公开(公告)号：JP2012137501A

公开(公告)日：2012-07-19

申请号：JP2012083533

申请日：2012-04-02

Applicant: Abbott Lab ,  アボット・ラボラトリーズAbbott Laboratories

Inventor： SAFAR SCOTT G ,  CHARLES M GEARLITZ ,  HERCHENBACH STEPHEN L ,  CHADWICK M DANN ,  MCDOWELL LARRY L

IPC: C12N15/09 ,  G01N35/02 ,  B01L3/14 ,  B01L9/06 ,  B03C1/00 ,  B03C1/02 ,  C12M1/00 ,  C12M1/26 ,  G01N35/00 ,  G01N35/10

CPC classification number: B01L3/5085 ,  B01D35/06 ,  B01L3/5082 ,  B01L9/06 ,  B01L2300/0848 ,  B03C1/02 ,  B03C1/0332 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  G01N35/0098 ,  G01N2035/00564 ,  G01N2035/103 ,  Y10S436/809 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: PROBLEM TO BE SOLVED: To provide a structure and method for handling magnetic particles in biological assays.SOLUTION: A magnetic handling structure 1a comprising a retractable magnet 4 and a probe 3 for manipulation of magnetic particles in biological samples and methods of handling magnetic particles in biological samples are provided.

Abstract translation: 要解决的问题：提供在生物测定中处理磁性颗粒的结构和方法。 解决方案：提供一种磁性处理结构1a，其包括可伸缩磁体4和用于操纵生物样品中的磁性颗粒的探针3和处理生物样品中的磁性颗粒的方法。 版权所有（C）2012，JPO＆INPIT

公开(公告)号：JP2009229470A

公开(公告)日：2009-10-08

申请号：JP2009160190

申请日：2009-07-06

Applicant: Abbott Lab ,  アボット・ラボラトリーズAbbott Laboratories

Inventor： SAFAR SCOTT G ,  GALITZ CHARLES M ,  HERCHENBACH STEPHEN L ,  DUNN CHADWICK M ,  MCDOWELL LARRY L

IPC: C12N15/09 ,  G01N35/02 ,  B01L3/14 ,  B01L9/06 ,  B03C1/00 ,  B03C1/02 ,  C12M1/00 ,  C12M1/26 ,  G01N35/00 ,  G01N35/10

CPC classification number: B01L3/5085 ,  B01D35/06 ,  B01L3/5082 ,  B01L9/06 ,  B01L2300/0848 ,  B03C1/02 ,  B03C1/0332 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  G01N35/0098 ,  G01N2035/00564 ,  G01N2035/103 ,  Y10S436/809 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: PROBLEM TO BE SOLVED: To provide a structure and method for handling magnetic particles in bioassay. SOLUTION: A magnetic handling structure 1a includes a retractable magnet 4 and a probe 3 for the manipulation of magnetic particles in a biological sample, and a method is provided for handling the magnetic particles in the biological sample. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：提供在生物测定中处理磁性颗粒的结构和方法。 解决方案：磁性处理结构1a包括可伸缩磁体4和用于操纵生物样品中的磁性颗粒的探针3，并且提供了用于处理生物样品中的磁性颗粒的方法。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：WO0155708A3

公开(公告)日：2002-05-02

申请号：PCT/US0102895

申请日：2001-01-29

Applicant: ABBOTT LAB

Inventor： GUNDLING GERARD J ,  KUKLA RONALD E ,  SAFAR SCOTT G

IPC: G01N35/00 ,  B01L7/00 ,  C12M1/00 ,  C12N15/09 ,  C12Q1/68 ,  G01N33/48 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

CPC classification number: G01N35/02 ,  B01L7/52 ,  G01N35/0098 ,  G01N35/0099 ,  G01N35/021 ,  G01N35/025 ,  G01N35/1065 ,  G01N35/109 ,  G01N2035/00366 ,  G01N2035/00524 ,  G01N2035/0408 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/103

Abstract: Embodiments described herein provide methods of processing a sample containing at least one biological element. In one method, a first conductor and a second conductor are introduced into or located adjacent the sample. A voltage is applied between the first conductor and the second conductor. The voltage is adjusted to reduce an ability of the at least one biological element to be amplified or detected in a PCT reaction process, such that the biological element is removed from a binding member, and/or to unzip the at least one biological element.

Abstract translation: 本文所述的实施方案提供了处理含有至少一种生物元素的样品的方法。 在一种方法中，将第一导体和第二导体引入或位于样品附近。 在第一导体和第二导体之间施加电压。 调节电压以降低在PCT反应过程中放大或检测至少一种生物元件的能力，使得生物元件从结合构件中移出和/或解压缩至少一种生物元件。

公开(公告)号：EP1499415A4

公开(公告)日：2009-10-28

申请号：EP03719947

申请日：2003-04-25

Applicant: ABBOTT LAB

Inventor： SAFAR SCOTT G ,  GALITZ CHARLES M ,  HERCHENBACH STEPHEN L ,  DUNN CHADWICK M ,  MCDOWELL LARRY L

IPC: C12N15/09 ,  B01L3/14 ,  B01L9/06 ,  B03C1/00 ,  B03C1/02 ,  C12M1/00 ,  C12M1/26 ,  G01N35/00 ,  B01D35/06 ,  G01N33/553 ,  G01N35/02 ,  G01N35/10

CPC classification number: B01L3/5085 ,  B01D35/06 ,  B01L3/5082 ,  B01L9/06 ,  B01L2300/0848 ,  B03C1/02 ,  B03C1/0332 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  G01N35/0098 ,  G01N2035/00564 ,  G01N2035/103 ,  Y10S436/809 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: Magnetic handling structure (1a) comprising a retractable magnet (4) and a probe (3) for the manipulation of magnetic particles in biological samples and methods of handling magnetic particles in biological samples.

Abstract translation: 磁性处理结构（1a）包括用于操纵生物样品中的磁性颗粒的可伸缩磁体（4）和探针（3）和处理生物样品中的磁性颗粒的方法。

公开(公告)号：CA2346951C

公开(公告)日：2008-12-23

申请号：CA2346951

申请日：1999-10-12

Applicant: ABBOTT LAB

Inventor： GRAY ROBERT C ,  BACH MARK C ,  PEPE CURTIS J ,  DAHLKE DANIEL G ,  BAY DANIEL ,  HERCHENBACH STEVE ,  HALAKA FOLIM ,  ZUCK GARY ,  GALITZ CHARLES M ,  PIERCE MARK ,  SAFAR SCOTT G ,  CARTER MICHAEL K ,  TOTH JULIUS ,  CLEMENS JOHN M ,  KUKLA RONALD E

IPC: G01N35/00 ,  G01N35/02 ,  B01L7/00 ,  C12M1/38 ,  C12M1/40 ,  C12N15/10 ,  C12P19/34 ,  C12Q1/68

Abstract: A method of performing a determination of an item of interest in a sample using a single structure is disclosed. A sample is provided accesssible to the single structure. A first container for processing the sample is placed in a first process path on the single structure. The sample is transferred to the first container in the first process path. A reagent is added to the first container in the first process path. Contents of the first container is mixed in the first process path. The item of interest in the sample is separated from the contents of the first container in the first process path. The separated item of interest in the sample is transferred from the first container in the first process path to a second container in a second process path on the single structure. Contents of the second container are brought to a first temperature different from a temperature of the first process path in the second process path. The item of interest in the second container is detected in the second process path.

公开(公告)号：CA2394411A1

公开(公告)日：2001-08-02

申请号：CA2394411

申请日：2001-01-29

Applicant: ABBOTT LAB

Inventor： SAFAR SCOTT G ,  GUNDLING GERARD J ,  KUKLA RONALD E

IPC: G01N35/00 ,  B01L7/00 ,  C12M1/00 ,  C12N15/09 ,  C12Q1/68 ,  G01N33/48 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

Abstract: Embodiments described herein provide methods of processing a sample containi ng at least one biological element. In one method, a first conductor and a seco nd conductor are introduced into or located adjacent the sample. A voltage is applied between the first conductor and the second conductor. The voltage is adjusted to reduce an ability of the at least one biological element to be amplified or detected in a PCT reaction process, such that the biological element is removed from a binding member, and/or to unzip the at least one biological element.

公开(公告)号：CA2483445C

公开(公告)日：2011-04-19

申请号：CA2483445

申请日：2003-04-25

Applicant: ABBOTT LAB

Inventor： SAFAR SCOTT G ,  GALITZ CHARLES M ,  HERCHENBACH STEPHEN L ,  DUNN CHADWICK M ,  MCDOWELL LARRY L

IPC: B01D35/06 ,  C12N15/09 ,  B01L3/14 ,  B01L9/06 ,  B03C1/00 ,  B03C1/02 ,  C12M1/00 ,  C12M1/26 ,  G01N33/553 ,  G01N35/00 ,  G01N35/02

Abstract: Magnetic handling structure (1a) comprising a retractable magnet (4) and a probe (3) for the manipulation of magnetic particles in biological samples and methods of handling magnetic particles in biological samples.

公开(公告)号：CA2289560C

公开(公告)日：2003-11-18

申请号：CA2289560

申请日：1998-05-01

Applicant: ABBOTT LAB

Inventor： SAFAR SCOTT G ,  KIMLER KIRK M ,  CLOONAN KEVIN M ,  HANAGAN TED J

IPC: B65D85/00 ,  B01L3/14 ,  B01L9/06 ,  B65D21/02 ,  B65D77/04

Abstract: Embodiments of a container for holding an item are diclosed. In one embodiment, the container comprises an open end, a closed end and a shank connecting the open end with the closed end. A flange extends from the open end. The flange has a configuration which supports the container in an intended relationship with respect to a relatively large tube, a relatively small tube or a carrier.

公开(公告)号：AT348660T

公开(公告)日：2007-01-15

申请号：AT99951904

申请日：1999-10-12

Applicant: ABBOTT LAB

Inventor： BACH MARK C ,  BAY DANIEL ,  CARTER MICHAEL K ,  CLEMENS JOHN M ,  DAHLKE DANIEL G ,  GALITZ CHARLES M ,  GRAY ROBERT C ,  HALAKA FOLIM ,  HERCHENBACH STEVE ,  KUKLA RONALD E ,  PEPE CURTIS J ,  PIERCE MARK ,  SAFAR SCOTT G ,  TOTH JULIUS ,  ZUCK GARY

IPC: G01N35/00 ,  B01L7/00 ,  G01N35/02

Abstract: A method of performing a determination of an item of interest in a sample using a single structure is disclosed. A sample is provided accessible to the single structure. A first container for processing the sample is placed in a first process path on the single structure. The sample is transferred to the first container in the first process path. A reagent is added to the first container in the first process path. Contents of the first container is mixed in the first process path. The item of interest in the sample is separated from the contents of the first container in the first process path. The separated item of interest in the sample is transferred from the first container in the first process path to a second container in a second process path on the single structure. Contents of the second container is brought to a first temperature different from a temperature of the first process path in the second process path. The item of interest in the second container is detected in the second process path.

公开(公告)号：CA2483445A1

公开(公告)日：2003-11-06

申请号：CA2483445

申请日：2003-04-25

Applicant: ABBOTT LAB

Inventor： GALITZ CHARLES M ,  MCDOWELL LARRY L ,  DUNN CHADWICK M ,  HERCHENBACH STEPHEN L ,  SAFAR SCOTT G

IPC: C12N15/09 ,  B01L3/14 ,  B01L9/06 ,  B03C1/00 ,  B03C1/02 ,  C12M1/00 ,  C12M1/26 ,  G01N35/00 ,  B01D35/06 ,  G01N35/02 ,  G01N33/553

Abstract: Magnetic handling structure (1a) comprising a retractable magnet (4) and a probe (3) for the manipulation of magnetic particles in biological samples a nd methods of handling magnetic particles in biological samples.