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公开(公告)号：KR101467350B1
公开(公告)日：2014-12-03
申请号：KR1020120132909
申请日：2012-11-22
Applicant: 한국식품연구원
IPC: C07K1/34 , C07K1/36 , C07K14/415 , A23L33/00
Abstract: 본발명은밀기울유래당단백분획및 이의제조방법에관한것으로, 좀더 상세하게는 (a) 밀기울을탈지하는단계; (b) 밀기울을 pH가 7.0 내지 8.0인완충용액에혼합하는단계; (c) 상기혼합물을원심분리하여상등액을수득하는단계; (d) 상기상등액을투석반투막(MWCO 6000-8000)으로투석하는단계; (e) 상기투석된상등액에단백질을침전시키는염을첨가하여당단백질을침전시키는단계; (f) 상기침전물을 pH가 7.0 내지 8.0인완충용액에용해하여투석반투막(MWCO 6000-8000)으로투석하는단계; 및 (g) 상기투석된침전용해물에서당단백분획물을수득하는단계를포함하는방법에의하여제조되고, 분자량이 16 내지 70kDa인것을특징으로하는밀기울유래당단백분획물및 이를유효성분으로포함하는면역기능증진용약학적, 식품조성물에관한것이다. 본발명의당단백분획물은대식세포의활성을면역활성증진용의약품인크레스틴(PSK) 보다도촉진하는효능이매우뛰어나며세포독성이전혀없어, 새로운기능성식품및 면역기능증강용의약품제조에효과적이다.
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公开(公告)号：KR101170998B1
公开(公告)日：2012-08-08
申请号：KR1020110142783
申请日：2011-12-26
Applicant: 한국식품연구원
Abstract: PURPOSE: A method for preparing a rice bran-derived glycoprotein fraction and a composition containing the fraction for enhancing immunity are provided to promote NO and TNF-alpha generation. CONSTITUTION: A rice bran-derived glycoprotein fraction comprises: a step of defatting rice bran; a step of mixing the rice bran in a buffer solution of pH 7.0-8.0; a step of centrifuging the mixture to obtain supernatant; a step of performing dialysis of the supernatant using dialysis semipermeable membrane; a step of adding salt to precipitate glycoproteins; a step of dissolving the precipitate in a buffer solution of pH 7.0-8.0 and performing dialysis with the dialysis semipermeable membrane; and a step of freeze-drying the dissolved precipitate. A composition for enhancing immunity contains the glycoprotein fraction as an active ingredient. A pharmaceutical composition for preventing or treating cold, atopy, chronic fatigue, or cancer contains the fraction as an active ingredient.
Abstract translation: 目的：提供一种制备米糠衍生的糖蛋白部分的方法和含有用于增强免疫力的级分的组合物，以促进NO和TNF-α的产生。 构成：米糠衍生的糖蛋白级分包括：将米糠脱脂的步骤; 将米糠混合在pH 7.0-8.0的缓冲溶液中的步骤; 将混合物离心以获得上清液的步骤; 使用透析半透膜进行上清液透析的步骤; 添加盐以沉淀糖蛋白的步骤; 将沉淀溶解在pH7.0-8.0的缓冲溶液中并用透析半透膜进行透析的步骤; 以及冷冻干燥溶解的沉淀物的步骤。 用于增强免疫力的组合物含有糖蛋白部分作为活性成分。 用于预防或治疗感冒，特应性，慢性疲劳或癌症的药物组合物含有该部分作为活性成分。
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公开(公告)号：KR1020140066821A
公开(公告)日：2014-06-02
申请号：KR1020120132891
申请日：2012-11-22
Applicant: 한국식품연구원
IPC: C07K1/34 , C07K1/36 , C07K14/195 , C07K14/37
Abstract: The present invention relates to a fraction of rice wine lees derived-glycoprotein, which is characterized in having a molecular weight of 15 to 110 kDa, and a method of producing the same and, more specifically, to a fraction of rice wine lees-derived glycoprotein and the uses thereof, which is prepared by a method comprising: (a) a step of removing fat in rice wine lees; (b) a step of mixing the rice wine lees in a buffer solution having a pH level of 7.0 to 8.0; (c) a step of obtaining a supernatant by centrifugation; (d) a step of dialyzing the supernatant with a dialysis semipermeable membrane (MWCO 6000-8000); (e) a step of adding a salt precipitating protein in the dialyzed supernatant to precipitate glycoprotein; (f) a step of dissolving the precipitate in a buffer solution having a pH level of 7.0 to 8.0 with a dialysis semipermeable membrane (MWCO 6000-8000); and (g) a step of obtaining a fraction of glycoprotein from the dialyzed and precipitated lysate. The fraction of glycoprotein of the present invention has a better effectiveness of promoting histiocyte vitality than Krestin (PSK), which is a medicine for enhancing immune vitality, and has no cytotoxicity, thereby being effective in producing a new functional food and a medicine for enhancing immune function.
Abstract translation: 本发明涉及分子量为15〜110kDa的米酒衍生糖蛋白的一部分及其制造方法，更具体地说，涉及一批来自米酒的糖酵母 糖蛋白及其用途，其通过以下方法制备：（a）在米酒中除去脂肪的步骤; （b）将米酒混合在pH为7.0〜8.0的缓冲液中的工序; （c）通过离心获得上清液的步骤; （d）用透析半透膜（MWCO 6000-8000）透析上清液的步骤; （e）在透析的上清液中加入沉淀蛋白质沉淀糖蛋白的步骤; （f）用透析半透膜（MWCO 6000-8000）将沉淀物溶解在pH值为7.0〜8.0的缓冲溶液中的步骤; 和（g）从透析和沉淀的裂解物中获得一部分糖蛋白的步骤。 与作为增强免疫活力的药物Krestin（PSK）相比，本发明的糖蛋白的分数具有更好的促进组织细胞活力的效果，并且没有细胞毒性，因此有效地生产新的功能性食品和增强药物 免疫功能。
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4.发明授权미강 유래 당단백질 분획물을 유효성분으로 포함하는 암 전이 억제 및 알러지성 질환 예방 또는 치료용 조성물 有权用于抑制癌症转移并预防或治疗过敏性疾病的组合物，其包含从米糠中分离出的糖蛋白组分
公开(公告)号：KR101826214B1
公开(公告)日：2018-02-06
申请号：KR1020160060599
申请日：2016-05-18
Applicant: 한국식품연구원
IPC: A23L1/305 , A61K36/899
Abstract: 본발명은미강유래당단백질분획물을유효성분으로포함하는암 전이억제및 알러지성질환의예방또는치료용조성물에관한것이다. 본발명의미강유래당당백질분획물은암 전이억제및 ovalbumin에의해감작된알러지의저감효능이뛰어나경쟁력있는암 전이억제및 알러지성질환의예방또는치료용의약품제조에효과적이다.
Abstract translation: 本发明涉及含有米糠衍生糖蛋白部分作为有效成分的用于预防或治疗过敏性疾病和抑制癌转移的组合物。 本发明的米糠衍生糖蛋白级分优异地抑制癌转移以及卵白蛋白致敏的过敏，从而能够有效地生产用于预防或治疗过敏性疾病和抑制癌症转移的竞争性药物。
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Patent Agency Ranking
公开(公告)号：KR101450773B1
公开(公告)日：2014-10-17
申请号：KR1020120132891
申请日：2012-11-22
Applicant: 한국식품연구원
IPC: C07K1/34 , C07K1/36 , C07K14/195 , C07K14/37
Abstract: 본 발명은 막걸리박 유래 당단백 분획 및 이의 제조방법에 관한 것으로, 좀 더 상세하게는 (a) 막걸리박을 탈지하는 단계; (b) 막걸리박을 pH가 7.0 내지 8.0인 완충용액에 혼합하는 단계; (c) 상기 혼합물을 원심분리하여 상등액을 수득하는 단계; (d) 상기 상등액을 투석 반투막(MWCO 6000-8000)으로 투석하는 단계; (e) 상기 투석된 상등액에 단백질을 침전시키는 염을 첨가하여 당단백질을 침전시키는 단계; (f) 상기 침전물을 pH가 7.0 내지 8.0인 완충용액에 용해하여 투석 반투막(MWCO 6000-8000)으로 투석하는 단계; 및 (g) 상기 투석된 침전 용해물에서 당단백 분획물을 수득하는 단계를 포함하는 방법에 의하여 제조되고, 분자량이 15 내지 110kDa인 것을 특징으로 하는 막걸리박 유래 당단백 분획물 및 이의 용도에 관한 것이다.
본 발명의 당단백 분획물은 대식세포의 활성을 면역활성 증진용 의약품인 크레스틴(PSK) 보다도 촉진하는 효능이 매우 뛰어나며 세포독성이 전혀 없어, 새로운 기능성 식품 및 면역기능 증강용 의약품 제조에 효과적이다.-
公开(公告)号：KR1020140066826A
公开(公告)日：2014-06-02
申请号：KR1020120132909
申请日：2012-11-22
Applicant: 한국식품연구원
IPC: C07K1/34 , C07K1/36 , C07K14/415 , A23L33/00
Abstract: The present invention relates to a fraction of wheat bran-derived glycoprotein and a method of producing the same and, more particularly, to a fraction of wheat bran-derived glycoprotein, which is characterized by having a molecular weight of 16 to 70 kDa and prepared by a method comprising: (a) step of removing fat in wheat bran; (b) a step of mixing the wheat bran in a buffer solution having a pH level of 7.0 to 8.0; (c) a step of obtaining a supernatant by centrifuging the mixture; (d) a step of dialyzing the supernatant with a dialysis semipermeable membrane (MWCO 6000-8000); (e) a step of adding a salt precipitating protein in the dialyzed supernatant to precipitate glycoprotein; (f) a step of dissolving the precipitate in a buffer solution having a pH level of 7.0 to 8.0 with a dialysis semipermeable membrane (MWCO 6000-8000); and (g) a step of obtaining a fraction of glycoprotein from the dialyzed and precipitated lysate. The present invention also relates to a pharmaceutical food composition containing the fraction as an active ingredient for enhancing the immune function. The fraction of glycoprotein of the present invention is more effective in promoting histiocyte vitality than Krestin (PSK), which is a medicine for enhancing immune vitality, and has no cytotoxicity, thereby being effective in producing a new functional food and a medicine for enhancing the immune function.
Abstract translation: 本发明涉及一部分麦麸衍生的糖蛋白及其制备方法，更具体地说，涉及一部分麦麸衍生的糖蛋白，其特征在于分子量为16至70kDa并制备 通过以下方法：（a）除去麦麸中的脂肪的步骤; （b）将麦麸混合在pH为7.0〜8.0的缓冲溶液中的工序; （c）通过离心混合物获得上清液的步骤; （d）用透析半透膜（MWCO 6000-8000）透析上清液的步骤; （e）在透析的上清液中加入沉淀蛋白质沉淀糖蛋白的步骤; （f）用透析半透膜（MWCO 6000-8000）将沉淀物溶解在pH值为7.0〜8.0的缓冲溶液中的步骤; 和（g）从透析和沉淀的裂解物中获得一部分糖蛋白的步骤。 本发明还涉及含有该级分作为增强免疫功能的活性成分的药物性食品组合物。 与作为增强免疫活力的药物Krestin（PSK）相比，本发明的糖蛋白的分数比促进组织细胞活力更有效，并且没有细胞毒性，因此有效地生产新的功能性食品和用于增强免疫活性的药物 免疫功能。
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公开(公告)号：KR102173359B1
公开(公告)日：2020-11-03
申请号：KR20180115331
申请日：2018-09-27
Applicant: 한국식품연구원
Abstract: 본발명은갈변생성을억제하기위한감자의분말제조방법에관한것으로, 구체적으로본 발명은감자를절단하여물에침지시키는단계;상기침지시킨감자를제1 열풍건조하는단계; 상기제1 열풍건조한감자를파쇄하는단계; 상기파쇄한감자를제2 열풍건조하는단계; 및상기제2 열풍건조한감자를분쇄하여분말화하는단계를포함할수 있다.
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8.发明公开미강 유래 당단백질 분획물을 유효성분으로 포함하는 암 전이 억제 및 알러지성 질환 예방 또는 치료용 조성물 无效一种抑制癌转移，预防或治疗过敏性疾病的组合物，其含有来自米胚芽的糖蛋白成分作为有效成分
公开(公告)号：KR1020170130059A
公开(公告)日：2017-11-28
申请号：KR1020160060599
申请日：2016-05-18
Applicant: 한국식품연구원
IPC: A23L1/305 , A61K36/899
CPC classification number: A23L33/185 , A23V2002/00 , A23V2200/304 , A23V2200/308 , A23V2250/5482 , A23V2300/18 , A61K36/899
Abstract: 본발명은미강유래당단백질분획물을유효성분으로포함하는암 전이억제및 알러지성질환의예방또는치료용조성물에관한것이다. 본발명의미강유래당당백질분획물은암 전이억제및 ovalbumin에의해감작된알러지의저감효능이뛰어나경쟁력있는암 전이억제및 알러지성질환의예방또는치료용의약품제조에효과적이다.
Abstract translation: 本发明涉及一种组合物用于预防或治疗含有米糠衍生作为活性成分，糖，和过敏性疾病的蛋白质级分癌转移抑制。 米糠原点本发明的正视蛋白质级分是有效的竞争性抑制和癌症转移的药物生产用于过敏性疾病的预防和治疗，其具有通过抑制癌转移和卵清蛋白减少变应性致敏的优异的效果。
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公开(公告)号：KR1020170078912A
公开(公告)日：2017-07-10
申请号：KR1020150188280
申请日：2015-12-29
Applicant: 한국식품연구원 , 중앙대학교 산학협력단
Abstract: 본발명은멍게추출분획물을이용한저항원성난백의제조방법과그 방법에의해제조된저항원성난백에관한것으로, 보다상세하게는엑소글라이코시다제활성을갖는멍게추출분획물을처리하여난백단백질에결합한당을제거하는단계를포함하는저항원성전란과난백의제조방법, 전란의항원성을감소시키는방법, 그리고상기방법에의해제조된저항원성전란과난백에대한것이다. 본발명은오랫동안식용으로이용되어온천연물을이용하여안전하고친환경적으로난백단백질의당을제거하는것으로서, 식품, 화장료또는약학적조성물등 다양한목적으로사용될수 있는저항원성난백또는전란의조성물을제조하는데유용하게사용될수 있다.
Abstract translation: 本发明处理具有的海鞘提取物馏分的是，更具体地是外切品番茄红素让涉及由该方法制备的电阻的免疫原性蛋白，并使用海鞘提取分数电阻免疫原性蛋白的方法结合于蛋清蛋白质的活性 全蛋和蛋清电阻的免疫原性，包括移除所述糖，降低了的全蛋的抗原性的方法的步骤，和电阻的方法是对整个蛋和蛋清的免疫原性通过上述方法生产的。 本发明是通过使用已使用了很长时间的食品和环境友好型除去蛋清蛋白的糖的天然产物，在制备食品，化妆品或药物组合物，例如可用于各种蛋白或全蛋中的目的电阻免疫原性组合物的有用的，以确保 它可以被使用。
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