公开(公告)号：CY1118246T1

公开(公告)日：2017-06-28

申请号：CY161101196

申请日：2016-11-21

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  COURT JOHN J ,  DENG HONGBO ,  DRUTU IOANA ,  DUFFY JOHN P ,  FARMER LUC ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN H ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  WANNAMAKER M WOODS ,  BYRN RANDAL ,  ZHOU YI ,  LIN CHAO ,  JIANG MIN ,  GERMANN URSULA A ,  JONES STEVEN

IPC: A61K31/506 ,  A61P31/16

Abstract: Μέθοδοιαναστολήςτηςαντιγραφήςιώνγρίπηςσεέναβιολογικόδείγμαή ασθενή, γιατημείωσητηςποσότηταςιώνγρίπηςσεέναβιολογικόδείγμαή ασθενήκαιγιατηθεραπευτικήαγωγήγρίπηςσεένανασθενή, ηοποίαπεριλαμβάνειχορήγησηστοενλόγωβιολογικόδείγμαή ασθενήμιαςαποτελεσματικήςποσότηταςμιαςένωσηςπουαντιπροσωπεύεταιαπότονΔομικόΤύπο (I): ήενόςφαρμακευτικώςαποδεκτούάλατοςαυτής, όπουοιτιμέςτουΔομικούΤύπου (ΙΑ) είναιόπωςπεριγράφεταιστοπαρόν. ΜιαένωσηαντιπροσωπεύεταιαπότονΔομικόΤύπο (ΙΑ) ήέναφαρμακευτικώςαποδεκτόάλαςαυτής, όπουοιτιμέςτουΔομικούΤύπου (ΙΑ) είναιόπωςπεριγράφεταιστοπαρόν. Μιαφαρμακευτικήσύνθεσηαποτελείταιαπόμιααποτελεσματικήποσότηταμιαςτέτοιαςένωσηςή φαρμακευτικώςαποδεκτούάλατοςαυτής, καιενόςφαρμακευτικώςαποδεκτούφορέα, ανοσοενισχυτικούή εκδόχου.

公开(公告)号：DK2739623T3

公开(公告)日：2017-04-24

申请号：DK12746215

申请日：2012-08-01

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  BOYD MICHAEL J ,  DENG HONGBO ,  DUFFY JOHN P ,  GAO HUAI ,  GU WENXIN ,  KENNEDY JOSEPH M ,  LEDFORD BRIAN ,  LEDEBOER MARK W ,  MALTAIS FRANCOIS ,  WANG TIANSHENG ,  DAVIES IOANA ,  FARMER LUC J ,  PEROLA EMANUELE

IPC: C07D471/04 ,  A61K31/444 ,  A61K31/506 ,  A61P31/16

公开(公告)号：DK2442809T3

公开(公告)日：2016-12-19

申请号：DK10726760

申请日：2010-06-17

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  COURT JOHN J ,  DENG HONGBO ,  DRUTU IOANA ,  DUFFY JOHN P ,  FARMER LUC ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN H ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  WANNAMAKER M WOODS ,  BYRN RANDAL ,  ZHOU YI ,  LIN CHAO ,  JIANG MIN ,  GERMANN URSULA A ,  JONES STEVEN ,  SALITURO FRANCESCO G ,  KWONG ANN DAK-YEE

IPC: A61K31/506 ,  A61P31/16

公开(公告)号：HK1215675A1

公开(公告)日：2016-09-09

申请号：HK16103636

申请日：2012-10-12

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL P ,  CLARK MICHAEL P MP ,  BANDARAGE UPUL K UK ,  BETHIEL RANDY S RS ,  COURT JOHN J JJ ,  DENG HONGBO ,  DRUTU IOANA I ,  DUFFY JOHN P JP ,  FARMER LUC L ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN H DH ,  KENNEDY JOSEPH M JM ,  LEDEBOER MARK W MW ,  LEDFORD BRIAN B ,  MALTAIS FRANCOIS F ,  PEROLA EMANUELE E ,  WANG TIANSHENG ,  WANNAMAKER M WOODS MW ,  GERMANN URSULA A UA ,  JONES STEVEN S ,  JIANG MIN ,  LIN CHAO ,  ZHOU YI ,  BYRN RANDAL R ,  SALITURO FRANCESCO G FG ,  ANN DAK-YEE KWONG

IPC: A61K20060101 ,  A61P20060101 ,  C07D20060101

公开(公告)号：NZ620086A

公开(公告)日：2016-05-27

申请号：NZ62008612

申请日：2012-08-01

Applicant: VERTEX PHARMA

Inventor： CLARK MICHAEL P ,  BANDARAGE UPUL K ,  DENG HONGBO ,  DUFFY JOHN P ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  PEROLA EMANUELE ,  CHARIFSON PAUL S ,  DAVIES IOANA ,  BETHIEL RANDY S ,  BOYD MICHAEL J ,  FARMER LUC J ,  GAO HUAI ,  GU WENXIN ,  KENNEDY JOSEPH M ,  MALTAIS FRANCOIS ,  WANG TIANSHENG

IPC: C07D471/04 ,  A61K31/407 ,  A61K31/437 ,  A61K31/444 ,  A61K31/506 ,  A61P31/16 ,  C07D239/30 ,  C07D239/42

Abstract: Disclosed is the compound (R)-3-((5-fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylpentanoic acid (2) and pharmaceutically acceptable salts thereof. Further disclosed is a pharmaceutical composition comprising the compound or a pharmaceutically acceptable salt thereof; a pharmaceutically acceptable carrier, adjuvant, or vehicle; and optionally one or more additional antiviral agents or an Influenza vaccine; for inhibiting the replication of influenza viruses.

公开(公告)号：ZA201500820B

公开(公告)日：2016-05-25

申请号：ZA201500820

申请日：2015-02-04

Applicant: VERTEX PHARMA

Inventor： KWONG ANN DAY-YEE ,  SALITURO FRANCESCO G ,  GERMANN URSULA A ,  JONES STEVEN ,  JIANG MIN ,  LIN CHAO ,  ZHOU YI ,  BYRN RANDAL ,  WANNAMAKER M WOODS ,  WANG TIANSHENG ,  PEROLA EMANUELE ,  MALTANIS FRANCOIS ,  LEDFORD BRIAN ,  LEDEBOER MARK W ,  KENNEDY JOSEPH M ,  JACOBS DYLAN H ,  GU WENXIN ,  GAO HUAI ,  FARMER LUC ,  DUFFY JOHN P ,  DRUTU IOANA ,  DENG HONGBO ,  COURT JOHN J ,  BETHIEL RANDY S ,  BANDARAGE UPUL K ,  CLARK MICHAEL P ,  CHARIFSON PAUL

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula ( I ): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula ( IA ) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( IA ) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

公开(公告)号：AP3631A

公开(公告)日：2016-03-08

申请号：AP2012006067

申请日：2010-06-17

Applicant: VERTEX PHARMA

Inventor： LEDFORD BRIAN ,  DRUTU IOANA ,  JACOBS DYLAN H ,  PEROLA EMANUELE ,  WANNAMAKER M WOODS ,  BANDARAGE UPUL K ,  DUFFY JOHN P ,  DENG HONGBO ,  LEDEBOER MARK W ,  KENNEDY JOSEPH M ,  FARMER LUC J ,  GAO HUAI ,  GU WENXIN ,  MALTAIS FRANCOIS ,  COURT JOHN J ,  CHARIFSON PAUL ,  CLARK MICHAEL P ,  BETHIEL RANDY S ,  WANG TIANSHENG

IPC: A61K31/506 ,  A61P31/16

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula ( I ): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula ( IA ) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( IA ) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

公开(公告)号：PE01272016A1

公开(公告)日：2016-02-24

申请号：PE0026832015

申请日：2010-06-17

Applicant: VERTEX PHARMA

Inventor： BANDARAGE UPUL K ,  ZHOU YI ,  BYRN RANDAL ,  CHARIFSON PAUL ,  CLARK MICHAEL P ,  COURT JOHN J ,  DENG HONGBO ,  DRUTU IOANA ,  DUFFY JOHN P ,  FARMER LUC ,  GAO HUAI ,  GERMANN URSULA A ,  GU WENXIN ,  JACOBS DYLAN H ,  JIANG MIN ,  JONES STEVEN ,  KENNEDY JOSEPH M ,  KWONG ANN DAK-YEE ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  LIN CHAO ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  SALITURO FRANCESCO G ,  WANG TIANSHENG ,  WANNAMAKER M WOODS ,  BETHIEL RANDY S

IPC: A61K31/506 ,  A61P31/16

CPC classification number: A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/553 ,  C07D239/30 ,  C07D401/04 ,  C07D401/10 ,  C07D471/04

Abstract: Referida a un compuesto derivado de pirrolopiridina de formula IA, donde Z1, Z2, Z3, R1, R2, R3 y R4 tienen la definicion dada en la memoria descriptiva. Dichos compuestos son utiles en la inhibicion de la replicacion de los virus de influenza. Tambien esta referida a una composicion farmaceutica

公开(公告)号：ZA201400604B

公开(公告)日：2015-10-28

申请号：ZA201400604

申请日：2014-01-24

Applicant: VERTEX PHARMA

Inventor： WANG TIANSHENG ,  PEROLA EMANUELE ,  MALTAIS FRANCOIS ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  KENNEDY JOSEPH M ,  GU WENXIN ,  GAO HUAI ,  FARMER LUC J ,  DUFFY JOHN P ,  DENG HONGBO ,  DAVIES IOANA ,  BOYD MICHAEL J ,  BETHIEL RANDY S ,  BANDARAGE UPUL K ,  CLARK MICHAEL P ,  CHARIFSON PAUL S

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula ( I ): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( I ) are as described herein. A compound is represented by Structural Formula ( I ) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( I ) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

公开(公告)号：ZA201109127B

公开(公告)日：2015-07-29

申请号：ZA201109127

申请日：2011-12-12

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  CLARK MICHAEL PHILIP ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  COURT JOHN J ,  DENG HONGBO ,  DRUTU IOANA ,  DUFFY JOHN P ,  FARMER LUC ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN H ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  WANNAMAKER M WOODS ,  BYRN RANDAL ,  ZHOU YI ,  LIN CHAO ,  JIANG MIN ,  JONES STEVEN ,  GERMANN URSULA A

IPC: A61K20060101 ,  A61P20060101

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula ( I ): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula ( IA ) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( IA ) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.