公开(公告)号：AU2011202922A1

公开(公告)日：2011-07-07

申请号：AU2011202922

申请日：2011-06-17

Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

Inventor： LUNDQUIST PAUL ,  ZACCARIN DENIS ,  LACROIX YVES ,  TURNER STEPHEN ,  DIXON JOHN

IPC: G01J3/30

Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing. Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional.

公开(公告)号：AU2007215173B2

公开(公告)日：2011-04-28

申请号：AU2007215173

申请日：2007-02-09

Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

Inventor： DIXON JOHN ,  LUNDQUIST PAUL ,  TURNER STEPHEN ,  ZACCARIN DENIS ,  LACROIX YVES

IPC: G01J3/30

Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.

公开(公告)号：CA2720247A1

公开(公告)日：2009-12-03

申请号：CA2720247

申请日：2009-03-30

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： EID JOHN ,  TURNER STEPHEN ,  DALAL RAVI ,  FLUSBERG BENJAMIN ,  KORLACH JONAS ,  LIN STEVEN ,  FEHR ADRIAN ,  CHRISTIANS FRED ,  EMIG ROBIN

IPC: G01N33/48 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/52

Abstract: Methods, compositions and arrays for non-random loading of single analyte molecules into array structures are provided.

公开(公告)号：AU2009251881A1

公开(公告)日：2009-12-03

申请号：AU2009251881

申请日：2009-03-30

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： CHRISTIANS FRED ,  KORLACH JONAS ,  DALAL RAVI ,  EID JOHN ,  LIN STEVEN ,  FEHR ADRIAN ,  EMIG ROBIN ,  FLUSBERG BENJAMIN ,  TURNER STEPHEN

IPC: G01N33/48 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/52

公开(公告)号：CA2991818A1

公开(公告)日：2009-10-01

申请号：CA2991818

申请日：2009-03-27

Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

Inventor： TRAVERS KEVIN ,  OTTO GEOFF ,  TURNER STEPHEN ,  HEINER CHERYL ,  MA CONGCONG

IPC: C12Q1/6869 ,  G16B30/00 ,  C12Q1/6806 ,  G16B30/10

Abstract: Compositions for nucleic acid sequencing are provided that include template constructs that comprise double stranded portions in partially or completely contiguous constructs, to provide for redundant sequence determination through one or both of sequencing sense and antisense strands, and iteratively sequencing the entire construct multiple times. Additional sequence components are also optionally included within such template constructs. Methods are also provided for the use and preparation of these constructs as well as sequencing compositions for their application.

公开(公告)号：CA2711560A1

公开(公告)日：2009-07-16

申请号：CA2711560

申请日：2009-01-09

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： LUONG KHAI ,  LUNDQUIST PAUL ,  DALAL RAVI ,  LYLE JOHN ,  TURNER STEPHEN

IPC: G01N21/64 ,  G01N21/00

Abstract: Methods, systems and their components for monitoring fluorescent signals and particularly transient fluorescent signals from reaction mixtures of interest, which methods and systems employ modulated excitation light sources to reduce impacts of excessive illumination on the reaction components or the data obtained therefrom.

公开(公告)号：AU2007289057A1

公开(公告)日：2008-03-06

申请号：AU2007289057

申请日：2007-08-31

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： LUNDQUIST PAUL ,  TURNER STEPHEN

IPC: F21V9/16

Abstract: Substrates, systems and methods for analyzing materials that include waveguide arrays disposed upon or within the substrate such that evanescent fields emanating from the waveguides illuminate materials disposed upon or proximal to the surface of the substrate, permitting analysis of such materials. The substrates, systems and methods are used in a variety of analytical operations, including, inter alia, nucleic acid analysis, including hybridization and sequencing analyses, cellular analyses and other molecular analyses.

公开(公告)号：GB2423819B

公开(公告)日：2008-02-06

申请号：GB0608338

申请日：2005-09-16

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： TURNER STEPHEN ,  KORLACH JONAS

IPC: G01N35/02 ,  B01L3/02

Abstract: The present invention relates to optical confinements, method of preparing and methods of using them for analyzing molecules and/or monitoring chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost single-molecular analysis.

公开(公告)号：CA2654470A1

公开(公告)日：2007-12-27

申请号：CA2654470

申请日：2007-06-11

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： FOQUET MATHIEU ,  ROITMAN DANIEL BERNARDO ,  TURNER STEPHEN ,  OTTO GEOFFREY ,  PELUSO PAUL

IPC: G02B6/10

Abstract: Substrates, including zero mode waveguide substrates that have been fabri cated to provide additional f.upsilon..pi.clionai elements and/or components including increased volumes for positioning of active surfaces and or compo nents for the mitigation of negative electrochemical properties of the under lying substrates.

公开(公告)号：AU2006320414A1

公开(公告)日：2007-06-07

申请号：AU2006320414

申请日：2006-12-01

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： OTTO GEOFFREY ,  TURNER STEPHEN ,  EID JOHN ,  MURPHY DEVON

IPC: A61K38/43 ,  A61K38/44

Abstract: Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.