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1.发明专利Azaadamantane derivatives and their uses as nicotinic acetylcholine receptors ligands 有权亚胺丹衍生物及其作为NICOTINIC乙酰胆碱受体配体的用途
公开(公告)号：JP2013121969A
公开(公告)日：2013-06-20
申请号：JP2013008959
申请日：2013-01-22
Applicant: Abbott Lab , アボット・ラボラトリーズAbbott Laboratories
Inventor： SCHRIMPF MICHAEL R , NERSESIAN DIANA L , SIPPY KEVIN B , JI JIANGUO , LI TAO , SCANIO MARC , SHI LEI , LEE CHIH-HUNG , BUNNELLE WILLIAM H , ZHANG GEOFF G Z , BRACKEMEYER PAUL J , CHEN SHUANG , HENRY RODGER F
IPC: C07D471/18 , A61K31/439 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61P3/10 , A61P9/00 , A61P9/10 , A61P15/08 , A61P17/02 , A61P19/02 , A61P21/02 , A61P25/04 , A61P25/14 , A61P25/18 , A61P25/28 , A61P25/34 , A61P29/00 , A61P43/00
CPC classification number: C07D471/18 , A61K31/095 , A61K31/439 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K45/06 , C07C309/29 , C07D451/14 , C07D471/08 , C07F5/022
Abstract: PROBLEM TO BE SOLVED: To provide novel azaadamantane derivatives.SOLUTION: The invention relates to compounds that are azaadamantane derivatives of formula (I), particularly ether- or amine-substituted azaadamantane derivatives and salts and prodrugs thereof. In the formula, Ldenotes -O- or -NR-; A denotes -Ar, -Ar-L-Aror -Ar-L-Ar; Ardenotes aryl or heteroaryl; Ardenotes aryl or monocyclic heteroaryl; Ardenotes aryl or heteroaryl; Ardenotes bicyclic heteroaryl; Ardenotes aryl or heteroaryl; Ldenotes a binding, -O -, -NR-, -CH- or -C(O)NR-; L3 denotes a binding, -O-, -NR-or -CH-; and Rdenotes hydrogen or alkyl.
Abstract translation: 待解决的问题：提供新的氮杂金刚烷衍生物。 解决方案：本发明涉及式（I）的氮杂金刚烷衍生物，特别是醚或胺取代的氮杂金刚烷衍生物及其盐和前药的化合物。 在该式中，L
1 表示-O-或-NR a - ; A表示-Ar 1 ，-Ar 2 -L 2 3 或-Ar 4 -L 3 -Ar 5 ; Ar 1 表示芳基或杂芳基; Ar 2表示芳基或单环杂芳基; Ar 3 表示芳基或杂芳基; Ar 4 表示双环杂芳基; Ar 5 表示芳基或杂芳基; L 2 表示结合，-O - ， - NR a - ，-CH 2 - 或-C（O）NR a - ; L3表示结合，-O-，-NR a - 或-CH 2 并且R a 表示氢或烷基。 版权所有（C）2013，JPO＆INPIT -
公开(公告)号：WO2008058096A9
公开(公告)日：2008-06-26
申请号：PCT/US2007083687
申请日：2007-11-06
Applicant: ABBOTT LAB , SCHRIMPF MICHAEL R , NERSESIAN DIANA L , SIPPY KEVIN B , JI JIANGUO , LI TAO , SCANIO MARC , SHI LEI , LEE CHIH-HUNG , BUNNELLE WILLAIM H , ZHANG GEOFF G Z , BRACKEMEYER PAUL J , CHEN SHUANG , HENRY RODGER F
Inventor： SCHRIMPF MICHAEL R , NERSESIAN DIANA L , SIPPY KEVIN B , JI JIANGUO , LI TAO , SCANIO MARC , SHI LEI , LEE CHIH-HUNG , BUNNELLE WILLAIM H , ZHANG GEOFF G Z , BRACKEMEYER PAUL J , CHEN SHUANG , HENRY RODGER F
IPC: C07D451/14 , A61K31/395
CPC classification number: C07D471/18 , A61K31/095 , A61K31/439 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K45/06 , C07C309/29 , C07D451/14 , C07D471/08 , C07F5/022
Abstract: The invention relates to compounds that are azaadamantane derivatives, particularly ether- or amine-substituted azaadamantane derivatives and salts and prodrugs thereof, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
Abstract translation: 本发明涉及作为氮杂金刚烷衍生物的化合物，特别是醚取代或胺取代的氮杂金刚烷衍生物及其盐和前体药物，包含这些化合物的组合物，使用这些化合物和组合物的方法，制备这些化合物的方法以及在此过程中获得的中间体 。
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3.发明申请[1,2,4]OXADIAZOL-3-YL ACID SALTS AND CRYSTALLINE FORMS AND THEIR PREPARATION 审中-公开[1,2,4] OXADIAZOL-3-YL酸盐和晶体形态及其制备
公开(公告)号：WO2012112841A3
公开(公告)日：2013-03-14
申请号：PCT/US2012025570
申请日：2012-02-17
Applicant: ABBOTT LAB , ZHANG GEOFF G , BRACKEMEYER PAUL J , CHEN SHAUNG , GORDON THOMAS D
Inventor： ZHANG GEOFF G , BRACKEMEYER PAUL J , CHEN SHAUNG , GORDON THOMAS D
CPC classification number: C07D413/04 , A61K31/4245 , A61K31/4439 , C07D271/06
Abstract: The present invention relates to salts and crystalline forms of [1,2,4]oxadiazol-3-yl]-phenoxy}-cycloalkyl carboxylic acids, processes for their preparation, pharmaceutical compositions comprising such compounds, and methods of using them.
Abstract translation: 本发明涉及[1,2,4]恶二唑-3-基] - 苯氧基} - 环烷基羧酸的盐和结晶形式，其制备方法，包含这些化合物的药物组合物及其使用方法。
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4.发明申请AZAADAMANTANE DERIVATIVES AND THEIR USES AS NICOTINIC ACETYLCHOLINE RECEPTORS LIGANDS 审中-公开亚胺丹衍生物及其作为NICOTINIC乙酰胆碱受体配体使用
公开(公告)号：WO2008058096A3
公开(公告)日：2008-08-07
申请号：PCT/US2007083687
申请日：2007-11-06
Applicant: ABBOTT LAB , SCHRIMPF MICHAEL R , NERSESIAN DIANA L , SIPPY KEVIN B , JI JIANGUO , LI TAO , SCANIO MARC , SHI LEI , LEE CHIH-HUNG , BUNNELLE WILLAIM H , ZHANG GEOFF G Z , BRACKEMEYER PAUL J , CHEN SHUANG , HENRY RODGER F
Inventor： SCHRIMPF MICHAEL R , NERSESIAN DIANA L , SIPPY KEVIN B , JI JIANGUO , LI TAO , SCANIO MARC , SHI LEI , LEE CHIH-HUNG , BUNNELLE WILLAIM H , ZHANG GEOFF G Z , BRACKEMEYER PAUL J , CHEN SHUANG , HENRY RODGER F
IPC: C07D451/14 , A61K31/395
CPC classification number: C07D471/18 , A61K31/095 , A61K31/439 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K45/06 , C07C309/29 , C07D451/14 , C07D471/08 , C07F5/022
Abstract: The invention relates to compounds that are azaadamantane derivatives of formula (I), particularly ether- or amine -substituted azaadamantane derivatives and salts and prodrugs thereof, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
Abstract translation: 本发明涉及作为式（I）的氮杂金刚烷衍生物的化合物，特别是醚或胺取代的氮杂金刚烷衍生物及其盐和前药，包含这些化合物的组合物，使用这些化合物和组合物的方法，制备这些化合物的方法和 在此过程中获得的中间体。
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公开(公告)号：CA2668962C
公开(公告)日：2016-05-03
申请号：CA2668962
申请日：2007-11-06
Applicant: ABBOTT LAB
Inventor： SCHRIMPF MICHAEL R , NERSESIAN DIANA L , SIPPY KEVIN B , JI JIANGUO , LI TAO , SCANIO MARC , SHI LEI , LEE CHIH-HUNG , BUNNELLE WILLIAM H , ZHANG GEOFF G Z , BRACKEMEYER PAUL J , CHEN SHUANG , HENRY RODGER F
IPC: C07D451/14 , A61K31/395
Abstract: The invention relates to compounds that are azaadamantane derivatives of formula (I), particularly ether- or amine -substituted azaadamantane derivatives and salts and prodrugs thereof, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
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Patent Agency Ranking6.发明专利
公开(公告)号：CA2771984A1
公开(公告)日：2011-03-24
申请号：CA2771984
申请日：2010-09-15
Applicant: ABBOTT LAB
Inventor： ZHANG GEOFF G Z , BRACKEMEYER PAUL J , CATRON NATHANIEL D , BORCHARDT THOMAS B
IPC: C07D295/155 , A61K31/5377 , A61P35/00
Abstract: ABT-263 free base and crystalline forms thereof are suitable active pharmaceutical ingredients for pharmaceutical compositions useful in treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.
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7.发明专利
公开(公告)号：ECSP099388A
公开(公告)日：2009-07-31
申请号：ECSP099388
申请日：2009-06-04
Applicant: ABBOTT LAB
Inventor： SCHRIMPF MICHAEL , JI JIANGUO , BUNNELLE WILLIAM H , SIPPY KEVIN B , HENRY RODGER F , ZHANG GEOFF G Z , LEE CHIH-HUNG , LI TAO , NERSESIAN DIANA L , SCANIO MARC , SHI LEI , BRACKEMEYER PAUL J , CHEN SHUANG
IPC: A61K31/395 , C07D451/14
Abstract: Compuestos que son derivados de azaadamantano, particularmente derivados de azaadamantano sustituidos con éter o amina, y sales y prodrogas de éstos, composiciones que comprenden estos compuestos, métodos para usar estos compuestos y composiciones, procesos para preparar estos compuestos, e intermediarios obtenidos durante estos procesos
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公开(公告)号：CR10743A
公开(公告)日：2009-06-05
申请号：CR10743
申请日：2009-04-23
Applicant: ABBOTT LAB
Inventor： SCHRIMPF MICHAEL R , NERSESIAN DIANA L , SIPPY KEVIN B , JI JIANJUO , LI TAO , SCANIO MARC , LEE CHIH-HUND , BUNNELLE WILLIAM H , ZHANG GEOFF G Z , BRACKEMEYER PAUL J , CHEN SHUANG , HENRY RODGER F
IPC: A61K31/395 , C07D451/14
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公开(公告)号：ZA200903944B
公开(公告)日：2016-08-31
申请号：ZA200903944
申请日：2009-06-05
Applicant: ABBOTT LAB
Inventor： BRACKEMEYER PAUL J , SHI LEI , SCANIO MARC , SIPPY KEVIN B , CHEN SHUANG , ZHANG GEOFF G Z , HENRY RODGER , NERSESIAN DIANA L , BUNNELLE WILLIAM H , SCHRIMPF MICHAEL R , LEE CHIH-HUNG , JI JIANGUO , LI TAO
Abstract: The invention relates to compounds that are azaadamantane derivatives, particularly ether- or amine-substituted azaadamantane derivatives and salts and prodrugs thereof, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
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公开(公告)号：BR112013005434A2
公开(公告)日：2016-06-07
申请号：BR112013005434
申请日：2011-09-21
Applicant: ABBOTT LAB
Inventor： ZHANG GEOFF G Z , NAPIER JAMES J , BRACKEMEYER PAUL J , CHEN SHUANG
IPC: C07D471/08 , A61K31/439 , A61P25/00 , A61P25/28
Abstract: novo mono-hidrato de derivados de aza-adamantano. a invenção referes-e a mono-hidrato cristalino de citrato dihidrogenado de (4s)-4-(5-fenil-1,3,4-tiadiazol-2-ilóxi)-1-azatriciclo[3,3,1,1^ 3,7^]decano, composições compreendendo tal compsto, e um processo para a preparação de tal composto.
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