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公开(公告)号：NO20021229D0
公开(公告)日：2002-03-12
申请号：NO20021229
申请日：2002-03-12
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , ZHANG PENGLIE , HUANG WENRONG , SONG YONGHONG , WANG LINGYAN , SCARBOROUGH ROBERT M , ZUCKETT JINGMEI , GOLDMAN ERIC , LI WENHAO
IPC: A61K31/18 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/4545 , A61K31/472 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/5513 , A61P7/02 , A61P9/10 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D521/00 , C07C
Abstract: Compounds of the formula A - Q - D - E - G - J - X in which D is a direct link, a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic ring system; X is a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic system; and the other variables are as defined in the claims, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号：AU743614B2
公开(公告)日：2002-01-31
申请号：AU4900397
申请日：1997-10-10
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , SCARBOROUGH ROBERT M
IPC: A61K38/00 , A61K31/425 , A61K38/05 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P43/00 , C07D413/14 , C07D417/12 , C07D417/14 , C07F5/02 , C07K5/06 , C07K5/097
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73.发明专利
公开(公告)号：AU733759B2
公开(公告)日：2001-05-24
申请号：AU2397399
申请日：1999-04-26
Applicant: COR THERAPEUTICS INC
Inventor： SUNDELIN JOHAN ATLES GR , SCARBOROUGH ROBERT M
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公开(公告)号：DE69328104T2
公开(公告)日：2000-12-21
申请号：DE69328104
申请日：1993-07-08
Applicant: COR THERAPEUTICS INC
Inventor： SCARBOROUGH ROBERT M
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公开(公告)号：CA2374820A1
公开(公告)日：2000-11-30
申请号：CA2374820
申请日：2000-05-24
Applicant: COR THERAPEUTICS INC
Inventor： CLIZBE LANE , SONG YONGHONG , ZHU BING-YAN , KANTER JAMES , MARLOWE CHARLES , SU TING , SCARBOROUGH ROBERT M
IPC: C07D233/61 , A61K31/165 , A61K31/167 , A61K31/18 , A61K31/198 , A61K31/216 , A61K31/277 , A61K31/341 , A61K31/40 , A61K31/404 , A61K31/415 , A61K31/422 , A61K31/4402 , A61K31/472 , A61K33/22 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , A61P43/00 , C07C311/46 , C07C317/32 , C07D209/08 , C07D213/56 , C07D217/22 , C07D231/12 , C07D295/16 , C07D307/54 , C07D307/68 , C07D413/04 , C07D521/00
Abstract: The present application relates to compounds of the general formula A-Y-D-E- G- J-Z-L, wherein A, Y, D, E, G, J, Z and L have the meanings given in the description, having activity against mammalian factor Xa. The compounds are useful in vitroor in vivofor preventing or treating coagulation disorders.
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Patent Agency Ranking
公开(公告)号：CA2374641A1
公开(公告)日：2000-11-30
申请号：CA2374641
申请日：2000-05-24
Applicant: COR THERAPEUTICS INC
Inventor： SCARBOROUGH ROBERT M , SONG YONGHONG , ZHU BING-YAN , SU TING , ZHAOZHANG JON JIA
IPC: A61P7/02 , A61K31/167 , A61K31/18 , A61K31/275 , A61K31/277 , A61K31/40 , A61K31/472 , A61K31/4725 , A61P9/00 , A61P9/04 , A61P9/10 , C07C311/16 , C07C311/18 , C07C311/40 , C07C311/44 , C07C311/46 , C07D207/16 , C07D217/22 , C07D401/06
Abstract: Novel compounds, their salts and compositions related thereto having activit y against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号：CA2362375A1
公开(公告)日：2000-08-17
申请号：CA2362375
申请日：2000-02-11
Applicant: COR THERAPEUTICS INC
Inventor： SONG YOUNGHONG , SCARBOROUGH ROBERT M , ZHU BING-YAN
IPC: C07D295/14 , A61K31/18 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/341 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4174 , A61K31/44 , A61K31/4409 , A61K31/472 , A61K31/4725 , A61K31/495 , A61K31/505 , A61K31/517 , A61P7/00 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/10 , A61P11/00 , A61P31/04 , A61P43/00 , C07C257/18 , C07C311/29 , C07C311/46 , C07C311/51 , C07D213/56 , C07D213/58 , C07D213/70 , C07D213/74 , C07D213/75 , C07D217/22 , C07D231/12 , C07D233/61 , C07D239/42 , C07D239/94 , C07D257/04 , C07D295/16 , C07D307/54 , C07D401/12 , C07D521/00
Abstract: Published without an
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公开(公告)号：CA2361428A1
公开(公告)日：2000-08-17
申请号：CA2361428
申请日：2000-02-11
Applicant: COR THERAPEUTICS INC
Inventor： TENG WILLY , SU TING , CLIZBE LANE , JIA ZHAOZHONG JON , SCARBOROUGH ROBERT M , ZHU BING-YAN , SONG YONGHONG
IPC: C07D295/14 , A61K31/18 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/341 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4174 , A61K31/44 , A61K31/4409 , A61K31/472 , A61K31/4725 , A61K31/495 , A61K31/505 , A61K31/517 , A61P7/00 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/10 , A61P11/00 , A61P31/04 , A61P43/00 , C07C257/18 , C07C311/29 , C07C311/46 , C07C311/51 , C07D213/56 , C07D213/58 , C07D213/70 , C07D213/74 , C07D213/75 , C07D217/22 , C07D231/12 , C07D233/61 , C07D239/42 , C07D239/94 , C07D257/04 , C07D295/16 , C07D307/54 , C07D401/12 , C07D521/00 , A61K31/16 , A61K31/33 , C07D231/56
Abstract: Novel compounds of formula in which A is a substituted or unsubstituted phenyl, naphthyl or monocyclic heterocyclic ring, D is a substituted or unsubstituted phenyl or aromatic six-membered heterocyclic ring, K is a substituted or unsubstituted phenyl, naphthyl or bicyclic heterocyclic ring, and the other variables are as defined in the claims, their salts and other derivatives and compositions related thereto having activity against mammali an Factor Xa are disclosed. The coumpounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号：AT190625T
公开(公告)日：2000-04-15
申请号：AT93917028
申请日：1993-07-08
Applicant: COR THERAPEUTICS INC
Inventor： SCARBOROUGH ROBERT M
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公开(公告)号：FI104364B
公开(公告)日：2000-01-14
申请号：FI915919
申请日：1991-12-16
Applicant: COR THERAPEUTICS INC
Inventor： SCARBOROUGH ROBERT M , WOLF DAVID LAWRENCE , CHARO ISRAEL F
IPC: A61K38/00 , A61K35/58 , A61K38/02 , A61K38/12 , A61K38/17 , A61K38/36 , A61K38/57 , A61P7/02 , C07K1/14 , C07K1/20 , C07K7/00 , C07K7/06 , C07K7/64 , C07K14/00 , C07K14/435 , C07K14/46 , C07K14/745 , C07K14/75 , C07K14/755 , C07K14/78 , C12N1/21 , C12N15/09 , C12N15/12 , C12P21/00 , C12P21/02 , C12Q1/56 , C12R1/19 , G01N33/86 , A61K38/54 , C07K1/00 , C07K2/00 , G01N33/566
Abstract: An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PAI from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K*-(G/Sar)-D wherein K* is a modified lysyl residue of the formula R 2 N(CH2)4CHNHCO- wherein each R is independently H, alkyl(1-6C) or at most one R is R -C=NR wherein R is H, alkyl(1-6C), phenyl or benzyl, or is NR 2 in which each R is independently H or alkyl(1-6C) and R is H, alkyl(1-6C), phenyl or benzyl, or R -C=NR is a radical selected from the group consisting of: where m is an integer of 2-3, and each R is independently H or alkyl(1-6C); and wherein one or two (CH2) may be replaced by O or S provided said O or S is not adjacent to another heteroatom are prepared and shown to specifically inhibit the binding of fibrinogen or von Willebrand Factor to GP IIb-IIIa.
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