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    Sequence symmetric modified IgG4 bispecific antibodies
    61.
    发明专利
    Sequence symmetric modified IgG4 bispecific antibodies 未知

    公开(公告)号：AU2018201232A1

    公开(公告)日：2018-03-15

    申请号：AU2018201232

    申请日：2018-02-21

    Applicant: UCB PHARMA SA

    Inventor： HUMPHREYS DAVID PAUL ,  PETERS SHIRLEY JANE

    IPC: C07K16/00

    Abstract: The present disclosure relates to a symmetric bispecific antibody of the class IgG4 comprising two heavy chains which each comprise a variable domain, CHI domain and a hinge region, wherein in each heavy chain: the cysteine in the CHI domain which forms an inter-chain disulphide bond with a cysteine in a light chain is substituted with another amino acid; and optionally one or more of the amino acids positioned in the upper hinge region is substituted with cysteine, wherein the constant region sequence of each heavy chain is similar or identical and the variable region in each heavy chain is different, formulations comprising the same, the use of each of the above in treatment and processes for preparing said antibodies and formulations. 9994710_1 (GHMatters) P97845.AU.1

    anticorpos melhorados da classe igg4.
    64.
    发明专利
    anticorpos melhorados da classe igg4. 未知

    公开(公告)号：BR112013003262A2

    公开(公告)日：2016-06-14

    申请号：BR112013003262

    申请日：2011-08-19

    Applicant: UCB PHARMA SA

    Inventor： HUMPHREYS DAVID PAUL ,  HEADS JAMES ,  ADAMS RALPH ,  PETERS SHIRLEU JANE

    IPC: A61K39/395 ,  C07K16/00

    Abstract: anticorpos melhorados da classe igg4. a presente invenção fornece um anticorpo da classe igg4 que compreendendo pelo menos uma cadeia pesada que compreende um domínio de c 1 e uma região da dobradiça em que em cada cadeia pesada: a. a cisteína inter-cadeias na posição 127, numerada de acordo com o sistema de numeração kabat, no domínio de c 1 é substituída com outro aminoácido; e b. um ou mais dos aminoácidos posicionados na região da dobradiça superior são substituídos com cisteína.

    anticorpos multivalentes
    66.
    发明专利
    anticorpos multivalentes 未知

    公开(公告)号：BR112012011704A2

    公开(公告)日：2016-03-01

    申请号：BR112012011704

    申请日：2010-11-17

    Applicant: UCB PHARMA SA

    Inventor： LAWSON ALASTAIR DAVID GRIFFITHS ,  HUMPHREYS DAVID PAUL ,  HEYWOOD SAM PHILIP

    IPC: C07K16/00 ,  C07K19/00

    Abstract: anticorpos multivalentes. uma proteína de fusão de anticorpos multivalentes compreendendo: uma cadeia pesada compreendendo em sequência a partir da ponta n, um domínio variável denominado v~h~1, um domínio cl e um domínio variável denominado, v~l~2, sendo que referidas cadeias pesada e leve são alinhadas de forma a proporcionar um primeiro sítio de ligação formado por um primeiro par de domínios variáveis de v~h~1 e v~l~1 e um segundo sítio de ligação formado por um segundo par de domínios variáveis de v~h~2 e v~l~2, sendo que há uma ligação dissulfeto entre um par de domínios variáveis formando um sítio de ligação, e referida proteína de fusão é conjugada a um polímerode peg.

    IMPROVED ANTIBODIES OF THE CLASS IGG4
    67.
    发明专利
    IMPROVED ANTIBODIES OF THE CLASS IGG4 未知

    公开(公告)号：SG10201506492PA

    公开(公告)日：2015-10-29

    申请号：SG10201506492P

    申请日：2011-08-19

    Applicant: UCB PHARMA SA

    Inventor： HUMPHREYS DAVID PAUL ,  PETERS SHIRLEY JANE ,  ADAMS RALPH ,  HEADS JAMES

    Abstract: The present invention provides an antibody of the class IgG4 comprising at least one heavy chain which comprises a CH1 domain and a hinge region, wherein in each heavy chain: a. the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b. one or more of the amino acids positioned in the upper hinge region is substituted with cysteine.

    SEQUENCE SYMMETRIC MODIFIED IGG4 BISPECIFIC ANTIBODIES
    69.
    发明专利
    SEQUENCE SYMMETRIC MODIFIED IGG4 BISPECIFIC ANTIBODIES 未知

    公开(公告)号：SG11201404789XA

    公开(公告)日：2014-09-26

    申请号：SG11201404789X

    申请日：2013-02-22

    Applicant: UCB PHARMA SA

    Inventor： HUMPHREYS DAVID PAUL ,  PETERS SHIRLEY JANE

    IPC: C07K16/00

    Abstract: The present disclosure relates to a symmetric bispecific antibody of the class IgG4 comprising two heavy chains which each comprise a variable domain, CH1 domain and a hinge region, wherein in each heavy chain the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, is substituted with another amino acid; and the cysteine at position 239 and/or the cysteine at position 242, numbered according to the Kabat numbering system, is substituted with another amino acid, wherein the constant region sequence of each heavy chain is similar or identical and the variable region in each heavy chain is different, formulations comprising the same, the use of each of the above in treatment and processes for preparing said antibodies and formulations.

    Albumin binding antibodies and binding fragments thereof
    70.
    发明专利
    Albumin binding antibodies and binding fragments thereof 未知

    公开(公告)号：AU2012335496A1

    公开(公告)日：2014-05-15

    申请号：AU2012335496

    申请日：2012-11-09

    Applicant: UCB PHARMA SA

    Inventor： ADAMS RALPH ,  BHATTA PALLAVI ,  HEYWOOD SAM PHILLIP ,  HUMPHREYS DAVID PAUL

    IPC: C07K16/18 ,  C07K16/28 ,  C07K16/46

    Abstract: A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or comprising a light chain variable domain having the sequence given in SEQ ID NO:3 or SEQ ID NO:4, in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 1 and SEQ ID NO:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 2 and SEQ ID NO:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments, vectors comprising same and host cells capable of expressing the polynucleotides. The disclosure further includes pharmaceutical compositions comprising the antibodies or fragments and therapeutic used of any one of the same.

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