公开(公告)号：AT554071T

公开(公告)日：2012-05-15

申请号：AT00942823

申请日：2000-06-15

Applicant: ABBOTT LAB

Inventor： ALLEN MICHAEL ,  PREMCHANDRAN RAMIYA ,  CHANG SOU-JEN ,  CONDON STEPHEN ,  DEMATTEI JOHN ,  KING STEVEN ,  KOLACZKOWSKI LAWRENCE ,  MANNA SUKUMAR ,  NICHOLS PAUL J ,  PATEL HEMANT ,  PATEL SUBHASH ,  PLATA DANIEL ,  STONER ERIC ,  TIEN JIEN-HEH ,  WITTENBERGER STEVEN

IPC: C07D215/14 ,  C07C33/03 ,  C07C43/303 ,  C07C47/22 ,  C07C68/06 ,  C07C69/96 ,  C07C269/06 ,  C07C271/12 ,  C07D215/18 ,  C07D401/12 ,  C07H17/08

Abstract: The invention relates to a process for preparing carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or a substrate that can be reduced to obtain the same. €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒR 1 -CH=CHCH 2 OC(O)-X-R 2 €ƒ€ƒ€ƒ€ƒ€ƒ(I)

公开(公告)号：ES2385963T3

公开(公告)日：2012-08-06

申请号：ES00942823

申请日：2000-06-15

Applicant: ABBOTT LAB

Inventor： ALLEN MICHAEL ,  PREMCHANDRAN RAMIYA ,  CHANG SOU-JEN ,  CONDON STEPHEN ,  DEMATTEI JOHN ,  KING STEVEN ,  KOLACZKOWSKI LAWRENCE ,  MANNA SUKUMAR ,  NICHOLS PAUL J ,  PATEL HEMANT ,  PATEL SUBHASH ,  PLATA DANIEL ,  STONER ERIC ,  TIEN JIEN-HEH ,  WITTENBERGER STEVEN

IPC: C07D215/14 ,  C07C33/03 ,  C07C43/303 ,  C07C47/22 ,  C07C57/04 ,  C07C68/06 ,  C07C69/96 ,  C07C269/06 ,  C07C271/12 ,  C07D215/18 ,  C07D401/12 ,  C07H17/08

Abstract: Un procedimiento de preparación de un compuesto de fórmulaR1-CH>=CHCH2OC(O)-X-R2 (I),dondeR1 es quinolilo eventualmente substituido con uno o más de:(i) alquilo,(ii) alcoxi,(iii) arilo,(iv) nitro y(v) halo;R2 es alquilo C1-C10;X es -O- o -NR3; yR3 es hidrógeno, alquilo C1-C6 o arilo; o R2 y R3, tomados conjuntamente, forman un anillo aromático o noaromático, que comprende las etapas de:(a) preparación de un intermediario seleccionado entre:(i) R1-CºCCH2OR4, donde R4 es hidrógeno o un grupo hidroxi-protector;(ii) R1-CºC-CH2-OC(O)-X-R2;(b) reducción o desprotección de un intermediario obtenido en la etapa (a); y(c) copulación eventual del compuesto obtenido en la etapa (b) con un reactivo acilante.

公开(公告)号：DE69420421T2

公开(公告)日：2000-05-04

申请号：DE69420421

申请日：1994-09-26

Applicant: ABBOTT LAB

Inventor： STUK TIMOTHY ,  KERDESKY FRANCIS ,  LIJEWSKI-LINCH LINDA M ,  NORBECK DANIEL ,  SCARPETTI DAVID ,  TIEN JIEN-HEH ,  ALLEN MICHAEL ,  LANGRIDGE DENTON ,  MELCHER LAURA ,  RENO DANIEL ,  SHAM HING ,  ZHAO CHEN ,  HAIGHT ANTHONY ,  LEANNA M ,  MORTON HOWARD ,  ROBBINS TIMOTHY ,  SOWIN THOMAS

IPC: C07C213/00 ,  C07C215/28 ,  C07C225/16 ,  C07C227/18 ,  C07C229/36 ,  C07C231/12 ,  C07C233/35 ,  C07C251/40 ,  C07C255/27 ,  C07C255/42 ,  C07C269/06 ,  C07C271/20 ,  C07D209/44 ,  C07D221/14

Abstract: Processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy, and halo; or R6 is as defined above and R7 is R7aOC (O)- wherein R7a is loweralkyl or benzyl; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen, and trifluoromethyl and R8 is hydrogen or -C(O)R'' wherein R'' is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.

公开(公告)号：DE69420421D1

公开(公告)日：1999-10-07

申请号：DE69420421

申请日：1994-09-26

Applicant: ABBOTT LAB

Inventor： STUK TIMOTHY ,  KERDESKY FRANCIS ,  LIJEWSKI LINDA ,  NORBECK DANIEL ,  SCARPETTI DAVID ,  TIEN JIEN-HEH ,  ALLEN MICHAEL ,  LANGRIDGE DENTON ,  MELCHER LAURA ,  RENO DANIEL ,  SHAM HING ,  ZHAO CHEN ,  HAIGHT ANTHONY ,  LEANNA M ,  MORTON HOWARD ,  ROBBINS TIMOTHY ,  SOWIN THOMAS

IPC: C07C213/00 ,  C07C215/28 ,  C07C225/16 ,  C07C227/18 ,  C07C229/36 ,  C07C231/12 ,  C07C233/35 ,  C07C251/40 ,  C07C255/27 ,  C07C255/42 ,  C07C269/06 ,  C07C271/20 ,  C07D209/44 ,  C07D221/14

Abstract: Processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy, and halo; or R6 is as defined above and R7 is R7aOC (O)- wherein R7a is loweralkyl or benzyl; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen, and trifluoromethyl and R8 is hydrogen or -C(O)R'' wherein R'' is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.