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公开(公告)号：WO2006023852A3
公开(公告)日：2006-08-31
申请号：PCT/US2005029780
申请日：2005-08-19
Applicant: VERTEX PHARMA , MAKINGS LEWIS R , GARCIA-GUZMAN BLANCO MIGUEL , HURLEY DENNIS J , DRUTU IOANA , RAFFAI GABRIEL , BERGERON DANIELE M , NAKATANI AKIKO , TERMIN ANDREAS P , SILINA ALINA
Inventor： MAKINGS LEWIS R , GARCIA-GUZMAN BLANCO MIGUEL , HURLEY DENNIS J , DRUTU IOANA , RAFFAI GABRIEL , BERGERON DANIELE M , NAKATANI AKIKO , TERMIN ANDREAS P , SILINA ALINA
IPC: A61K31/435 , A61K31/438 , A61P25/00 , A61P43/00 , C07D471/00
CPC classification number: C07D401/06 , A61K31/435 , A61K31/438 , A61K31/4747 , A61K31/55 , C07D221/20 , C07D223/32 , C07D405/04 , C07D405/06 , C07D405/12 , C07D451/02 , C07D451/04 , C07D471/10 , C07D491/10
Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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公开(公告)号：WO2006058303A3
公开(公告)日：2006-12-21
申请号：PCT/US2005042967
申请日：2005-11-29
Applicant: VERTEX PHARMA , DRUTU IOANA , HURLEY DENNIS J , BANDARAGE UPUL K , BERGERON DANIELE M , CHARIFSON PAUL S , DAVIES ROBERT J , GARCIA-GUZMAN BLANCO MIGUEL , MAKINGS LEWIS R , NAKATANI AKIKO , RAFFAI GABRIEL
Inventor： DRUTU IOANA , HURLEY DENNIS J , BANDARAGE UPUL K , BERGERON DANIELE M , CHARIFSON PAUL S , DAVIES ROBERT J , GARCIA-GUZMAN BLANCO MIGUEL , MAKINGS LEWIS R , NAKATANI AKIKO , RAFFAI GABRIEL
IPC: A61K31/4747 , A61K31/435 , A61K31/439 , A61K31/444 , A61K31/4545 , A61P1/00 , A61P3/04 , A61P9/00 , A61P17/02 , A61P25/00 , A61P27/02 , A61P43/00 , C07D471/00
CPC classification number: C07D471/10 , A61K31/435 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/4747 , C07D471/08 , C07D491/08 , C07D491/10
Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
Abstract translation: 本发明涉及毒蕈碱受体的调节剂。 本发明还提供了包含这种调节剂的组合物，以及用于治疗毒蕈碱性受体介导的疾病的方法。
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公开(公告)号：WO2007076070A2
公开(公告)日：2007-07-05
申请号：PCT/US2006049141
申请日：2006-12-22
Applicant: VERTEX PHARMA , MAKINGS LEWIS R , GARCIA-GUZMAN BLANCO MIGUEL , HURLEY DENNIS J , DRUTU IOANA , RAFFAI GABRIEL , BERGERON DANIELE M , NAKATANI AKIKO , TERMIN ANDREAS P , SILINA ALINA
Inventor： MAKINGS LEWIS R , GARCIA-GUZMAN BLANCO MIGUEL , HURLEY DENNIS J , DRUTU IOANA , RAFFAI GABRIEL , BERGERON DANIELE M , NAKATANI AKIKO , TERMIN ANDREAS P , SILINA ALINA
CPC classification number: A61K31/4545 , A61K31/438 , A61K31/46 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , C07D221/20 , C07D401/04 , C07D401/06 , C07D405/04 , C07D417/14 , C07D471/10 , C07D487/08 , C07D491/10
Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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公开(公告)号：WO2006105035A3
公开(公告)日：2006-11-16
申请号：PCT/US2006011139
申请日：2006-03-28
Applicant: VERTEX PHARMA , DRUTU IOANA , GARCIA-GUZMAN BLANCO MIGUEL , MAKINGS LEWIS R , RAFFAI GABRIEL , ZUNIC VALENTIN BORIS
Inventor： DRUTU IOANA , GARCIA-GUZMAN BLANCO MIGUEL , MAKINGS LEWIS R , RAFFAI GABRIEL , ZUNIC VALENTIN BORIS
IPC: A61K31/46 , A61K31/4468 , A61K31/453 , A61P25/00 , C07D211/58 , C07D401/04 , C07D451/04
CPC classification number: C07D211/58 , A61K31/4468 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/46 , A61K31/4709 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/502 , A61K31/52 , A61K31/53 , C07D451/04 , C07D519/00
Abstract: The present invention relates to modulators of muscarinic receptors formula (I). The present invention also provides compositions comprising such modulators/ and methods therewith for treating muscarinic receptor mediated diseases.
Abstract translation: 本发明涉及式（I）的毒蕈碱受体调节剂。 本发明还提供包含这样的调节剂的组合物和/或其用于治疗毒蕈碱受体介导的疾病的方法。
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公开(公告)号：WO2006058294A2
公开(公告)日：2006-06-01
申请号：PCT/US2005042931
申请日：2005-11-29
Applicant: VERTEX PHARMA , HURLEY DENNIS J , BERGERON DANIELE M , DRUTU IOANA , GARCIA-GUZMAN BLANCO MIGUEL , MAKINGS LEWIS R , NAKATANI AKIKO , RAFFAI GABRIEL , SILINA ALINA
Inventor： HURLEY DENNIS J , BERGERON DANIELE M , DRUTU IOANA , GARCIA-GUZMAN BLANCO MIGUEL , MAKINGS LEWIS R , NAKATANI AKIKO , RAFFAI GABRIEL , SILINA ALINA
CPC classification number: C07D211/10 , A61K31/4439 , C07D211/18 , C07D211/32 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/52 , C07D211/64 , C07D401/04 , C07D401/06 , C07D401/10 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/10 , C07D417/10 , C07D417/12 , C07D451/02 , C07D493/08
Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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Patent Agency Ranking
公开(公告)号：HRP20181715T1
公开(公告)日：2019-04-05
申请号：HRP20181715
申请日：2018-10-19
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL , CLARK MICHAEL P , BANDARAGE UPUL K , BETHIEL RANDY S , COURT JOHN J , DENG HONGBO , DRUTU IOANA , DUFFY JOHN P , FARMER LUC , GAO HUAI , GU WENXIN , JACOBS DYLAN H , KENNEDY JOSEPH M , LEDEBOER MARK W , LEDFORD BRIAN , MALTAIS FRANCOIS , PEROLA EMANUELE , WANG TIANSHENG , WANNAMAKER M WOODS , BYRN RANDAL , ZHOU YI , LIN CHAO , JIANG MIN , GERMANN URSULA A , JONES STEVEN , SALITURO FRANCESCO G , KWONG ANN DAK-YEE
IPC: A61K31/506 , A61P31/16
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公开(公告)号：AU2018200219A1
公开(公告)日：2018-02-22
申请号：AU2018200219
申请日：2018-01-11
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL , CLARK MICHAEL P , BANDARAGE UPUL K , BETHIEL RANDY S , COURT JOHN J , DENG HONGBO , DRUTU IOANA , DUFFY JOHN P , FARMER LUC , GAO HUAI , GU WENXIN , JACOBS DYLAN H , KENNEDY JOSEPH M , LEDEBOER MARK W , LEDFORD BRIAN , MALTAIS FRANCOIS , PEROLA EMANUELE , WANG TIANSHENG , WANNAMAKER M WOODS , BYRN RANDAL , ZHOU YI , LIN CHAO , JIANG MIN , JONES STEVEN , GERMANN URSULA A , SALITURO FRANCESCO G , KWONG ANN DAK YEE
IPC: A61K31/506 , A61P31/16
Abstract: 2-(3H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-amine derivatives and their use in inhibiting influenza virus replication.
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公开(公告)号：HUE031048T2
公开(公告)日：2017-06-28
申请号：HUE10726760
申请日：2010-06-17
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL , CLARK MICHAEL P , BANDARAGE UPUL K , BETHIEL RANDY S , COURT JOHN J , DENG HONGBO , DRUTU IOANA , DUFFY JOHN P , FARMER LUC , GAO HUAI , GU WENXIN , JACOBS DYLAN H , KENNEDY JOSEPH M , LEDEBOER MARK W , LEDFORD BRIAN , MALTAIS FRANCOIS , PEROLA EMANUELE , WANG TIANSHENG , WANNAMAKER M WOODS , BYRN RANDAL , ZHOU YI , LIN CHAO , JIANG MIN , GERMANN URSULA A , JONES STEVEN , SALITURO FRANCESCO G , KWONG ANN DAK-YEE
IPC: A61P31/16
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公开(公告)号：PL2442809T3
公开(公告)日：2017-02-28
申请号：PL10726760
申请日：2010-06-17
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL , CLARK MICHAEL P , BANDARAGE UPUL K , BETHIEL RANDY S , COURT JOHN J , DENG HONGBO , DRUTU IOANA , DUFFY JOHN P , FARMER LUC , GAO HUAI , GU WENXIN , JACOBS DYLAN H , KENNEDY JOSEPH M , LEDEBOER MARK W , LEDFORD BRIAN , MALTAIS FRANCOIS , PEROLA EMANUELE , WANG TIANSHENG , WANNAMAKER M WOODS , BYRN RANDAL , ZHOU YI , LIN CHAO , JIANG MIN , GERMANN URSULA A , JONES STEVEN , SALITURO FRANCESCO G , KWONG ANN DAK-YEE
IPC: A61K31/506 , A61P31/16
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公开(公告)号：ME02558B
公开(公告)日：2017-02-20
申请号：MEP27216
申请日：2010-06-17
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL , CLARK MICHAEL P , BANDARAGE UPUL K , BETHIEL RANDY S , COURT JOHN J , DENG HONGBO , DRUTU IOANA , DUFFY JOHN P , FARMER LUC , GAO HUAI , GU WENXIN , JACOBS DYLAN H , KENNEDY JOSEPH M , LEDEBOER MARK W , LEDFORD BRIAN , MALTAIS FRANCOIS , PEROLA EMANUELE , WANG TIANSHENG , WANNAMAKER M WOODS , BYRN RANDAL , ZHOU YI , LIN CHAO , JIANG MIN , GERMANN URSULA A , JONES STEVEN , SALITURO FRANCESCO G , KWONG ANN DAK-YEE
IPC: A61K31/506 , A61P31/16
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