公开(公告)号：SG10201601352UA

公开(公告)日：2016-03-30

申请号：SG10201601352U

申请日：2012-11-23

Applicant: PORTOLA PHARM INC

Inventor： SONG YONGHONG ,  XU QING ,  JIA ZHAOZHONG J ,  KANE BRIAN ,  BAUER SHAWN M ,  PANDEY ANJALI

公开(公告)号：PT2323993E

公开(公告)日：2015-10-12

申请号：PT09742982

申请日：2009-04-16

Applicant: PORTOLA PHARM INC

Inventor： HUANG WOLIN ,  PANDEY ANJALI ,  MEHROTRA MUKUND ,  JIA ZHAOZHONG J ,  VENKATARAMANI CHANDRASEKAR ,  SONG YONGHONG ,  XU QING ,  BAUER SHAWN M ,  KANE BRIAN ,  ROSE JACK W

IPC: C07D239/48 ,  A61K31/506 ,  A61P9/00 ,  A61P35/00 ,  C07D401/12 ,  C07D403/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

公开(公告)号：IN4065CHN2014A

公开(公告)日：2015-09-04

申请号：IN4065CHN2014

申请日：2014-05-30

Applicant: PORTOLA PHARM INC

Inventor： SONG YONGHONG ,  XU QING ,  JIA ZHAOZHONG J ,  KANE BRIAN ,  BAUER SHAWN M ,  PANDEY ANJALI

IPC: A61K31/496

Abstract: Provided are pyrazine compounds for inhibiting of Syk kinase intermediates used in making such compounds methods for their preparation pharmaceutical compositions thereof methods for inhibition Syk kinase activity and methods for treating conditions mediated at least in part by Syk kinase activity.

公开(公告)号：IN2906KON2014A

公开(公告)日：2015-05-08

申请号：IN2906KON2014

申请日：2014-12-12

Applicant: PORTOLA PHARM INC

Inventor： JIA ZHAOZHONG J ,  KANE BRIAN ,  ROSE JACK ,  BAUER SHAWN M ,  SONG YONGHONG ,  XU QING ,  PANDEY ANJALI

IPC: A01N43/64 ,  A01N43/707 ,  A61K31/53

Abstract: Provided are triazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibiting Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

公开(公告)号：AU2013277473A1

公开(公告)日：2015-02-05

申请号：AU2013277473

申请日：2013-06-14

Applicant: PORTOLA PHARM INC

Inventor： SONG YONGHONG ,  XU QING ,  SRAN ARVINDER ,  BAUER SHAWN M ,  JIA ZHAOZHONG J ,  KANE BRIAN ,  PANDEY ANJALI

IPC: C07D401/02 ,  A61K31/16 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4709

Abstract: Provided are picolinamide compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibiting Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

公开(公告)号：SG11201408074VA

公开(公告)日：2015-01-29

申请号：SG11201408074V

申请日：2013-06-14

Applicant: PORTOLA PHARM INC

Inventor： SONG YONGHONG ,  XU QING ,  SRAN ARVINDER ,  BAUER SHAWN M ,  JIA ZHAOZHONG J ,  KANE BRIAN ,  PANDEY ANJALI

IPC: A61K31/16 ,  A61K31/435 ,  A61K31/44

公开(公告)号：AU2009251863B2

公开(公告)日：2014-09-25

申请号：AU2009251863

申请日：2009-04-16

Applicant: PORTOLA PHARM INC

Inventor： PANDEY ANJALI ,  VENKATARAMANI CHANDRASEKAR ,  BAUER SHAWN M ,  SONG YONGHONG ,  JIA ZHAOZHONG J ,  MEHROTRA MUKUND ,  HUANG WOLIN ,  XU QING ,  ROSE JACK W

IPC: C07D239/48 ,  A61K31/506 ,  A61P9/00 ,  A61P35/00 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

Abstract: The present invention is directed to compounds of formula I-II and pharmaceutically acceptable tautomers, salts, or stereoisomers thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as cardiovascular disease, inflammatory disease, autoimmune disease and cell proliferative disorder, thrombosis, allergy, asthma, rheumatoid arthritis, leukemia, or non-Hodgkin's lymphoma.

公开(公告)号：MX2010011464A

公开(公告)日：2014-06-16

申请号：MX2010011464

申请日：2009-04-16

Applicant: PORTOLA PHARM INC

Inventor： BAUER SHAWN M ,  JIA ZHAOZHONG J ,  SONG YONGHONG ,  XU QING ,  MEHROTRA MUKUND ,  ROSE JACK W ,  HUANG WOLIN ,  VENKATARAMANI CHANDRASEKAR ,  PANDEY ANJALI

IPC: C07D239/48 ,  A61K31/506 ,  A61P9/00 ,  A61P35/00 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

Abstract: La presente invención se dirige a compuestos de la Fórmula I-II y tautómeros, sales o estereoisómeros farmacéuticamente aceptables de la misma que son inhibidores de syk y/o JAK quinasas. La presente invención también se dirige a intermediarios usados para realizar dichos compuestos, a la preparación de dicho compuesto, composiciones farmacéuticas que contienen dicho compuesto, métodos de inhibición de syk y/o JAK quinasa, métodos para la inhibición de agregación de plaquetas, y métodos para evitar o tratar una cantidad de enfermedades mediadas, al menos en parte, por la actividad syk y/o JAK quinasa, como por ejemplo trombosis y Linfoma no- Hodgkin.

公开(公告)号：AU2012340555A1

公开(公告)日：2014-06-05

申请号：AU2012340555

申请日：2012-11-23

Applicant: PORTOLA PHARM INC

Inventor： SONG YONGHONG ,  XU QING ,  JIA ZHAOZHONG J ,  KANE BRIAN ,  BAUER SHAWN M ,  PANDEY ANJALI

IPC: A61K31/4965

Abstract: Provided are pyrazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibition Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

公开(公告)号：GT201000298A

公开(公告)日：2014-05-07

申请号：GT201000298

申请日：2010-10-15

Applicant: PORTOLA PHARM INC

Inventor： YONGHONG SONG ,  QING XU ,  MUKUND MEHROTRA ,  ROSE JACK W ,  WOLIN HUANG ,  CHANDRASEKAR VENKATARAMANI ,  ANJALI PANDEY ,  BAUER SHAWN M ,  JIA ZHAOZHONG J

IPC: C07D239/48 ,  A61K31/506 ,  C07D413/12 ,  C07D417/12

Abstract: LA PRESENTE INVENCIÓN SE RELACIONA CON COMPUESTOS DERIVADOS DE 2,6-DIAMINO-PIRIMIDIN-5-IL-CARBOXAMIDAS, A SALES FARMACÉUTICAMENTE ACEPTABLES, TAUTÓMEROS, ESTEREOISÓMEROS, Y SU USO COMO INHIBIDORES DE JAK QUINASAS.