公开(公告)号：WO0049387A3

公开(公告)日：2001-02-15

申请号：PCT/US0004069

申请日：2000-02-18

Applicant: IDEXX LAB INC ,  FERRANTE ANTHONY A ,  HANSEN W PETER

Inventor： FERRANTE ANTHONY A ,  HANSEN W PETER

IPC: G01N15/00 ,  G01N15/14

CPC classification number: G01N15/14 ,  G01N2015/008 ,  G01N2015/1447

Abstract: The high numerical aperture flow cytometer of the present invention includes a flow cell and a laser input. The laser input emits a beam of light that is oriented substantially orthoganilly to the flow of blood cells through the flow cell such that laser light impinges upon the blood cells as they pass through the flow cell. A portion of the beam from the laser input that impinges upon the blood cells in the flow cell is scattered at a substantially right angle to the beam of laser input ("right angle scatter"). A second portion of the beam from the laser input that impinges upon the cells in the flow cell is scattered at a much lower angle than 90 DEG . This scatter is termed "low angle forward scatter light" and has an angle of from about 2 DEG to about 5 DEG from the orientation of the original beam from laser input. A right angle scatter light detector is oriented to receive the previously mentioned right angle scatter light. A low angle forward scatter light detector is oriented to capture the previously mentioned low angled forward scatter light oriented at about 2 DEG to about 5 DEG beam from laser input.

Abstract translation: 本发明的高数值孔径流式细胞仪包括流动池和激光输入。 激光输入发射光束，该光束基本上与血细胞流动通过流动池流动正交，使得激光在穿过流动池时撞击血细胞。 来自激光输入的撞击流通池中的血细胞的光束的一部分以与激光束输入（“直角散射”）基本成直角的角度散射。 来自激光输入的撞击流通池中的电池的光束的第二部分以比90度更低的角度散射。 这种散射被称为“低角度前向散射光”，并且与来自激光输入的原始光束的取向具有约2°至约5°的角度。 直角散射光检测器被定向为接收前述直角散射光。 低角度前向散射光检测器被定向成捕获从激光输入到约2°至约5°光束的前述的低角度前向散射光。

公开(公告)号：WO9804920A3

公开(公告)日：1998-06-04

申请号：PCT/US9712737

申请日：1997-07-22

Applicant: IDEXX LAB INC

Inventor： KUMAR AMIT ,  JANG LARRY SHELDON ,  LEUNG DANTON KAI-YU ,  ROCCO RICHARD MICHELE ,  PLATSHON MARK CHARLES

IPC: G01N21/03 ,  G01N21/64 ,  G01N33/543 ,  G01N33/552 ,  G01N33/94 ,  G01N35/00 ,  B01L3/00 ,  B01L9/06 ,  G01N35/04

CPC classification number: G01N21/03 ,  G01N21/6428 ,  G01N33/54366 ,  G01N33/552 ,  G01N33/94 ,  G01N35/00 ,  G01N2021/0346 ,  G01N2021/6482

Abstract: A fluorescent immunoassay employing the interior surface of a capillary tube is provided. Devices to permit immunoassays using one or more capillary tubes, an apparatus for use with the devices, and a process for screening for analyte in a sample using the devices and apparatus are also provided. Samples suspected of containing analyte are added to a disposable self-contained sample tray containing one or more sample wells, mixed with a reagent, drawn into one or more spaced-apart capillary tubes held within a disposable cartridge connected to an analytical apparatus, reacted with a binding member on the surface of the capillary tube, washed to stop the reaction, and dried by the apparatus. The capillary tube is then exposed to a signal generation device to create a fluorescence signal that is detected using a signal detector. The apparatus determines the presence of the analyte and optionally determines the amount of analyte present in the sample, and presents the results to the operator.

公开(公告)号：WO9730156A3

公开(公告)日：1997-10-09

申请号：PCT/US9702322

申请日：1997-02-14

Applicant: IDEXX LAB INC

Inventor： MERMER BRION ,  HARRIS RACHEL A ,  SIEFRING ANN E

IPC: A61K38/00 ,  C07K16/00 ,  C12N15/13 ,  A61K39/395 ,  C07K1/21 ,  C07K1/42 ,  C07K16/85 ,  C12N5/10 ,  C12N15/11

CPC classification number: C07K16/00 ,  A61K38/00 ,  C07K2319/02

Abstract: Recombinant DNA molecules encoding complete canine IgE heavy chain constant region and the DNA sequence for all six exons of canine IgE are disclosed. The canine IgE heavy chain constant region DNA sequence was isolated using a nested walking procedure that is also disclosed. Also disclosed are peptides encoded by said sequences, including recombinant canine IgE heavy chain peptides produced by prokaryotic or eukaryotic cells. Such peptides are used in methods to treat the manifestation of allergy in dogs. Disclosed are antibodies that bind to peptides disclosed herein, as well as such antibodies for use to treat the manifestations of allergy in dogs.

公开(公告)号：WO9614432A3

公开(公告)日：1996-10-24

申请号：PCT/US9513887

申请日：1995-10-27

Applicant: IDEXX LAB INC

Inventor： EHRENFELD ELIZABETH ,  FRICKER COLIN ,  TOWNSEND DAVID E

IPC: C12Q1/20 ,  C12N1/20 ,  C12Q1/04 ,  C12Q1/10 ,  C12Q1/37 ,  C12Q1/54

CPC classification number: C12Q1/04 ,  C12Q1/045 ,  C12Q1/10 ,  C12Q1/37 ,  C12Q1/54 ,  G01N2333/245

Abstract: The invention features a medium for the detection of target microbes in particular coliform, in a liquified environmental or biological sample in less than 24 hours.

公开(公告)号：EP2970853A4

公开(公告)日：2016-04-20

申请号：EP14780060

申请日：2014-03-11

Applicant: IDEXX LAB INC

Inventor： MYLES MATTHEW H

IPC: C12M1/34 ,  C12M3/00 ,  C12Q1/10

CPC classification number: G01N33/56983 ,  G01N1/30 ,  G01N33/569 ,  G01N33/56911 ,  G01N33/5695 ,  G01N2469/10 ,  Y10S436/811

Abstract: Management of the health status of an animal colony using a plurality of blood collection cards and the analysis of dried blood from members of the colony that has been collected on the cards. Members of the colony may be removed from the colony as a result of the analysis.

公开(公告)号：EP2553452A4

公开(公告)日：2013-09-11

申请号：EP11763513

申请日：2011-04-01

Applicant: IDEXX LAB INC

Inventor： O'CONNOR THOMAS PATRICK ,  ANDERSEN PHILIP ,  GROAT RANDALL ,  KRAH EUGENE REGIS ,  SAUCIER JILL

IPC: G01N33/53 ,  C07K14/005 ,  C07K16/10 ,  G01N33/569 ,  G01N33/577 ,  G01N33/68

CPC classification number: G01N33/6854 ,  C07K14/005 ,  C07K16/1045 ,  C07K2317/34 ,  C12N2740/15011 ,  G01N33/56983 ,  G01N33/56988 ,  G01N33/577

公开(公告)号：EP2335070A4

公开(公告)日：2012-07-25

申请号：EP09819862

申请日：2009-10-08

Applicant: IDEXX LAB INC

Inventor： LIU JIAYOU ,  KRAH EUGENE REGIS ,  O'CONNOR JR THOMAS PATRICK ,  RIEGER DANIEL KARL

IPC: G01N33/53 ,  A61K38/00

CPC classification number: C07K14/29 ,  A61K38/00 ,  A61K39/0233 ,  A61K47/6835 ,  A61K2039/575 ,  A61K2039/6056 ,  G01N33/56911 ,  G01N2333/29 ,  G01N2469/10 ,  G01N2469/20

Abstract: The invention provides methods and compositions for the detection and treatment of Anaplasma phagocytophilum and Anaplasma platys infection.

公开(公告)号：EP2281196A4

公开(公告)日：2011-10-19

申请号：EP09751311

申请日：2009-05-18

Applicant: IDEXX LAB INC ,  DIVERGENCE INC

Inventor： ELSEMORE DAVID ALLEN ,  GENG JINMING ,  FLYNN LAURIE A ,  CRAWFORD MICHAEL

IPC: G01N33/53 ,  G01N33/569

CPC classification number: G01N33/56966 ,  G01N33/5308 ,  G01N33/6893 ,  G01N2333/43526 ,  G01N2333/4353 ,  G01N2469/10

Abstract: Methods, devices, kits and antibodies for detecting the presence or absence of one or more helminthic co-proantigens in a sample are disclosed herein. The methods, devices, kits and antibodies of the present invention may be used to confirm the presence or absence of roundworm, whipworm and/or hookworm in a fecal sample from a mammal and may also be able to distinguish between one or more helminth infections. Confirmation of the presence or absence of roundworm, whipworm and/or hookworm in the mammal may be made for example, for the pupose of selecting an optimal course of treatment of the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.

公开(公告)号：EP2170056A4

公开(公告)日：2010-11-10

申请号：EP08771733

申请日：2008-06-23

Applicant: IDEXX LAB INC

Inventor： MURTHY YERRAMILLI V S N ,  OBARE EDWARD

IPC: A01N43/04 ,  A61K31/20 ,  A61P31/04

CPC classification number: A61K31/7048

公开(公告)号：EP1825264A4

公开(公告)日：2009-05-13

申请号：EP05852751

申请日：2005-12-02

Applicant: IDEXX LAB INC

Inventor： HUTH STACEY PAZAR ,  STRONG-TOWNSEND MARILYN I

IPC: C12Q1/34 ,  C12M1/34

CPC classification number: C12Q1/34 ,  G01N2333/918 ,  G01N2800/067

Abstract: A method and device for determining pancreatic lipase in an animal blood sample. In one aspect, the device includes a compartmentalized container for storing and reacting the reagents for use in the assay. In another aspect, the device include a multilayer device having a spreading layer and reagents layers with dried reagents for detecting pancreatic lipase. The devices also includes a system for the optical determination of a color change in the reaction mixture. The method includes the use of the device to detect pancreatic lipase in samples.