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公开(公告)号：KR101670967B1
公开(公告)日：2016-11-09
申请号：KR1020090103559
申请日：2009-10-29
Applicant: 삼성전자주식회사 , 서울대학교산학협력단
Abstract: 질병또는약물에관련된유전체마커를선택하기위한방법및 장치가개시된다. 상기유전체마커를포함하는유전체마커군이상기질병또는약물에관련된정도를나타내는평가지표를계산하고, 상기평가지표에기초하여유전체마커를선택한다.
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公开(公告)号：KR1020110046866A
公开(公告)日：2011-05-06
申请号：KR1020090103559
申请日：2009-10-29
Applicant: 삼성전자주식회사 , 서울대학교산학협력단
CPC classification number: G06F19/18 , C12Q1/68 , C12Q2600/156
Abstract: PURPOSE: A method for selecting a gene marker relating to diseases or drugs is provided to select a gene marker group of excellent performance. CONSTITUTION: A method for selecting a gene marker comprises: a step of providing an object gene; a step of collecting a plurality of gene markers corresponding to the object gene; a step of determining standard infect of evaluation; a step of calculating the index of evaluation of a gene marker group containing two or more gene markers; and a step of selecting gene marker having optimal evaluation index. The gene marker is SNP(Single Nucleotide Polymorphism), CNV(Copy Number Variation), STS(Sequence Tagged Site), STR(Short Tandem Repeat), LTR(Long Terminal Repeat), or Indel(Insertion Deletion).
Abstract translation: 目的：提供选择与疾病或药物相关的基因标记的方法，以选择性能优异的基因标记组。 构成：选择基因标记物的方法包括：提供对象基因的步骤; 收集与所述对象基因相对应的多个基因标记物的步骤; 确定评价标准感染的一个步骤; 计算含有两个以上基因标记物的基因标记组的评价指标的步骤; 选择具有最佳评价指标的基因标记的步骤。 基因标记是SNP（单核苷酸多态性），CNV（拷贝数变异），STS（序列标记位点），STR（短串联重复），LTR（长末端重复）或Indel（插入缺失）。
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公开(公告)号：KR1020110046865A
公开(公告)日：2011-05-06
申请号：KR1020090103558
申请日：2009-10-29
Applicant: 서울대학교산학협력단
CPC classification number: C12Q1/6837 , C12Q1/6834 , G06F17/11 , G06F19/00
Abstract: PURPOSE: A method for determining microarray product quality is provided to digitize signal intensity by the length of a product quality management probe and to effectively determine the product quality. CONSTITUTION: A method for determining microarray product quality comprises: a step of providing a microarray containing a product quality probe nucleic acid fixed on a substrate; a step of hybridizing a sample containing signal material-labeled oligonucleotide with the probe nucleic acid; a step of measuring label signal; and a step of selecting microarray which satisfies selection criteria. The oligonucleotide contains 2-100 bases. The signal material contains fluorescent substance or radioactive substance.
Abstract translation: 目的：提供一种确定微阵列产品质量的方法，通过产品质量管理探针的长度将信号强度数字化，并有效确定产品质量。 构成：用于测定微阵列产品质量的方法包括：提供包含固定在底物上的产品质量探针核酸的微阵列的步骤; 将含有信号材料标记的寡核苷酸的样品与探针核酸杂交的步骤; 测量标签信号的步骤; 以及选择满足选择标准的微阵列的步骤。 寡核苷酸含有2-100个碱基。 信号材料含有荧光物质或放射性物质。
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公开(公告)号：KR101024975B1
公开(公告)日：2011-03-25
申请号：KR1020090031074
申请日：2009-04-10
Applicant: 건국대학교 산학협력단 , 서울대학교산학협력단
Abstract: 본 발명은 리케차 질환 진단항원의 생산방법에 관한 것으로, 더욱 상세하게는
R.
conorii 의 OmpA 또는 OmpB와 MBP(maltose-binding protein)를 포함하는 재조합 진단항원의 생산방법에 관한 것이다.
리케차, 재조합 OmpA, 재조합 OmpB-
Patent Agency Ranking
公开(公告)号：KR1020100112678A
公开(公告)日：2010-10-20
申请号：KR1020090031074
申请日：2009-04-10
Applicant: 건국대학교 산학협력단 , 서울대학교산학협력단
Abstract: PURPOSE: A method for diagnosis antigen for rickettsiosis is provided to use as a diagnosis marker for rickettsiosi. CONSTITUTION: A method for preparing diagnosis antigen for rickettsiosi comprises: a step of isolating R. conorii OmpA gene(AE008674) or OmpB gene(AE0085659) to fragments; a step of inserting gene fragment into an expression vector having MBP gene to obtain a recombinant gene; a step of transforming the expression vector to E.coli and culturing; and a step of isolating and purifying the recombinant protein of OmpA or OmpB from E.coli. The R. conorii OmpA gene(AE008674) fragment and R. conorii OmpB gene(AE008659) is OmpA4048-5352 and OmpB2401-3807 or OmpB3679-4902.
Abstract translation: 目的：提供用于诊断抗病克氏病的方法，用作立克次体诊断标记物。 构成：用于制备立克次体诊断抗原的方法包括：将番茄红素OmpA基因（AE008674）或OmpB基因（AE0085659）分离成片段的步骤; 将基因片段插入到具有MBP基因的表达载体中以获得重组基因的步骤; 将表达载体转化到大肠杆菌并培养的步骤; 以及从大肠杆菌中分离和纯化OmpA或OmpB的重组蛋白的步骤。 R.cororii OmpA基因（AE008674）片段和R. conorii OmpB基因（AE008659）是OmpA4048-5352和OmpB2401-3807或OmpB3679-4902。
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公开(公告)号：KR1020150007878A
公开(公告)日：2015-01-21
申请号：KR1020130082465
申请日：2013-07-12
Applicant: 삼성전자주식회사
CPC classification number: C12Q1/6886 , C12Q2600/178 , G01N33/48 , G01N33/5308 , G01N33/57415 , G01N2033/57403
Abstract: The present invention relates to a composition and a kit for diagnosing breast cancer, wherein microRNA or a polynucleotide which is the same as or is complementary to the fragment thereof and an integrin protein or a material specifically bonding to the fragment thereof which are contained in a vesicle are included. The present invention also relates to a method for diagnosing breast cancer using the same and obtaining information needed to diagnose breast cancer. Breast cancer can be diagnosed early in a minimally invasive manner, and patient convenience can be improved.
Abstract translation: 本发明涉及用于诊断乳腺癌的组合物和试剂盒，其中微RNA或与其片段相同或互补的多核苷酸和整合素蛋白质或与其片段特异性结合的材料，其包含在 包括囊泡。 本发明还涉及使用该乳腺癌诊断乳腺癌并获得诊断乳腺癌所需的信息的方法。 可以以微创方式早期诊断乳腺癌，并且可以改善患者的便利性。
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9.发明授权１기 폐암 환자의 병기 구분용 마커, 상기 마커에 대한프라이머를 포함하는 키트, 상기 마커 또는 상기 마커에대한 항체를 포함하는 마이크로어레이, 및 １기 폐암환자의 병기를 구분하는 방법 有权用于分类1期肺癌患者的分级标记物，包含标记引物的试剂盒，包含针对标记物的标记物或抗体的微阵列，以及分阶段1肺癌患者的分级方法
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10.发明授权단일염기 다형을 포함하는 유방암과 관련된 폴리뉴클레오티드, 그를 포함하는 마이크로어레이 및 진단 키트 및 그를이용한 유방암 진단 방법 有权与包含单核苷酸多态性的乳腺癌相关的多核苷酸，微阵列和包含该多核苷酸的诊断试剂盒以及使用该多核苷酸诊断乳腺癌的方法
公开(公告)号：KR101138862B1
公开(公告)日：2012-05-14
申请号：KR1020050012038
申请日：2005-02-14
Applicant: 삼성전자주식회사
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/156
Abstract: Provided is a polynucleotide for diagnosis or treatment of breast cancer, including at least 10 contiguous nucleotides of a nucleotide sequence selected from the group consisting of nucleotide sequences of SEQ ID No: 1 to SEQ ID No: 5 and comprising a nucleotide at 101st position of the nucleotide sequence, or a complementary polynucleotide thereof.
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