公开(公告)号：AU7729696A

公开(公告)日：1997-06-05

申请号：AU7729696

申请日：1996-11-13

Applicant: ABBOTT LAB

Inventor： FESIK STEPHEN W ,  SUMMERS JAMES B JR ,  DAVIDSEN STEVEN K ,  SHEPPARD GEORGE S ,  STEINMAN DOUGLAS H ,  CARRERA GEORGE M JR ,  FLORJANCIC ALAN ,  HOLMS JAMES H

IPC: A61P19/02 ,  A61K31/185 ,  A61K31/275 ,  A61P29/00 ,  A61P35/04 ,  A61P43/00 ,  C07C259/06 ,  C07C323/60 ,  A61K31/16

Abstract: Compounds of formula or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNF alpha secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinases and TNF alpha secretion inhibiting compositions and a method for inhibiting matrix metalloproteinases and TNF alpha secretion.

公开(公告)号：AU652433B2

公开(公告)日：1994-08-25

申请号：AU1434292

申请日：1992-02-14

Applicant: ABBOTT LAB

Inventor： SUMMERS JAMES B ,  SHEPPARD GEORGE S ,  PHILLIPS JAMES G ,  PIREH DAISY ,  STEINMAN DOUGLAS H ,  MAY PAUL D ,  GUINN DENISE E ,  HEYMAN H ROBIN ,  CARRERA GEORGE M JR ,  DAVIDSEN STEVEN K

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/4433 ,  A61P7/02 ,  A61P11/00 ,  A61P29/00 ,  C07D401/14 ,  C07D403/14 ,  C07D409/14 ,  C07D417/14

Abstract: Indole compounds substituted at the 1- or 3-position by a (pyrid-3-yl)thiazolid-4-yl)alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- or (pyrid-3-yl)dithiolan-4-oyl)- group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including septic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.

公开(公告)号：PT100314A

公开(公告)日：1993-06-30

申请号：PT10031492

申请日：1992-03-27

Applicant: ABBOTT LAB

Inventor： SUMMERS JAMES B ,  MAY PAUL D ,  GUINN DENISE E ,  STEINMAN DOUGLAS H ,  DAVIDSEN STEVEN K

IPC: C07D401/04 ,  C07D409/04 ,  C07D417/04 ,  C07D409/00 ,  A61K31/385 ,  A61K31/44

Abstract: Benzoylphenyl derivatives of 2-(3-pyridinyl)-3-alkyl-4-thiazolidinecarboxamide, 2-(3-pyridinyl)-thiazolid-4-ylacetamide, 2-(3-pyridinyl)-4-dithiolanecarboxamide or 2-(3-pyridinyl)dithiolan-4-yl] urea are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including anaphylactic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.