公开(公告)号：ZA8104688B

公开(公告)日：1982-08-25

申请号：ZA8104688

申请日：1981-07-10

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  LENKE DIETER ,  GRIES JOSEF ,  WEIFENBACH HARALD ,  HOFMANN HANS PETER ,  KREISKOTT HORST

IPC: C07D295/08 ,  A61K31/495 ,  A61P9/12 ,  A61P25/20 ,  C07C45/70 ,  C07D295/092 ,  C07D303/22 ,  A61K ,  C07C

CPC classification number: C07D295/088 ,  C07C45/70 ,  C07D303/22 ,  C07C49/755

公开(公告)号：DD156262A5

公开(公告)日：1982-08-11

申请号：DD22758981

申请日：1981-02-12

Applicant: BASF AG

Inventor： THIEME PETER C ,  FRANKE ALBRECHT ,  LENKE DIETER ,  LEHMANN HANS D ,  GRIES JOSEF

IPC: C07D413/12 ,  A61K31/495 ,  A61K31/496 ,  A61P9/12 ,  C07D271/10 ,  C07D405/12

Abstract: Novel phenylpiperazinylpropanols of 1,3,4-oxadiazolylphenols and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and are useful in the treatment of hypertonia.

公开(公告)号：CA1128050A

公开(公告)日：1982-07-20

申请号：CA325385

申请日：1979-04-11

Applicant: BASF AG

Inventor： THIEME PETER C ,  FRICKEL FRITZ-FRIEDER ,  HAGEN HELMUT ,  FRANKE ALBRECHT ,  LENKE DIETER ,  GRIES JOSEF

IPC: A61K31/41 ,  A61K31/433 ,  A61P9/00 ,  A61P9/06 ,  A61P9/12 ,  C07D285/12 ,  C07D417/12

Abstract: ;; The present invention relates to novel alkylaminopropanol derivatives of 2-methyl-5-(2-hydroxystyryl)-1,3,4-thia-diazole corresponding to the general formula (I) (I) where R is hydrogen, alkyl of 1 to 8 carbon atoms, which is unsubstituted or substituted by hydroxyl, alkoxy of 1 to 3 carbon atoms or cycloalkyl with 3 to 8 carbon atoms in the ring, alkenyl or alkynyl of 2 to 8 carbon atoms, or cycloalkyl or cycloalkenyl with 3 to 8 carbon atoms in the ring, the cycloalkyl rings being unsubstituted or mono- or di-substituted by alkyl of 1 to 3 carbon atoms, and their addition salts with physiologically acceptable acids. The invention is also directed to their process of preparation. These compounds thus obtained may be used for the treatment of coronary diseases of the heart, of hypertonia and of cardiac arrhythmias.

公开(公告)号：HU177287B

公开(公告)日：1981-09-28

申请号：HUBA003641

申请日：1978-03-16

Applicant: BASF AG

Inventor： VON PHILIPSBORN GERDA ,  BOELL WALTER ,  LENKE DIETER

IPC: A61C8/00 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4415 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/455 ,  A61K31/495 ,  A61K31/496 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  C07D213/127 ,  C07D213/65 ,  C07D213/66 ,  C07D213/67 ,  C07D213/79 ,  C07D213/80 ,  C07D221/04 ,  C07D263/32 ,  C07D401/12 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D491/056 ,  C07D213/62 ,  C07D413/12

Abstract: New pyridinyl aminoalkyl ethers, their N-oxides and their physiologically acceptable addition salts with acids, processes for their preparation and pharmaceutical formulations which contain these compounds and are useful in the treatment of cardiac arrhythmias.

公开(公告)号：NO810761A

公开(公告)日：1981-09-09

申请号：NO810761

申请日：1981-03-05

Applicant: BASF AG

Inventor： STEINER GERD ,  HOFMAN HANS PETER ,  KREISKOTT HORST ,  TESCHENDORF HANS-JUERGEN ,  LENKE DIETER

IPC: C07D295/14 ,  A61K31/275 ,  A61K31/395 ,  A61P25/20 ,  C07C67/00 ,  C07C253/00 ,  C07C255/37 ,  C07C255/42 ,  C07D243/08 ,  C07D295/08 ,  C07D295/155 ,  C07D

CPC classification number: C07D295/155 ,  C07D243/08

公开(公告)号：NO803176L

公开(公告)日：1981-04-27

申请号：NO803176

申请日：1980-10-24

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER ,  THIEME PETER C ,  FRANKE ALBRECHT ,  THEOBALD HANS ,  LENKE DIETER ,  GRIES JOSEF

IPC: A61K31/42 ,  A61P9/00 ,  A61P9/12 ,  A61P25/02 ,  C07C43/12 ,  C07C45/61 ,  C07C45/64 ,  C07C45/70 ,  C07D261/08 ,  C07F9/653 ,  C07D

Abstract: Novel aminopropanol derivatives of 5-(2-hydroxystyryl)-isoxazole and their addition salts with acids, their preparation, pharmaceutical formulations containing these compounds, and their use in the treatment of hypertonia, coronary heart disease and cardiac arrhythmias.

公开(公告)号：NO803047A

公开(公告)日：1981-04-14

申请号：NO803047

申请日：1980-10-10

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER ,  FRANKE ALBRECHT ,  PHILIPSBORN GERDA VON ,  MUELLER CLAUS D ,  LENKE DIETER

IPC: A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/454 ,  A61K31/47 ,  A61P9/00 ,  A61P9/06 ,  C07C271/22 ,  C07D207/34 ,  C07D207/36 ,  C07D209/42 ,  C07D401/12 ,  C07D401/14 ,  C07D

CPC classification number: C07D209/42 ,  C07C271/22 ,  C07D207/36 ,  Y10S514/821

公开(公告)号：NO802862L

公开(公告)日：1981-03-30

申请号：NO802862

申请日：1980-09-26

Applicant: BASF AG

Inventor： WIERSDORFF WALTER-WIELANT ,  GEISS KARL-HEINZ ,  WEIFENBACH HARALD ,  WORSTMANN WOLFGANG ,  LENKE DIETER ,  KRETZSCHMAR ROLF

IPC: A61K31/27 ,  A61K31/325 ,  A61K31/34 ,  A61K31/341 ,  A61K31/357 ,  A61K31/38 ,  A61K31/381 ,  A61P25/20 ,  C07C45/62 ,  C07C45/69 ,  C07C45/75 ,  C07C45/79 ,  C07C45/81 ,  C07C49/21 ,  C07C49/337 ,  C07C49/345 ,  C07C49/543 ,  C07C49/553 ,  C07C49/573 ,  C07C67/00 ,  C07C68/02 ,  C07C68/06 ,  C07C69/96 ,  C07C239/00 ,  C07C271/06 ,  C07C271/08 ,  C07C313/00 ,  C07C319/20 ,  C07C323/43 ,  C07D307/14 ,  C07D307/22 ,  C07D307/52 ,  C07D309/04 ,  C07D309/14 ,  C07D317/28 ,  C07D319/06 ,  C07D333/20 ,  C07C

Abstract: Novel carbamates derived from substituted cyclic beta -keto-alcohols, their preparation, and pharmaceutical formulations which contain these compounds and which may be used as hypnotics in the treatment of sleep disturbance and as sedatives.

公开(公告)号：CS202011B2

公开(公告)日：1980-12-31

申请号：CS168078

申请日：1978-03-16

Applicant: BASF AG

Inventor： VON PHILIPSBORN GERDA ,  BOELL WALTER ,  LENKE DIETER

IPC: A61C8/00 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4415 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/455 ,  A61K31/495 ,  A61K31/496 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  C07D213/127 ,  C07D213/65 ,  C07D213/66 ,  C07D213/67 ,  C07D213/79 ,  C07D213/80 ,  C07D221/04 ,  C07D263/32 ,  C07D401/12 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D491/056 ,  C07D213/04

Abstract: New pyridinyl aminoalkyl ethers, their N-oxides and their physiologically acceptable addition salts with acids, processes for their preparation and pharmaceutical formulations which contain these compounds and are useful in the treatment of cardiac arrhythmias.

公开(公告)号：HU175881B

公开(公告)日：1980-11-28

申请号：HUBA003627

申请日：1978-02-03

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER ,  HAGEN HELMUT ,  OHNSORGE ULRICH ,  FRANKE ALBRECHT ,  LENKE DIETER ,  GRIES JOSEF ,  LEHMANN HANS D

IPC: A61K31/428 ,  C07D275/04 ,  C07D417/12

Abstract: New aminopropanol derivatives of 4-hydroxy-1,2-benzisothiazole and their addition salts with acids, their preparation, and pharmaceutical formulations which contain the said compounds and may be used for the treatment and prophylaxis of cardiac and circulatory disorders.