公开(公告)号：WO2012083122A8

公开(公告)日：2013-12-05

申请号：PCT/US2011065389

申请日：2011-12-16

Applicant: VERTEX PHARMA ,  CHARIFSON PAUL S ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  DENG HONGBO ,  DAVIES IOANA ,  DUFFY JOHN P ,  FARMER LUC J ,  GAO HUAI ,  GU WENXIN ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANNAMAKER MARION W ,  WANG TIANSHENG ,  SALITURO FRANCESCO G

Inventor： CHARIFSON PAUL S ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  DENG HONGBO ,  DAVIES IOANA ,  DUFFY JOHN P ,  FARMER LUC J ,  GAO HUAI ,  GU WENXIN ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANNAMAKER MARION W ,  WANG TIANSHENG ,  SALITURO FRANCESCO G

IPC: C07D471/04 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/506 ,  A61K31/53

CPC classification number: C07D471/04

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

Abstract translation: 抑制生物样品或患者中流感病毒的复制，减少生物样品或患者中流感病毒的量以及治疗患者中的流感的方法包括向所述生物样品或患者施用有效量的 由结构式（I）表示的化合物或其药学上可接受的盐，其中结构式（I）的值如本文所述。 结构式（I）表示的化合物或其药学上可接受的盐，其中结构式（I）的值如本文所述。 药物组合物包含有效量的这样的化合物或其药学上可接受的盐和药学上可接受的载体，助剂或媒介物。

公开(公告)号：UA122808C2

公开(公告)日：2021-01-06

申请号：UAA201807026

申请日：2012-08-01

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  BOYD MICHAEL J ,  DAVIES IOANA ,  DENG HONGBO ,  DUFFY JOHN P ,  FARMER LUC J ,  GAO HUAI ,  GU WENXIN ,  KENNEDY JOSEPH M ,  LEDFORD BRIAN ,  LEDEBOER MARK W ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG

Abstract: Способиінгібуванняреплікаціївірусугрипув біологічномузразкуабов пацієнта, зменшеннякількостівірусугрипув біологічномузразкуабов пацієнтаі лікуваннягрипув пацієнтавключаютьвведенняу вказанийбіологічнийзразокабопацієнтуефективноїкількостісполуки, щовідповідаєструктурнійформулі (I): абоїїфармацевтичноприйнятноїсолі, дезмінніструктурноїформули (I) єтакими, якописанов даномуописі. Сполукавідповідаєструктурнійформулі (I) абоструктурнійформуліїїфармацевтичноприйнятноїсолі, дезмінніструктурноїформули (I) єтакими, якописанов даномуописі. Фармацевтичнакомпозиціяміститьефективнукількістьтакоїсполукиабоїїфармацевтичноприйнятноїсоліі фармацевтичноприйнятнийносій, ад'ювантабонаповнювач.

公开(公告)号：CA2844054C

公开(公告)日：2020-09-01

申请号：CA2844054

申请日：2012-08-01

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  BOYD MICHAEL J ,  DAVIES IOANA ,  DENG HONGBO ,  DUFFY JOHN P ,  FARMER LUC J ,  GAO HUAI ,  GU WENXIN ,  KENNEDY JOSEPH M ,  LEDFORD BRIAN ,  LEDEBOER MARK W ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG

IPC: C07D471/04 ,  A61K31/444 ,  A61K31/506 ,  A61P31/16

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

公开(公告)号：AR113753A2

公开(公告)日：2020-06-10

申请号：ARP180102912

申请日：2018-10-09

Applicant: VERTEX PHARMA

Inventor： WANNAMAKER M WOODS ,  WANG TIANSHENG ,  PEROLA EMANUELE ,  MALTAIS FRANCOIS ,  LEDFORD BRIAN ,  LEDEBOER MARK W ,  KENNEDY JOSEPH M ,  JACOBS DYLAN H ,  GU WENXIN ,  GAO HUAI ,  FARMER LUC J ,  DUFFY JOHN P ,  DRUTU IOANA ,  DENG HONGBO ,  COURT JOHN J ,  BETHIEL RANDY S ,  CLARK MICHAEL P ,  CHARIFSON PAUL

IPC: A61K31/437 ,  A61P31/16 ,  C07D471/04

Abstract: Métodos de inhibición de la replicación del virus de la gripe en una muestra biológica o un paciente, de reducción de la cantidad del virus de la gripe en una muestra biológica o un paciente y de tratamiento de gripe en un paciente, que comprende la administración a dicha muestra biológica o paciente de una cantidad efectiva de un compuesto representado por la fórmula estructural (1), o una de sus sales farmacéuticamente aceptables, en donde los valores de la fórmula estructural (1) son como se describen en la presente. Un compuesto está representado por la fórmula estructural (1) o una de sus sales farmacéuticamente aceptables, en donde los valores de la fórmula estructural (1) son como se describen en la presente. Una composición farmacéutica comprende una cantidad efectiva de tal compuesto o su sal farmacéuticamente aceptable y un portador, adyuvante o vehículo farmacéuticamente aceptable.

公开(公告)号：CA2764177C

公开(公告)日：2018-06-05

申请号：CA2764177

申请日：2010-06-17

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  COURT JOHN J ,  DENG HONGBO ,  DRUTU IOANA ,  DUFFY JOHN P ,  FARMER LUC J ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN H ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  WANNAMAKER M WOODS ,  BYRN RANDAL ,  ZHOU YI ,  LIN CHAO ,  JIANG MIN ,  JONES STEVEN ,  GERMANN URSULA A ,  SALITURO FRANCESCO G ,  KWONG ANN DAK-YEE

IPC: C07D471/04 ,  A61K31/506 ,  A61P31/16

Abstract: Methods of inhibiting the replica-tion of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating in-fluenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula (IA) or a pharmaceutically ac-ceptable salt thereof, wherein the values of Struc-tural Formula (IA) are as described herein. A phar-maceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically ac-ceptable carrier, adjuvant or vehicle.

公开(公告)号：HRP20161577T1

公开(公告)日：2017-01-27

申请号：HRP20161577

申请日：2016-11-28

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  COURT JOHN J ,  DENG HONGBO ,  DRUTU IOANA ,  DUFFY JOHN P ,  FARMER LUC ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN H ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  WANNAMAKER M WOODS ,  BYRN RANDAL ,  ZHOU YI ,  LIN CHAO ,  JIANG MIN ,  GERMANN URSULA A ,  JONES STEVEN ,  SALITURO FRANCESCO G ,  KWONG ANN DAK-YEE

IPC: A61K31/506 ,  A61P31/16

公开(公告)号：EA025276B1

公开(公告)日：2016-12-30

申请号：EA201270032

申请日：2010-06-17

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  COURT JOHN J ,  DENG HONGBO ,  DRUTU IOANA ,  DUFFY JOHN P ,  FARMER LUC ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN H ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  WANNAMAKER M WOODS ,  BYRN RANDAL ,  ZHOU YI ,  LIN CHAO ,  JIANG MIN ,  JONES STEVEN ,  GERMANN URSULA A

IPC: A61K31/506 ,  A61P31/16

Abstract: Изобретениеотноситсяк новомусоединению, аименно - к (2S,3S)-3-((2-(5-фтор-1Н-пирроло[2,3-b]пиридин-3-ил)-5-фторпиримидин-4-ил)амино)бицикло[2,2,2]октан-2-карбоновойкислоте, обладающейсвойствомингибированиярепликациивирусагриппаА вбиологическомобразцеилиу пациента, уменьшенияколичествавирусовгриппав биологическомобразцеилиу пациента. Изобретениетакжеотноситсяк фармацевтическойкомпозиции, содержащейэффективноеколичествотакогосоединенияилиегофармацевтическиприемлемойсолии фармацевтическиприемлемыйноситель, наполнительилиразбавитель, ипредназначенодлясниженияколичествавирусовгриппаА. ТакжераскрываетсяспособсниженияколичествавирусовгриппаА в in vitro биологическомобразце, включающийвведениев указанныйбиологическийобразецэффективногоколичестваданногосоединения.

公开(公告)号：AU2016228190A1

公开(公告)日：2016-10-27

申请号：AU2016228190

申请日：2016-09-14

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  BOYD MICHAEL J ,  DAVIES IOANA ,  DENG HONGBO ,  DUFFY JOHN P ,  FARMER LUC J ,  GAO HUAI ,  GU WENXIN ,  KENNEDY JOSEPH M ,  LEDFORD BRIAN ,  LEDEBOER MARK W ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG

IPC: C07D471/04 ,  A61K31/444 ,  A61K31/506 ,  A61P31/16

Abstract: Abstract The present invention relates to compounds of Formula I or a pharmaceutically acceptable salt thereof and methods of inhibiting the replication of influenza viruses and/or reducing the amount of influenza viruses in a biological sample or patient comprising administering an effective amount of a compound of Formula I or a pharmaceutically acceptable salt thereof to the biological sample or patient. The present invention further provides for pharmaceutical compositions comprising a compound of Formula I or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle. x2 "'N \Z1Z" Formula I

公开(公告)号：AU2016204286A1

公开(公告)日：2016-08-11

申请号：AU2016204286

申请日：2016-06-23

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  COURT JOHN J ,  DENG HONGBO ,  DRUTU IOANA ,  DUFFY JOHN P ,  FARMER LUC ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN H ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  WANNAMAKER M WOODS ,  BYRN RANDAL ,  ZHOU YI ,  LIN CHAO ,  JIANG MIN ,  JONES STEVEN ,  GERMANN URSULA A ,  SALITURO FRANCESCO G ,  KWONG ANN DAK-YEE

IPC: A61K31/506 ,  A61P31/16

Abstract: Abstract Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula (IA) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

公开(公告)号：SG10201503833SA

公开(公告)日：2015-06-29

申请号：SG10201503833S

申请日：2012-08-01

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  BOYD MICHAEL J ,  DAVIES IOANA ,  DENG HONGBO ,  DUFFY JOHN P ,  FARMER LUC J ,  GAO HUAI ,  GU WENXIN ,  KENNEDY JOSEPH M ,  LEDFORD BRIAN ,  LEDEBOER MARK W ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula ( I ): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( I ) are as described herein. A compound is represented by Structural Formula ( I ) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( I ) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.