公开(公告)号：DE3462688D1

公开(公告)日：1987-04-23

申请号：DE3462688

申请日：1984-12-10

Applicant: BASF AG

Inventor： KREISKOTT HORST PROF DR ,  SEITZ WERNER DR ,  RASCHACK MANFRED DR

IPC: C07B57/00 ,  A61K20060101 ,  A61K31/275 ,  A61P9/00 ,  C07B31/00 ,  C07C20060101 ,  C07C67/00 ,  C07C253/00 ,  C07C255/32 ,  C07C255/42 ,  C07C255/58 ,  C07D20060101 ,  C07C121/66

Abstract: 1,7-diphenyl-3-methylaza-7-cyano-8-methylnonane and its antipodes and salts are used for the treatment of diseases.

公开(公告)号：DE3243518A1

公开(公告)日：1984-05-30

申请号：DE3243518

申请日：1982-11-25

Applicant: BASF AG

Inventor： SEITZ WERNER DR ,  MICHEL ALFRED ,  TESCHENDORF HANS-JUERGEN DR ME ,  KREISKOTT HORST PROF DR ,  HOFMANN HANS PETER DR ,  TRAUT MARTIN DR

IPC: C07C225/18 ,  A61K31/135 ,  A61K31/205 ,  A61K31/395 ,  A61P25/24 ,  A61P25/26 ,  C07D207/08 ,  C07D211/32 ,  C07D295/10 ,  C07D295/116 ,  C07D295/12 ,  C07D295/145 ,  C07C97/10

Abstract: 1-Oxo-2-phenyl-2-(2-alkylaminoethyl)-1,2,3,4-tetrahydronaphthalenes of the formula I I where R1 and R2 are identical or different and are each hydrogen, halogen, trifluoromethyl, C1-C4-alkyl or C1-C4-alkoxy, R3 is C1-C6-alkyl and R4 is hydrogen, C1-C6-alkyl or benzyl, or R3 and R4 together may furthermore be a C2-C5-alkylene chain, and their salts with physiologically tolerated acids, and their preparation, are described. The novel compounds are useful active compounds for treating disorders.

公开(公告)号：DE3362130D1

公开(公告)日：1986-03-27

申请号：DE3362130

申请日：1983-11-11

Applicant: BASF AG

Inventor： TREIBER HANS JOERG DR ,  HOFMANN HANS PETER DR ,  KREISKOTT HORST PROF DR ,  TESCHENDORF HANS-JUERGEN DR ,  TRAUT MARTIN DR

IPC: A61K31/55 ,  A61P25/24 ,  A61P25/26 ,  C07D267/08 ,  C07D267/10

公开(公告)号：DE3361181D1

公开(公告)日：1985-12-12

申请号：DE3361181

申请日：1983-11-17

Applicant: BASF AG

Inventor： SEITZ WERNER DR ,  TESCHENDORF HANS-JUERGEN DR ,  MICHEL ALFRED DR ,  TRAUT MARTIN DR ,  HOFMANN HANS PETER DR ,  KREISKOTT HORST PROF DR

IPC: C07C225/18 ,  A61K31/135 ,  A61K31/205 ,  A61K31/395 ,  A61P25/24 ,  A61P25/26 ,  C07D207/08 ,  C07D211/32 ,  C07D295/10 ,  C07D295/116 ,  C07D295/12 ,  C07D295/145 ,  C07C97/10

Abstract: 1-Oxo-2-phenyl-2-(2-alkylaminoethyl)-1,2,3,4-tetrahydronaphthalenes of the formula I I where R1 and R2 are identical or different and are each hydrogen, halogen, trifluoromethyl, C1-C4-alkyl or C1-C4-alkoxy, R3 is C1-C6-alkyl and R4 is hydrogen, C1-C6-alkyl or benzyl, or R3 and R4 together may furthermore be a C2-C5-alkylene chain, and their salts with physiologically tolerated acids, and their preparation, are described. The novel compounds are useful active compounds for treating disorders.

公开(公告)号：DE3243158A1

公开(公告)日：1984-05-24

申请号：DE3243158

申请日：1982-11-23

Applicant: BASF AG

Inventor： SCHLECKER RAINER DR ,  SCHMIDT PETER DR ,  THIEME PETER C DR ,  LENKE DIETER PROF DR ,  TESCHENDORF HANS-JUERGEN DR ME ,  TRAUT MARTIN DR ,  MUELLER CLAUS D DR MED ,  HOFMANN HANS PETER DR ,  KREISKOTT HORST PROF DR

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/365 ,  A61K31/37 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  A61P37/08 ,  A61P43/00 ,  C07D311/08 ,  C07D311/16 ,  C07D311/78 ,  C07D311/80

Abstract: Sulfonates of hydroxycoumarins of the formula I (I) where R1 and R2 are identical or different and are each hydrogen, halogen or alkyl of 1 to 5 carbon atoms which can be substituted by -NR4R5, -OR4 or -OC(O)R4, where R4 and R5 are identical or different and are each hydrogen or alkyl of 1 to 4 carbon atoms, or R1 and R2 are each a carboxylic acid group -OC(O)R4 or a carboxamido radical, with the proviso that R1 is not methyl when R2 is hydrogen, or R1 and R2 together form a -(CH2)n- chain where n is 3-5, and R3 is a straight-chain or branched alkyl radical of 1 to 8 carbon atoms or cycloalkyl of 3 to 8 carbon atoms, each of which can be substituted by halogen, -OR4, -NR4R5, -CN or phenyl, or R3 is a straight-chain or branched alkenyl radical of 3 to 8 carbon atoms, an amino group - NR4R5, or phenyl or naphthyl, each of which is unsubstituted or monosubstituted or polysubstituted by -OR4, -NR4R5, -NO2, halogen, -SR4, -S(O)R4, -OS(O)R4, -SCF3, -OS(O)CF3, -CN, -C(O)R4, -OC(O)R4, -NHC(O)R4, -CF3, C1-C4-alkyl or a combination of these substituents, a process for their preparation, drugs containing these compounds, and compounds of the formula I, in which R1 is methyl and R2 is hydrogen, for use as drugs.

公开(公告)号：AT17945T

公开(公告)日：1986-02-15

申请号：AT83111275

申请日：1983-11-11

Applicant: BASF AG

Inventor： TREIBER HANS JOERG DR ,  HOFMANN HANS PETER DR ,  KREISKOTT HORST PROF DR ,  TESCHENDORF HANS-JUERGEN DR ,  TRAUT MARTIN DR

IPC: A61K31/55 ,  A61P25/24 ,  A61P25/26 ,  C07D267/08 ,  C07D267/10

公开(公告)号：AT16382T

公开(公告)日：1985-11-15

申请号：AT83111501

申请日：1983-11-17

Applicant: BASF AG

Inventor： SEITZ WERNER DR ,  TESCHENDORF HANS-JUERGEN DR ,  MICHEL ALFRED DR ,  TRAUT MARTIN DR ,  HOFMANN HANS PETER DR ,  KREISKOTT HORST PROF DR

IPC: C07C225/18 ,  A61K31/135 ,  A61K31/205 ,  A61K31/395 ,  A61P25/24 ,  A61P25/26 ,  C07D207/08 ,  C07D211/32 ,  C07D295/10 ,  C07D295/116 ,  C07D295/12 ,  C07D295/145 ,  C07C97/10

公开(公告)号：DE3360991D1

公开(公告)日：1985-11-14

申请号：DE3360991

申请日：1983-11-11

Applicant: BASF AG

Inventor： TREIBER HANS JOERG DR ,  HOFMANN HANS PETER DR ,  KREISKOTT HORST PROF DR ,  TESCHENDORF HANS-JURGEN DR ,  TRAUT MARTIN DR

IPC: A61K31/13 ,  A61K31/135 ,  A61K31/215 ,  A61K31/265 ,  A61P25/24 ,  A61P25/26 ,  C07C47/00 ,  C07C67/00 ,  C07C213/00 ,  C07C217/30 ,  C07C217/48 ,  C07C219/22 ,  C07C239/00 ,  C07C271/10 ,  C07C313/00 ,  C07C319/20 ,  C07C323/12 ,  C07C323/25 ,  C07D295/08 ,  C07D295/084 ,  C07D295/10 ,  C07D295/104 ,  C07C93/00 ,  C07C125/065 ,  C07C149/00

公开(公告)号：DE3226242A1

公开(公告)日：1984-01-26

申请号：DE3226242

申请日：1982-07-14

Applicant: BASF AG

Inventor： ALBRECHT HANS PETER DR ,  KREISKOTT HORST PROF DR

IPC: A61K38/00 ,  A61P25/00 ,  C07K1/00 ,  C07K5/06 ,  C07K5/08 ,  C07K5/097 ,  C07C103/52 ,  A61K37/02

公开(公告)号：DE3373655D1

公开(公告)日：1987-10-22

申请号：DE3373655

申请日：1983-11-12

Applicant: BASF AG

Inventor： SCHLECKER RAINER DR ,  SCHMIDT PETER DR ,  THIEME PETER C DR ,  LENKE DIETER PROF DR ,  TESCHENDORF HANS-JURGEN DR ,  TRAUT MARTIN DR ,  MUELLER CLAUS D DR ,  HOFMANN HANS PETER DR ,  KREISKOTT HORST PROF DR

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/365 ,  A61K31/37 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  A61P37/08 ,  A61P43/00 ,  C07D311/08 ,  C07D311/16 ,  C07D311/78 ,  C07D311/80

Abstract: Sulfonates of hydroxycoumarins of the formula I (I) where R1 and R2 are identical or different and are each hydrogen, halogen or alkyl of 1 to 5 carbon atoms which can be substituted by -NR4R5, -OR4 or -OC(O)R4, where R4 and R5 are identical or different and are each hydrogen or alkyl of 1 to 4 carbon atoms, or R1 and R2 are each a carboxylic acid group -OC(O)R4 or a carboxamido radical, with the proviso that R1 is not methyl when R2 is hydrogen, or R1 and R2 together form a -(CH2)n- chain where n is 3-5, and R3 is a straight-chain or branched alkyl radical of 1 to 8 carbon atoms or cycloalkyl of 3 to 8 carbon atoms, each of which can be substituted by halogen, -OR4, -NR4R5, -CN or phenyl, or R3 is a straight-chain or branched alkenyl radical of 3 to 8 carbon atoms, an amino group - NR4R5, or phenyl or naphthyl, each of which is unsubstituted or monosubstituted or polysubstituted by -OR4, -NR4R5, -NO2, halogen, -SR4, -S(O)R4, -OS(O)R4, -SCF3, -OS(O)CF3, -CN, -C(O)R4, -OC(O)R4, -NHC(O)R4, -CF3, C1-C4-alkyl or a combination of these substituents, a process for their preparation, drugs containing these compounds, and compounds of the formula I, in which R1 is methyl and R2 is hydrogen, for use as drugs.