公开(公告)号：PL3141548T3

公开(公告)日：2020-09-07

申请号：PL16190960

申请日：2012-07-03

Applicant: VERTEX PHARMA

Inventor： TANOURY GERALD J ,  JUNG YOUNG CHUN ,  MAGDZIAK DEREK ,  LOOKER ADAM ,  KLINE BILLIE J ,  DOMINGUEZ OLMO BEATRIZ ,  JURCÍK VÁCLAV

IPC: C07D471/04

公开(公告)号：DK3141548T3

公开(公告)日：2020-07-06

申请号：DK16190960

申请日：2012-07-03

Applicant: VERTEX PHARMA

Inventor： TANOURY GERALD J ,  JUNG YOUNG CHUN ,  MAGDZIAK DEREK ,  LOOKER ADAM ,  KLINE BILLIE J ,  DOMINGUEZ OLMO BEATRIZ ,  JURCÍK VÁCLAV

IPC: C07D471/04

公开(公告)号：DK3068782T3

公开(公告)日：2018-08-13

申请号：DK14802788

申请日：2014-11-12

Applicant: VERTEX PHARMA

Inventor： TANOURY GERALD J ,  NUGENT WILLIAM ALOYSIUS ,  DVORNIKOVS VADIMS ,  ROSE PETER JAMISON

IPC: C07D471/04 ,  C07C51/083

公开(公告)号：NZ714502A

公开(公告)日：2017-04-28

申请号：NZ71450212

申请日：2012-07-03

Applicant: VERTEX PHARMA

Inventor： TANOURY GERALD J ,  JUNG YOUNG CHUN ,  MAGDZIAK DEREK ,  LOOKER ADAM ,  KLINE BILLIE J ,  JURČÍK VÁCLAV ,  DOMINGUEZ OLMO BEATRIZ

IPC: C07D471/04 ,  A61K31/437 ,  C07D239/42 ,  C07F5/02 ,  C07F5/04

Abstract: Disclosed herein is a process for preparing an compound of Formula 1, wherein the substituents are as defined in the specification. The process comprises reacting intermediates with p-toluenesulfonyl chloride, triisopropyl borate and pinacolate alcohol in organic solvents in the presence of a lithium base. In a particular embodiment, the process produces the compound 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-pyrrolo[2,3-b].

公开(公告)号：CY1116276T1

公开(公告)日：2017-02-08

申请号：CY151100232

申请日：2015-03-06

Applicant: VERTEX PHARMA

Inventor： TANOURY GERALD J ,  CHEN MINZHANG ,  JONES ANDREW D ,  NYCE PHILIP L ,  TRUDEAU MARTIN ,  GUERIN DAVID J ,  SNOONIAN JOHN R

IPC: C07D405/12

Abstract: Ηεφεύρεσηαφοράσεμίαμέθοδοπαρασκευήςμίαςένωσηςπουπεριλαμβάνεικαθαρισμόμίγματος, όπου R8 είναιπροστατευτικήομάδακαιο καθαρισμόςπεριλαμβάνειχρωματογραφία, επιλεκτικώςκρυστάλλωσηή δυναμικώςκρυστάλλωσητουμίγματος.

公开(公告)号：AU2011242712B2

公开(公告)日：2016-01-28

申请号：AU2011242712

申请日：2011-04-21

Applicant: VERTEX PHARMA

Inventor： LEE ELAINE CHUNGMIN ,  TANOURY GERALD J ,  HARRISON CRISTIAN ,  LITTLER BENJAMIN JOSEPH ,  ROSE PETER JAMISON ,  HUGHES ROBERT MICHAEL ,  JUNG YOUNG CHUN ,  SIESEL DAVID ANDREW ,  BELMONT DANIEL T

IPC: C07D209/12 ,  C07D317/60 ,  C07D405/12

Abstract: The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2- (1 -hydroxy-2-methylpropan-2-yl)- 1H-indol-5 -yl)cyclopropanecarboxamide (Compound 1 ), useful for treating CFTR mediated diseases such as cystic fibrosis.

公开(公告)号：PT2399915E

公开(公告)日：2015-03-30

申请号：PT11178126

申请日：2005-03-11

Applicant: VERTEX PHARMA

Inventor： NYCE PHILIP L ,  CHEN MINZHANG ,  TANOURY GERALD J ,  TRUDEAU MARTIN ,  GUERIN DAVID J ,  SNOONIAN JOHN R ,  JONES ANDREW D

IPC: C07D405/12 ,  C07B43/04 ,  C07B57/00

公开(公告)号：NZ603721A

公开(公告)日：2014-11-28

申请号：NZ60372111

申请日：2011-04-21

Applicant: VERTEX PHARMA

Inventor： LITTLER BENJAMIN JOSEPH ,  JUNG YOUNG CHUN ,  LEE ELAINE CHUNGMIN ,  HUGHES ROBERT MICHAEL ,  ROSE PETER JAMISON ,  TANOURY GERALD J ,  BELMONT DANIEL T ,  HARRISON CRISTIAN ,  SIESEL DAVID ANDREW

IPC: C07D209/12 ,  C07D317/60 ,  C07D405/12

Abstract: Disclosed herein is a method for preparing cycloalkylcarboxamido-indole compounds which are useful for treating CFTR mediated diseases such as cystic fibrosis. In particular a method of preparing a compound of formula I comprising the steps of: Reacting a compound of formula IA in a first organic solvent with a compound of formula IB; to form a compound of formula IC in the presence of a palladium catalyst; and Removing the –CO2RJ group from compound IC in a second organic solvent to form the compound of formula I.

公开(公告)号：NZ604087A

公开(公告)日：2014-07-25

申请号：NZ60408706

申请日：2006-08-18

Applicant: VERTEX PHARMA

Inventor： CHEN MINZHANG ,  TANOURY GERALD J ,  COCHRAN JOHN E

IPC: C07D209/52 ,  A61K31/403

Abstract: Disclosed are t-butyl octahydrocyclopenta[c]pyrrole derivatives of formula (1a) e.g. (1S,3aR,6aS)-t-butyl 2-((S)-2-((S)-2-(benzyloxycarbonylamino)-2-cyclohexylacetamido)-3,3-dimethylbutanoyl)octahydrocyclopenta[c]pyrrole-1-carboxylate, wherein the variables are defined in the specification.

公开(公告)号：SI2194043T1

公开(公告)日：2014-04-30

申请号：SI200631745

申请日：2006-08-18

Applicant: VERTEX PHARMA

Inventor： TANOURY GERALD J ,  CHEN MINZHANG ,  COCHRAN JOHN E

IPC: C07D209/00 ,  A61K31/00 ,  C07D471/00