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71.发明公开公开(公告)号：US20230414566A1
公开(公告)日：2023-12-28
申请号：US18462920
申请日：2023-09-07
Applicant: University of Houston System
Inventor： Anton Dubrovskiy , Arcadius V. Krivoshein
IPC: A61K31/4015 , A61P25/08
CPC classification number: A61K31/4015 , A61K31/165 , A61P25/08
Abstract: Aryl-substituted acetamide and pyrrolidin-2-one (γ-butyrolactam) derivatives have useful activity in the inhibition, prevention, or treatment of seizures. The derivatives may be useful in the treatment of epilepsy, including medically refractory epilepsy, and nerve agent poisoning.
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公开(公告)号：US20230409945A1
公开(公告)日：2023-12-21
申请号：US17981322
申请日：2022-11-04
Applicant: UNIVERSITY OF HOUSTON SYSTEM
Inventor： John H. Miller, JR.
CPC classification number: G06N10/40 , H10N60/12 , H10N60/0912
Abstract: The disclosed qudits interchange the roles of linear and nonlinear in the nonlinear LC resonators formed by existing superconducting qudits. The disclosed qudits include a nonlinear capacitor (e.g., a material that forms charge density waves, a material that forms spin density waves, a ferroelectric material, an incipient ferroelectric material, or a quantum paraelectric material) coupled to a linear or nearly linear inductance (e.g., a high temperature superconductive coil, an array of Josephson junctions in series, etc.). The disclosed qudits can operate at significantly higher temperatures than existing quantum computing technologies due to reduced quasiparticle poisoning and collective quantum behavior that enhance thermal robustness. The disclosed qudits are also easier to manufacture uniformly at scale than existing qubits. Finally, the disclosed qudits are also compatible with many of the gating, coupling, readout, and pulse-sequence methodologies that have already been developed for existing superconducting qubits.
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公开(公告)号：US11821818B2
公开(公告)日：2023-11-21
申请号：US16624643
申请日：2018-07-06
Applicant: University of Houston System
Inventor： Dmitri Litvinov , Long Chang , Richard Willson
IPC: G01N27/74 , G01N33/543
CPC classification number: G01N27/745 , G01N33/54326 , G01N33/54346 , G01N33/54373
Abstract: A biosensor may provide a magnetoresistive (MR) film comprising a nonmagnetic layer may be sandwiched between the two ferromagnetic layers. The MR film may be positioned on a substrate, where the edges of the MR film are in contact with leads. Additionally, the leads may be in contact with pads. The sensors may provide quasi-digital readout that enable greatly enhanced sensitivity. In some embodiments, biosensors may be arranged as array of sensors. The array of sensors may be arranged as a symmetric or asymmetric N1×N2 array, where N1 and N2 are integers, N1 represents the number of sensors linked together in series, and N2 represents the number of sensor sets in parallel, where each sensor set may comprise one or more sensors. Further, the array of sensors may be coupled to a voltmeter, which may be a single voltmeter in some cases that allows the sensors to all be probed simultaneously.
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74.发明公开公开(公告)号：US20230331777A1
公开(公告)日：2023-10-19
申请号：US18015927
申请日：2021-04-07
Applicant: UNIVERSITY OF HOUSTON SYSTEM
Inventor： Damith Gomika Udugamasooriya , Bin Guo , Satya Prakash Shukla , Kwang Bog Cho
Abstract: Embodiments of the present disclosure pertain to methods of blocking virus entry into cells by associating the cells with an anti-viral peptoid to result in the blocking of virus entry into the cells. Additional embodiments of the present disclosure pertain to methods of treating or preventing a viral infection in a subject by administering an anti-viral peptoid composition to the subject to result in the blocking of virus entry into the cells of the subject. Further embodiments of the present disclosure pertain to anti-viral peptoids and compositions that include the anti-viral peptoids of the present disclosure. Additional embodiments of the present disclosure pertain to the use of the anti-viral peptoids and compositions to block virus entry into cells for numerous purposes, such as treating or preventing viral infections.
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公开(公告)号：US20230314348A1
公开(公告)日：2023-10-05
申请号：US18129723
申请日：2023-03-31
Applicant: UNIVERSITY OF HOUSTON SYSTEM
Inventor： Byron Freelon
IPC: G01N23/20058 , G01N23/205 , G01N23/2055 , H01J37/295 , G01N23/20008
CPC classification number: G01N23/20058 , G01N23/205 , G01N23/2055 , H01J37/295 , G01N23/20008 , G01N2223/413
Abstract: A device and system for ultrafast electron diffraction is disclosed. The electron diffraction device includes an electron source, anode, and magnetic lens. A laser probe pulse interacts with electrons from the electron source to generate an electron probe pulse that passes through the anode and diffracts from a sample yielding a diffraction pattern. Data is configured to be collected at one instance using the diffraction pattern to yield a first snapshot of diffractive information. Snapshots may be merged to produce an atomic stroboscopic motion image history of atomic lattice changes. The electron source may include a gas jet with photo-ionizable noble gas atoms to produce photoionized, spin-polarized electrons to form the electron probe pulse when the laser probe pulse impinges upon the electron source.
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Patent Agency Ranking
公开(公告)号：US20230293783A1
公开(公告)日：2023-09-21
申请号：US18118359
申请日：2023-03-07
Applicant: UNIVERSITY OF HOUSTON SYSTEM
Inventor： Ji Chen , Jianfeng Zheng
CPC classification number: A61L31/088 , A61L31/14 , A61L2400/00 , A61L2420/06
Abstract: Embodiments of the present disclosure pertain to implantable medical devices that are operational for mitigating radiofrequency (RF)-induced heating. The implantable medical devices generally include a ferrite material that is associated with at least one component of the implantable medical device and operational to reduce the RF-induced heating of the implantable medical device. Additional embodiments of the present disclosure pertain to methods of mitigating radiofrequency (RF)-induced heating of an implantable medical device by applying a ferrite material to at least one component of the implantable medical device. Thereafter, the ferrite material reduces the RF-induced heating of the medical device. In some embodiments, the methods of the present disclosure also include a step of implanting the implantable medical device into a subject, such as a human being.
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公开(公告)号：US11742808B1
公开(公告)日：2023-08-29
申请号：US17945811
申请日：2022-09-15
Applicant: University of Houston System
Inventor： Harish S. Krishnamoorthy , Yu Yao
IPC: H03F3/217 , H02M7/5387
CPC classification number: H03F3/2178
Abstract: A nuclear magnetic resonance (NMR) power supply system and method are disclosed. The architecture adopts a two-stage topology to reduce the required capacitance by over ten times, leading to a four-fold improvement in power density. The first stage is an isolated converter that only supplies average power, therefore input filter and transformer sizes can be reduced. The second stage is a fast response DC-DC converter followed by a RF transmitter to produce a pulsed RF signal, so that the mid-point voltage after the first stage can be allowed to droop considerably, leading to much smaller sized capacitors. These and other embodiments enforce the isolated converter to only transfer average power, which reduces the power rating and the volume of the system's transformer.
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公开(公告)号：US11723556B1
公开(公告)日：2023-08-15
申请号：US17878036
申请日：2022-07-31
Applicant: University of Houston System
Inventor： Marc T. Hamilton
CPC classification number: A61B5/1107 , A61B5/1121 , A61B5/6829 , A61B5/742
Abstract: A soleus contraction measurement system includes a sensor configured to measure rotational movement when positioned on a user's foot with an X-axis oriented laterally across the user's foot, a Y-axis oriented parallel to the user's foot, a Z-axis orthogonal to the X-axis and the Y-axis, and a positive X-axis rotational movement corresponding to an increasing ankle angle, and a memory storing computer-executable instructions for controlling a processor to: measure an X-axis rotational movement, identify a positive X-axis rotational movement as a plantarflexion and a negative X-axis rotational movement as an ankle dorsiflexion, deem the plantarflexion a performed soleus contraction when the plantarflexion is immediately followed by the ankle dorsiflexion for two consecutive cycles of plantarflexion and ankle dorsiflexion, and cause performance information regarding the performed soleus contractions to be communicated.
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79.发明授权公开(公告)号：US11723529B2
公开(公告)日：2023-08-15
申请号：US17882682
申请日：2022-08-08
Applicant: University of Houston System
Inventor： Kirill V. Larin , Achuth Nair , Manmohan Singh , Salavat Aglyamov
CPC classification number: A61B3/0025 , A61B3/102 , A61B3/16 , A61B3/165 , A61B5/0051 , A61B5/0053 , A61B5/0066 , A61B5/0093 , A61B8/10 , A61B8/485 , A61B5/0097 , A61B2576/00
Abstract: A system and method for measuring biomechanical properties of tissues without external excitation are capable of measuring and quantifying these parameters of tissues in situ and in vivo. The system and method preferably utilize a phase-sensitive optical coherence tomography (OCT) system for measuring the displacement caused by the intrinsic heartbeat. The method allows noninvasive and nondestructive quantification of tissue mechanical properties. Preferably, the method is used to detect tissue stiffness and to evaluate its stiffness due to intrinsic pulsatile motion from the heartbeat. This noninvasive method can evaluate the biomechanical properties of the tissues in vivo for detecting the onset and progression of degenerative or other diseases and evaluating the efficacy of therapies.
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公开(公告)号：US20230218708A1
公开(公告)日：2023-07-13
申请号：US18157648
申请日：2023-01-20
Inventor： Damith Gomika UDUGAMASOORIYA , Aaron RAYMOND , John MINNA
Abstract: Described herein are pharmaceutical compositions containing peptoids of general formula (I), (II), or (III) capable of reducing proliferation of cancer stem cells in a subject and methods of treatment or prophylactic administration of these pharmaceutical compositions to treat cancer. Also provided herein are method of detecting and treating cancerous cell masses by use of peptoids of general formula (I), (II), or (III).
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