公开(公告)号：CA2713342A1

公开(公告)日：2009-08-13

申请号：CA2713342

申请日：2009-01-29

Applicant: ABBOTT LAB

Inventor： ARGIRIADI MARIA A ,  BORHANI DAVID W ,  XIANG TAO ,  WU CHENGBIN ,  GHAYUR TARIQ

IPC: A61K39/395

Abstract: The invention provides methods of crystallizing antibodies and fragments thereof as well as crystals produced thereby. More particularly, the invention provides methods of crystallizing human and non-human Fab fragments of antibodies, either alone or as co-crystals with their target ligand. For example, a crystal comprising a murine Fab fragment of the antibody 125-2H or a human Fab fragment of the antibody ABT-325, which bind to IL-18, are provided as well as a co-crystal of a murine Fab fragment bound to IL-18. ABT-325 and 125-2H differ significantly in combining site character and architecture, thus explaining their ability to bind IL-18 simultaneously at distinct epitopes.

公开(公告)号：BRPI0416255A

公开(公告)日：2007-01-09

申请号：BRPI0416255

申请日：2004-11-12

Applicant: ABBOTT LAB

Inventor： GHAYUR TARIQ ,  LABKOVSKY BORIS ,  VOSS JEFFREY W ,  GREEN LARRY ,  BABCOOK JOHN ,  JIA XIAO-CHI ,  WIELER JAMES ,  KANG JASPAL SINGH ,  HEDBERG BRAD

IPC: C07K16/24 ,  G01N33/68 ,  C07K16/00 ,  C07H21/04 ,  C12N15/00 ,  A61K39/395 ,  G01N33/53

Abstract: The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hIL-18 and/or that neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.

公开(公告)号：NO20026239L

公开(公告)日：2003-02-27

申请号：NO20026239

申请日：2002-12-27

Applicant: ABBOTT LAB

Inventor： COLLINSON ALBERT ,  GHAYUR TARIQ ,  AVGERINOS GEORGE ,  DIXON RICHARD WOODWARD ,  KAYMAKCALAN ZEHRA

IPC: G01N33/50 ,  A61K39/395 ,  A61K47/48 ,  A61K49/00 ,  A61P1/04 ,  A61P17/06 ,  A61P25/00 ,  A61P29/00 ,  A61P37/06 ,  C07K16/24 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/13 ,  C12P21/08 ,  G01N33/15 ,  G01N33/53 ,  G01N33/68

Abstract: Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-1 alpha and IL-1 beta and neutralize IL-1 alpha and IL-1 beta activity in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using these antibodies are also provided. These antibodies, or antibody portions, are useful for detecting two different but structurally related antigens (e.g., IL-1 alpha and IL-1 beta) and for inhibiting the activity of the antigens, (e.g., in a human subject suffering from a disorder in which IL-1 alpha and/or IL-1 beta activity is detrimental.

公开(公告)号：CY1112893T1

公开(公告)日：2016-04-13

申请号：CY121100602

申请日：2012-07-05

Applicant: ABBOTT LAB

Inventor： GHAYUR TARIQ ,  LABKOVSKY BORIS ,  VOSS JEFFREY W ,  GREEN LARRY ,  BABCOOK JOHN ,  JIA XIAO-CHI ,  WIELER JAMES ,  KANG JASPAL SINGH ,  HEDBERG BRAD

IPC: C07K16/24 ,  A61K39/395 ,  A61P19/02 ,  A61P25/28 ,  A61P37/06 ,  G01N33/68

Abstract: Ηπαρούσαεφεύρεσηπεριλαμβάνει IL-18-δεσμευόμενεςπρωτεΐνες, ιδίωςαντισώματαπουδεσμεύονταιμεανθρώπινηιντερλευκίνη-18 (hIL-18). Συγκεκριμένα, ηεφεύρεσησχετίζεταιμεαντισώματαπουείναιεξολοκλήρουανθρώπινααντισώματα. Ταπροτιμητέααντισώματαέχουνυψηλήσυγγένειαγια hlL-18 και/ήεξουδετερώνουνδραστικότητα hIL-18 in vitro και in vivo. Αντίσωματηςεφεύρεσηςμπορείναείναιαντίσωμαπλήρουςμήκουςή τμήμααυτούπουδεσμεύεταιμεαντιγόνο. Παρέχεταιεπίσηςμέθοδοςπαρασκευήςκαιμέθοδοςχρήσηςτωναντισωμάτωντηςεφεύρεσης. Τααντισώματα, ήτμήματααντισωμάτων, τηςεφεύρεσηςείναιχρήσιμαγιαανίχνευση hIL-18 καιγιααναστολήδραστικότητας hIL-18, π.χ. σεάνθρωποπουυποφέρειαπόδιαταραχήστηνοποίαη δραστικότητα hIL-18 είναιεπιβλαβής.

公开(公告)号：BRPI0922807A2

公开(公告)日：2015-12-22

申请号：BRPI0922807

申请日：2009-12-04

Applicant: ABBOTT LAB

Inventor： WU CHENGBIN ,  JAKOB CLARISSA G ,  WALTER KARL A ,  GHAYUR TARIQ

IPC: C07K16/46 ,  A61K39/00

公开(公告)号：BR112012002095A2

公开(公告)日：2015-09-01

申请号：BR112012002095

申请日：2010-07-29

Applicant: ABBOTT LAB

Inventor： GHAYUR TARIQ ,  LIU JUNJIAN ,  IBRAGHIMOV ALEXANDER

IPC: C12P21/08

公开(公告)号：CA2618482C

公开(公告)日：2014-10-07

申请号：CA2618482

申请日：2006-08-18

Applicant: ABBOTT LAB

Inventor： WU CHENGBIN ,  GHAYUR TARIQ ,  DIXON RICHARD W ,  SALFELD JOCHEN G

IPC: C07K16/46 ,  A61K39/395 ,  A61K47/48 ,  A61K49/00 ,  A61K51/10 ,  C12N15/13

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.

公开(公告)号：SG192489A1

公开(公告)日：2013-08-30

申请号：SG2013052725

申请日：2009-07-08

Applicant: ABBOTT LAB

Inventor： GHAYUR TARIQ ,  GU JIJIE ,  ISAKSON PETER C

Abstract: PROSTAGLANDIN E2 DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOFAbstractThe present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.Figure 1

公开(公告)号：SG191625A1

公开(公告)日：2013-07-31

申请号：SG2013041603

申请日：2009-06-03

Applicant: ABBOTT LAB

Inventor： GHAYUR TARIQ ,  HAHN ALFRED ,  MUELLER BERNHARD

Abstract: DUAL VARIABLE DOMAIN I MUNOGLOBULINS AND USES THEREOF Abstract 5 The present invention relates to engineered multivalent and multispecific bindingproteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.Figure I

公开(公告)号：MX2013004979A

公开(公告)日：2013-07-30

申请号：MX2013004979

申请日：2011-11-01

Applicant: ABBOTT LAB

Inventor： GHAYUR TARIQ ,  LIU JUNJIAN ,  GU JIJIE ,  HARRIS MARIA C

IPC: C12P21/08 ,  A61K39/395 ,  C07K16/00

Abstract: Se proporcionan proteínas de unión multivalentes y multiespecíficas diseñadas por ingeniería, métodos para elaborarlas y sus usos en la prevención, el diagnóstico y/o el tratamiento de enfermedades.