公开(公告)号：AU2005295403B2

公开(公告)日：2011-05-19

申请号：AU2005295403

申请日：2005-10-18

Applicant: ARRAY BIOPHARMA INC

Inventor： LYSSIKATOS JOSEPH P ,  ALLEN SHELLEY ,  WALLACE ELI M ,  LAIRD ELLEN ,  AICHER TOM ,  ROBINSON JOHN ,  ZHAO QIAN ,  HANS JEREMY

IPC: C07D413/04 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/675 ,  A61K38/04 ,  C07D417/04

Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.

公开(公告)号：NZ554306A

公开(公告)日：2010-12-24

申请号：NZ55430605

申请日：2005-10-18

Applicant: ARRAY BIOPHARMA INC

Inventor： HANS JEREMY ,  WALLACE ELI M ,  ZHAO QIAN ,  LYSSIKATOS JOSEPH P ,  AICHER TOM ,  LAIRD ELLEN ,  ROBINSON JOHN ,  ALLEN SHELLEY

IPC: A61K31/4245 ,  C07D413/00 ,  C07D417/00

Abstract: Disclosed is a compound of formula (I), wherein the substituents are as defined in the specification. The compounds are mitotic kinesin KSP inhibitors useful in the treatment of diseases that can be treated by inhibiting mitosis, for example hyperproliferative disorders such cancer and autoimmune disease.

公开(公告)号：BRPI0610193A2

公开(公告)日：2010-06-01

申请号：BRPI0610193

申请日：2006-05-01

Applicant: ARRAY BIOPHARMA INC

Inventor： HANS JEREMY ,  WALLACE ELI M ,  ZHAO QIAN ,  ALLEN SHELLEY ,  LAIRD ELLEN ,  LYSSIKATOS JOSEPH P ,  ROBINSON JOHN E ,  CORRETTE CHRISTOPHER P ,  DELISLE ROBERT KIRK ,  VOEGTLI WALTER CHARLES

IPC: C07D417/04

Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.

公开(公告)号：BRPI0615781A2

公开(公告)日：2009-06-16

申请号：BRPI0615781

申请日：2006-08-31

Applicant: ARRAY BIOPHARMA INC

Inventor： MIKINIS GREG ,  LYSSIKATOS JOSEPH L ,  TARLTON EUGENE ,  BUCKMELTER ALEXANDRE J ,  REN LI ,  RAST BRYSON ,  SCHLACHTER STEPHEN T ,  WENGLOWSKY STEVEN MARK ,  LAIRD ELLEN

IPC: C07D495/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00 ,  C07D491/04

Abstract: Compounds of Formula I are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：MA29310B1

公开(公告)日：2008-03-03

申请号：MA30151

申请日：2007-08-17

Applicant: GENENTECH INC ,  ARRAY BIOPHARMA INC

Inventor： LAIRD ELLEN ,  LYSSIKATOS JOSEPH P ,  WELCH MIKE ,  GRINA JONAS ,  HANSEN JOSH ,  NEWHOUSE BRAD ,  OLIVERO ALAN ,  TOPOLAV GEORGE

IPC: C07D401/04 ,  A61K31/415 ,  A61P17/06

Abstract: LA PRÉSENTE INVENTION CONCERNE DES COMPOSÉS PYRAZOLYLE REPRÉSENTÉS PAR LA FORMULE IA QUI CONVIENNENT POUR INHIBER LA KINASE RAF ET POUR TRAITER DES TROUBLES INDUITS PAR CELLE-CI. CETTE INVENTION CONCERNE AUSSI DES PROCÉDÉS D'UTILISATION DES COMPOSÉS PYRAZOLYLE DE FAÇON À DIAGNOSTIQUER, PRÉVENIR OU TRAITER IN VITRO, IN SITU ET IN VIVO CES TROUBLES DANS DES CELLULES MAMMALIENNES OU DES ÉTATS PATHOLOGIQUES ASSOCIÉS.

公开(公告)号：MX2007014510A

公开(公告)日：2008-02-05

申请号：MX2007014510

申请日：2006-05-18

Applicant: ARRAY BIOPHARMA INC

Inventor： LYSSIKATOS JOSEPH P ,  LAIRD ELLEN ,  WELCH MIKE ,  GRINA JONAS ,  HANSEN JOSH ,  NEWHOUSE BRAD ,  TOPALOV GEORGE

IPC: C07D487/04 ,  A61K31/4985 ,  A61P35/00

Abstract: Los compuestos de la formula (I) son utiles para inhibir la cinasa Raf y para tratar trastornos mediados de este modo. Se describen metodos para usar los compuestos de la formula (I), estereoisomeros, tautomeros, solvatos y sales farmaceuticamente aceptables de los mismos, para diagnosis, prevencion o tratamiento in vitro, in situ e in vivo de estos trastornos en celulas de mamifero o condiciones patologicas asociadas.

公开(公告)号：NO20076186A

公开(公告)日：2008-02-01

申请号：NO20076186

申请日：2007-11-30

Applicant: ARRAY BIOPHARMA INC

Inventor： HANS JEREMY ,  WALLACE ELI M ,  ZHAO QIAN ,  ALLEN SHELLEY ,  LAIRD ELLEN ,  LYSSIKATOS JOSEPH P ,  ROBINSON JOHN E ,  CORRETTE CHRISTOPHER P ,  DELISLE ROBERT KIRK ,  VOEGTLI WALTER CHARLES

IPC: C07D417/04

CPC classification number: C07D513/04 ,  C07D285/12 ,  C07D417/04 ,  C07D417/14 ,  C07D419/04 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D497/04 ,  C07F9/65395

公开(公告)号：AU2006284751A1

公开(公告)日：2007-03-08

申请号：AU2006284751

申请日：2006-08-31

Applicant: ARRAY BIOPHARMA INC

Inventor： WENGLOWSKY STEVEN MARK ,  LAIRD ELLEN ,  BUCKMELTER ALEXANDRE J ,  RAST BRYSON ,  TARLTON EUGENE ,  MIKNIS GREG ,  LYSSIKATOS JOSEPH P ,  SCHLACTER STEPHEN T ,  REN LI

IPC: C07D495/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00 ,  C07D491/04

Abstract: Compounds of Formula I are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：CA2606708A1

公开(公告)日：2006-11-09

申请号：CA2606708

申请日：2006-05-01

Applicant: ARRAY BIOPHARMA INC

Inventor： ALLEN SHELLEY ,  HANS JEREMY ,  LYSSIKATOS JOSEPH P ,  ZHAO QIAN ,  WALLACE ELI M ,  LAIRD ELLEN ,  CORRETTE CHRISTOPHER P ,  DELISLE ROBERT KIRK ,  ROBINSON JOHN E ,  VOEGTLI WALTER CHARLES

IPC: C07D417/04

Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.

公开(公告)号：AU2006210626A1

公开(公告)日：2006-08-10

申请号：AU2006210626

申请日：2006-02-02

Applicant: OLIVERO ALAN ,  NEWHOUSE BRAD ,  LYSSIKATOS JPSEPH ,  ARRAY BIOPHARMA INC ,  TOPOLAV GEORGE ,  GENENTECH INC ,  WELCH MIKE ,  GRINA JONAS ,  LAIRD ELLEN ,  HANSEN JOSH

Inventor： TOPOLAV GEORGE ,  OLIVERO ALAN ,  LYSSIKATOS JOSEPH P ,  GRINA JONAS ,  NEWHOUSE BRAD ,  WELCH MIKE ,  HANSEN JOSH ,  LAIRD ELLEN

IPC: C07D401/04 ,  A61K31/415 ,  A61P3/10 ,  A61P9/00 ,  A61P17/06 ,  A61P25/00 ,  A61P35/00 ,  A61P37/00 ,  C07D401/14 ,  C07D471/04

Abstract: Pyrazolyl compounds of Formulas Ia and Ib are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using pyrazolyl compounds for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.