公开(公告)号：CA2347521A1

公开(公告)日：2000-04-27

申请号：CA2347521

申请日：1999-10-13

Applicant: BASF AG

Inventor： RESS-LOSCHKE MARION ,  HAUER BERNHARD ,  ENGELS DIRK ,  FRIEDRICH THOMAS ,  MATTES RALF

IPC: C12N15/09 ,  C07H21/00 ,  C12N1/21 ,  C12N9/78 ,  C12N15/55 ,  C12P7/40 ,  C12P7/42 ,  C12P41/00 ,  C12R1/05 ,  C12N15/63

Abstract: The invention relates to nucleic acid sequences which code for a polypeptide with nitrilase activity, to nucleic acid constructs containing the nucleic acid sequences, and to vectors containing the nucleic acid sequences or the nucleic acid constructs. The invention also relates to amino acid sequences which are coded by the nucleic acid sequences, and to microorganisms containing the nucleic acid sequences, the nucleic acid constructs or vector s containing the nucleic acid sequences or the nucleic acid constructs. In addition, the invention relates to a method for producing chiral carboxylic acids from the racemic nitriles.

公开(公告)号：DK0720655T3

公开(公告)日：2000-04-10

申请号：DK94928365

申请日：1994-09-16

Applicant: BASF AG

Inventor： BALKENHOHL FRIEDHELM ,  HAUER BERNHARD ,  LADNER WOLFGANG ,  PRESSLER UWE ,  N BLING CHRISTOPH

IPC: C12P13/02 ,  C12P41/00 ,  C12R1/38

Abstract: PCT No. PCT/EP94/03102 Sec. 371 Date Mar. 11, 1996 Sec. 102(e) Date Mar. 11, 1996 PCT Filed Sep. 16, 1994 PCT Pub. No. WO95/08636 PCT Pub. Date Mar. 30, 1995A process for producing optically active primary and secondary amines from the corresponding racemates is characterised in that (a) a racemic amine is enantioselectively acylated in the presence of a hydrolase with an ester whose acid component bears a fluorine, nitrogen, oxygen or sulphur atom at the proximity of the carbonyl carbon atom; (b) the mixture of optically active amine and optically active acylated amine is separated so that an enantiomer of amine is produced; (c) if desired the other enantiomer of the amine is extracted from the acylated amine by amide cleavage.

公开(公告)号：DE59409010D1

公开(公告)日：2000-01-20

申请号：DE59409010

申请日：1994-09-16

Applicant: BASF AG

Inventor： BALKENHOHL FRIEDHELM ,  HAUER BERNHARD ,  LADNER WOLFGANG ,  PRESSLER UWE ,  NUEBLING CHRISTOPH

IPC: C12P13/02 ,  C12P41/00 ,  C12R1/38

Abstract: PCT No. PCT/EP94/03102 Sec. 371 Date Mar. 11, 1996 Sec. 102(e) Date Mar. 11, 1996 PCT Filed Sep. 16, 1994 PCT Pub. No. WO95/08636 PCT Pub. Date Mar. 30, 1995A process for producing optically active primary and secondary amines from the corresponding racemates is characterised in that (a) a racemic amine is enantioselectively acylated in the presence of a hydrolase with an ester whose acid component bears a fluorine, nitrogen, oxygen or sulphur atom at the proximity of the carbonyl carbon atom; (b) the mixture of optically active amine and optically active acylated amine is separated so that an enantiomer of amine is produced; (c) if desired the other enantiomer of the amine is extracted from the acylated amine by amide cleavage.

公开(公告)号：AT187774T

公开(公告)日：2000-01-15

申请号：AT94928365

申请日：1994-09-16

Applicant: BASF AG

Inventor： BALKENHOHL FRIEDHELM ,  HAUER BERNHARD ,  LADNER WOLFGANG ,  PRESSLER UWE ,  NUEBLING CHRISTOPH

IPC: C12P13/02 ,  C12P41/00 ,  C12R1/38

Abstract: PCT No. PCT/EP94/03102 Sec. 371 Date Mar. 11, 1996 Sec. 102(e) Date Mar. 11, 1996 PCT Filed Sep. 16, 1994 PCT Pub. No. WO95/08636 PCT Pub. Date Mar. 30, 1995A process for producing optically active primary and secondary amines from the corresponding racemates is characterised in that (a) a racemic amine is enantioselectively acylated in the presence of a hydrolase with an ester whose acid component bears a fluorine, nitrogen, oxygen or sulphur atom at the proximity of the carbonyl carbon atom; (b) the mixture of optically active amine and optically active acylated amine is separated so that an enantiomer of amine is produced; (c) if desired the other enantiomer of the amine is extracted from the acylated amine by amide cleavage.

公开(公告)号：AU4145099A

公开(公告)日：1999-12-06

申请号：AU4145099

申请日：1999-05-20

Applicant: BASF AG

Inventor： HAUER BERNHARD ,  SCHMID ROLF D ,  ENZELBERGER MARKUS ,  MINNING STEPHAN

IPC: G01N33/53 ,  C07K1/16 ,  C07K7/04 ,  C07K19/00 ,  C12N9/14 ,  C12N15/09 ,  C12N15/55 ,  C12P21/02 ,  C12N15/62 ,  C07K1/22

Abstract: The invention relates to new peptide fragments, fusion proteins containing said peptide fragments, methods for producing same and the use of the peptide fragments. The invention also relates to a method for the purification of fusion proteins and a method for detecting proteins. The invention further relates to nucleic acids coding for the peptide fragments or the fusion proteins and to vectors containing said nucleic acids.

公开(公告)号：DK0609244T3

公开(公告)日：1999-08-23

申请号：DK92920080

申请日：1992-09-23

Applicant: BASF AG

Inventor： STAUDENMAIER HORST RALF ,  HAUER BERNHARD ,  LADNER WOLFGANG ,  MUELLER URSULA ,  PRESSLER UWE ,  MEYER JOACHIM

IPC: C12P7/42 ,  C12R1/645

公开(公告)号：AU8732798A

公开(公告)日：1999-03-08

申请号：AU8732798

申请日：1998-07-25

Applicant: BASF AG

Inventor： BREUER MICHAEL ,  HAUER BERNHARD ,  MESCH KATHRIN ,  IDING HANS ,  GOETZ GUNTER ,  POHL MARTINA ,  KULA MARIA-REGINA

IPC: C12N9/88 ,  C12P7/26

公开(公告)号：ES2120055T3

公开(公告)日：1998-10-16

申请号：ES94919662

申请日：1994-06-24

Applicant: BASF AG

Inventor： PRESSLER UWE ,  BALKENHOHL FRIEDHELM ,  HAUER BERNHARD ,  LADNER WOLFGANG ,  SCHNELL URSULA ,  STAUDENMAIER HORST RALF

IPC: C07D319/06 ,  C12P7/04 ,  C12P7/22 ,  C12P7/24 ,  C12P7/40 ,  C12P17/00 ,  C12P17/06 ,  C12P17/10 ,  C12P17/12 ,  C12P17/14 ,  C12R1/01 ,  C12R1/06 ,  C12R1/07 ,  C12R1/13 ,  C12R1/15 ,  C12R1/265 ,  C12R1/365 ,  C12R1/44

Abstract: PCT No. PCT/EP94/02071 Sec. 371 Date Dec. 28, 1995 Sec. 102(e) Date Dec. 28, 1995 PCT Filed Jun. 24, 1994 PCT Pub. No. WO95/02061 PCT Pub. Date Jan. 19, 1995A process for the biotechnological preparation of alcohols, aldehydes and carboxylic acids by oxidation of compounds of the formula R1-C(CH3)=CR2R3, where R1, R2 and R3 have the meanings indicated in the description, with the aid of microorganisms is described.\!

公开(公告)号：DE59209468D1

公开(公告)日：1998-09-24

申请号：DE59209468

申请日：1992-09-25

Applicant: BASF AG

Inventor： STAUDENMAIER HORST ,  HAUER BERNHARD ,  LADNER WOLFGANG ,  MUELLER URSULA ,  PRESSLER UWE ,  MEYER JOACHIM

IPC: C12P7/42 ,  C12R1/645 ,  C12R1/66 ,  C12R1/69

公开(公告)号：ES2106314T3

公开(公告)日：1997-11-01

申请号：ES93900043

申请日：1992-12-14

Applicant: BASF AG

Inventor： LADNER WOLFGANG ,  STAUDENMAIER HORST RALF ,  HAUER BERNHARD ,  MUELLER URSULA ,  PRESSLER UWE ,  MEYER JOACHIM

IPC: C12P7/42 ,  C12R1/465 ,  C12R1/645 ,  C12R1/66 ,  C12R1/685