公开(公告)号：JP2507406B2

公开(公告)日：1996-06-12

申请号：JP7749587

申请日：1987-04-01

Applicant: TORAY INDUSTRIES

Inventor： SATO HARUYO ,  IMAMURA SHINZO

IPC: C12P41/00 ,  C12R1/38 ,  C12R1/40

公开(公告)号：JPH0364496B2

公开(公告)日：1991-10-07

申请号：JP25491685

申请日：1985-11-15

Applicant: TORAY INDUSTRIES

Inventor： MYATA AKIRA ,  IMAMURA SHINZO

IPC: C07B31/00 ,  C07B57/00 ,  C07C67/00 ,  C07C231/20 ,  C07C233/46 ,  C07C233/47 ,  C07C233/82 ,  C07C233/83

公开(公告)号：JPH0311090A

公开(公告)日：1991-01-18

申请号：JP14386689

申请日：1989-06-06

Applicant: TORAY INDUSTRIES

Inventor： MATSUNAGA KEIICHI ,  IMAMURA SHINZO ,  MUTOU MASATO ,  OKAMOTO YUTAKA

IPC: A61K31/28 ,  A61K31/282 ,  A61K33/24 ,  A61P35/00 ,  C07C49/733 ,  C07C211/65 ,  C07F15/00

Abstract: NEW MATERIAL:2-Acetylindane-1,3-dionyl-monohydroxo(trans-l- diaminocyclohexane)platinum of formula I. USE:A remedy for malignant tumor. PREPARATION:The objective compound can be produced by reacting dinitrato(1,2-diaminocyclohexano)platinum(II) or sulfato(1,2-diaminocyclohexane)platinum(II) of formula II [R is (NO3)2 or SO4] with 2-acetylindane-1,3-dione of formula III in the presence of an alkali metal or alkaline-earth metal hydroxide (preferably sodium hydroxide, potassium hydroxide or barium hydroxide) or reacting dihydroxo(1,2-diaminocyclohexane)platinum(II) of formula IV with the compound of formula III.

公开(公告)号：JPH0223545B2

公开(公告)日：1990-05-24

申请号：JP3993281

申请日：1981-03-19

Applicant: TORAY INDUSTRIES

Inventor： IMAMURA SHINZO ,  KURAMOTO HIROYOSHI ,  SATO HARUYO

IPC: C07D209/20

公开(公告)号：JPH0144702B2

公开(公告)日：1989-09-29

申请号：JP609979

申请日：1979-01-24

Applicant: TORAY INDUSTRIES

Inventor： SATO HARUYO ,  IMAMURA SHINZO

IPC: C07D223/12 ,  C08G65/26 ,  C08G65/28 ,  C08G69/14

公开(公告)号：JPH01165593A

公开(公告)日：1989-06-29

申请号：JP32499487

申请日：1987-12-21

Applicant: TORAY INDUSTRIES

Inventor： MUTOU MASANORI ,  FUJIKAWA KAZUHIRO ,  IMAMURA SHINZO ,  HASHIMOTO HIDEYUKI

IPC: C07F15/00 ,  A61K31/28 ,  A61K31/282 ,  A61K33/24 ,  A61P35/00

Abstract: NEW MATERIAL:A compound expressed by formula I. USE:A remedy for malignant tumor having low toxicity. PREPARATION:Methoxyethoxymethylcarboxylic acid expressed by formula II is reacted with dihydroxodiaminocyclohexane platinum (II) expressed by formula III, normally under ordinary temperature and ordinary pressure to provide the compound expressed by formula I. Furthermore, the compound expressed by formula III which is a starting raw material can be produced by reacting a compound expressed by the formula K2PtCl4 with a compound expressed by formula IV, reacting the resultant compound expressed by formula V with AgNO3 and treating the resultant compound expressed by formula VI with a OH type anion exchange resin. The compound expressed by formula II can be synthesized from methylcellosolve and monochloroacetic acid using metal sodium.

公开(公告)号：JPH0129786B2

公开(公告)日：1989-06-14

申请号：JP12174780

申请日：1980-09-04

Applicant: TORAY INDUSTRIES

Inventor： SATO HARUYO ,  IMAMURA SHINZO

IPC: C07C255/28 ,  C07C67/00 ,  C07C253/00 ,  C07C253/30 ,  C07D211/88

公开(公告)号：JPH01143884A

公开(公告)日：1989-06-06

申请号：JP30519487

申请日：1987-12-01

Applicant: TORAY INDUSTRIES

Inventor： MUTOU MASANORI ,  FUJIKAWA KAZUHIRO ,  IMAMURA SHINZO ,  SUGAWARA YOSHINORI

IPC: A61K31/555 ,  A61K31/28 ,  A61K31/282 ,  A61K33/24 ,  A61P35/00 ,  C07F15/00

Abstract: NEW MATERIAL:A compound expressed by formula I (R represents 2-buryl or 2-tetrahydrofuryl). EXAMPLE:Bis(2-furancarboxylate) (trans-l-diaminocyxlohexane) platinum (II) complex. USE:A remedy for malignant tumor, which is administered at a daily dose of 0.01-50mg/adult body weight. PREPARATION:2-Furancarboxylic acid or 2-tetrahydrofurancarboxylic acid is reacted with dihydroxodiaminocyclohexane platinum (II) expressed by formula II normally at ordinary temperature under ordinary pressure in an aqueous solution.

公开(公告)号：JPS63245693A

公开(公告)日：1988-10-12

申请号：JP7749587

申请日：1987-04-01

Applicant: TORAY INDUSTRIES

Inventor： SATOU HARUYO ,  IMAMURA SHINZO

IPC: C12P41/00 ,  C12R1/38 ,  C12R1/40

Abstract: PURPOSE:To industrially and advantageously obtain D-(-)-tartaric acid useful in the field of organic chemistry, by cultivating a specific microorganism in a culture fluid containing DL-tartaric acid. CONSTITUTION:A microorganism, such as Pseudomonas subtilis ATCC17642, belonging to the genus Pseudomonas and having the ability to assimilate L-(+)- tartaric acid without assimilating D-(-)-tartaric acid is inoculated into a culture fluid containing DL-tartaric acid in 1-300g/l concentration and cultivated at 20-35 deg.C for about 30hr by aerating and stirring at 0.5-2VVM aeration flow rate while regulating pH to 7-8. The L-(-)-tartaric acid is then asymmetrically decomposed and wholly consumed by cultivation to centrifuge the culture fluid. Microbial cells are removed to provide a supernatant liquid. CaCl2 is added to the supernatant liquid to form calcium D-(-)-tartrate. H2SO4 is subsequently added to the resultant salt to remove Ca and the obtained aqueous solution of the D-(-)-tartaric acid is then concentrated and purified.

公开(公告)号：JPS6259102B2

公开(公告)日：1987-12-09

申请号：JP25768484

申请日：1984-12-07

Applicant: TORAY INDUSTRIES

Inventor： SATO HARUYO ,  FURUYA MASAAKI ,  IMAMURA SHINZO

IPC: C07C271/22 ,  C07C67/00 ,  C07C239/00