公开(公告)号：BG63975B1

公开(公告)日：2003-08-29

申请号：BG10355399

申请日：1999-07-05

Applicant: ABBOTT LAB

Inventor： MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  BASHA FATIMA ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F ,  WENDT MICHAEL D ,  HAIGHT ANTHONY R ,  ZHANG WEIJIANG

IPC: A61K31/517 ,  A61K31/519 ,  A61P13/08 ,  A61P13/10 ,  A61P15/04 ,  A61P43/00 ,  C07D207/26 ,  C07D311/58 ,  C07D491/04 ,  C07D491/052 ,  C07D495/04 ,  C07D519/00 ,  A61K31/415

Abstract: The invention relates to alpha-1 adrenergic antagonists, to alpha -1 antagonistic compositions and to a method for the antagonization of alpha-1 adrenoreceptors applicable for the treatment of benignant hyperplasia of the prostate gland (BPH). The compound and its pharmaceutically aceeptable salts have the general formula where W means bicyclic heterocyclic ring system. 54 claims

公开(公告)号：ES2168682T3

公开(公告)日：2002-06-16

申请号：ES97951555

申请日：1997-12-04

Applicant: ABBOTT LAB

Inventor： MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  BASHA FATIMA ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F

IPC: A61K31/517 ,  A61K31/519 ,  A61P13/08 ,  A61P13/10 ,  A61P15/04 ,  A61P43/00 ,  C07D207/26 ,  C07D311/58 ,  C07D491/04 ,  C07D491/052 ,  C07D495/04 ,  C07D519/00 ,  A61K31/415

Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 adrenoreceptors and treating BPH.

公开(公告)号：BR9713682A

公开(公告)日：2000-03-28

申请号：BR9713682

申请日：1997-12-04

Applicant: ABBOTT LAB

Inventor： MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  BASHA FATIMA ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F ,  WENDT MICHAEL D ,  HAIGHT ANTHONY R ,  ZHANG WEIJIANG

IPC: A61K31/415 ,  C07D491/04

公开(公告)号：CZ194499A3

公开(公告)日：1999-11-17

申请号：CZ194499

申请日：1997-12-04

Applicant: ABBOTT LAB

Inventor： MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  BASHA FATIMA ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F ,  WENDT MICHAEL D ,  HAIGHT ANTHONY R ,  ZHANGH WEIJIANG

IPC: A61K31/517 ,  A61K31/519 ,  A61P13/08 ,  A61P13/10 ,  A61P15/04 ,  A61P43/00 ,  C07D207/26 ,  C07D311/58 ,  C07D491/04 ,  C07D491/052 ,  C07D495/04 ,  C07D519/00 ,  A61K31/415

Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 adrenoreceptors and treating BPH.

公开(公告)号：SK283580B6

公开(公告)日：2003-09-11

申请号：SK71799

申请日：1997-12-04

Applicant: ABBOTT LAB

Inventor： MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  BASHA FATIMA ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F ,  WENDT MICHAEL D ,  HAIGHT ANTHONY R ,  ZHANG WEIJIANG

IPC: A61K31/517 ,  A61K31/519 ,  A61P13/08 ,  A61P13/10 ,  A61P15/04 ,  A61P43/00 ,  C07D207/26 ,  C07D311/58 ,  C07D491/04 ,  C07D491/052 ,  C07D495/04 ,  C07D519/00 ,  A61K31/415

Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are 'alpha'-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are 'alpha'-1 antagonist compositions and a method for antagonising 'alpha'-1 adrenoreceptors and treating BPH.

公开(公告)号：PT942911E

公开(公告)日：2002-04-29

申请号：PT97951555

申请日：1997-12-04

Applicant: ABBOTT LAB

Inventor： ALTENBACH ROBERT J ,  BASHA FATIMA ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F ,  WENDT MICHAEL D ,  HAIGHT ANTHONY R ,  MEYER MICHAEL D ,  ZHANG WEIJIANG

IPC: A61K31/517 ,  A61K31/519 ,  A61P13/08 ,  A61P13/10 ,  A61P15/04 ,  A61P43/00 ,  C07D207/26 ,  C07D311/58 ,  C07D491/04 ,  C07D491/052 ,  C07D495/04 ,  C07D519/00 ,  A61K31/415

Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 adrenoreceptors and treating BPH.

公开(公告)号：NO20005570D0

公开(公告)日：2000-11-03

申请号：NO20005570

申请日：2000-11-03

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  CHEN YIYUAN ,  DRIZIN IRENE ,  KERWIN JAMES F ,  MOORE JIMMIE L

IPC: A61K31/435 ,  A61P9/12 ,  A61P11/06 ,  A61P13/00 ,  A61P15/10 ,  A61P25/08 ,  A61P25/28 ,  C07C45/29 ,  C07D221/04 ,  C07D221/06 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D

Abstract: Compounds of formula Iare useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

公开(公告)号：CA2330541A1

公开(公告)日：2000-09-08

申请号：CA2330541

申请日：2000-03-06

Applicant: ABBOTT LAB

Inventor： CHEN YIYUAN ,  DRIZIN IRENE ,  MOORE JIMMIE L ,  KERWIN JAMES F ,  CARROLL WILLIAM A

IPC: A61K31/435 ,  A61P9/12 ,  A61P11/06 ,  A61P13/00 ,  A61P15/10 ,  A61P25/08 ,  A61P25/28 ,  C07C45/29 ,  C07D221/04 ,  C07D221/06 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D211/82 ,  C07D215/20 ,  A61K31/473 ,  C07D211/90

Abstract: Compounds of formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

公开(公告)号：NO992661L

公开(公告)日：1999-07-30

申请号：NO992661

申请日：1999-06-02

Applicant: ABBOTT LAB

Inventor： MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  BASHA FATIMA ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F ,  WENDT MICHAEL D ,  HAIGHT ANTHONY R ,  ZHANG WEIJIANG

IPC: A61K31/517 ,  A61K31/519 ,  A61P13/08 ,  A61P13/10 ,  A61P15/04 ,  A61P43/00 ,  C07D207/26 ,  C07D311/58 ,  C07D491/04 ,  C07D491/052 ,  C07D495/04 ,  C07D519/00 ,  C07D311/00 ,  C07D209/00 ,  A61K31/415

Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 adrenoreceptors and treating BPH.

公开(公告)号：ZA9710926B

公开(公告)日：1998-09-16

申请号：ZA9710926

申请日：1997-12-04

Applicant: ABBOTT LAB

Inventor： MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  BASHA FATIMA ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F ,  WENDT MICHAEL D ,  HAIGHT ANTHONY R ,  ZHANG WEIJTANG

IPC: C07D491/04 ,  C07D ,  A61K

Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 adrenoreceptors and tr