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公开(公告)号：KR1020150145820A
公开(公告)日：2015-12-31
申请号：KR1020140075016
申请日：2014-06-19
Applicant: 한국식품연구원
IPC: A61K36/896 , A61P11/02 , A61P11/00
Abstract: 본발명은둥글레추출물을유효성분으로함유하는후각과민증예방또는치료용약학조성물에관한것이다. 또한, 본발명은둥글레추출물을유효성분으로함유하는후각과민증예방또는개선용건강기능식품에관한것이다. 또한, 본발명은둥글레추출물을함유하는악취억제용방향제조성물에관한것이다. 본발명의옥죽을함유하는조성물은후각자극에의한 cAMP의생성을억제내지감소시켜다양한후각자극물질에대해뇌에서냄새인지를못하게하는역할을한다.
Abstract translation: 本发明涉及一种药物组合物，其包含作为预防或治疗高血糖症的活性成分的金atum提取物。 此外，本发明涉及一种保健功能食品，其包含atum atum提取物作为预防或缓解高血症的活性成分。 此外，本发明涉及一种空气清新剂组合物，其包含用于抑制恶臭的金缕梅提取物。 通过抑制或减少由嗅觉刺激引起的cAMP产生，本发明的包含藿香的组合物在通过抑制或减少cAMP产生方面起到防止嗅觉刺激的各种物质对脑中的气味识别的作用。
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72.发明授权
公开(公告)号：KR101536232B1
公开(公告)日：2015-07-15
申请号：KR1020120158100
申请日：2012-12-31
Applicant: 한국식품연구원
Abstract: 본발명은산씀바귀() 추출물을유효성분으로포함하는 TRPV1(Transient Receptor Potential channel, Vanilloid subfamily member 1)-매개질환의예방, 치료또는개선용조성물에관한것이다. 본발명의조성물은천연식물재료인산씀바귀로부터추출한조성물로써인체에부작용이없는조성물이고, 상기조성물은통증및 염증의예방, 치료또는개선효과를제공한다.
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公开(公告)号：KR1020150071686A
公开(公告)日：2015-06-26
申请号：KR1020150027565
申请日：2015-02-26
Applicant: 한국식품연구원
IPC: A61K36/28 , A61K36/899
CPC classification number: A61K36/28 , A23L33/105 , A61K36/899
Abstract: 본발명은부작용이적어안전하면서도 TGR5 작용제활성이뛰어난약학조성물또는식품조성물에관한것으로서, 상기개망초, 조릿대, 편백, 피마자, 까마중, 벼룩나물, 구릿대및 초피씨로이루어진군에서선택된어느하나이상의추출물을유효성분으로포함한다. 본발명의조성물은당뇨치료또는예방; 비만치료또는예방; 신경세포보호; 또는소화및 흡수조절; 또는간질환, 또는심장병개선또는치료등을위한약학조성물또는식품조성물로유용하게사용될수 있다.
Abstract translation: 本发明产生不利影响安全和大约TGR5激动剂活性优异的药物组合物或食品组合物的降低，一年蓬，竹子，柏树，蓖麻，龙葵，蚤草药，选自一种或多种的提取物由guritdae和第二PC的 它被包括作为一种有效成分。 本发明的组合物可用于治疗或预防糖尿病; 治疗或预防肥胖; 神经细胞保护; 或调节消化吸收; 或肝病，或用于改善或治疗心脏病等的药物组合物或食物组合物。
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74.发明公开십자화과 또는 산형과 식물 추출물을 포함하는 ｈＴＲＰＡ１ 활성화 조성물 및 그의 용도 有权用于激活包含BRASSICACEAE或UMBELLIFERAE植物提取物的HTRPA1的组合物及其用途
公开(公告)号：KR1020140022940A
公开(公告)日：2014-02-25
申请号：KR1020140011621
申请日：2014-01-29
Applicant: 한국식품연구원
Abstract: The present invention provides various uses of a composition containing extracts of Brassicaceae or Umbelliferae plants related to the improvement of hTRPA1 activity; for example, uses for screening a pungent flavoring agent, an obesity treatment agent, and an hTRPA1 antagonist. The extracts of Brassicaceae or Umbelliferae plants provide various uses regarding hTRPA1 activity, have fewer side effects on human body as a natural compound, and has lots of possibilities for industrial usage. The extracts of Brassicaceae or Umbelliferae plants are materials for new medicines and food which help the human body maintain homeostasis regarding hTRPA1 activity, and can be used for screening the hTRPA1 antagonist.
Abstract translation: 本发明提供含有与提高hTRPA1活性相关的十字花科或伞形植物提取物的组合物的各种用途; 例如，用于筛选刺鼻调味剂，肥胖症治疗剂和hTRPA1拮抗剂的用途。 芸苔科或伞形科植物的提取物提供了关于hTRPA1活性的各种用途，对人体作为天然化合物具有较少的副作用，并且具有许多工业用途的可能性。 甘蓝科或伞形植物的提取物是新药和食物的材料，有助于人体维持hTRPA1活性的稳态，并可用于筛选hTRPA1拮抗剂。
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公开(公告)号：KR101361147B1
公开(公告)日：2014-02-13
申请号：KR1020120068890
申请日：2012-06-27
Applicant: 한국식품연구원
Abstract: 본 발명은 국화과 식물 추출물을 유효성분으로 포함하는 조성물의 hTRPA1 활성 증가와 관련된 다양한 용도, 예를 들어 자극성 향미제, 비만 치료제 및 hTRPA1 길항제 스크리닝에 대한 용도를 제공한다. 본 발명의 국화과 식물 추출물은 hTRPA1 활성화와 관련된 다양한 용도를 제공하며, 천연 화합물로서 인체에 부작용이 비교적 적고 산업적 이용 가능성이 크다. 본 발명의 국화과 식물 추출물은 hTRPA1의 활성화와 관련된 인체내 항상성 유지에 도움이 되는 신규한 의약 또는 식품 소재일 뿐만 아니라, hTRPA1의 길항제의 스크리닝에 유용하게 이용될 수 있다.
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Patent Agency Ranking
公开(公告)号：KR1020140006376A
公开(公告)日：2014-01-16
申请号：KR1020120073081
申请日：2012-07-04
Applicant: 한국식품연구원
IPC: A61K31/404 , A61K31/4025 , A61P35/00 , A61P25/28
CPC classification number: A61K31/404 , A23L29/045 , A61K9/0095 , A61K9/08 , A61K9/10 , A61K9/14 , A61K9/20 , A61K9/48 , Y10S514/886
Abstract: The present invention relates to a pharmaceutical composition containing 3,3'-Diindolymethane as an active ingredient for preventing and treating inflammatory diseases and angiogenesis inhibitory activity. According to the present invention, the 3,3'-Diindolymethane has an excellent effect in inhibiting angiogenesis and inflammation, thereby being used as the active ingredient in the pharmaceutical composition and health functional food for preventing and treating inflammatory diseases. [Reference numerals] (AA,EE,II,MM) Normal group; (BB,FF,JJ,NN) Control group; (CC,GG,KK,OO) Experimental group 1; (DD,HH,LL,PP) Experimental group 2
Abstract translation: 本发明涉及含有3,3'-二取代甲烷作为预防和治疗炎性疾病和血管生成抑制活性的活性成分的药物组合物。 根据本发明，3,3'-二聚甲烷在抑制血管发生和炎症中具有优异的效果，因此用作用于预防和治疗炎性疾病的药物组合物和保健功能食品中的活性成分。 （标号）（AA，EE，II，MM）正常组; （BB，FF，JJ，NN）对照组; （CC，GG，KK，OO）实验组1; （DD，HH，LL，PP）实验组2
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77.发明公开십자화과 또는 산형과 식물 추출물을 포함하는 ｈＴＲＰＡ１ 활성화 조성물 및 그의 용도 有权用于激活包含BRASSICACEAE或UMBELLIFERAE植物提取物的HTRPA1的组合物及其用途
公开(公告)号：KR1020140002852A
公开(公告)日：2014-01-09
申请号：KR1020120068891
申请日：2012-06-27
Applicant: 한국식품연구원
Abstract: The present invention provides various uses of a composition containing plant extracts from Brassicaceae or Umbelliferae, associated with increased hTRPA1 activity; for example use in screening pungent flavoring agents, diet pills, and hTRPA1 antagonist. The plant extracts from Brassicaceae or Umbelliferae in the present invention provides various uses associated with hTRPA1 activation, and, being a natural compound, involves relatively few side effects in the body and has substantial industrial applicability. The plant extracts from Brassicaceae or Umbelliferae in the present invention not only will be a novel medical or food raw material which is helpful in maintaining homeostasis in the body associated with hTRPA1 activation, but can also be used to advantage in hTRPA1 antagonist screening.
Abstract translation: 本发明提供含有与增加的hTRPA1活性相关的来自十字花科或翁布利埃的植物提取物的组合物的各种用途; 例如用于筛选刺鼻调味剂，减肥药和hTRPA1拮抗剂。 在本发明中，来自甘蓝科或伞形科的植物提取物提供了与hTRPA1活化相关的各种用途，并且作为天然化合物在体内涉及相对较少的副作用并具有实质的工业适用性。 在本发明中，来自甘蓝科或伞形科的植物提取物不仅是有助于维持与hTRPA1活化相关的体内的体内平衡的新型医药或食品原料，而且还可用于hTRPA1拮抗剂筛选中。
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公开(公告)号：KR101327938B1
公开(公告)日：2013-11-14
申请号：KR1020110037694
申请日：2011-04-22
Applicant: 한국식품연구원
IPC: A61K31/215 , A61K31/21 , A61K9/48 , A61P3/04
Abstract: 본 발명은 메틸 카페이트를 유효성분으로 함유하는 비만 및 지질 관련 대사성 질환의 예방 및 치료용 약학적 조성물과 건강기능식품에 관한 것이다. 상기 조성물 또는 건강기능식품은 지방세포분화 저해 효능이 우수하다.
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公开(公告)号：KR1020130098759A
公开(公告)日：2013-09-05
申请号：KR1020120020537
申请日：2012-02-28
Applicant: 한국식품연구원
CPC classification number: Y02A90/26
Abstract: PURPOSE: A method for diagnosing aging is provided to diagnose aging and related diseases by measuring a change in the concentration of a specific metabolite in a liver extract and to treat aging-related diseases. CONSTITUTION: A method for diagnosing aging comprises the steps of: measuring the concentration of one selected among a metabolite group including 3-methylglutarylcarnitine, isovalerylcarnitine, palmitoylcarnitine, iobutyrylcarnitine, hypoxanthine, patothenic acid, lysophosphatidylcholine(C18:0) and lysophosphatidylcholine(C22:6); measuring the concentration of one selected among the metabolite group; and determining aging when the primarily measured concentration is higher than the secondarily measured concentration.
Abstract translation: 目的：通过测量肝脏提取物中特定代谢物浓度的变化和治疗老化相关疾病，提供诊断衰老的方法诊断衰老及相关疾病。 构成：用于诊断老化的方法包括以下步骤：测量选自包括3-甲基戊二酰肉碱，异戊基肉毒碱，棕榈酰肉碱，异丁酸肉碱，次黄嘌呤，氨基苯甲酸，溶血磷脂酰胆碱（C18：0）和溶血磷脂酰胆碱（C22：6） ）; 测定代谢组中选出的1种浓度; 并且当主要测量的浓度高于二次测量的浓度时，确定老化。
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公开(公告)号：KR1020130001510A
公开(公告)日：2013-01-04
申请号：KR1020110062313
申请日：2011-06-27
IPC: A61K36/752 , A61P3/10 , A61P3/00
CPC classification number: A61K36/752 , A23L33/105 , A23V2200/328 , A23V2250/21 , A61K2236/331 , Y10S514/866
Abstract: PURPOSE: An anti-diabetic composition containing citron peel extract and a method for preparing the same are provided to reduce blood glucose and to improve anti-diabetic effect. CONSTITUTION: An anti-diabetic pharmaceutical composition contains citron peel extract as an active ingredient. The citron peel extract is prepared through hot water extraction using an organic solvent. The organic solvent is phenoxy ethanol, propyl paraben, benzophenone, or ethanol. The concentration of the organic solvent is 400-1200 ug/ml. The pharmaceutical composition is manufactured in the form of a powder, granules, a capsule, a suspension, an emulsion, a syrup, or an aerosol. An anti-diabetic food composition contains the extract as an active ingredient. [Reference numerals] (AA) 2NBDG-absorption; (BB) Normal group; (CC,EE) Flesh; (DD,FF) Peel; (GG) Positive control group; (HH) Negative control group; (II) Ethanol; (JJ) Water
Abstract translation: 目的：提供含有柚皮提取物的抗糖尿病药物组合物及其制备方法，以降低血糖并改善抗糖尿病作用。 构成：抗糖尿病药物组合物含有柚皮提取物作为活性成分。 柚皮提取物通过使用有机溶剂的热水提取制备。 有机溶剂是苯氧基乙醇，对羟基苯甲酸丙酯，二苯甲酮或乙醇。 有机溶剂的浓度为400-1200ug / ml。 药物组合物以粉末，颗粒，胶囊，悬浮液，乳剂，糖浆或气雾剂的形式制备。 抗糖尿病食品组合物含有提取物作为活性成分。 （标号）（AA）2NBDG吸收; （BB）正常组; （CC，EE）肉; （DD，FF）去皮; （GG）阳性对照组; （HH）阴性对照组; （二）乙醇; （JJ）水
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