公开(公告)号：WO2007027651A2

公开(公告)日：2007-03-08

申请号：PCT/US2006033620

申请日：2006-08-25

Applicant: ABBOTT LAB ,  PEI ZHONGHUA ,  VON GELDERN THOMAS ,  MADAR DAVID J ,  LI XIAOFENG ,  BASHA FATIMA ,  YONG HONG ,  LONGENECKER KENTON L ,  BACKES BRADLEY J ,  JUDD ANDREW S ,  MULHERN MATHEW M ,  STEWART KENT D

Inventor： PEI ZHONGHUA ,  VON GELDERN THOMAS ,  MADAR DAVID J ,  LI XIAOFENG ,  BASHA FATIMA ,  YONG HONG ,  LONGENECKER KENTON L ,  BACKES BRADLEY J ,  JUDD ANDREW S ,  MULHERN MATHEW M ,  STEWART KENT D

IPC: C07C217/54 ,  C07C211/40 ,  C07D213/38 ,  C07D213/68 ,  C07D317/64

CPC classification number: C07C211/48 ,  C07C211/40 ,  C07C217/52 ,  C07C217/54 ,  C07C217/74 ,  C07C217/84 ,  C07C217/86 ,  C07C225/22 ,  C07C229/42 ,  C07C229/48 ,  C07C229/60 ,  C07C233/43 ,  C07C233/78 ,  C07C235/46 ,  C07C237/24 ,  C07C237/30 ,  C07C237/42 ,  C07C255/54 ,  C07C255/58 ,  C07C311/22 ,  C07C311/36 ,  C07C317/22 ,  C07C317/36 ,  C07C2601/14 ,  C07C2601/16 ,  C07D207/16 ,  C07D209/08 ,  C07D209/48 ,  C07D211/46 ,  C07D211/60 ,  C07D211/62 ,  C07D213/30 ,  C07D213/38 ,  C07D213/64 ,  C07D213/68 ,  C07D213/74 ,  C07D213/82 ,  C07D217/04 ,  C07D263/56 ,  C07D263/60 ,  C07D277/04 ,  C07D277/64 ,  C07D295/135 ,  C07D295/185 ,  C07D295/205 ,  C07D317/66 ,  C07D319/18 ,  C07D333/34 ,  C07D333/38 ,  C07D409/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04

Abstract: The present invention relates to compounds, which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, metabolic syndrome , hyperinsulinemia, obesity, atherosclerosis, various immunomodulatory diseases, and other diseases.

Abstract translation: 本发明涉及抑制二肽基肽酶IV（DPP-IV）的化合物，其可用于预防或治疗糖尿病，特别是II型糖尿病，以及高血糖症，代谢综合征，高胰岛素血症，肥胖症，动脉粥样硬化，各种免疫调节疾病 ，等疾病。

公开(公告)号：NZ565461A

公开(公告)日：2011-08-26

申请号：NZ56546106

申请日：2006-08-25

Applicant: ABBOTT LAB

Inventor： PEI ZHONGHUA ,  VON GELDERN THOMAS ,  MADAR DAVID J ,  LI XIAOFENG ,  BASHA FATIMA ,  YONG HONG ,  LONGENECKER KENTON L ,  BACKES BRADLEY J ,  JUDD ANDREW S ,  MULHERN MATHEW M ,  STEWART KENT D

IPC: C07D317/64 ,  A61K31/137 ,  C07C211/40 ,  C07C211/54 ,  C07C211/62 ,  C07D213/38 ,  C07D213/68 ,  C07D487/04

Abstract: Disclosed is a cyclohexyl amine of formula (Ia) or a pharmaceutically acceptable salt thereof, wherein m is 4; Ar 1 is aryl, R1 is hydrogen, and R2 and R3 are defined in the specification for treating diabetes, type II diabetes, hyperglycemia, metabolic syndrome, hyperinsulinemia, or obesitycardiovascular disease, atherosclerosis, cerebrovascular diseases, diseases and disorders of the central nervous system, schizophrenia, anxiety, bipolar disease, depression, insomnia, cognitive disorders, gastrointestinal diseases and disorders, cancer, inflammation and inflammatory diseases, respiratory diseases and disorders, musculo-skeletal disorders, osteoporosis, menopausal symptoms, periodontal diseases and gingivitis.

公开(公告)号：CA2617495A1

公开(公告)日：2007-03-08

申请号：CA2617495

申请日：2006-08-25

Applicant: ABBOTT LAB

Inventor： PEI ZHONGHUA ,  VON GELDERN THOMAS ,  MADAR DAVID J ,  LONGENECKER KENTON L ,  STEWART KENT D ,  LI XIAOFENG ,  YONG HONG ,  BACKES BRADLEY J ,  MULHERN MATHEW M ,  BASHA FATIMA ,  JUDD ANDREW S

IPC: C07C211/40 ,  A61K31/137 ,  C07C211/54 ,  C07C211/62 ,  C07D213/38 ,  C07D213/68 ,  C07D317/64 ,  C07D487/04

Abstract: The present invention relates to compounds, which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II, as well as hyperglycemia, metabolic syndrome, hyperinsulinemia, obesity, atherosclerosis, various immunomodulatory diseases, and other diseases.

公开(公告)号：BRPI0615102A2

公开(公告)日：2011-05-03

申请号：BRPI0615102

申请日：2006-08-25

Applicant: ABBOTT LAB

Inventor： PEI ZHONGHUA ,  GELDERN THOMAS VON ,  MADAR DAVID J ,  LI XIAOFENG ,  BASHA FATIMA ,  YONG HONG ,  LONGENECKER KENTON L ,  BACKES BRADLEY J ,  JUDD ANDREW S ,  MULHERN MATHEW M ,  STEWART KENT D

IPC: C07C211/40 ,  A61K31/137 ,  C07C211/54 ,  C07C211/62 ,  C07D213/38 ,  C07D213/68 ,  C07D317/64 ,  C07D487/04

Abstract: The present invention relates to compounds, which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II, as well as hyperglycemia, metabolic syndrome, hyperinsulinemia, obesity, atherosclerosis, various immunomodulatory diseases, and other diseases.

公开(公告)号：AU2006285005A1

公开(公告)日：2007-03-08

申请号：AU2006285005

申请日：2006-08-25

Applicant: ABBOTT LAB

Inventor： JUDD ANDREW S ,  YONG HONG ,  BACKES BRADLEY J ,  GELDERN THOMAS VON ,  LONGENECKER KENTON L ,  BASHA FATIMA ,  PEI ZHONGHUA ,  LI XIAOFENG ,  STEWART KENT D ,  MADAR DAVID J ,  MULHERN MATHEW M

IPC: C07C211/40 ,  A61K31/137 ,  C07C211/54 ,  C07C211/62 ,  C07D213/38 ,  C07D213/68 ,  C07D317/64 ,  C07D487/04

Abstract: The present invention relates to compounds, which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II, as well as hyperglycemia, metabolic syndrome, hyperinsulinemia, obesity, atherosclerosis, various immunomodulatory diseases, and other diseases.

公开(公告)号：ZA200801007B

公开(公告)日：2009-08-26

申请号：ZA200801007

申请日：2008-01-30

Applicant: ABBOTT LAB

Inventor： ZHONGHUA PEI ,  MADAR DAVID J ,  FATIMA BASHA ,  LONGENECKER KENTON L ,  JUDD ANDREW S ,  STEWART KENT D ,  THOMAS VON GELDERN ,  XIAOFENG LI ,  HONG YONG ,  BACKES BRADLEY J ,  MULHERN MATHEW M

IPC: A61K20090101 ,  C07C20090101 ,  C07D20090101

Abstract: The present invention relates to compounds, which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II, as well as hyperglycemia, metabolic syndrome, hyperinsulinemia, obesity, atherosclerosis, various immunomodulatory diseases, and other diseases.