these compounds. The compounds have, inter alia, a blood pressure-reducing action.

公开(公告)号：DE2966809D1

公开(公告)日：1984-04-19

申请号：DE2966809

申请日：1979-12-06

Applicant: BASF AG

Inventor： THYES MARCO DR DIPL CHEM ,  GRIES JOSEF DR ,  LEHMANN HANS DIETER DR ,  LENKE DIETER DR ,  KUNZE JOHANNES DR

IPC: A61K31/50 ,  A61K31/395 ,  A61K31/502 ,  A61P7/02 ,  A61P9/12 ,  C07C62/38 ,  C07C205/56 ,  C07D231/54 ,  C07D237/26

Abstract: 2-Aryl-3,4-diaza-bicyclo-[4.1.0]hept-2-en-5-ones, substituted in the phenyl ring, of the general formula their preparation, and therapeutic agents, containing these compounds, which may be used for the treatment of hypertension or of thrombo-embolic disorders.

公开(公告)号：DE2962700D1

公开(公告)日：1982-06-24

申请号：DE2962700

申请日：1979-08-07

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER DR ,  FRANKE ALBRECHT DR ,  KOENIG HORST DR ,  LENKE HANS-DIETER DR ,  GRIES JOSEF DR

IPC: A61K31/40 ,  A61P9/00 ,  C07D207/32 ,  C07D207/333 ,  C07D405/12

Abstract: Alkylaminopropanol derivatives of 2-(o-hydroxyphenyl)-pyrrole of the formula (I) (I) where R is hydrogen or is alkyl of 1 to 8 carbon atoms which is unsubstituted or substituted by hydroxyl, alkoxy of 1 to 3 carbons atoms or cycloalkyl of 3 to 8 carbon atoms in the ring, or is alkenyl or alkynyl of 2 to 8 carbon atoms or is cycloalkyl or cycloalkenyl of 3 to 8 carbon atoms in the ring, the cycloalkyl rings being unsubstituted or monosubstituted or disubstituted by alkyl or 1 to 3 carbon atoms, and their physiologically acceptable acid addition salts, processes for their preparation, and pharmaceutical formulations which contain the said compounds and may be used in the treatment of cardiac and circulatory disorders.

公开(公告)号：DE2961499D1

公开(公告)日：1982-01-28

申请号：DE2961499

申请日：1979-03-31

Applicant: BASF AG

Inventor： THIEME PETER C DR ,  FRICKEL FRITZ-FRIEDER DR ,  HAGEN HELMUT DR ,  FRANKE ALBRECHT DR ,  LENKE DIETER DR ,  GRIES JOSEF DR

IPC: A61K31/41 ,  A61K31/433 ,  A61P9/00 ,  A61P9/06 ,  A61P9/12 ,  C07D285/12 ,  C07D417/12

Abstract: Alkylaminopropanol derivatives of 2-methyl-5-(2-hydroxystyryl)-1,3,4-thiadiazole and their addition salts with acids, their preparation, and pharmaceutical formulations, containing these compounds, which may be used for the treatment of coronary diseases of the heart, of hypertonia and of cardiac arrhythmias.

公开(公告)号：DE3022177A1

公开(公告)日：1982-01-07

申请号：DE3022177

申请日：1980-06-13

Applicant: BASF AG

Inventor： THYES MARCO DR ,  FRANKE ALBRECHT DR ,  KOENIG HORST PROF DR ,  LENKE DIETER PROF DR ,  LEHMANN HANS DIETER DR ,  GRIES JOSEF DR

IPC: A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04

Abstract: -pyridazinone derivs. (I) are new. X is O or S; R1 is H or 1-3C alkyl; and R2 is 1-8C alkyl (opt. substd. by 1-4 halogen atoms, 1-4C alkoxy (sepd. from X by at least 2 C-atoms), 3-8C cycloalkyl (opt. carrying 1 or 2 1-3C alkyl gps.) or phenyl (opt. in turn carrying 1-3 substits. from 1-3C alkyl, 1-3C alkoxy, halogen, CF3 or NO2), 3-8C cycloalkyl (opt. mono- to tetra substd. by 1-4C alkyl), 3-8C alkenyl, 3-8C alkynyl or phenyl (opt. carrying 1-3 substits. from 1-4C alkyl, 1-4C alkoxy, halogen, CF3, CN and NO2). (I) have thrombocyte aggregation inhibiting and hypotensive properties. They can be used as antihypertensive agents and for the prophylaxis and treatment of thrombo-embolid diseases. Results of tests for pharmacological activity are given in the spec.

公开(公告)号：DE3022176A1

公开(公告)日：1982-01-07

申请号：DE3022176

申请日：1980-06-13

Applicant: BASF AG

Inventor： THYES MARCO DIPL CHEM DR ,  KOENIG HORST DIPL CHEM DR ,  LENKE DIETER PROF DR ,  LEHMANN HANS DIETER DR ,  GRIES JOSEF DR

IPC: A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04

Abstract: Novel 6-(p-acylaminophenyl)-4,5-dihydro-3(2H)-pyridazinones, whose acyl radical is derived from a cycloalkylcarboxylic acid, processes for their preparation, pharmaceutical formulations containing these compounds, and their use as drugs in thrombo-embolic disorders and as anti-hypertensives.

公开(公告)号：DE2861089D1

公开(公告)日：1981-12-03

申请号：DE2861089

申请日：1978-06-01

Applicant: BASF AG

Inventor： LEBKUECHER ROLF DR ,  THYES MARCO DR ,  KOENIG HORST DR ,  LEHMANN HANS DIETER DR ,  GRIES JOSEF DR ,  LENKE DIETER DR ,  KUNZE JOHANNES DR

IPC: C07D237/00 ,  A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04

Abstract: 6-(p-Acylaminophenyl)-4,5-dihydropyridaz-3-ones of the formula I I where R1 is hydrogen or alkyl of 1 to 3 carbon atoms and R2, if R1 is hydrogen, is halogen-substituted alkyl of 3 to 6 carbon atoms or beta -haloethyl or, if R1 is alkyl of 1 to 3 carbon atoms, is halogen-substituted alkyl of 1 to 6 carbon atoms, their manufacture, and therapeutic agents which contain, as the active ingredient, a compound of the formula I, where R2 may also be halomethyl or alpha -haloethyl if R1 is hydrogen. These compounds may be used as anti-hypertensive agents and for the prophylaxis and therapy of thromboembolic disorders.

公开(公告)号：DE3011327A1

公开(公告)日：1981-10-01

申请号：DE3011327

申请日：1980-03-24

Applicant: BASF AG

Inventor： MAY HANS-JOACHIM DIPL CHEM DR ,  LENKE DIETER PROF DR ,  GRIES JOSEF DR ,  TESCHENDORF HANS-JUERGEN DR ,  WORSTMANN WOLFGANG DR

IPC: C07D409/06 ,  A61K31/33 ,  A61K31/415 ,  A61K31/465 ,  A61K31/47 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P43/00 ,  C07D233/54 ,  C07D233/64 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D413/06 ,  C07D417/06 ,  C07D233/50 ,  C07D401/12 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  A61K31/435 ,  A61K31/42 ,  A61K31/425

Abstract: 1-Aroyl-2-phenylamino-2-imidazolines of the general formula where R1 and R2 are identical or different and each is chlorine, bromine, fluorine, methyl, ethyl, methoxy, trifluoromethyl or cyano, R3 has the meanings given for R1 and R2 or is hydrogen and Ar is an unsubstituted or substituted monocyclic or bicyclic heteroaromatic radical containing 1, 2 or 3 nitrogen and/or oxygen and/or sulfur atoms, their salts with physiologically tolerated acids, their preparation, and drugs containing these compounds. The compounds have, inter alia, a blood pressure-reducing action.