Patent search ap:("VERTEX PHARMA") AND inv:"PEROLA EMANUELE" Page 1

1.

发明申请
INHIBITORS OF INFLUENZA VIRUSES REPLICATION 审中-公开
Title translation: 流感病毒复制抑制剂

公开(公告)号：WO2012083122A8

公开(公告)日：2013-12-05

申请号：PCT/US2011065389

申请日：2011-12-16

Applicant: VERTEX PHARMA , CHARIFSON PAUL S , CLARK MICHAEL P , BANDARAGE UPUL K , DENG HONGBO , DAVIES IOANA , DUFFY JOHN P , FARMER LUC J , GAO HUAI , GU WENXIN , KENNEDY JOSEPH M , LEDEBOER MARK W , LEDFORD BRIAN , MALTAIS FRANCOIS , PEROLA EMANUELE , WANNAMAKER MARION W , WANG TIANSHENG , SALITURO FRANCESCO G

Inventor： CHARIFSON PAUL S , CLARK MICHAEL P , BANDARAGE UPUL K , DENG HONGBO , DAVIES IOANA , DUFFY JOHN P , FARMER LUC J , GAO HUAI , GU WENXIN , KENNEDY JOSEPH M , LEDEBOER MARK W , LEDFORD BRIAN , MALTAIS FRANCOIS , PEROLA EMANUELE , WANNAMAKER MARION W , WANG TIANSHENG , SALITURO FRANCESCO G

IPC: C07D471/04 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/53

CPC classification number: C07D471/04

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

Abstract translation: 抑制生物样品或患者中流感病毒的复制，减少生物样品或患者中流感病毒的量以及治疗患者中的流感的方法包括向所述生物样品或患者施用有效量的由结构式（I）表示的化合物或其药学上可接受的盐，其中结构式（I）的值如本文所述。结构式（I）表示的化合物或其药学上可接受的盐，其中结构式（I）的值如本文所述。药物组合物包含有效量的这样的化合物或其药学上可接受的盐和药学上可接受的载体，助剂或媒介物。

2.

发明申请
INHIBITORS OF SERINE PROTEASES 审中-公开
Title translation: 丝氨酸蛋白酶抑制剂

公开(公告)号：WO2007025307A3

公开(公告)日：2007-04-26

申请号：PCT/US2006033770

申请日：2006-08-28

Applicant: VERTEX PHARMA , COTTRELL KEVIN M , MAXWELL JOHN , TANG QING , GRILLOT ANNE-LAURE , LE TIRAN ARNAUD , PEROLA EMANUELE

Inventor： COTTRELL KEVIN M , MAXWELL JOHN , TANG QING , GRILLOT ANNE-LAURE , LE TIRAN ARNAUD , PEROLA EMANUELE

IPC: C07D498/10 , C07K5/08

CPC classification number: C07D498/10 , A61K38/00 , C07D498/20 , C07D519/00 , C07K5/06026 , C07K5/06191 , C07K5/0804 , C07K5/0808 , C07K5/081 , C07K5/0827

Abstract: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease.

Abstract translation: 本发明涉及抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒NS3-NS4A蛋白酶活性的式（I）化合物或其药学上可接受的盐或混合物。

3.

发明专利
INHIBITORI REPLIKACIJE VIRUSA GRIPE 未知

公开(公告)号：HRP20181715T1

公开(公告)日：2019-04-05

申请号：HRP20181715

申请日：2018-10-19

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL , CLARK MICHAEL P , BANDARAGE UPUL K , BETHIEL RANDY S , COURT JOHN J , DENG HONGBO , DRUTU IOANA , DUFFY JOHN P , FARMER LUC , GAO HUAI , GU WENXIN , JACOBS DYLAN H , KENNEDY JOSEPH M , LEDEBOER MARK W , LEDFORD BRIAN , MALTAIS FRANCOIS , PEROLA EMANUELE , WANG TIANSHENG , WANNAMAKER M WOODS , BYRN RANDAL , ZHOU YI , LIN CHAO , JIANG MIN , GERMANN URSULA A , JONES STEVEN , SALITURO FRANCESCO G , KWONG ANN DAK-YEE

IPC: A61K31/506 , A61P31/16

4.

发明专利
ІНГІБІТОРИ РЕПЛІКАЦІЇ ВІРУСІВ ГРИПУ 未知

公开(公告)号：UA118010C2

公开(公告)日：2018-11-12

申请号：UAA201402082

申请日：2012-08-01

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S , CLARK MICHAEL P , BANDARAGE UPUL K , BETHIEL RANDY S , BOYD MICHAEL J , DAVIES IOANA , DENG HONGBO , DUFFY JOHN P , FARMER LUC J , GAO HUAI , GU WENXIN , KENNEDY JOSEPH M , LEDFORD BRIAN , LEDEBOER MARK W , MALTAIS FRANCOIS , PEROLA EMANUELE , WANG TIANSHENG

IPC: C07D471/04 , A61K31/444 , A61K31/506 , A61P31/16

Abstract: Способиінгібуванняреплікаціївірусугрипув біологічномузразкуабоу пацієнта, зменшеннякількостівірусугрипув біологічномузразкуабов пацієнтаі лікуваннягрипуу пацієнтавключаютьвведенняу вказанийбіологічнийзразокабопацієнтуефективноїкількостісполуки, щовідповідаєструктурнійформулі (І): EMBED ISISServer , (I) абоїїфармацевтичноприйнятноїсолі, дезмінніструктурноїформули (І) єтакими, якрозкритов даномуописі. Сполукавідповідаєструктурнійформулі (І) абоструктурнійформуліїїфармацевтичноприйнятноїсолі, дезмінніструктурноїформули (І) єтакими, якрозкритов даномуописі. Фармацевтичнакомпозиціяміститьефективнукількістьтакоїсполукиабоїїфармацевтичноприйнятноїсоліі фармацевтичноприйнятнийносій, ад'ювантабонаповнювач.

5.

发明专利
Inhibitors of Influenza Viruses Replication 未知

公开(公告)号：AU2018200219A1

公开(公告)日：2018-02-22

申请号：AU2018200219

申请日：2018-01-11

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL , CLARK MICHAEL P , BANDARAGE UPUL K , BETHIEL RANDY S , COURT JOHN J , DENG HONGBO , DRUTU IOANA , DUFFY JOHN P , FARMER LUC , GAO HUAI , GU WENXIN , JACOBS DYLAN H , KENNEDY JOSEPH M , LEDEBOER MARK W , LEDFORD BRIAN , MALTAIS FRANCOIS , PEROLA EMANUELE , WANG TIANSHENG , WANNAMAKER M WOODS , BYRN RANDAL , ZHOU YI , LIN CHAO , JIANG MIN , JONES STEVEN , GERMANN URSULA A , SALITURO FRANCESCO G , KWONG ANN DAK YEE

IPC: A61K31/506 , A61P31/16

Abstract: 2-(3H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-amine derivatives and their use in inhibiting influenza virus replication.

6.

发明专利
Inhibitors of influenza viruses replication 未知

公开(公告)号：NZ716783A

公开(公告)日：2017-08-25

申请号：NZ71678312

申请日：2012-08-01

Applicant: VERTEX PHARMA

Inventor： CLARK MICHAEL P , BANDARAGE UPUL K , DENG HONGBO , DUFFY JOHN P , LEDEBOER MARK W , LEDFORD BRIAN , PEROLA EMANUELE , CHARIFSON PAUL S , DAVIES IOANA , BETHIEL RANDY S , BOYD MICHAEL J , FARMER LUC J , GAO HUAI , GU WENXIN , KENNEDY JOSEPH M , MALTAIS FRANCOIS , WANG TIANSHENG

IPC: C07D471/04 , A61K31/407 , A61K31/4162 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/506 , A61P31/16 , C07D213/61 , C07D213/74 , C07D239/30 , C07D239/42

Abstract: Disclosed are 3-((2-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylpentanoic acid and 3-((6-(1H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl)amino)-4,4-dimethylpentanoic acid derivatives and analogues as represented by Formula (IV): or a pharmaceutically acceptable salt thereof, wherein: X1 is fluoro, chloro, trifluoromethyl, cyano, or methyl; X2 is hydrogen, fluoro, or chloro; Z1 is N or CH; Z2 is N or CH, CF, or CCN; R1, R2, and R3 are each independently methyl, fluoromethyl, trifluoromethyl, ethyl, 2-fluoroethyl, or 2,2,2,-trifluoroethyl; R4 and R5 are hydrogen; Q is –C(O)OR; and R is hydrogen or alkyl; provided that the compound of Formula (IV) is not (R)-3-((5-fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylpentanoic acid. Also disclosed is a pharmaceutical composition which comprises a compound of Formula (IV) or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier, adjuvant or vehicle; for treating or preventing influenza virus infection in a patient.

7.

发明专利
INHIBITORS OF INFLUENZA VIRUSES REPLICATION 未知

公开(公告)号：GEP201706698B

公开(公告)日：2017-07-10

申请号：GEAP2012013685

申请日：2012-08-01

Applicant: VERTEX PHARMA

Inventor： BANDARAGE UPUL K , DENG HONGBO , LEDEBOER MARK W , DUFFY JOHN P , CHARIFSON PAUL S , CLARK MICHAEL P , BETHIEL RANDY S , BOYD MICHAEL J , DAVIES IOANA , FARMER LUC J , GAO HUAI , GU WENXIN , KENNEDY JOSEPH M , LEDFORD BRIAN , MALTAIS FRANCOIS , WANG TIANSHENG , PEROLA EMANUELE

IPC: C07D471/04 , A61K31/444 , A61K31/506 , A61P31/16

Abstract: Compound of formula (IV), which values Z1, Z2, X1, X2, Q, R1, R2, R3, R4, R5 are provided in the claims or pharmaceutically acceptable salt thereof, pharmaceutical composition on basis thereof, and their usage for viral infection treating drug preparation. Table: 4