公开(公告)号：WO1995011717A1

公开(公告)日：1995-05-04

申请号：PCT/US1994011606

申请日：1994-10-12

Applicant: ABBOTT LABORATORIES ,  GENGA, Rodolfo

Inventor： ABBOTT LABORATORIES

IPC: A61M16/18

CPC classification number: A61M16/183 ,  B65D51/002

Abstract: The closure has a locking ring (7) connected to an internally threaded collar (8) at a frangible annular portion (10), which can be ruptured to gain immediate access to the contents of a container. A stopper member (20) is fixed to the threaded collar (8) for selectively connecting the closure (1) to an anaesthetic transfer device. A discharge passage (23) and a venting passage (24) extend through the stopper member (20) for communication with a container (3) engaged by the threaded collar (8). A first pierceable diaphragm (25) is located within and occludes the discharge passage (23), and second pierceable diaphragm (29) is located within and occludes the venting passage (24).

Abstract translation: 封闭件具有在易碎的环形部分（10）处连接到内螺纹套环（8）的锁定环（7），其可破裂以便立即进入容器的内容物。 止动构件（20）固定到螺纹轴环（8）上，用于选择性地将闭合件（1）连接到麻醉转移装置。 排出通道（23）和排气通道（24）延伸穿过止动件（20），用于与由螺纹轴环（8）接合的容器（3）连通。 第一可穿透隔膜（25）位于排出通道（23）内并封闭，第二可穿透隔膜（29）位于通气通道（24）内并封闭。

公开(公告)号：WO1995008774A2

公开(公告)日：1995-03-30

申请号：PCT/US1994010850

申请日：1994-09-22

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  CLARK, Frederick, L. ,  CLEMENS, John, M. ,  HANCE, Robert, B. ,  HENDRICK, Kendall, B. ,  TAYI, Apparao ,  KANEWSKE, William, J., III ,  LAGOCKI, Peter, A. ,  MARTIN, Richard, R. ,  McDOWELL, Douglas, D. ,  MERRIAM, Richard, A. ,  MOORE, Larry, W. ,  OLEKSAK, Carl, M. ,  PENNINGTON, Charles, D. ,  RAYMOURE, William, J. ,  RUMBAUGH, William, D. ,  SCHMIDT, Linda, S. ,  SCHRIER, Paul, R. ,  SMITH, B., Jane ,  SPRONK, Adrian, M. ,  WALKER, Edna, S. ,  VAUGHT, James, A. ,  VICKSTROM, Richard, L. ,  WALKER, Donny, Ray ,  WATKINS, William, E., III ,  WINTER, Gary, E.

IPC: G01N35/02

CPC classification number: G01N35/0092 ,  B01F11/0022 ,  B01L3/5025 ,  B29C45/00 ,  G01N21/6445 ,  G01N21/6452 ,  G01N21/76 ,  G01N33/5302 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2021/6482 ,  G01N2035/00148 ,  G01N2035/00356 ,  G01N2035/0405 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0446 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: An automated, continuous and random access analytical system, having apparatus and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a unit dose disposable and separately transferring a first liquid sample and reagents to a reaction vessel without initiation of an assay reaction sequence, followed by physical transfer of the unit dose disposable to a processing workstation, whereby a mixture of the unit dose disposable reagents and sample are achieved during incubation. The system is capable of performing more than one scheduled assay in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system is also capable of analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.

Abstract translation: 一种自动化，连续和随机存取分析系统，其具有能够使用不同测定方法同时进行液体样品的多个测定的装置和方法，并且在相同或不同样品的同一或不同样品上进行多个不同测定 时间段被披露。 还公开了一种操作自动化连续和随机存取分析系统的方法，其能够同时进行多个液体样品的多次测定，其中多个液体样品的各种测定的调度之后是产生单位剂量一次性并单独转移 将第一液体样品和试剂加入到反应容器中，而不引发测定反应顺序，随后将单位剂量一次性物理转移到加工工作站，由此在孵育期间实现单位剂量的一次性试剂和样品的混合物。 该系统能够以任何顺序执行多于一次的计划分析，以及提供多于此类计划的测定的测定。 自动，连续和随机存取分析系统还能够通过至少两种测定程序独立地和单独地分析温育的反应混合物。

公开(公告)号：WO1995007277A1

公开(公告)日：1995-03-16

申请号：PCT/US1994009734

申请日：1994-08-30

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  LIN, Nan-Horng ,  HE, Yun ,  ELLIOTT, Richard, L. ,  CHORGHADE, Mukund, S. ,  WITTENBERGER, Steven, J. ,  BUNNELLE, William, H. ,  NARAYANAN, Bikshandar, A. ,  SINGAM, Pulla, R. ,  ESCH, Thomas, K., J. ,  BEER, Dieter, O. ,  WITZIG, Christian, C. ,  HERZIG, Thomas, C. ,  RAO, Alla, V., Rama

IPC: C07D413/04

CPC classification number: C07D413/04

Abstract: A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.

Abstract translation: 以高产率制备对映异构纯的3-甲基-5-（1-（C 1 -C 3 - 烷基）-2-吡咯烷基）异恶唑的新方法，其中将受保护的吡咯烷或2-氧代 - 吡咯烷起始原料与 合适的有机阴离子和所得的β-酮肟中间体被环化和脱水，以及可用于其制备的中间体。

公开(公告)号：WO1995007260A1

公开(公告)日：1995-03-16

申请号：PCT/US1994009757

申请日：1994-08-30

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  DeBERNARDIS, John, F. ,  KERKMAN, Daniel, J. ,  ZELLE, Robert, E. ,  McCLELLAN, William

IPC: C07D217/14

CPC classification number: C07D401/04 ,  C07D217/04 ,  C07D491/04

Abstract: The present invention provides a tetrahydroisoquinoline compound of formula (I) or a pharmaceutically acceptable salt thereof which is an antagonist for alpha-2 adrenoreceptors and/or which inhibits biogenic amine uptake.

Abstract translation: 本发明提供了式（I）的四氢异喹啉化合物或其药学上可接受的盐，其是α-2肾上腺素受体的拮抗剂和/或抑制生物胺吸收。

公开(公告)号：WO1995006878A1

公开(公告)日：1995-03-09

申请号：PCT/JP1993001227

申请日：1993-08-31

Applicant: ALOKA CO., LTD. ,  ABBOTT LABORATORIES ,  TAKEDA, Masaaki ,  KATO, Yuko ,  KATAGI, Hitomi ,  KAWANABE, Junichi

Inventor： ALOKA CO., LTD. ,  ABBOTT LABORATORIES

IPC: G01N35/06

CPC classification number: G01N35/1016 ,  G01N35/10 ,  G01N2035/1018 ,  G06F19/00

Abstract: An apparatus for pipetting a specimen with a nozzle, which can detect not only complete but also incomplete closure of the nozzle. A pressure of an air hose (12) connected to a nozzle (10) for sucking a specimen is detected by a pressure sensor (20) and its detection value is sent to a closure detection portion (26). A plurality of pressure calculation periods are provided to the closure detection portion (26) and a pressure difference in each of the calculation periods is calculated. When a pressure difference exceeds a predetermined threshold value corresponding to each calculation period in that calculation period, a closure alarm is raised. Since a plurality of pressure calculation periods are set, incomplete closure can also be detected besides complete closure, and a pipetting accuracy can be improved.

Abstract translation: 用于用喷嘴移取样品的装置，其不仅可以检测到喷嘴的完全而且不完全的关闭。 通过压力传感器（20）检测连接到用于吸取样本的喷嘴（10）的空气软管（12）的压力，并将其检测值发送到闭合检测部分（26）。 向闭合检测部（26）提供多个压力计算期间，计算出各计算期间的压力差。 当压力差超过与该计算期间的每个计算期间对应的预定阈值时，提高关闭报警。 由于设定了多个压力计算期间，除了完全关闭之外，还可以检测不完全的闭合，并且可以提高移液精度。

公开(公告)号：WO1995004283A1

公开(公告)日：1995-02-09

申请号：PCT/US1994008604

申请日：1994-08-01

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  ADAMCZYK, Maciej ,  CHEN, Yon-Yih ,  WALLING, John, A. ,  JAMES, Bryan, D. ,  ARTRIP, Sharon, G.

IPC: G01N33/74

CPC classification number: G01N33/53 ,  C07J1/0022 ,  C07K16/26 ,  G01N33/743 ,  Y02P20/55 ,  Y10S435/81 ,  Y10S435/962 ,  Y10S435/968 ,  Y10S436/817 ,  Y10S436/822 ,  Y10S530/812

Abstract: The present invention discloses novel immunogens, antibodies prepared from such immunogens, and labeled reagents useful in immunoassays for the detection and quantification of testosterone in a test sample. Also disclosed are immunoassays using these reagents and methods for synthesizing these reagents. The immunoassays are preferably microparticle enzyme immunoassays (MEIAs) and fluorescence polarization immunoassays (FPIAs). Further discloded are novel starting materials for making the above novel immunogens and labeled reagents. Methods for making the novel immunogens and labeled reagents from the novel starting materials are also disclosed.

Abstract translation: 本发明公开了由免疫原制备的新型免疫原，抗体以及用于免疫测定的标记试剂，用于检测和定量测试样品中的睾酮。 还公开了使用这些试剂的免疫测定法和合成这些试剂的方法。 免疫测定优选为微粒酶免疫测定（MEIAs）和荧光偏振免疫测定（FPIAs）。 进一步揭示了制备上述新型免疫原和标记试剂的新型起始材料。 还公开了从新型起始材料制备新型免疫原和标记试剂的方法。

公开(公告)号：WO1995001297A1

公开(公告)日：1995-01-12

申请号：PCT/US1994007219

申请日：1994-06-27

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  ILES, Kenneth, Ernest

IPC: B65G47/90

CPC classification number: B01L9/50 ,  B01L9/06 ,  G01N35/0099 ,  G01N35/04 ,  Y10S435/809 ,  Y10S436/809 ,  Y10S436/81

Abstract: A sample container holder (18) is provided for gripping a sample container (34) which contains a sample. The sample container holder (18) comprises a body (42) having a bore (60) for receiving a sample container (34). A flexible element (82) is disposed within the bore (60). A fluid passage is operatively connected with the flexible element (82) for supplying a fluid to the flexible element (82) such that, when the sample container (34) is received in the bore (60) in the body (42) of the sample container holder (18), the flexible element (82) engages the sample container (34) with a conforming, cushioning compression of sufficient magnitude to resist removal of the container (34) from the bore (60). A method of holding a container with a container holder is also provided comprising the following steps. The container is received within a bore on the container holder, and a fluid is conveyed through a fluid passage operatively connected with a flexible element within the bore such that the flexible element engages the container to retain the container within the bore.

Abstract translation: 提供样品容器保持器（18），用于夹持包含样品的样品容器（34）。 样品容器保持器（18）包括具有用于容纳样品容器（34）的孔（60）的主体（42）。 柔性元件（82）设置在孔（60）内。 流体通道与柔性元件（82）可操作地连接，用于向柔性元件（82）供应流体，使得当样本容器（34）被容纳在主体（42）中的孔（60）中时 样品容器保持器（18），柔性元件（82）以足够大的顺应性缓冲压缩接合样品容器（34），以抵抗容器（34）从孔（60）的移除。 还提供了一种容纳容器的容器的方法，包括以下步骤。 容器被容纳在容器保持器上的孔内，并且流体被传送通过与孔内的柔性元件可操作地连接的流体通道，使得柔性元件接合容器以将容器保持在孔内。

公开(公告)号：WO1994021635A1

公开(公告)日：1994-09-29

申请号：PCT/US1994002711

申请日：1994-03-14

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  LULY, Jay, R. ,  KAWAI, Megumi ,  OR, Yat, Su ,  WIEDEMAN, Paul, E. ,  WAGNER, Rolf

IPC: C07D471/16

CPC classification number: C07D498/18 ,  C07D487/14 ,  C07D513/14 ,  C07F7/1804 ,  C07F9/6561 ,  C07H19/01

Abstract: Immunomodulatory macrocyclic compounds having formula (I), and the pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein Y is selected from one of formulae (Ia) and (Ib), as well as pharmaceutical compositions containing the same and methods of their use.

Abstract translation: 具有式（I）的免疫调节大环化合物及其药学上可接受的盐，酯，酰胺和前药，其中Y选自式（Ia）和（Ib）之一，以及含有它们的药物组合物及其制备方法 使用。

公开(公告)号：WO1994021254A1

公开(公告)日：1994-09-29

申请号：PCT/US1994002684

申请日：1994-03-11

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  KAWAI, Megumi ,  LULY, Jay, R.

IPC: A61K31/395

CPC classification number: C07D498/18

Abstract: Compounds having formula (I), and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein one of R and R is hydrogen, and the other of R and R is a group having formula (II), as well as pharmaceutically compositions containing such compounds and methods of immunomodulative therapy utilizing the same.

Abstract translation: 具有式（I）的化合物及其药学上可接受的盐，酯，酰胺和前药，其中R 104和R 105中的一个是氢，R 104和R 105中的另一个是基团 具有式（II）的化合物，以及含有这些化合物的药物组合物和利用其的免疫调节治疗方法。

公开(公告)号：WO1994018217A1

公开(公告)日：1994-08-18

申请号：PCT/US1993000928

申请日：1993-02-03

Applicant: ABBOTT LABORATORIES ,  TASSOPOULOS, Nic, C. ,  HATZAKIS, Angelos, E. ,  TROONEN, Hugo

Inventor： ABBOTT LABORATORIES ,  KUHNS, Mary, C.

IPC: C07H21/02

CPC classification number: C07H21/00 ,  A61K39/00 ,  C07K14/005 ,  C07K2319/00 ,  C12N2770/24222

Abstract: Hepatitis G Virus (HGV) nucleic aic sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HGV nucleic acid sequences, HGV immunogenic particles, and a method for producing antibodies to HGV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HGV nucleic acid sequences.

Abstract translation: 可用于各种诊断和治疗应用的乙型肝炎病毒（HGV）核酸序列，使用HGV核酸序列的试剂盒，HGV免疫原性颗粒和用于产生HGV抗体的方法。 还提供了从HGV核酸序列产生抗体，多克隆或单克隆抗体的方法。