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1.发明专利
公开(公告)号：SK286686B6
公开(公告)日：2009-03-05
申请号：SK8232003
申请日：2001-11-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY STEPHEN L II , HASVOLD LISA A , LI QUN , LI TOMGMEI , LIN NAN-HORNG , MANTEI ROBERT A , ROCKWAY TODD W , SHAM HING L , SULLIVAN GERARD M , TONG YUNSONG , WANG GARY T , WANG LE , WANG XILU , WANG WEIBO
IPC: C07D233/00 , A61K31/00 , A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/00 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Disclosed are substituted imidazoles and thiazoles having formula (I) useful for inhibiting farnesyltransferase and also disclosed are farnesyltransferase-inhibiting compositions and the use these compounds in the production of medicaments for inhibiting farnesyltransferase.
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公开(公告)号：HU0600331A2
公开(公告)日：2006-10-28
申请号：HU0600331
申请日：2001-11-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY STEPHEN L II , HASVOLD LISA A , LI QUN , LI TOMGMEI , LIN NAN-HORNG , MANTEI ROBERT A , ROCKWAY TODD W , SHAM HING L VERNON HILLS , SULLIVAN GERARD M , TONG YUNSONG , WANG GARY T , WANG LE , WANG XILU , WANG WEIBO
IPC: C07D233/64 , A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
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公开(公告)号：HK1059260A1
公开(公告)日：2004-06-25
申请号：HK04100551
申请日：2004-01-27
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY STEPHEN L II , HASVOLD LISA A , LI QUN , LI TOMGMEI , LIN NAN-HORNG , MANTEI ROBERT A , ROCKWAY TODD W , SHAM HING L , SULLIVAN GERARD M , TONG YUNSONG , WANG GARY T , WANG LE , WANG XILU , WANG WEIBO
IPC: C07D20060101 , A61K20060101 , A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P20060101 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
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公开(公告)号：SK8232003A3
公开(公告)日：2004-01-08
申请号：SK8232003
申请日：2001-11-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY STEPHEN L II , HASVOLD LISA A , LI QUN , LI TOMGMEI , LIN NAN-HORNG , MANTEI ROBERT A , ROCKWAY TODD W , SHAM HING L , SULLIVAN GERARD M , TONG YUNSONG , WANG GARY T , WANG LE , WANG XILU , WANG WEIBO
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
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公开(公告)号：CZ20031804A3
公开(公告)日：2003-11-12
申请号：CZ20031804
申请日：2001-11-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY STEPHEN L II , HASVOLD LISA A , LI QUN , LI TOMGMEI , LIN NAN-HORNG , MANTEL ROBERT A , ROCKWAY TODD W , SHAM HING L , SULLIVAN GERARD M , TONG YUNSONG , WANG GARY T , WANG LE , WANG XILU , WANG WEIBO
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
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Patent Agency Ranking
公开(公告)号：CA2430619A1
公开(公告)日：2002-09-26
申请号：CA2430619
申请日：2001-11-30
Applicant: ABBOTT LAB
Inventor： LI QUN , SULLIVAN GERARD M , HASVOLD LISA A , GWALTNEY STEPHEN L II , CLAIBORNE AKIYO K , WANG XILU , WANG LE , WANG GARY T , LI TOMGMEI , LIN NAN-HORNG , SHAM HING L , TONG YUNSONG , ROCKWAY TODD W , MANTEI ROBERT A , WANG WEIBO
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Substituted imidazoles and thiazoles having formula (I), are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase- inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
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公开(公告)号：SA1686B1
公开(公告)日：2007-01-27
申请号：SA01220565
申请日：2001-12-02
Applicant: ABBOTT LAB
Inventor： CLAIBORN AKIYO K , GWALTNEY STEPHEN L , HASVOLD LISA A , LI QUN , LI TONGMEI , GIN NAN- HORNG , MANTEI ROBERT A , ROCKWAY TODD W , SHAM HING L , SULLIVAN GERARD M , TONGG YUNSONG , WANG RAY T , WANG LE , WANG XILU , WANG WEIBO
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: الملخص: يتعلقالاختراعالراهنبمركباتإيميدازول imidazoles وثيازول thiazoles تحملبدائللهاالصيغةوطرقلتثبيطأنزيمنقلالفارنسيلfranesylransferase فيمريض.وهيمفيدةلتثبيطأنزيمنقلالفارنسيلكمايتعلقالاختراعبتراكيبسطأنزيمنقلالفارنسيل franesyltransferase
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公开(公告)号：SI1339695T1
公开(公告)日：2006-10-31
申请号：SI200130573
申请日：2001-11-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY STEPHEN , HASVOLD LISA A , LI QUN , LI TOMGMEI , LIN NAN-HORNG , MANTEI ROBERT A , ROCKWAY TODD W , SHAM HING L , SULLIVAN GERARD M , TONG YUNSONG , WANG GARY T , WANG LE , WANG XILU , WANG WEIBO
IPC: C07D233/00 , A61K31/00 , A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/00 , C07D401/12 , C07D405/12 , C07D409/12
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公开(公告)号：ZA200304270B
公开(公告)日：2004-08-30
申请号：ZA200304270
申请日：2003-05-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , HASVOLD LISA A , LI TOMGMEI , MANTEI ROBERT A , SHAM HING L , TONG YUNSONG , WANG LE , WANG WEIBO , GWALTNEY STEPHEN L II , LI QUN , LIN NAN-HORNG , ROCKWAY TODD W , SULLIVAN GERARD M , WANG GARY T , WANG XILU
IPC: A61K20060101 , A61P20060101 , C07D20060101 , C07D , A61K , A61P
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公开(公告)号：PE20020687A1
公开(公告)日：2002-08-03
申请号：PE2001001198
申请日：2001-11-29
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY II STEPHEN L , LI QUN , LIN NAN-HORNG , ROCKWAY TODD W , SULLIVAN GERARD M , WANG GARY T , WANG XILU , WANG WEIBO , WANG LE , TONG YUNSONG , SHAM HING L , MANTEI ROBERT A , LI TONGMEI , HASVOLD LISA A
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12 , C07D401/01
Abstract: SE REFIERE A IMIDAZOLES Y TIAZOLES DE FORMULA I DONDE E ES UN ANILLO CARBOCICLICO AROMATICO O NO AROMATICO DE CINCO, SEIS O SIETE MIEMBROS DONDE ENTRE 0-3 ATOMOS DE CARBONO ESTAN REEMPLAZADOS POR NITROGENO; F Y G SON C Y N CON LA SALVEDAD DE QUE CUANDO UNO DE F Y G ES N EL OTRO ES C; L1 Y L2 SON ALQUENILENO, ALQUINILENO, O, NR9, C(O), S, ENTRE OTROS; X ES S, NR7; R1 ES ARILO, ARILALQUILO, HETEROCICLO, (HETEROCICLO)ALQUILO; R2 ES H, ALCOXI, ALQUILO, AMINO, AMINOALQUILO, CIANO, CIANOALQUILO, ENTRE OTROS; R3 ES ARILO, HETEROCICLO Y CICLOALQUILO; R4-R6 SON H, NR9C(O), C(N)NR9, ALCANOILO, ALQUENILO, ENTRE OTROS; R7 ES H, ALQUILO, ARILO, CICLOALQUILO, ENTRE OTROS; R9 ES H, ALCOXIALQUILO, ALQUILO, AMIDOALQUILO, ENTRE OTROS; R12 ES H, ALCOXI, ALQUILO, ENTRE OTROS; m, n, p, q SON 0-4. SON COMPUESTOS PREFERIDOS 4-(((6-CLORO-2-(3-CLOROFENIL)-3-PIRIDINIL)METOXI)(1-METIL-1H-IMIDAZOL-5-IL)METIL)BENZONITRILO, 4-(((2-(3-CLOROFENIL)-6-METIL-3-PIRIDINIL)METOXI)(1-METIL-1H-IMIDAZOL-5-IL)METIL)BENZONITRILO, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE LA FARNESIL TRANSFERASA Y SON UTILES PARA EL TRATAMIENTO DE TUMORES
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