公开(公告)号：WO2007027651A2

公开(公告)日：2007-03-08

申请号：PCT/US2006033620

申请日：2006-08-25

Applicant: ABBOTT LAB ,  PEI ZHONGHUA ,  VON GELDERN THOMAS ,  MADAR DAVID J ,  LI XIAOFENG ,  BASHA FATIMA ,  YONG HONG ,  LONGENECKER KENTON L ,  BACKES BRADLEY J ,  JUDD ANDREW S ,  MULHERN MATHEW M ,  STEWART KENT D

Inventor： PEI ZHONGHUA ,  VON GELDERN THOMAS ,  MADAR DAVID J ,  LI XIAOFENG ,  BASHA FATIMA ,  YONG HONG ,  LONGENECKER KENTON L ,  BACKES BRADLEY J ,  JUDD ANDREW S ,  MULHERN MATHEW M ,  STEWART KENT D

IPC: C07C217/54 ,  C07C211/40 ,  C07D213/38 ,  C07D213/68 ,  C07D317/64

CPC classification number: C07C211/48 ,  C07C211/40 ,  C07C217/52 ,  C07C217/54 ,  C07C217/74 ,  C07C217/84 ,  C07C217/86 ,  C07C225/22 ,  C07C229/42 ,  C07C229/48 ,  C07C229/60 ,  C07C233/43 ,  C07C233/78 ,  C07C235/46 ,  C07C237/24 ,  C07C237/30 ,  C07C237/42 ,  C07C255/54 ,  C07C255/58 ,  C07C311/22 ,  C07C311/36 ,  C07C317/22 ,  C07C317/36 ,  C07C2601/14 ,  C07C2601/16 ,  C07D207/16 ,  C07D209/08 ,  C07D209/48 ,  C07D211/46 ,  C07D211/60 ,  C07D211/62 ,  C07D213/30 ,  C07D213/38 ,  C07D213/64 ,  C07D213/68 ,  C07D213/74 ,  C07D213/82 ,  C07D217/04 ,  C07D263/56 ,  C07D263/60 ,  C07D277/04 ,  C07D277/64 ,  C07D295/135 ,  C07D295/185 ,  C07D295/205 ,  C07D317/66 ,  C07D319/18 ,  C07D333/34 ,  C07D333/38 ,  C07D409/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04

Abstract: The present invention relates to compounds, which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, metabolic syndrome , hyperinsulinemia, obesity, atherosclerosis, various immunomodulatory diseases, and other diseases.

Abstract translation: 本发明涉及抑制二肽基肽酶IV（DPP-IV）的化合物，其可用于预防或治疗糖尿病，特别是II型糖尿病，以及高血糖症，代谢综合征，高胰岛素血症，肥胖症，动脉粥样硬化，各种免疫调节疾病 ，等疾病。

公开(公告)号：WO2007137107A3

公开(公告)日：2008-01-10

申请号：PCT/US2007069112

申请日：2007-05-17

Applicant: ABBOTT LAB ,  IYENGAR RAJESH R ,  ZHAO GANG ,  FREEMAN JENNIFER C ,  GAO JU ,  JUDD ANDREW S ,  KYM PHILIP R ,  LYNCH JOHN K ,  MULHERN MATHEW M ,  SOUERS ANDREW J

Inventor： IYENGAR RAJESH R ,  ZHAO GANG ,  FREEMAN JENNIFER C ,  GAO JU ,  JUDD ANDREW S ,  KYM PHILIP R ,  LYNCH JOHN K ,  MULHERN MATHEW M ,  SOUERS ANDREW J

IPC: C07C211/22 ,  A61K31/155 ,  A61K31/17 ,  A61K31/381 ,  A61K31/4164 ,  A61K31/435 ,  A61P3/04 ,  C07C275/30 ,  C07C279/18 ,  C07C335/16 ,  C07D213/55 ,  C07D213/75 ,  C07D277/28 ,  C07D333/36

CPC classification number: C07C335/22 ,  C07C229/46 ,  C07C275/30 ,  C07C275/32 ,  C07C275/38 ,  C07C279/28 ,  C07C2601/08 ,  C07C2601/14 ,  C07D213/55 ,  C07D213/75 ,  C07D277/30 ,  C07D333/22 ,  C07D333/36 ,  C07D401/04 ,  C07D401/12 ,  C07D409/12 ,  C07D409/14

Abstract: The present invention relates to compounds of formula (I) wherein R 1 , R 3 , X, Q, Z, A, D, m, and n are defined herein. Pharmaceutical compositions and methods for treating DGAT-1 related diseases or conditions are also disclosed.

Abstract translation: 本发明涉及式（I）化合物，其中R 1，R 3，X，Q，Z，A，D，m和n如本文所定义。 还公开了治疗DGAT-1相关疾病或病症的药物组合物和方法。

公开(公告)号：BRPI0810719A2

公开(公告)日：2014-10-21

申请号：BRPI0810719

申请日：2008-04-30

Applicant: ABBOTT LAB

Inventor： JUDD ANDREW S ,  MULHERN MATHEW M ,  IYENGAR RAJESH R ,  KYM PHILIP R ,  SOUERS ANDREW J

IPC: C07D277/20 ,  A61K31/427 ,  A61K31/44 ,  A61P3/04 ,  A61P3/10 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D493/08

Abstract: The present invention relates to compounds of formula (I): wherein Q, G 1 , G 2 , and G 3 , are defined herein. Pharmaceutical compositions and methods for treating DGAT-1 related diseases or conditions are also disclosed.

公开(公告)号：NZ565461A

公开(公告)日：2011-08-26

申请号：NZ56546106

申请日：2006-08-25

Applicant: ABBOTT LAB

Inventor： PEI ZHONGHUA ,  VON GELDERN THOMAS ,  MADAR DAVID J ,  LI XIAOFENG ,  BASHA FATIMA ,  YONG HONG ,  LONGENECKER KENTON L ,  BACKES BRADLEY J ,  JUDD ANDREW S ,  MULHERN MATHEW M ,  STEWART KENT D

IPC: C07D317/64 ,  A61K31/137 ,  C07C211/40 ,  C07C211/54 ,  C07C211/62 ,  C07D213/38 ,  C07D213/68 ,  C07D487/04

Abstract: Disclosed is a cyclohexyl amine of formula (Ia) or a pharmaceutically acceptable salt thereof, wherein m is 4; Ar 1 is aryl, R1 is hydrogen, and R2 and R3 are defined in the specification for treating diabetes, type II diabetes, hyperglycemia, metabolic syndrome, hyperinsulinemia, or obesitycardiovascular disease, atherosclerosis, cerebrovascular diseases, diseases and disorders of the central nervous system, schizophrenia, anxiety, bipolar disease, depression, insomnia, cognitive disorders, gastrointestinal diseases and disorders, cancer, inflammation and inflammatory diseases, respiratory diseases and disorders, musculo-skeletal disorders, osteoporosis, menopausal symptoms, periodontal diseases and gingivitis.

公开(公告)号：CA2685529A1

公开(公告)日：2008-11-06

申请号：CA2685529

申请日：2008-04-30

Applicant: ABBOTT LAB

Inventor： MULHERN MATHEW M ,  JUDD ANDREW S ,  SOUERS ANDREW J ,  IYENGAR RAJESH R ,  KYM PHILIP R

IPC: C07D277/20 ,  A61K31/427 ,  A61K31/44 ,  A61P3/04 ,  A61P3/10 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D493/08

Abstract: The present invention relates to compounds of formula (I): wherein Q, G1, G2, and G3, are defined herein. Pharmaceutical compositions and methods for treating DGAT-1 related diseases or conditions are also disclosed.

公开(公告)号：CA2617495A1

公开(公告)日：2007-03-08

申请号：CA2617495

申请日：2006-08-25

Applicant: ABBOTT LAB

Inventor： PEI ZHONGHUA ,  VON GELDERN THOMAS ,  MADAR DAVID J ,  LONGENECKER KENTON L ,  STEWART KENT D ,  LI XIAOFENG ,  YONG HONG ,  BACKES BRADLEY J ,  MULHERN MATHEW M ,  BASHA FATIMA ,  JUDD ANDREW S

IPC: C07C211/40 ,  A61K31/137 ,  C07C211/54 ,  C07C211/62 ,  C07D213/38 ,  C07D213/68 ,  C07D317/64 ,  C07D487/04

Abstract: The present invention relates to compounds, which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II, as well as hyperglycemia, metabolic syndrome, hyperinsulinemia, obesity, atherosclerosis, various immunomodulatory diseases, and other diseases.

公开(公告)号：CA2488635A1

公开(公告)日：2003-12-24

申请号：CA2488635

申请日：2003-06-11

Applicant: ABBOTT LAB

Inventor： VASUDEVAN ANIL ,  WODKA DARIUSZ ,  BLACKBURN CHRISTOPHER ,  MULHERN MATHEW M ,  LAMARCHE MATTHEW J ,  FREEMAN JENNIFER C ,  SOUERS ANDREW J ,  MAGUIRE MARTIN ,  BROWN JAMES ,  LYNCH JOHN K ,  IYENGAR RAJESH ,  CULLIS COURTNEY A ,  LEE JENNIFER G ,  GAO JU ,  PATANE MICHAEL A ,  LAI SU-JEN

IPC: C07D403/14 ,  A61K31/453 ,  A61K31/4535 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/517 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P5/00 ,  A61P15/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D451/04 ,  A61K31/4468

Abstract: This invention provides compounds that are antagonists of melanin concentrating hormone receptor-1 (MCH-R1). The compounds are represented by formula (I): where m is zero or one, n is zero to two, Y is oxygen or -N (R9 )- , R1, R2, R3, R4, R5, R9, and Ring A are defined in the specification. Coumarin and quinolone compounds where R1 and R2 together form a fused benzo ring are preferred. The invention also provides compounds of formula (VI) where the coumarin moiety is replaced by a quinazolinone ring. The compounds are useful for treating MCH-R1-related disorders, particularly overweight conditions including obesity.

公开(公告)号：MX2009011754A

公开(公告)日：2009-12-01

申请号：MX2009011754

申请日：2008-04-30

Applicant: ABBOTT LAB

Inventor： JUDD ANDREW S ,  MULHERN MATHEW M ,  SOUERS ANDREW J ,  IYENGAR RAJESH R ,  KYM PHILIP R

IPC: C07D277/20 ,  A61K31/427 ,  A61K31/44 ,  A61P3/04 ,  A61P3/10 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D493/08

Abstract: La presente invención se refiere a compuestos de la fórmula (I): en donde Q, G1, G2 y G3, son como aquí se definen. También se describen composiciones farmacéuticas y métodos para el tratamiento de las enfermedades o padecimientos relacionados con la enzima DGAT-1.

公开(公告)号：ZA200801007B

公开(公告)日：2009-08-26

申请号：ZA200801007

申请日：2008-01-30

Applicant: ABBOTT LAB

Inventor： ZHONGHUA PEI ,  MADAR DAVID J ,  FATIMA BASHA ,  LONGENECKER KENTON L ,  JUDD ANDREW S ,  STEWART KENT D ,  THOMAS VON GELDERN ,  XIAOFENG LI ,  HONG YONG ,  BACKES BRADLEY J ,  MULHERN MATHEW M

IPC: A61K20090101 ,  C07C20090101 ,  C07D20090101

Abstract: The present invention relates to compounds, which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II, as well as hyperglycemia, metabolic syndrome, hyperinsulinemia, obesity, atherosclerosis, various immunomodulatory diseases, and other diseases.

公开(公告)号：BRPI0615102A2

公开(公告)日：2011-05-03

申请号：BRPI0615102

申请日：2006-08-25

Applicant: ABBOTT LAB

Inventor： PEI ZHONGHUA ,  GELDERN THOMAS VON ,  MADAR DAVID J ,  LI XIAOFENG ,  BASHA FATIMA ,  YONG HONG ,  LONGENECKER KENTON L ,  BACKES BRADLEY J ,  JUDD ANDREW S ,  MULHERN MATHEW M ,  STEWART KENT D

IPC: C07C211/40 ,  A61K31/137 ,  C07C211/54 ,  C07C211/62 ,  C07D213/38 ,  C07D213/68 ,  C07D317/64 ,  C07D487/04

Abstract: The present invention relates to compounds, which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II, as well as hyperglycemia, metabolic syndrome, hyperinsulinemia, obesity, atherosclerosis, various immunomodulatory diseases, and other diseases.