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    REFERENCE APPARATUS FOR CALIBRATION OF PRESSURE AND CALIBRATION USING THE SAME
    81.
    发明专利
    REFERENCE APPARATUS FOR CALIBRATION OF PRESSURE AND CALIBRATION USING THE SAME 失效

    公开(公告)号：JPH021525A

    公开(公告)日：1990-01-05

    申请号：JP28990388

    申请日：1988-11-15

    Applicant: ABBOTT LAB

    Inventor： ROBAATO UEIN BIAADO

    IPC: A61B5/0215 ,  A61B5/03 ,  A61M5/48 ,  G01L27/00

    Abstract: PURPOSE: To set the pressure in a tube at a desired level by connecting a pressure transducer with a digital indicator and indicating a fluid pressure generated in a syringe body. CONSTITUTION: When a calibrator 10 is used, a push button 32 is pushed to reset an indicator 30. A pressure transducer 56 provides an output voltage proportional to a pressure acting on the central part of a silicon membrane 74. A plunger 14 is then inserted deep into a syringe body 12 and a tube 22 is coupled with an injection port 20. When the plunger 14 is drawn out partially from the syringe body 12, a pressure lower than the atmospheric pressure prevails in an injection chamber 18. Since the low pressure is transmitted through the tube 22 and a reference pressure port 24 to a pressure monitor 26, it is simply required to displace the plunger 14 with respect to the syringe body 12 until a desired calibration pressure is indicated on the indicator 30. Finally, the calibration pressure is compared with a pressure indicated on the pressure monitor 26.

    ANTI HBC ANTIBODY IMMUNOASSAY
    82.
    发明专利
    ANTI HBC ANTIBODY IMMUNOASSAY 失效

    公开(公告)号：JPH01321365A

    公开(公告)日：1989-12-27

    申请号：JP11718289

    申请日：1989-05-10

    Applicant: ABBOTT LAB

    Inventor： RICHIYAADO EICHI DETSUKAA ,  JIYON EI UEA

    IPC: G01N33/53 ,  G01N33/543 ,  G01N33/576

    Abstract: PURPOSE: To avoid detection of false-positive reaction to anti-HBc based on several criteria by employing a reducing agent in the assay. CONSTITUTION: In the immunoassay, a reducing agent is fed additionally to the assay in order to detect an anti-HBc antibody in a biological sample. More specifically, a solid phase is coated with an HBc antigen and caused to react on a sample and then a labeled anti-HBc before the quantity of labeled anti-HBc bonded with the solid phase is detected. The reducing agent is added to the sample before the solid phase is added or it is added simultaneously with the sample and solid phase. When a reducing agent is employed in the assay of anti-HBc, false-positive sample is removed without having any effect on the control value or the presence of true positive sample thus ensuring positive reaction only on anti-HBc.

    SOLID PHASE ANALYZER
    83.
    发明专利
    SOLID PHASE ANALYZER 失效

    公开(公告)号：JPH01299464A

    公开(公告)日：1989-12-04

    申请号：JP7638289

    申请日：1989-03-27

    Applicant: ABBOTT LAB

    Inventor： UIRIAMU II BURAUN ZA SAADO ,  SARAA II SAFUOODO ,  JIYON EMU KUREMENZU

    IPC: G01N33/52 ,  G01N33/543 ,  G01N33/569 ,  G01N33/576 ,  G01N33/76

    Abstract: PURPOSE: To obtain accurate results with high sensitivity and reproducibility through simple operation by providing a reaction matrix with a specified positive/negative control region and an analyte bonding region. CONSTITUTION: The solid phase analyzer 10 comprises a reaction matrix 12 provided in a carrier 14, a barrier substance 18, a suction means 20, and a filter means 22. The matrix 12 is composed of micro solid particles fixed onto a fibrous substance having a diameter of 0.1-10 micron. The matrix 10 is provided with a negative control region 30, a positive control region 32, and an analyte bonding region 34. The region 30 does not contain any substance for holding an enzyme label or other sign responsive substance but the region 32 contains that substance and micro particles in the region 34 are applied with a substance to be bonded with the analyte, e.g. an antigen or an antibody. A sample liquid containing an antigen or antibody is applied to the matric 12 through the filter 22 and the response is detected by sandwich immunoassay under presence of an enzyme linked antibody.

    ASSAY OF THYROID HORMONE AND REAGENT SYSTEM USED THEREFOR
    85.
    发明专利
    ASSAY OF THYROID HORMONE AND REAGENT SYSTEM USED THEREFOR 失效

    公开(公告)号：JPH01153962A

    公开(公告)日：1989-06-16

    申请号：JP26699988

    申请日：1988-10-20

    Applicant: ABBOTT LAB

    Inventor： BIRII JIEI GURIIN ,  UIRIAMU AARU GUROSUKOTSUPU ,  ROBAATO KOWAARU ,  TOOMASU ARAN RAASON ,  POORU BII WAANKU JIYUNIA

    IPC: G01N33/74 ,  G01N33/53 ,  G01N33/78

    Abstract: PURPOSE: To directly measure thyroid gland hormone in serum or plasma by treating a sample by furosemide, substituting triopfpyjutpmomr (T3 ) and thyroxine (T4 ) from binding protein, and measuring the amount of substituted T3 and T4 . CONSTITUTION: A sample is treated by furosemide, T3 and T4 are substituted from a binding protein, and the amount of substituted T3 and T4 is measured. The amount of the substituted T3 and T4 can be measured by using either various kinds of thyroid gland hormone assay reagents and methods. Also, the amount of forosemide to be used can be calculated as a function of the size of a sample to substitute essentially all T3 and T4 . Also, either fluorescence, absorption, fluorescent polarization, chemical lunescence, or radioactive means can be used as a detection method.

    ELECTROLYTE MEASURING APPARATUS
    89.
    发明专利
    ELECTROLYTE MEASURING APPARATUS 失效

    公开(公告)号：JPS6488147A

    公开(公告)日：1989-04-03

    申请号：JP13662588

    申请日：1988-06-01

    Applicant: ABBOTT LAB

    Inventor： JIYON JII PANFURII ,  POORU II GIYARETSUTO ,  CHIYAARUZU ERU DEIBISU ,  ROORENSU SUPIRITSUTSUA ,  BENTON EI DAARII SAADO ,  EDOWAADO JII PANFURII ,  FUREDERITSUKU ERU KURAAKU

    IPC: G01N27/28 ,  G01D5/14 ,  G01N27/27 ,  G01N27/403 ,  G01N27/416 ,  G01N33/487

    Abstract: PURPOSE: To measure the concentration of an electrolyte by providing a detection means for generating an electrical signal by contacting a sample in a liquid, a means for converting the signal to a second signal corresponding to a generated signal, and an optical means for responding to the second signal. CONSTITUTION: Detection parts 12a-12c and conductive pins 14a-14d are provided at a substrate 11 of an ion selection electrode device 10 and a voltage corresponding to the concentration of an electrolyte is generated by contacting a liquid sample. The pin 14a drives an analog switch means 76 via a buffer 72 and gives the offset voltage of an electrode by an adjusting means 74. An operational amplifier consisting of the buffer 72 and an integrating means 82 amplifies the voltage, a pulse is generated via a pulse generation circuit 84, and an optical means 70 emits light by a driving means 85. The order for selecting pins is changed by the switch 76 using a sample rate counting means 78 and an LED 116 is driven via a synchronization circuit 105 to create an optical synchronization signal. With this configuration, a specific electrolyte concentration can be measured.

    IMMUNOCHROMATOGRAPH METHOD USING COLLOIDAL PARTICLE
    90.
    发明专利
    IMMUNOCHROMATOGRAPH METHOD USING COLLOIDAL PARTICLE 失效

    公开(公告)号：JPS6432169A

    公开(公告)日：1989-02-02

    申请号：JP17365088

    申请日：1988-07-12

    Applicant: ABBOTT LAB

    Inventor： SHIYANFUAN CHIN ,  PATORISHIA EI BIRINGU ,  JIYURIAN GOODON

    IPC: G01N30/88 ,  G01N30/90 ,  G01N33/532 ,  G01N33/543 ,  G01N33/558 ,  G01N33/58 ,  G01N33/76 ,  G01N37/00

    Abstract: PURPOSE: To establish a method by which a chromatographically mobile and visually detectable signals can be generated by passing a sample/indicator solution mixture containing a labeled first reagent and an object to be analyzed through a chromatographic substrate material. CONSTITUTION: A fixed amount of sample to be tested is mixed with an indicator solution composed of a first reagent labeled with colloidal particles under the presence of a chromatographic movement accelerator and the first terminal 14 of a testing device 10 is dipped in the mixture 17 contained in a container 16. The sample/indicator solution mixture containing the labeled first reagent and the object to be analyzed advances to a first zone 13 through a chromatographic substrate material 11. Then the reagent and object are competitively bonded to a second specific binding reagent immobilized to the first zone 13. However, the chromatographic solvent moves so that the object to be analyzed and the material of the first reagent labeled with colloidal particles which are not specifically bonded to the immobilized second reagent can be eliminated from the zone 13 and the movement is continued until the sample/ indicator solution mixture is exhausted.

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