公开(公告)号：AU2012201325A1

公开(公告)日：2012-03-29

申请号：AU2012201325

申请日：2012-03-05

Applicant: VERTEX PHARMA

Inventor： RUAH SARA HADIDA ,  HAMILTON MATTHEW ,  MILLER MARK ,  GROOTENHUIS PETER D J ,  BEAR BRIAN ,  MCCARTHY JASON ,  ZHOU JINGLAN

IPC: C07D405/12 ,  A61K31/4418 ,  A61K31/5585 ,  A61P11/00 ,  C07D213/75 ,  C07D405/14

Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

公开(公告)号：HK1152707A1

公开(公告)日：2012-03-09

申请号：HK11106875

申请日：2011-07-05

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARAH S ,  HAZLEWOOD ANNA R ,  GROOTENHUIS PETER D J ,  GOOR FREDERICK F VAN ,  SINGH ASHVANI K ,  ZHOU JINGLAN ,  MCCARTNEY J

IPC: C07D20060101 ,  A61K20060101 ,  A61P20060101 ,  C07C20060101 ,  G01N20060101

Abstract: The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, composition thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：AU2010282986A1

公开(公告)日：2012-02-16

申请号：AU2010282986

申请日：2010-02-18

Applicant: VERTEX PHARMA

Inventor： ROWE WILLIAM ,  HURTER PATRICIA ,  YOUNG CHRISTOPHER R ,  DINEHART KIRK ,  VERWIJS MARINUS JACOBUS ,  OVERHOFF KIRK ,  GROOTENHUIS PETER D J ,  BOTFIELD MARTYN ,  GROSSI ALFREDO ,  ZLOKARNIK GREGOR ,  VAN GOOR FREDRICK F

IPC: A61K9/14 ,  A61K31/47 ,  A61P19/00 ,  A61P19/10 ,  A61P43/00

Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis( 1, 1 -dimethylethyl)-5-hydroxyphenyl]- 1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.

公开(公告)号：MX2011009868A

公开(公告)日：2012-01-12

申请号：MX2011009868

申请日：2010-03-19

Applicant: VERTEX PHARMA

Inventor： BOTFIELD MARTYN C ,  GROOTENHUIS PETER D J ,  ZLOKARNIK GREGOR ,  YANG XIAOQING ,  RUAH SARA S HADIDA ,  GOOR FREDRICK F VAN

IPC: C07D215/233 ,  A61K31/47 ,  A61P3/00

Abstract: Esta invención se relaciona con un compuesto de la Fórmula I (ver fórmula (I)) o una sal farmacéuticamente aceptable del mismo, en donde R es COOH o CH2OH.

公开(公告)号：MX2011004834A

公开(公告)日：2011-07-28

申请号：MX2011004834

申请日：2009-11-06

Applicant: VERTEX PHARMA

Inventor： MILLER MARK T ,  RUAH SARA S HADIDA ,  GROOTENHUIS PETER D J ,  ZHOU JINGLAN ,  MCCARTNEY JASON ,  GOOR FREDRICK VAN ,  NUMA MEHDI MICHEL DJAMEL ,  BEAR BRIAN

IPC: C07D405/12 ,  A61K31/404 ,  A61P3/00 ,  A61P25/00 ,  C07D209/08 ,  C07D209/12 ,  C07D209/18

Abstract: Los compuestos de la presente invención y composiciones farmacéuticamente aceptables de los mismos, son útiles como moduladores de los transportadores de Casetes Enlazadores de ATP ("ABC") o sus fragmentos, incluyendo el Regulador de Conductancia Transmembranal de la Fibrosis Cística (CFTR"). La presente invención igualmente se refiere a métodos para tratar enfermedades mediadas por el transportador de ABC, utilizando los compuestos de la presente invención.

公开(公告)号：AU2009282419A2

公开(公告)日：2011-03-31

申请号：AU2009282419

申请日：2009-08-13

Applicant: VERTEX PHARMA

Inventor： ROWE WILLIAM ,  HURTER PATRICIA ,  YOUNG CHRISTOPHER ,  DINEHART KIRK ,  VERWIJS MARINUS JACOBUS ,  OVERHOFF KIRK ,  GROOTENHUIS PETER D J ,  BOTFIELD MARTYN ,  GROSSI ALFREDO

IPC: A61K47/32

Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.

公开(公告)号：AU2010251789A1

公开(公告)日：2011-01-06

申请号：AU2010251789

申请日：2010-12-14

Applicant: VERTEX PHARMA

Inventor： RUAH SARAH S HADIDA ,  SINGH ASHVANI K ,  GROOTENHUIS PETER D J ,  HAZLEWOOD ANNA R ,  GOOR FREDRICK F VAN ,  ZHOU JINGLAN ,  MCCARTNEY JASON

IPC: C07D401/12 ,  A61K31/47 ,  A61K31/4709 ,  A61P25/00 ,  A61P31/00 ,  C07C215/76 ,  C07D209/08 ,  C07D209/12 ,  C07D209/14 ,  C07D209/18 ,  C07D215/56 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, composition thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：AU2010249302A1

公开(公告)日：2011-01-06

申请号：AU2010249302

申请日：2010-12-13

Applicant: VERTEX PHARMA

Inventor： RUAH SARAH S HADIDA ,  SINGH ASHVANI K ,  GROOTENHUIS PETER D J ,  HAZLEWOOD ANNA R ,  GOOR FREDRICK F VAN ,  ZHOU JINGLAN ,  MCCARTNEY JASON

IPC: C07D401/12 ,  A61K31/47 ,  A61K31/4709 ,  A61P25/00 ,  A61P31/00 ,  C07C215/76 ,  C07D209/08 ,  C07D209/12 ,  C07D209/14 ,  C07D209/18 ,  C07D215/56 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, composition thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：NZ552543A

公开(公告)日：2010-09-30

申请号：NZ55254305

申请日：2005-06-24

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARAH S ,  HAZLEWOOD ANNA R ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK F ,  SINGH ASHVANI K ,  ZHOU JINGLAN ,  MCCARTNEY JASON

IPC: A61K31/47 ,  A61K31/4709 ,  A61P25/00 ,  A61P31/00 ,  C07C215/76 ,  C07D209/08 ,  C07D209/12 ,  C07D209/14 ,  C07D209/18 ,  C07D215/233 ,  C07D215/56 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: Disclosed are 4-oxo-quinoline-3-carboxamide derivatives of general formula (I), wherein the substituents are as defined herein. Of particular importance is the compound N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-caboxamide, or a pharmaceutically acceptable salt thereof. Also disclosed is a pharmaceutical composition comprising a compound as defined above and a pharmaceutically acceptable carrier or adjuvant. Further disclosed is the use of a compound or composition as described above in the manufacture of a medicament for treating or lessening the severity of cystic fibrosis in a patient (wherein the patient may possess a cystic fibrosis transmembrane receptor (CFTR)).

公开(公告)号：CA2742980A1

公开(公告)日：2010-05-14

申请号：CA2742980

申请日：2009-11-06

Applicant: VERTEX PHARMA

Inventor： RUAH SARA S HADIDA ,  GROOTENHUIS PETER D J ,  MILLER MARK T ,  MCCARTNEY JASON ,  VAN GOOR FREDRICK ,  NUMA MEHDI MICHEL DJAMEL ,  ZHOU JINGLAN ,  BEAR BRIAN

IPC: C07D405/02 ,  A61K31/404 ,  A61P3/00 ,  A61P25/00 ,  C07D209/08 ,  C07D209/12 ,  C07D209/18

Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.