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1.发明专利
公开(公告)号：UY32681A
公开(公告)日：2011-02-28
申请号：UY32681
申请日：2010-06-02
Applicant: ABBOTT LAB
Inventor： MANTEI ROBERT A , MILAN BRUNCKO , HONG DING , DOHERTY GEORGE A , ELMORE STEVEN W , LISA HASVOLD , LAURA HEXAMER , KUNZER AARON R , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , SOUERS ANDREW J , SULLIVAN GERARD M , XILU WANG , WENDT MICHAEL D , WANG GARY T , LE WANG , HANSEN TODD M , XIAOHLONG SONG , YUJIA DAI , TAO ZHI-FU
IPC: A61P35/00 , C07D207/04 , C07D209/04 , C07D211/06 , C07D215/02 , C07D217/00 , C07D231/54 , C07D235/04 , C07D241/10 , C07D277/60 , C07D295/04 , C07D305/02 , C07D309/04 , C07D319/10 , C07D403/00 , C07D405/00 , C07D417/10
Abstract: Compuestos que inhiben la actividad de proteínas anti-apoptóticas Bcl-2, composiciones que contienen a dichos compuestos y métodos de tratamiento de enfermedades durante cuyo transcurso hay expresión de la proteína anti-apoptótica Bcl-2.
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公开(公告)号：BR112012013457A2
公开(公告)日：2020-08-25
申请号：BR112012013457
申请日：2010-06-01
Applicant: ABBOTT LAB
Inventor： AARON KUNZER , ANDREW J SOUERS , ANDREW M PETROS , CHANG H PARK , CHEOL-MIN PARK , GARY T WANG , GEORGE A DOHERTY , GERARD M SULLIVAN , HONG DING , LAURA HEXAMER , LE WANG , LISA HASVOLD , MICHAEL D WENDT , MILAN BRUNCKO , ROBERT A MANTEI , STEVEN W ELMORE , TODD M HANSEN , WILLIAM J MCCLELLAN , XIAOHONG SONG , XILU WANG , ZHI-FU TAO
IPC: C07D209/32 , A61K31/404 , A61P35/00 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/14 , C07D309/14 , C07D401/12 , C07D405/12 , C07D405/14
Abstract: derivados de sulfonamida como agentes indutores de apoptose bcl-2-seletivos para o tratamento do câncer e doenças imunes são divulgados compostos (i) que inibem a atividade de proteínas bcl-xl ou bcl-2 anti-apoptóticas, composições contendo os compostos e métodos de tratamento de doenças durante as quais é expressa proteína bcl-2 anti-apoptótica.
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公开(公告)号：UY32305A
公开(公告)日：2010-07-30
申请号：UY32305
申请日：2009-12-07
Applicant: ABBOTT LAB
Inventor： WANG GARY T , MANTEI ROBERT A , MILAN BRUNCKO , HONG DING , DOHERTY GEORGE A , ELMORE STEVEN W , LISA HASVOLD , LAURA HEXAMER , KUNZER AARON R , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , XIAOHONG SONG , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , LE WANG , XILU WANG , WENDT MICHAEL D
IPC: A61K31/635 , A61P35/00 , C04B35/632 , C07C311/51 , C07D211/44 , C07D213/00 , C07D295/14 , C07D413/12
Abstract: Compuestos que inhiben la actividad de las proteínas anti-apoptóticas Bcl-2 o Bc1-XL, composiciones que contienen dichos compuestos y métodos para tratar enfermedades durante las cuales se expresa la proteína anti-apoptótica Bcl-2
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4.发明专利
公开(公告)号：CR20110352A
公开(公告)日：2011-10-27
申请号：CR20110352
申请日：2011-06-22
Applicant: ABBOTT LAB
Inventor： MILAN BRUNCKO , YUJIA DAI , HONG DING , GEORGE A DOHERTY , STEVEN W ELMORE , LISA HASVOLD , LAURA HEXAMER , AARON R KUNZER , ROBERT A MANTEI , WILLIAM J MCCLELLAN , CHANG H PARK , CHEOL-MIN PARK , ANDREW M PETROS , XIAOHONG SONG , ANDREW J SOUERS , GERARD M SULLIVAN , ZHI-FU TAO , GARY T WANG , LE WANG , XILU WANG , MICAHEL D WENDT
IPC: A61K31/496 , A61P35/00 , C07D403/12
Abstract: Compuestos que inhiben la actividad de proteínas anti-apoptóticas Bcl-2, composiciones que contienen a dichos compuestos y métodos de tratamiento de enfermedades durante cuyo transcurso hay expresión de la proteína anti-apoptótica Bcl-2.
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公开(公告)号：AU2010204555A1
公开(公告)日：2011-08-04
申请号：AU2010204555
申请日：2010-01-15
Applicant: ABBOTT LAB
Inventor： KUNZER AARON R , ELMORE STEVEN W , LAURA HEXAMER , CHEOL-MIN PARK , SOUERS ANDREW J , SULLIVAN GERARD M , WANG GARY T , XILU WANG , WENDT MICHAEL D
IPC: C07C311/51 , A61K31/18 , A61P35/00 , C07D207/36 , C07D211/96 , C07D231/18 , C07D261/10 , C07D275/03 , C07D277/36 , C07D285/125 , C07D285/135 , C07D295/155 , C07D295/26 , C07D333/34
Abstract: Disclosed are compounds of Formula (1), in which A, Z, Z, Z, Z, L and Z are as defined in the claims, which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and their use in treating diseases during which anti-apoptotic Bcl-2 protein is expressed.
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Patent Agency Ranking
公开(公告)号：AU2009322269A1
公开(公告)日：2011-06-30
申请号：AU2009322269
申请日：2009-12-04
Applicant: ABBOTT LAB
Inventor： MILAN BRUNCKO , YUJIA DAI , HONG DING , DOHERTY GEORGE A , ELMORE STEVEN W , LISA HASVOLD , LAURA HEXAMER , KUNZER AARON R , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PARK CHANG H , CHEOL-MIN PARK , PETROS ANDREW M , XIAOHONG SONG , SOUERS ANDREW J , SULLIVAN GERARD M , ZHI-FU TAO , WANG GARY T , LE WANG , XILU WANG , WENDT MICHAEL D
IPC: A61P35/00 , A61K31/496 , C07D403/12
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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">7.发明专利
公开(公告)号：BRPI1006116A2
公开(公告)日：2018-03-13
申请号：BRPI1006116
申请日：2010-01-15
Applicant: ABBOTT LAB
Inventor： AAARON R KUNZER , ANDREW J SOUERS , GERARD M SULLIVAN , HONG DING , LAURA HEXAMER , MICHAEL D WENDT , STEVEN W ELMORE , XIAOHONG SONG , ZHI-FU TAO
IPC: A61K31/635 , A61P35/00 , C07D209/08 , C07D213/71 , C07D231/56 , C07D235/04 , C07D265/02 , C07D285/14 , C07D295/155 , C07D311/14
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公开(公告)号：BRPI1006115A2
公开(公告)日：2017-05-30
申请号：BRPI1006115
申请日：2010-01-15
Applicant: ABBOTT LAB
Inventor： ANDREW J SOUERS , AAARON R KUNZER , CHEOL-MIN PARK , GARY T WANG , GERARD M SULLIVAN , LAURA HEXAMER , MICHAEL D WENDT , STEVEN W ELMORE , XILU WANG
IPC: A61K31/18 , A61P35/00 , C07C311/51 , C07D207/36 , C07D211/96 , C07D231/18 , C07D261/10 , C07D275/03 , C07D277/36 , C07D285/125 , C07D285/135 , C07D295/155 , C07D295/26 , C07D333/34
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公开(公告)号：UY33047A
公开(公告)日：2011-09-30
申请号：UY33047
申请日：2010-11-23
Applicant: ABBOTT LAB
Inventor： MILAN BRUNCKO , GEORGE DOHERTY , STEVEN ELMORE , LISA HASVOLD , LAURA HEXAMER , KUNZER AARON R , SOUERS ANDREW J , GERARD SULLIVAN , WANG GARY T , LE WANG , XILU WANG , MICHAEL WENDT , ROBERT MANTEI , HONG DING , XIAOHONG SONG , ZHI-FU TAO , HANSEN TODD M
IPC: A61K31/403 , A61K31/437 , A61P37/00 , C07D209/04 , C07D295/00 , C07D309/04 , C07D319/12 , C07D405/14 , C07D413/14 , C07D471/02
Abstract: Compuestos que inhiben la actividad de las proteínas anti-apoptóticas Bcl-2, composiciones que contienen dichos compuestos y métodos para tratar enfermedades durante las cuales se expresa la proteína anti-apoptótica Bcl-2.
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10.发明专利
公开(公告)号：AU2010204554A1
公开(公告)日：2011-07-14
申请号：AU2010204554
申请日：2010-01-15
Applicant: ABBOTT LAB
Inventor： LAURA HEXAMER , HONG DING , ELMORE STEVEN W , KUNZER AARON R , XIAOHONG SONG , SOUERS ANDREW J , SULLIVAN GERARD M , ZHI-FU TAO , WENDT MICHAEL D
IPC: C07D209/08 , A61K31/635 , A61P35/00 , C07D213/71 , C07D231/56 , C07D235/04 , C07D265/02 , C07D285/14 , C07D295/155 , C07D311/14
Abstract: Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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