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公开(公告)号：KR1020070023827A
公开(公告)日：2007-03-02
申请号：KR1020050077365
申请日：2005-08-23
Applicant: 삼성전자주식회사
CPC classification number: G01N33/5079 , C12Q1/005 , G01N27/00
Abstract: A method and an apparatus for analyzing toxicity are provided to very easily and electrically measure the toxicity and the degree of harmfulness using the proton amount emitted from mitochondria, and to be easily applied to a lab-on-a-chip. The method for analyzing toxicity using mitochondria comprises a step of contacting a toxic sample to be subject to analysis with mitochondria so ad to electrically measure the proton amount emitted by the mitochondria. The apparatus for analyzing the toxicity comprises a measuring portion which electrically measures the proton amount emitted by the mitochondria, a proton diffusible layer placed at the measuring portion, and a plurality of mitochondria attached to the proton diffusible layer.
Abstract translation: 提供了一种用于分析毒性的方法和装置，以非常容易且电动地测量使用从线粒体发射的质子量的毒性和危害程度，并且易于应用于片上实验室。 使用线粒体分析毒性的方法包括将待分析的有毒样品与线粒体接触的步骤，以电测量线粒体发射的质子量。 用于分析毒性的装置包括电测量由线粒体发射的质子量的测量部分，放置在测量部分处的质子扩散层和连接到质子扩散层的多个线粒体。
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2.发明公开단일염기 다형을 포함하는 2형 당뇨병과 관련된폴리뉴클레오티드, 그를 포함하는 마이크로어레이 및 진단키트 및 그를 이용한 폴리뉴클레오티드 분석방법 有权与包含单核多聚核苷酸的微型糖尿病和诊断试剂盒的II型糖尿病相关的多核苷酸和使用其分析多核苷酸的方法
公开(公告)号：KR1020050065386A
公开(公告)日：2005-06-29
申请号：KR1020040111102
申请日：2004-12-23
Applicant: 삼성전자주식회사
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , C12Q1/6837
Abstract: 본 발명은 서열번호 1 내지 80으로 구성된 군으로부터 유래한 10 개 이상의 연속 뉴클레오티드를 포함하는 폴리뉴클레오티드로서, 101 번째 염기를 포함하는 2형 당뇨병 진단 또는 치료용 폴리뉴클레오티드 또는 그의 상보적 폴리뉴클레오티드를 제공한다.
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Patent Agency Ranking
公开(公告)号：KR101138866B1
公开(公告)日：2012-05-14
申请号：KR1020050047195
申请日：2005-06-02
Applicant: 삼성전자주식회사
Abstract: Genetic polymorphisms associated with myocardial infarction and uses thereof are provided to identify the single polymorphism(SNP) capable of diagnosing or anticipating the presence or a risk of myocardial infarction at an early stage. A polynucleotide comprising more than 8 continuous nucleotides containing each SNP site base(101st base) in the nucleotide sequence selected from SEQ ID NO:1 to SEQ ID NO:60 or its complementary polynucleotide is provided, wherein the polynucleotide for diagnosis of myocardial infarction of males and nonsmokers comprises nucleotide sequences of SEQ ID NO:57 to SEQ ID NO:60; the polynucleotide is an allele specific probe. A polypeptide encoded by the polynucleotide is provided. An antibody specifically binding to the polypeptide is provided, wherein the antibody is monoclonal antibody. A microarray or kit for detecting the single polymorphism(SNP) contains the polynucleotide, polypeptide encoded thereby or its cDNA. A method for identifying a subject having a changed risk of myocardial infarction comprises the steps of: (a) isolating the nucleic acid sample from the subject; and (b) determining the allele genotype of a polymorphism site which is each 101th base of at least one polynucleotide selected from SEQ ID NO:1 to SEQ ID NO:60.
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4.发明授权심혈관 질환 진단용 다중 ＳＮＰ, 그를 포함하는마이크로어레이 및 키트 및 그를 이용한 심혈관 질환 진단방법 有权用于诊断心血管疾病的多重SNP，包含该心血管疾病的微阵列和试剂盒以及使用该SNP诊断心血管疾病的方法
公开(公告)号：KR100754398B1
公开(公告)日：2007-08-31
申请号：KR1020060018449
申请日：2006-02-24
Applicant: 삼성전자주식회사
IPC: C12Q1/68
Abstract: 본 발명은 서열번호 1 내지 35로 구성된 폴리뉴클레오티드들에 있어서 각 SNP 위치(서열번호 4의 경우 76번째, 서열번호 8의 경우 85번째, 서열번호 9의 경우 51번째, 서열번호 10의 경우 35번째, 서열번호 19의 경우 85번째 및 나머지 서열번호의 경우 101번째) 염기를 포함하는 10개 이상의 연속 염기로 구성되는 폴리뉴클레오티드들로부터 선택되는 하나 이상의 폴리뉴클레오티드 또는 그의 상보적 폴리뉴클레오티드를 포함하는 심혈관 질환 진단용 다중 SNP를 제공한다. 또한, 본 발명은 상기 폴리뉴클레오티드를 포함하는 마이크로어레이 및 키트 및 상기 폴리뉴클레오티드를 이용한 심혈관 질환 진단 방법을 제공한다. 본 발명에 의하면, 심혈관 질환의 발병 또는 발병 가능성을 조기에 효과적으로 진단할 수 있다.
SNP(single nucleotide polymorphism), 심혈관 질환, 심근경색증, 폴리뉴클레오티드, 다중 SNP-
公开(公告)号：KR1020060125252A
公开(公告)日：2006-12-06
申请号：KR1020050047195
申请日：2005-06-02
Applicant: 삼성전자주식회사
CPC classification number: C12Q1/6883 , C12Q1/6827 , C12Q1/6837 , C12Q1/6858
Abstract: Genetic polymorphisms associated with myocardial infarction and uses thereof are provided to identify the single polymorphism(SNP) capable of diagnosing or anticipating the presence or a risk of myocardial infarction at an early stage. A polynucleotide comprising more than 8 continuous nucleotides containing each SNP site base(101st base) in the nucleotide sequence selected from SEQ ID NO:1 to SEQ ID NO:60 or its complementary polynucleotide is provided, wherein the polynucleotide for diagnosis of myocardial infarction of males and nonsmokers comprises nucleotide sequences of SEQ ID NO:57 to SEQ ID NO:60; the polynucleotide is an allele specific probe. A polypeptide encoded by the polynucleotide is provided. An antibody specifically binding to the polypeptide is provided, wherein the antibody is monoclonal antibody. A microarray or kit for detecting the single polymorphism(SNP) contains the polynucleotide, polypeptide encoded thereby or its cDNA. A method for identifying a subject having a changed risk of myocardial infarction comprises the steps of: (a) isolating the nucleic acid sample from the subject; and (b) determining the allele genotype of a polymorphism site which is each 101th base of at least one polynucleotide selected from SEQ ID NO:1 to SEQ ID NO:60.
Abstract translation: 提供与心肌梗死相关的遗传多态性及其用途，以鉴定能够早期诊断或预测心肌梗死的存在或风险的单一多态性（SNP）。 提供了含有选自SEQ ID NO：1至SEQ ID NO：60的核苷酸序列中含有每个SNP位点碱基（101st碱基）的多于8个连续核苷酸或其互补多核苷酸的多核苷酸，其中用于诊断心肌梗死的多核苷酸 男性和非吸烟者包含SEQ ID NO：57至SEQ ID NO：60的核苷酸序列; 多核苷酸是等位基因特异性探针。 提供了由多核苷酸编码的多肽。 提供了与多肽特异性结合的抗体，其中抗体是单克隆抗体。 用于检测单个多态性（SNP）的微阵列或试剂盒含有多核苷酸，由此编码的多肽或其cDNA。 用于鉴定具有改变的心肌梗死风险的受试者的方法包括以下步骤：（a）从受试者分离核酸样品; 和（b）确定选自SEQ ID NO：1至SEQ ID NO：60的至少一种多核苷酸的每个第101位的多态性位点的等位基因基因型。
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6.发明公开심혈관 질환 진단용 다중 ＳＮＰ, 그를 포함하는마이크로어레이 및 키트 및 그를 이용한 심혈관 질환 진단방법 有权用于诊断心血管疾病的多单核苷酸多态性，包含其的微阵列和试剂盒以及使用该方法诊断心血管疾病的方法
公开(公告)号：KR1020060119737A
公开(公告)日：2006-11-24
申请号：KR1020060018449
申请日：2006-02-24
Applicant: 삼성전자주식회사
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , C12Q1/6837 , C12Q2600/156
Abstract: A multiple SNP for diagnosing cardiovascular disease is provided to be able to diagnose an attack and the possibility of the cardiovascular disease at the initial stage by using specific SNPs. And a method for diagnosing cardiovascular disease is provided to be able to effectively diagnose the existence or danger of the cardiovascular disease by analyzing the SNP related with the cardiovascular disease. The multiple SNP for diagnosing cardiovascular disease comprises at least one polynucleotide or a complementary polynucleotide thereof selected from the group consisting of polynucleotides consisting of at least 10 consecutive nucleotides including each SNP position nucleotide of polynucleotides consisting of SEQ ID : NOs. 1 to 35(76th for the SEQ ID : NO. 4, 85th for the SEQ ID : NO. 8, 51st for SEQ ID : NO. 9, 35th for the SEQ ID : NO. 10, 85th for the SEQ ID : NO. 19, and 101st for number of the remaining SEQ ID). The microarray comprises the polynucleotide, a polynucleotide encoded by the same or a cDNA thereof. The method for diagnosing cardiovascular disease comprises the steps of: (a) separating a nucleic acid sample from an object to be tested; and (b) determining a genotype of the polymorphic portion of the each SNP position nucleotide consisting of SEQ ID : NOs. 1 to 35(76th for the SEQ ID : NO. 4, 85th for the SEQ ID : NO. 8, 51st for the SEQ ID : NO. 9, 35th for the SEQ ID : NO. 10, 85th for the SEQ ID : NO. 19, and 101st for number of the remaining SEQ ID).
Abstract translation: 提供用于诊断心血管疾病的多重SNP以能够通过使用特异性SNP来诊断初始阶段的心血管疾病的发作和可能性。 提供了一种心血管疾病诊断方法，通过分析与心血管疾病相关的SNP，能够有效地诊断心血管疾病的存在或危险。 用于诊断心血管疾病的多重SNP包含至少一种多核苷酸或其互补多核苷酸，其选自由至少10个连续核苷酸组成的组，所述多核苷酸包括SEQ ID NO：所组成的多核苷酸的每个SNP位点核苷酸。 1至35（SEQ ID：NO.4为第76位，SEQ ID NO：8为第85位，SEQ ID：NO.9为第51位，SEQ ID NO：10为第35位，SEQ ID NO：85为第85位 19，101st为剩余的SEQ ID）。 微阵列包含多核苷酸，由其编码的多核苷酸或其cDNA。 用于诊断心血管疾病的方法包括以下步骤：（a）将核酸样品与待测试对象分离; 和（b）确定由SEQ ID NO：组成的每个SNP位置核苷酸的多态性部分的基因型。 1至35（对SEQ ID NO：4为SEQ ID NO：8为第76位，SEQ ID NO：8为第85位，SEQ ID：NO.9为第51位，SEQ ID：NO.10为第35位，SEQ ID NO： 第19号，第101号为剩余的SEQ ID）。
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7.发明授权단일염기 다형을 포함하는 2형 당뇨병과 관련된폴리뉴클레오티드, 그를 포함하는 마이크로어레이 및 진단키트 및 그를 이용한 폴리뉴클레오티드 분석방법 有权与包含单核苷酸多态性的II型糖尿病相关的多核苷酸，包含该多核苷酸的微阵列和诊断试剂盒以及使用该多核苷酸分析多核苷酸的方法
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