公开(公告)号：WO0078773A3

公开(公告)日：2001-02-22

申请号：PCT/US0016579

申请日：2000-06-15

Applicant: ABBOTT LAB

Inventor： STONER ERIC J ,  PETERSON MATTHEW J ,  KU YI-YIN ,  CINK RUSSELL D ,  COOPER ARTHUR J ,  DESHPANDE MAHENDRA N ,  GRIEME TIM ,  HAIGHT ANTHONY R ,  HILL DAVID R ,  HSU MARGARET CHI-PING ,  KING STEVEN A ,  LEANNA MARVIN R ,  LEE ELAINE C ,  MCLAUGHLIN MAUREEN A ,  MORTON HOWARD E ,  NAPIER JAMES J ,  PLATA DANIEL J ,  RAJE PRASAD S ,  RASMUSSEN MICHAEL ,  RILEY DAVID ,  TIEN JIEN-HEH J ,  WITTENBERGER STEVEN J

IPC: A61P31/04 ,  C07B61/00 ,  C07H1/00 ,  C07H17/08 ,  A61K31/70

CPC classification number: C07H17/08

Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4"-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.

Abstract translation: 一方面，本发明涉及一种制备6-O-取代的红霉素衍生物的方法，包括在钯催化剂和膦存在下使2'-取代的和任选的4'-取代的9-肟红霉素衍生物与烷基化剂反应。 另一方面，本发明涉及使用钯催化的烷基化反应制备6-O-取代的红霉素酮内酯的方法。

公开(公告)号：MY169288A

公开(公告)日：2019-03-21

申请号：MYPI2011004471

申请日：2010-03-24

Applicant: ABBOTT LAB ,  ABBVIE BAHAMAS LTD

Inventor： NAPIER JAMES J ,  CALIFANO JEAN-CHRISTOPHE ,  BECKER CALVIN L ,  YU SU

Abstract: This invention is directed to: (a) processes for preparing a compound and salts thereof that, inter alia, are useful for inhibiting hepatitis C virus (HCV); (b) intermediates useful for the preparation of the compound and salts; (c) pharmaceutical compositions comprising the compound or salts; and (d) methods of use of such compositions.

公开(公告)号：RU2524573C2

公开(公告)日：2014-07-27

申请号：RU2011142757

申请日：2010-03-24

Applicant: ABBOTT LAB

Inventor： NAPIER JAMES J ,  CALIFANO JEAN-CHRISTOPHE ,  YU SU ,  BECKER CALVIN L

IPC: C07D239/54 ,  C07C311/08

Abstract: Изобретениеотноситсяк способуполучения (Е)-N-(4-(3-трет-бутил-5-(2,4-диоксо-3,4-дигидропиримидин-1(2H)-ил)-2-метокси-стирил)фенил) метансульфонамида (соединение I) илиегосоли, включающий: восстановление N-(4-((3-трет-бутил-5-(2,4-диоксо-3,4-дигидропиримидин-1(2H)-ил)-2-метоксифенил)этинил)фенил)-метансульфонамида (соединение 6) сиспользованиемпокрайнеймереодноговосстанавливающегоагента, выбранногоизгруппы, состоящейизисточникаводорода, силанаи дисилана, вприсутствиипокрайнеймереодногокатализатора, основанияилирастворителя. Такжеизобретениеотноситсяк промежуточнымсоединениям, применимымдляполучениясоединения I иегосолей. Техническийрезультат: разработанновыйспособполучениясоединения I, полезногоприлечениивирусагепатитаС. 4 н. и 15 з.п. ф-лы. 8 пр.

公开(公告)号：ECSP11011415A

公开(公告)日：2011-11-30

申请号：ECSP11011415

申请日：2011-08-24

Applicant: ABBOTT LAB

Inventor： CALIFANO JEAN C ,  NAPIER JAMES J

IPC: C07D239/54 ,  C07D311/08

Abstract: Objeto de la presente invención son compuestos novedosos sustituidos de la fórmula 1,en la que A, R1, R2, R3 y R4 se definen como en la descripción. Otro objeto de la presente invención es proporcionar antagonistas de CCR3, más particularmente proporcionar composiciones farmacéuticas que comprenden un vehículo farmacéuticamente aceptable y una cantidad terapéuticamente eficaz de al menos uno de los compuestos de la presente invención o una sal farmacéuticamente aceptable del mismo.

公开(公告)号：SG174211A1

公开(公告)日：2011-10-28

申请号：SG2011063179

申请日：2010-03-24

Applicant: ABBOTT LAB

Inventor： NAPIER JAMES J ,  CALIFANO JEAN-CHRISTOPHE ,  BECKER CALVIN L ,  YU SU

Abstract: This invention is directed to: (a) processes for preparing a compound and salts thereof that, inter alia, are useful for inhibiting hepatitis C virus (HCV); (b) intermediates useful for the preparation of the compound and salts; (c) pharmaceutical compositions comprising the compound or salts; and (d) methods of use of such compositions.

公开(公告)号：AU2010229975A1

公开(公告)日：2011-09-29

申请号：AU2010229975

申请日：2010-03-24

Applicant: ABBOTT LAB

Inventor： NAPIER JAMES J ,  CALIFANO JEAN-CHRISTOPHE ,  YU SU ,  BECKER CALVIN L

IPC: C07D239/54 ,  C07D311/08

Abstract: This invention is directed to: (a) processes for preparing a compound and salts thereof that,, are useful for inhibiting hepatitis C virus (HCV); (b) intermediates useful for the preparation of the compound and salts; (c) pharmaceutical compositions comprising the compound or salts; and (d) methods of use of such compositions.

公开(公告)号：CA2753825A1

公开(公告)日：2010-09-30

申请号：CA2753825

申请日：2010-03-24

Applicant: ABBOTT LAB

Inventor： NAPIER JAMES J ,  CALIFANO JEAN-CHRISTOPHE ,  YU SU ,  BECKER CALVIN L

IPC: C07D239/54 ,  C07D311/08

Abstract: This invention is directed to: (a) processes for preparing a compound and salts thereof that, inter alia, are useful for inhibiting hepatitis C virus (HCV); (b) intermediates useful for the preparation of the compound and salts; (c) pharmaceutical compositions comprising the compound or salts; and (d) methods of use of such compositions.

公开(公告)号：CA2375364C

公开(公告)日：2008-11-25

申请号：CA2375364

申请日：2000-06-15

Applicant: ABBOTT LAB

Inventor： MCLAUGHLIN MAUREEN A ,  HAIGHT ANTHONY R ,  MORTON HOWARD E ,  PETERSON MATTHEW J ,  GRIEME TIM ,  RILEY DAVID ,  DESHPANDE MAHENDRA N ,  WITTENBERGER STEVEN J ,  NAPIER JAMES J ,  TIEN JIEN-HEH J ,  RAJE PRASAD S ,  PLATA DANIEL J ,  KU YI-YIN ,  CINK RUSSELL D ,  COOPER ARTHUR J ,  KING STEVEN A ,  RASMUSSEN MICHAEL ,  STONER ERIC J ,  HSU MARGARET CHI-PING ,  LEE ELAINE C ,  LEANNA MARVIN R ,  HILL DAVID R

IPC: C07H17/08 ,  A61K31/7048 ,  A61P31/04 ,  C07B61/00 ,  C07H1/00

Abstract: In one aspect, the invention relates to a process for preparing 6-O- substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4"-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates t o processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.

公开(公告)号：NZ594923A

公开(公告)日：2013-11-29

申请号：NZ59492310

申请日：2010-03-24

Applicant: ABBOTT LAB

Inventor： BECKER CALVIN L ,  YU SU ,  NAPIER JAMES J

IPC: C07D239/54 ,  A61K31/513 ,  C07C311/08

Abstract: 594923 Provided are processes for preparing (E)-N-(4-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydro- pyrimidin-1(2H)-yl)-2-methoxystyryl)phenyl)methanesulfonamide) and salts thereof. The compound and its salts can act as antivirals that inhibit hepatitis C virus (HCV). Also provided are intermediates that can be used in the preparation of the compound and its salts, pharmaceutical compositions comprising them and methods of use of such compositions.

公开(公告)号：AR083100A1

公开(公告)日：2013-01-30

申请号：ARP110103496

申请日：2011-09-23

Applicant: ABBOTT LAB

Inventor： CHEN SHUANG ,  NAPIER JAMES J ,  ZHANG GEOGG G Z ,  BRACKEMEYER PAUL J

IPC: C07D471/08 ,  A61K31/439 ,  A61P25/00 ,  A61P25/28

Abstract: Forma cristalina monohidrato del citrato diácido de (4s)-4-(5-fenil-1,3,4-tiadiazol-2-iloxi)-1-azatriciclo[3.3.1.13,7]decano, composiciones que comprenden dicho compuesto y un proceso para preparar el compuesto.Reivindicación 1: Una forma cristalina monohidrato del citrato diácido de (4s)-4-(5-fenil-1,3,4-tiadiazol-2-iloxi)-1-azatriciclo[3.3.1.13,7]decano, caracterizada porque el (4s)-4-(5-fenil-1,3,4-tiadiazol-2-iloxi)-1-azatriciclo[3.3.1.13,7]decano está representada por la fórmula (1) y en donde el citrato diácido está representado por la fórmula (2).