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公开(公告)号：WO9834917A3
公开(公告)日：1999-01-14
申请号：PCT/US9802439
申请日：1998-02-06
Applicant: ABBOTT LAB
Inventor： LEANNA M ROBERT , HANNICK STEVEN M , RASMUSSEN MICHAEL , TIEN JIEN-HEH J , BHAGAVATULA LAKSHMI , SINGAM PULLA REDDY , GATES BRADLEY D , KOLACZKOWSKI LAWRENCE , PATEL RAMESH R , WAYNE GREG , LANNOYE GREG , ZHANG WEIJIANG , TIAN ZHENPING , LUKIN KIRILL L , NARAYANAN BIKSHANDARKOR A , RILEY DAVID A , MORTON HOWARD , CHANG SOU-JEN
IPC: C12P7/62 , A61K31/52 , A61P31/12 , A61P31/18 , A61P31/22 , C07C69/16 , C07C309/73 , C07D473/18 , C07D473/40 , C07D73/00
CPC classification number: C07D473/18
Abstract: Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of formula (I) where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a -C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acceptable salt thereof.
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公开(公告)号：DK0942911T3
公开(公告)日：2002-12-02
申请号：DK97951555
申请日：1997-12-04
Applicant: ABBOTT LAB
Inventor： MEYER MICHAEL D , ALTENBACH ROBERT J , BASHA FATIMA , CARROLL WILLIAM A , DRIZIN IRENE , KERWIN JAMES F , HAIGHT ANTHONY R , ZHANG WEIJIANG , WENDT MICHAEL D
IPC: A61K31/517 , A61K31/519 , A61P13/08 , A61P13/10 , A61P15/04 , A61P43/00 , C07D207/26 , C07D311/58 , C07D491/04 , C07D491/052 , C07D495/04 , C07D519/00 , A61K31/415
Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 adrenoreceptors and treating BPH.
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公开(公告)号：BG103553A
公开(公告)日：2000-06-30
申请号：BG10355399
申请日：1999-07-05
Applicant: ABBOTT LAB
Inventor： MEYER MICHAEL D , ALTENBACH ROBERT J , BASHA FATIMA , CARROLL WILLIAM A , DRIZIN IRENE , KERWIN JAMES F , WENDT MICHAEL D , HAIGHT ANTHONY R , ZHANG WEIJIANG
IPC: A61K31/517 , A61K31/519 , A61P13/08 , A61P13/10 , A61P15/04 , A61P43/00 , C07D207/26 , C07D311/58 , C07D491/04 , C07D491/052 , C07D495/04 , C07D519/00 , A61K31/415
Abstract: The invention relates to alpha-1 adrenergic antagonists, to alpha-1 antagonistic compositions and to a method for the antagonization of alpha-1 adrenoreceptors applicable for the treatment of benignant hyperplasia of the prostate gland (BPH). The compound and its pharmaceutically aceeptable salts have the general formula where W means bicyclic heterocyclic ring system. 54 claims
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公开(公告)号：NO992661D0
公开(公告)日：1999-06-02
申请号：NO992661
申请日：1999-06-02
Applicant: ABBOTT LAB
Inventor： MEYER MICHAEL D , ALTENBACH ROBERT J , BASHA FATIMA , CARROLL WILLIAM A , DRIZIN IRENE , KERWIN JAMES F , WENDT MICHAEL D , HAIGHT ANTHONY R , ZHANG WEIJIANG
IPC: A61K31/517 , A61K31/519 , A61P13/08 , A61P13/10 , A61P15/04 , A61P43/00 , C07D207/26 , C07D311/58 , C07D491/04 , C07D491/052 , C07D495/04 , C07D519/00 , C07D
Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 adrenoreceptors and treating BPH.
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公开(公告)号：CA2305770A1
公开(公告)日：1999-04-22
申请号：CA2305770
申请日：1998-10-08
Applicant: ABBOTT LAB
Inventor： ZHANG WEIJIANG
IPC: C07D295/02 , C07D241/24 , C07D241/26 , C07D295/03 , C07D295/12 , C07D295/125
Abstract: The present invention relates to novel intermediate, processes, and novel pyrazine compounds which are ultimately useful in the preparation of chemicals and pharmaceuticals.
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Patent Agency Ranking
公开(公告)号：HK1064390A1
公开(公告)日：2005-01-28
申请号：HK04107052
申请日：2004-09-15
Applicant: ABBOTT LAB
Inventor： ZHANG WEIJIANG , HSU MARGARET CHI-PING , HAIGHT ANTHONY R , PETERSON MATTHEW JOHN , NARAYANAN BIKSHANDARKOIL A
IPC: A61K31/7048 , A61P31/04 , C07B61/00 , C07H17/08 , C07H
Abstract: An efficient arylation technique for use in the synthesis of erythromycin derivatives, involving a modified Heck reaction which employs less than six mole percent of palladium catalyst and no phosphine is disclosed. With this modified Heck reaction, an O-alkenylaryl macrolide can be obtained in a much shorter reaction time than under conventional Heck reaction conditions. The modified Heck reaction can be utilized in a method for phosphine-free arylation of an O-allylic erythromycin derivative, in a method for preparing an O-alkenylaryl erythromycin A derivative, or in a method for preparing a 2', 4''-hydroxyl protected 6-O-alkenylaryl erythromycin A derivative.
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公开(公告)号：BG63975B1
公开(公告)日：2003-08-29
申请号：BG10355399
申请日：1999-07-05
Applicant: ABBOTT LAB
Inventor： MEYER MICHAEL D , ALTENBACH ROBERT J , BASHA FATIMA , CARROLL WILLIAM A , DRIZIN IRENE , KERWIN JAMES F , WENDT MICHAEL D , HAIGHT ANTHONY R , ZHANG WEIJIANG
IPC: A61K31/517 , A61K31/519 , A61P13/08 , A61P13/10 , A61P15/04 , A61P43/00 , C07D207/26 , C07D311/58 , C07D491/04 , C07D491/052 , C07D495/04 , C07D519/00 , A61K31/415
Abstract: The invention relates to alpha-1 adrenergic antagonists, to alpha -1 antagonistic compositions and to a method for the antagonization of alpha-1 adrenoreceptors applicable for the treatment of benignant hyperplasia of the prostate gland (BPH). The compound and its pharmaceutically aceeptable salts have the general formula where W means bicyclic heterocyclic ring system. 54 claims
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公开(公告)号：DE69707497T2
公开(公告)日：2002-07-11
申请号：DE69707497
申请日：1997-12-04
Applicant: ABBOTT LAB
Inventor： MEYER D , ALTENBACH J , BASHA FATIMA , CARROLL A , DRIZIN IRENE , KERWIN F , WENDT D , HAIGHT R , ZHANG WEIJIANG
IPC: A61K31/517 , A61K31/519 , A61P13/08 , A61P13/10 , A61P15/04 , A61P43/00 , C07D207/26 , C07D311/58 , C07D491/04 , C07D491/052 , C07D495/04 , C07D519/00 , A61K31/415
Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 adrenoreceptors and treating BPH.
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公开(公告)号：DE69707497D1
公开(公告)日：2001-11-22
申请号：DE69707497
申请日：1997-12-04
Applicant: ABBOTT LAB
Inventor： MEYER D , ALTENBACH J , BASHA FATIMA , CARROLL A , DRIZIN IRENE , KERWIN F , WENDT D , HAIGHT R , ZHANG WEIJIANG
IPC: A61K31/517 , A61K31/519 , A61P13/08 , A61P13/10 , A61P15/04 , A61P43/00 , C07D207/26 , C07D311/58 , C07D491/04 , C07D491/052 , C07D495/04 , C07D519/00 , A61K31/415
Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 adrenoreceptors and treating BPH.
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公开(公告)号：BR9713682A
公开(公告)日：2000-03-28
申请号：BR9713682
申请日：1997-12-04
Applicant: ABBOTT LAB
Inventor： MEYER MICHAEL D , ALTENBACH ROBERT J , BASHA FATIMA , CARROLL WILLIAM A , DRIZIN IRENE , KERWIN JAMES F , WENDT MICHAEL D , HAIGHT ANTHONY R , ZHANG WEIJIANG
IPC: A61K31/415 , C07D491/04
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