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    ИНГИБИТОРЫ ТИРОЗИНКИНАЗЫ БРУТОНА
    81.
    发明专利
    ИНГИБИТОРЫ ТИРОЗИНКИНАЗЫ БРУТОНА 未知

    公开(公告)号：EA018573B1

    公开(公告)日：2013-09-30

    申请号：EA200900351

    申请日：2006-12-28

    Applicant: PHARMACYCLICS INC

    Inventor： HONIGBERG LEE ,  VERNER ERIK ,  PAN ZHENGYING

    IPC: A01N43/90 ,  A61K31/519

    Abstract: Визобретенииприведеныописаниясоединений, образующихковалентныесвязис тирозинкиназойБрутона (Btk). Крометого, описанынеобратимыеингибиторы Btk, атакжеспособыполучениятакихсоединений. Такжеописаныфармацевтическиекомпозиции, содержащиетакиесоединения, атакжеспособыпримененияингибиторов Btk отдельноилив комбинациис другимитерапевтическимиагентамидлялеченияаутоиммунныхзаболеванийилисостояний, гетероиммунныхзаболеванийилисостояний, рака, включаялимфому, ивоспалительныхзаболеванийилисостояний.

    Inhibitors of Bruton's tyrosine kinase
    83.
    发明专利
    Inhibitors of Bruton's tyrosine kinase 未知

    公开(公告)号：AU2012205166A8

    公开(公告)日：2013-06-27

    申请号：AU2012205166

    申请日：2012-07-16

    Applicant: PHARMACYCLICS INC

    Inventor： VERNER ERIK ,  PAN ZHENGYING ,  HONIGBERG LEE

    IPC: C07D471/04 ,  A01N43/90 ,  A61K31/519 ,  A61K31/52 ,  A61P29/00 ,  A61P35/00 ,  A61P35/02

    Abstract: INHIBITORS OF BRUTON'S TYROSINE KINASE Abstract Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions. (64408731 ):KZA

    Pyrimidinopyrazole derivatives as inhibitors of Bruton's tyrosine kinase
    84.
    发明专利
    Pyrimidinopyrazole derivatives as inhibitors of Bruton's tyrosine kinase 未知

    公开(公告)号：NZ595230A

    公开(公告)日：2013-02-22

    申请号：NZ59523006

    申请日：2006-12-28

    Applicant: PHARMACYCLICS INC

    Inventor： HONIGBERG LEE ,  VERNER ERIK ,  PAN ZHENGYING

    IPC: A01N43/90 ,  A61K31/519

    Abstract: Disclosed are pyrazolo-pyrimidin derivatives of formula (D) that form covalent bonds with Bruton's tyrosine kinase (Btk), which is a member of the Tec family of non-receptor tyrosrne kinaces, and is a key signaling enzyme expressed in all hematopoietic cell types except T lymphocytes and natural killer cells, wherein the variables shown in the structure of formula (D) are as defined in the specification. Also described are irreversible inhibitors of Btk; methods for the preparation of these compounds; and pharmaceutical compositions that include the compounds. These Btk inhibitors are suitable for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

    INHIBITORS OF BRUTON'S TYROSINE KINASE BRUTON
    88.
    发明专利
    INHIBITORS OF BRUTON'S TYROSINE KINASE BRUTON 未知

    公开(公告)号：HK1140107A1

    公开(公告)日：2010-10-08

    申请号：HK10106827

    申请日：2009-09-14

    Applicant: PHARMACYCLICS INC

    Inventor： HONIGBERG LEE ,  VERNER ERIK ,  PAN ZHENGYING

    IPC: A01N20060101 ,  A61K20060101 ,  A61P20060101 ,  C07D20060101

    Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

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