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    Inhibitors of bruton’s tyrosine kinase
    64.
    发明专利
    Inhibitors of bruton’s tyrosine kinase 未知

    公开(公告)号：NZ599396A

    公开(公告)日：2014-03-28

    申请号：NZ59939610

    申请日：2010-10-12

    Applicant: PHARMACYCLICS INC

    Inventor： CHEN WEI ,  MODY TARAK D ,  LOURY DAVID J ,  VERNER ERIK ,  LUO WENCHEN ,  SMYTH MARK STEPHEN

    IPC: C07D487/04 ,  A61K31/519 ,  A61P19/02 ,  A61P19/10 ,  C07D401/04 ,  C07D401/14

    Abstract: NZ 599396 The disclosure relates to pyrazolo-pyrimidine derivatives of formula (II) that are inhibitors of bruton’s tyrosine kinase (Btk), wherein the variables are as defined in the specification. The disclosure also relates to methods for synthesizing such inhibitors, and methods, assays and systems for determining an appropriate inhibitor of a protein, including a kinase. These compounds are suitable for treating an autoimmune disease or condition, a heteroimmune disease or condition, cancers including B-cell proliferative disorder is diffuse large B cell lymphoma, follicular lymphoma or chronic lymphocytic leukemia, mastocytosis, osteoporosis, and an inflammatory disease or condition.

    Inhibitors of Bruton's tyrosine kinase
    67.
    发明专利
    Inhibitors of Bruton's tyrosine kinase 未知

    公开(公告)号：AU2012205166A1

    公开(公告)日：2012-08-02

    申请号：AU2012205166

    申请日：2012-07-16

    Applicant: PHARMACYCLICS INC

    Inventor： VERNER ERIK ,  PAN ZHENGYING ,  HONIBERG LEE

    IPC: C07D471/04 ,  A01N43/90 ,  A61K31/519 ,  A61K31/52 ,  A61P29/00 ,  A61P35/00 ,  A61P35/02

    Abstract: INHIBITORS OF BRUTON'S TYROSINE KINASE Abstract Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions. (64408731 ):KZA

    Inhibitors of Bruton's tyrosine kinase
    68.
    发明专利
    Inhibitors of Bruton's tyrosine kinase 未知

    公开(公告)号：AU2006348662B2

    公开(公告)日：2012-04-19

    申请号：AU2006348662

    申请日：2006-12-28

    Applicant: PHARMACYCLICS INC

    Inventor： HONIGBERG LEE ,  PAN ZHENGYING ,  VERNER ERIK

    IPC: C07D471/04 ,  A01N43/90 ,  A61K31/519 ,  A61K31/52 ,  A61P29/00 ,  A61P35/00 ,  A61P35/02

    Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

    INHIBIDORES DE TIROSINA CINASA DE BRUTON.
    69.
    发明专利
    INHIBIDORES DE TIROSINA CINASA DE BRUTON. 未知

    公开(公告)号：ES2376424T3

    公开(公告)日：2012-03-13

    申请号：ES10155834

    申请日：2006-12-28

    Applicant: PHARMACYCLICS INC

    Inventor： HONIGBERG LEE ,  VERNER ERIK ,  PAN ZHENGYING

    IPC: A01N43/90 ,  A61K31/519 ,  A61P35/00 ,  C07D487/04

    Abstract: Un compuesto de fórmula (D) que tiene la estructura: en la que: La es CH2, O, NH o S; Ar es un arilo sustituido o no sustituido, o un heteroarilo sustituido o no sustituido; Y es un grupo opcionalmente sustituido seleccionado de entre alquilo, heteroalquilo, cicloalquilo, heterocicloalquilo, arilo y heteroarilo; Z es C(=O), OC(=O), NHC(=O), C(=S), S(=O)x, OS(=O)x, NHS(=O)x, donde x es 1 o 2; R es H o alquilo C1-C6; y R7 y R8 son H o tomados conjuntamente forman un enlace; R6 es H, o una sal farmacéuticamente aceptable del mismo.

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