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Patent Agency Ranking
公开(公告)号：KR1020140033905A
公开(公告)日：2014-03-19
申请号：KR1020120100420
申请日：2012-09-11
Applicant: 강원대학교산학협력단 , 주식회사 엔자임바이오
Abstract: The present invention relates to a composition comprising an Oenanthe javanica extract for preventing or alleviating a brain ischemia disease and, more specifically, to a composition comprising an Oenanthe javanica extract for preventing or alleviating a brain ischemia disease which is expected to be variously used for treatment, prevention, or alleviation of diseases caused by brain ischemia since the Oenanthe javanica has excellent neuroprotective ability for hippocampal brain and neuronal death inhibitory ability, is confirmed that inhibitory ability of glial activation is superior, effectively prevents a nerve damage of hippocampal CA1 region of the brain that is known as to be sensitive for the ischemia, and is harmless to the human body.
Abstract translation: 本发明涉及一种组合物，其包含用于预防或减轻脑缺血疾病的美洲爪哇ica提取物，更具体地，涉及一种包含用于预防或减轻预期用于治疗的脑缺血疾病的美洲爪蟾提取物的组合物 预防或缓解脑缺血引起的疾病，因为爪哇ica对海马脑神经保护能力和神经元死亡抑制能力均有优异的表现，证实了胶质细胞活化的抑制能力优越，有效防止了海马CA1区神经损伤 被认为对缺血敏感的大脑，对人体无害。
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公开(公告)号：KR1020140136846A
公开(公告)日：2014-12-01
申请号：KR1020130057432
申请日：2013-05-21
Applicant: 강원대학교산학협력단
IPC: A61K36/185 , A61P25/28 , A61P25/00
Abstract: 본 발명은 비타민나무 추출물을 유효성분으로 포함하는 퇴행성 뇌질환 개선, 치료 또는 예방용 조성물에 관한 것으로, 본 발명의 조성물에 의하는 경우 내인성 신경줄기세포의 증식 및 분화를 현저하게 증가시킴으로써, 신경세포의 재생을 효과적으로 유도할 수 있으므로, 노화 또는 뇌의 여러 병리적 상황에 의한 신경세포의 손상으로 인한 퇴행성 질환을 치료, 개선 또는 예방할 수 있고, 상기 신경세포의 손상으로 인한 기억력이나 인지능력 저하 등과 같은 기능 저하를 개선 또는 예방할 수 있을 뿐만 아니라, 안정성이 인정되어 부작용 발생 가능성이 낮은 천연물을 이용하는 것이므로, 퇴행성 뇌질환의 치료, 개선 또는 예방을 위해 유용하게 이용될 수 있다.
Abstract translation: 本发明涉及包含沙棘沙门氏菌提取物作为缓解，治疗或预防退行性脑病的活性成分的组合物。 本发明的组合物显着增加内源性神经干细胞的增殖和分化，从而有效地诱导神经元的再生。 因此，该组合物可以治疗，缓解或预防由老化或脑的各种病理状况引起的神经元的损伤引起的退行性疾病，并且可以缓解或预防由于脑的损伤引起的记忆恶化或认知能力等的故障 神经元的损伤。 此外，组合物使用具有稳定性和很小副作用的可能性的天然物质，因此可用于治疗，缓解或预防退行性脑病。
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公开(公告)号：KR1020140077483A
公开(公告)日：2014-06-24
申请号：KR1020120146340
申请日：2012-12-14
Applicant: 강원대학교산학협력단
IPC: A61K36/234 , A61P9/10 , A61P9/00
Abstract: The present invention relates to a composition for prevention or alleviation of ischemic cerebrovascular diseases comprising a Glehnia littoralis extract as an active ingredient. The composition comprising the Glehnia littoralis extract as an active ingredient can effectively inhibit apoptosis of nerve cells in brain tissue and also inhibit abnormal activation of neuroglial cells, and thus can be variously applied for prevention, alleviation, or treatment of cerebrovascular diseases.
Abstract translation: 本发明涉及一种用于预防或缓解缺血性脑血管疾病的组合物，其包含小叶提取物作为活性成分。 作为活性成分的洛氏提取物的组合物能够有效地抑制脑组织中的神经细胞的凋亡，并且能够抑制神经胶质细胞的异常活化，可以各种应用于预防，缓解或治疗脑血管疾病。
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公开(公告)号：KR1020140136843A
公开(公告)日：2014-12-01
申请号：KR1020130057429
申请日：2013-05-21
Applicant: 강원대학교산학협력단
Abstract: The present invention relates to a composition for improving, treating or preventing neurodegenerative disease containing an oenanthe javanica extract as an active ingredient wherein the composition of the present invention increases the proliferation and differentiation of endogenous neural stem cells, which efficiently induces the regeneration of neuron cells and accordingly treats, improves or prevents neurodegenerative disease caused by neuron cells damaged by aging or brain diseases and functional problems like memory loss and cognitive dysfunction. In the present invention, the composition uses natural substances whose safety is recognized and which have little possibility of generating side effects, so the composition can be widely used for treating, improving or preventing neurodegenerative disease.
Abstract translation: 本发明涉及一种用于改善，治疗或预防神经变性疾病的组合物，其含有爪哇爪提取物作为活性成分，其中本发明的组合物增加内源性神经干细胞的增殖和分化，其有效诱导神经元细胞的再生 因此治疗，改善或预防由衰老或脑部疾病以及如记忆丧失和认知功能障碍等功能性问题引起的神经元细胞引起的神经变性疾病。 在本发明中，组合物使用其安全性被认可并且几乎不产生副作用的天然物质，因此该组合物可广泛用于治疗，改善或预防神经变性疾病。
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公开(公告)号：KR1020140106817A
公开(公告)日：2014-09-04
申请号：KR1020130020897
申请日：2013-02-27
Applicant: 강원대학교산학협력단
Abstract: The present invention relates to a composition for alleviating, treating, or preventing degenerative brain disease containing vanillin as an active ingredient. The composition of the present invention significantly increases proliferation and differentiation of endogenous neural stem cells, significantly enhances inhibition of proliferation and differentiation of endogenous neural stem cells, and induces regeneration of neural stem cells. Thus, the present invention alleviates or treats decrease phenomenon of regeneration of neural stem cells caused by memory impairment disease and aging, and may be used as a composition for alleviating or treating degenerative brain disease without side effects by achieving stability.
Abstract translation: 本发明涉及用于缓解，治疗或预防含有香草醛作为活性成分的退行性脑病的组合物。 本发明的组合物显着增加内源性神经干细胞的增殖和分化，显着增强内源性神经干细胞的增殖和分化的抑制，并诱导神经干细胞的再生。 因此，本发明缓解或治疗由记忆障碍疾病和衰老引起的神经干细胞再生的减少现象，并且可以通过实现稳定性而用作缓解或治疗退行性脑疾病而没有副作用的组合物。
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